Koichi Sasaki
@ko1ssk.bsky.social
Postdoc @ImperialBioeng. PhD @KyushuUniv. Developing molecular biotech to tackle diseases. 佐々木 光一 @Ko1Sasaki on X.
IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy: Immunity www.cell.com/immunity/ful...
IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy
Cytokines optimize and fine-tune effector T cell responses. Here, Jiang et al. utilize
IL-9, with scarce receptor expression in normal tissues, to boost IL-9R engineered
T cells for cancer therapy. IL...
www.cell.com
November 22, 2025 at 3:01 PM
IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy: Immunity www.cell.com/immunity/ful...
Reposted by Koichi Sasaki
Could CAR-T cells carrying collagen targeted IL-12 be a safe therapy for #ProstateCancer?
A team including Prostate Cancer UK fellow @Ko1ssk.bsky.social & Jun Ishihara @imperialcollegeldn.bsky.social share new results in @natbiomedeng.nature.com.
Grab a ☕ and read:
doi.org/10.1038/s415...
A team including Prostate Cancer UK fellow @Ko1ssk.bsky.social & Jun Ishihara @imperialcollegeldn.bsky.social share new results in @natbiomedeng.nature.com.
Grab a ☕ and read:
doi.org/10.1038/s415...
November 11, 2025 at 5:01 PM
Could CAR-T cells carrying collagen targeted IL-12 be a safe therapy for #ProstateCancer?
A team including Prostate Cancer UK fellow @Ko1ssk.bsky.social & Jun Ishihara @imperialcollegeldn.bsky.social share new results in @natbiomedeng.nature.com.
Grab a ☕ and read:
doi.org/10.1038/s415...
A team including Prostate Cancer UK fellow @Ko1ssk.bsky.social & Jun Ishihara @imperialcollegeldn.bsky.social share new results in @natbiomedeng.nature.com.
Grab a ☕ and read:
doi.org/10.1038/s415...
Reposted by Koichi Sasaki
@natbiomedeng.nature.com had a 🔥🔥 week this week! Why don't we have any followers on this site 😆😭
October 24, 2025 at 11:26 PM
@natbiomedeng.nature.com had a 🔥🔥 week this week! Why don't we have any followers on this site 😆😭
Reposted by Koichi Sasaki
So far, immune cells that have been engineered to kill cancers, known as CAR T-cells, haven’t worked well against solid cancers - but a study in mice suggests that could soon change
'Weaponised' CAR T-cell therapy shows promise against solid tumours
So far, immune cells that have been engineered to kill cancers, known as CAR T-cells, haven’t worked well against solid cancers - but a study in mice suggests that could soon change
www.newscientist.com
October 24, 2025 at 8:46 AM
So far, immune cells that have been engineered to kill cancers, known as CAR T-cells, haven’t worked well against solid cancers - but a study in mice suggests that could soon change
Glad to see our work on an advanced CAR-T cell therapy for prostate cancer out now @natbiomedeng.nature.com (www.nature.com/articles/s41...). We will continue to work on developing safer and more efficacious immunotherapies!
Collagen-binding IL-12-armoured STEAP1 CAR-T cells reduce toxicity and treat prostate cancer in mouse models - Nature Biomedical Engineering
CAR-T cells are engineered to express CBD-IL-12 upon STEAP1 recognition to enhance tumour-specific immune responses in mice.
www.nature.com
October 23, 2025 at 6:07 PM
Glad to see our work on an advanced CAR-T cell therapy for prostate cancer out now @natbiomedeng.nature.com (www.nature.com/articles/s41...). We will continue to work on developing safer and more efficacious immunotherapies!
Reposted by Koichi Sasaki
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues
go.nature.com/3VNrH1s
go.nature.com/3VNrH1s
Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.
go.nature.com
October 6, 2025 at 10:52 AM
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues
go.nature.com/3VNrH1s
go.nature.com/3VNrH1s
Reposted by Koichi Sasaki
Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 3, 2025 at 12:11 AM
Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Koichi Sasaki
Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...
May 30, 2025 at 11:37 AM
Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...
Reposted by Koichi Sasaki
1/10 Today in @science.org in collaboration with
the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...
the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...
May 15, 2025 at 10:49 PM
1/10 Today in @science.org in collaboration with
the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...
the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...
Reposted by Koichi Sasaki
Protein editing using a coordinated transposition reaction | Science www.science.org/doi/10.1126/...
Protein editing using a coordinated transposition reaction
Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding step...
www.science.org
April 4, 2025 at 10:37 AM
Protein editing using a coordinated transposition reaction | Science www.science.org/doi/10.1126/...
Reposted by Koichi Sasaki
CAR trogocytosis transfers antitumor immunity between T cells and is dictated by their transmembrane domain
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
January 31, 2025 at 11:25 PM
CAR trogocytosis transfers antitumor immunity between T cells and is dictated by their transmembrane domain
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social
www.science.org/doi/10.1126/...