Location: Lincoln Memorial Park (Between the Capitol and Civic Center Park) **In America, we don’t put up with would-be kings.** NO KINGS is a national day of action and mass mobilization in response...

YouTube video by Senator Chris Murphy

Home>Infectious diseases>Infectious Diseases 2025>Computational modeling of H5 Influenza variants vs. HA1 antibodies eBioMedicine 2025;114: 105632 The H5N1 influenza virus poses a significant threat to public health due to its potential to shift from an epidemic to a pandemic. Since its emergence in the 1990s, H5N1 has demonstrated a concerning capacity for zoonotic transmission to humans. A new study published in eBioMedicine leverages high-performance computational modeling to investigate mutations in the virus's haemagglutinin (HA) protein and their implications for human immunity and healthcare preparedness. This research provides a comprehensive analysis of mutational dynamics in H5N1 influenza, emphasizing the binding interactions between HA1-neutralizing antibodies and diverse viral isolates collected over several decades. Using data from 18,693 sequences, the authors identified changes in antibody binding affinities and highlighted a trend of diminishing effectiveness in existing vaccine strategies. The study also includes phylogenetic analyses illustrating ongoing avian-to-mammalian transmission events. The findings reveal a significant decline in the binding affinity of neutralizing antibodies to H5N1 variants, indicating that the virus is evolving mechanisms to evade immune detection. Continuous transmission of H5N1 from birds to mammals, coupled with mutational changes in haemagglutinin, heightens the risk of future zoonotic spillover events, posing an ongoing threat to human health. The primary concern arising from this study is the observed trend of diminishing neutralizing antibody binding affinity against H5N1 variants. This decline in antibody effectiveness reflects the virus’s ongoing evolution, allowing it to evade immune detection and response. As H5N1 adapts through haemagglutinin mutations, existing neutralizing antibodies become less effective, increasing the risk of zoonotic transmission to humans and potentially leading to a rise in human infections.

The SAVE Act is a direct attack on voting rights, and we must stop it from passing!

“My family and I survived April 27, 2011, due in part to the work they do,” Britt wrote in a statement.

People who in were the Royal Columbian Hospital emergency department between 2:30 p.m. on March 3 and 2:30 a.m. March 4 may have been exposed.

Check out the info you need before coming to the People's House.

Human Rights lawyer Qasim Rashid’s Substack has provided an explanation of why Elon Musk and his minions messing with our private information at the Treasury Department is illegal, and also a template...

Members reportedly sought access to IT systems at agency that Project 2025 has called ‘harmful to US prosperity’

The U.S. State Department has approved the potential sale of Lockheed Martin and Northrop Grumman Corp's defense systems to Egypt, the Pentagon's Defense Security Cooperation Agency said on Tuesday.

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