Klaus Groschner
@kgroschner.bsky.social
Semiretired Biophysicist and Pharmacologist; enthusiastic grandfather
https://orcid.org/0000-0002-8659-377X
https://orcid.org/0000-0002-8659-377X
Excited to share our recent findings about high efficiency coupling between Ca2+ entry and NFAT signaling within TRPC6 nanodomains. Just published - great job by Denis Krivic. Special thanks to our collaborators Roland Malli and Johannes Pilic.
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
www.frontiersin.org
July 24, 2025 at 1:04 PM
Excited to share our recent findings about high efficiency coupling between Ca2+ entry and NFAT signaling within TRPC6 nanodomains. Just published - great job by Denis Krivic. Special thanks to our collaborators Roland Malli and Johannes Pilic.
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
Once again, the focus is on the complex interactions between alcohol and cellular signaling. Manuscripts are now being accepted for a special issue of Biomolecules. The issue will summarize recent advances in understanding the molecular basis of alcohol-induced impairment of cardiovascular health.
www.mdpi.com
June 23, 2025 at 6:37 PM
Once again, the focus is on the complex interactions between alcohol and cellular signaling. Manuscripts are now being accepted for a special issue of Biomolecules. The issue will summarize recent advances in understanding the molecular basis of alcohol-induced impairment of cardiovascular health.
Reposted by Klaus Groschner
Was schützt vor Desinformation?
Ein starker, unabhängiger öffentlich-rechtlicher Rundfunk trägt mit dazu bei, Menschen vor Fehl- und Desinformation zu schützen
Deshalb: Hier kann man die Petition „Unser ORF“ unterstützen, und sich gegen eine Zerstörung des ORF aussprechen
Empfehlung!
Ein starker, unabhängiger öffentlich-rechtlicher Rundfunk trägt mit dazu bei, Menschen vor Fehl- und Desinformation zu schützen
Deshalb: Hier kann man die Petition „Unser ORF“ unterstützen, und sich gegen eine Zerstörung des ORF aussprechen
Empfehlung!
Unser ORF - unsere Demokratie
Jetzt Petition unterzeichnen und Verhandler:innen kontaktieren!
www.unser-orf.at
January 31, 2025 at 12:09 PM
Was schützt vor Desinformation?
Ein starker, unabhängiger öffentlich-rechtlicher Rundfunk trägt mit dazu bei, Menschen vor Fehl- und Desinformation zu schützen
Deshalb: Hier kann man die Petition „Unser ORF“ unterstützen, und sich gegen eine Zerstörung des ORF aussprechen
Empfehlung!
Ein starker, unabhängiger öffentlich-rechtlicher Rundfunk trägt mit dazu bei, Menschen vor Fehl- und Desinformation zu schützen
Deshalb: Hier kann man die Petition „Unser ORF“ unterstützen, und sich gegen eine Zerstörung des ORF aussprechen
Empfehlung!
Great contribution to the TRPC field by the Soboloff Lab - congrats to all and thanks for the collaboration!
pubmed.ncbi.nlm.nih.gov/39813349/
pubmed.ncbi.nlm.nih.gov/39813349/
Targeting TRPC channels for control of arthritis-induced bone erosion - PubMed
Arthritis leads to bone erosion due to an imbalance between osteoclast and osteoblast function. Our prior investigations revealed that the Ca<sup>2+</sup>-selective ion channel, Orai1, is critical for...
pubmed.ncbi.nlm.nih.gov
January 16, 2025 at 5:06 PM
Great contribution to the TRPC field by the Soboloff Lab - congrats to all and thanks for the collaboration!
pubmed.ncbi.nlm.nih.gov/39813349/
pubmed.ncbi.nlm.nih.gov/39813349/
Reposted by Klaus Groschner
A remarkable genetic model provides an important message to researchers in the TRPC field - have a look:
pubmed.ncbi.nlm.nih.gov/39602257/t
pubmed.ncbi.nlm.nih.gov/39602257/t
Genetic evidence against involvement of TRPC proteins in SOCE, ROCE, and CRAC channel function - PubMed
Using genetically engineered mice and cell lines derived from genetically engineered mice we show that depletion of ER delimited Ca<sup>2+</sup> stores activates heteromeric Ca<sup>2+</sup> entry (SOC...
pubmed.ncbi.nlm.nih.gov
December 2, 2024 at 8:36 AM
A remarkable genetic model provides an important message to researchers in the TRPC field - have a look:
pubmed.ncbi.nlm.nih.gov/39602257/t
pubmed.ncbi.nlm.nih.gov/39602257/t
Reposted by Klaus Groschner
Ion Channels in Synaptic & Neural Circuit Physiology, June 2 - 22, 2025.
This is an intensive and fantastic patch-clamp course for new electrophysiologists. #ephys #patchclamp 🧪
meetings.cshl.edu/courses.aspx...
This is an intensive and fantastic patch-clamp course for new electrophysiologists. #ephys #patchclamp 🧪
meetings.cshl.edu/courses.aspx...
Ion Channels in Synaptic & Neural Circuit Physiology
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
November 30, 2024 at 7:16 PM
Hazel Erkan-Candag performed pioneering work in the field of lipid regulation of ion channels and defended her PhD thesis successfully today. Congratulations Dr. Hazel Erkan-Candag🥂 PhDone😊
November 28, 2024 at 7:18 PM
Hazel Erkan-Candag performed pioneering work in the field of lipid regulation of ion channels and defended her PhD thesis successfully today. Congratulations Dr. Hazel Erkan-Candag🥂 PhDone😊
Reposted by Klaus Groschner
This is really getting quite remarkable
• BlueSky user numbers have doubled in the past week and now total 3.5 million across US & UK 🚀
• Number of people deleting their X/Twitter account remains way up
And the next chart is particularly notable...
• BlueSky user numbers have doubled in the past week and now total 3.5 million across US & UK 🚀
• Number of people deleting their X/Twitter account remains way up
And the next chart is particularly notable...
November 19, 2024 at 9:39 PM
This is really getting quite remarkable
• BlueSky user numbers have doubled in the past week and now total 3.5 million across US & UK 🚀
• Number of people deleting their X/Twitter account remains way up
And the next chart is particularly notable...
• BlueSky user numbers have doubled in the past week and now total 3.5 million across US & UK 🚀
• Number of people deleting their X/Twitter account remains way up
And the next chart is particularly notable...
Those of you deeply interested in TRPCs and in particular in TRPC3 as a potential therapeutic target may have a look on my opinion - hope you enjoy!
www.tandfonline.com/eprint/PIBZK...
www.tandfonline.com/eprint/PIBZK...
TRPC3: how current mechanistic understanding provides a basis for therapeutic targeting
Intensive and detailed investigations of the molecular function and cellular role of mammalian transient receptor potential canonical (TRPC) channels started back in the early 90th of the past cent...
www.tandfonline.com
November 18, 2024 at 9:02 PM
Those of you deeply interested in TRPCs and in particular in TRPC3 as a potential therapeutic target may have a look on my opinion - hope you enjoy!
www.tandfonline.com/eprint/PIBZK...
www.tandfonline.com/eprint/PIBZK...