Kentsis Research Group
@kentsisresearch.bsky.social
Human biology and cancer therapeutics group @MSKCancerCenter
+ @WeillCornellGS + @TPCB_NYC + @TriIMDPhD | + a bit of @oleg8r | Views our own | https://alexkentsis.net
+ @WeillCornellGS + @TPCB_NYC + @TriIMDPhD | + a bit of @oleg8r | Views our own | https://alexkentsis.net
Reposted by Kentsis Research Group
DNA damage provides a bright spot in rhabdoid & epithelioid sarcomas
Alex Kentsis @kentsisresearch.bsky.social @oleg8r.bsky.social show combined EZH2/ATR inhibition improves response in SMARCB1-deficient tumor models via epigenetic induction of transposase-derived PGBD5: www.jci.org/articles/vie...
Alex Kentsis @kentsisresearch.bsky.social @oleg8r.bsky.social show combined EZH2/ATR inhibition improves response in SMARCB1-deficient tumor models via epigenetic induction of transposase-derived PGBD5: www.jci.org/articles/vie...
October 23, 2025 at 4:15 PM
DNA damage provides a bright spot in rhabdoid & epithelioid sarcomas
Alex Kentsis @kentsisresearch.bsky.social @oleg8r.bsky.social show combined EZH2/ATR inhibition improves response in SMARCB1-deficient tumor models via epigenetic induction of transposase-derived PGBD5: www.jci.org/articles/vie...
Alex Kentsis @kentsisresearch.bsky.social @oleg8r.bsky.social show combined EZH2/ATR inhibition improves response in SMARCB1-deficient tumor models via epigenetic induction of transposase-derived PGBD5: www.jci.org/articles/vie...
Reposted by Kentsis Research Group
A summary of training, fellowship, and career development awards
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Fiscal year 2025 (compared to fiscal year 2024)
1/12
a dog is sitting on a rug in front of a brick wall and a plant .
ALT: a dog is sitting on a rug in front of a brick wall and a plant .
media.tenor.com
October 16, 2025 at 12:25 AM
A summary of training, fellowship, and career development awards
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Fiscal year 2025 (compared to fiscal year 2024)
1/12
Developmental Mutators: A unified theory of why young people develop cancer ☛ alexkentsis.net/lecture-deve...
Lecture: Developmental Mutators: A unified theory of why young people develop cancer - Kentsis Research Group at Memorial Sloan Kettering Cancer Center
Listen to my lecture at the St. Jude Science of Childhood Cancer Series
alexkentsis.net
September 23, 2025 at 10:42 PM
Developmental Mutators: A unified theory of why young people develop cancer ☛ alexkentsis.net/lecture-deve...
Reposted by Kentsis Research Group
@kentsisresearch.bsky.social develop a proteogenomics workflow to detect 1000s of unknown cancer proteins. PG3 combines long-read RNA sequencing with multi-protease MS to discover non-canonical proteins in cancer cells. Used a timsTOF HT, nanoElute 2 & Aurora Ultimate 25x75 column:
bit.ly/4mlQSmu
bit.ly/4mlQSmu
September 16, 2025 at 12:19 AM
@kentsisresearch.bsky.social develop a proteogenomics workflow to detect 1000s of unknown cancer proteins. PG3 combines long-read RNA sequencing with multi-protease MS to discover non-canonical proteins in cancer cells. Used a timsTOF HT, nanoElute 2 & Aurora Ultimate 25x75 column:
bit.ly/4mlQSmu
bit.ly/4mlQSmu
Reposted by Kentsis Research Group
A deep dive into the destruction of US cancer research by @jonathanmahler.bsky.social “It’s an absolutely unmitigated disaster,” a former top official at NIH told him. “It will take decades to recover from this, if we ever do.” Gift link: nyti.ms/48iH3Cr
nyti.ms
September 14, 2025 at 2:44 PM
A deep dive into the destruction of US cancer research by @jonathanmahler.bsky.social “It’s an absolutely unmitigated disaster,” a former top official at NIH told him. “It will take decades to recover from this, if we ever do.” Gift link: nyti.ms/48iH3Cr
Listen to my new lecture "Developmental mutagenesis: A unified theory of why young people develop cancer" as part of
@stjude.bsky.social @stjuderesearch.bsky.social
Science of Childhood Lecture Series on September 18, 2025: www.linkedin.com/events/73719...
@stjude.bsky.social @stjuderesearch.bsky.social
Science of Childhood Lecture Series on September 18, 2025: www.linkedin.com/events/73719...
LinkedIn Login, Sign in | LinkedIn
Login to LinkedIn to keep in touch with people you know, share ideas, and build your career.
www.linkedin.com
September 11, 2025 at 7:32 PM
Listen to my new lecture "Developmental mutagenesis: A unified theory of why young people develop cancer" as part of
@stjude.bsky.social @stjuderesearch.bsky.social
Science of Childhood Lecture Series on September 18, 2025: www.linkedin.com/events/73719...
@stjude.bsky.social @stjuderesearch.bsky.social
Science of Childhood Lecture Series on September 18, 2025: www.linkedin.com/events/73719...
Reposted by Kentsis Research Group
These are the most challenging times for early-career scientists and engineers.
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
August 11, 2025 at 11:54 AM
These are the most challenging times for early-career scientists and engineers.
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
Reposted by Kentsis Research Group
Patterns in genomic mutations among patients with early-onset colorectal cancer: an international, multicohort, observational study - The Lancet Oncology www.thelancet.com/journals/lan...
Patterns in genomic mutations among patients with early-onset colorectal cancer: an international, multicohort, observational study
Within hypermutated colorectal cancer, younger patients exhibited a higher mutational
burden than older patients. Our study reveals an abnormal accumulation of distinct
somatic mutations in hypermutat...
www.thelancet.com
August 11, 2025 at 11:49 AM
Patterns in genomic mutations among patients with early-onset colorectal cancer: an international, multicohort, observational study - The Lancet Oncology www.thelancet.com/journals/lan...
Reposted by Kentsis Research Group
NEW pub: The role of metabolism in shaping #enzyme structures over 400 million years. Now out in @nature.com
Super grateful to have played a small role in this project - congrats to lead/corr authors Oliver, Benjamin, and Markus!
www.nature.com/articles/s41...
#alphafold #evolution #genomics
Super grateful to have played a small role in this project - congrats to lead/corr authors Oliver, Benjamin, and Markus!
www.nature.com/articles/s41...
#alphafold #evolution #genomics
July 10, 2025 at 7:57 PM
NEW pub: The role of metabolism in shaping #enzyme structures over 400 million years. Now out in @nature.com
Super grateful to have played a small role in this project - congrats to lead/corr authors Oliver, Benjamin, and Markus!
www.nature.com/articles/s41...
#alphafold #evolution #genomics
Super grateful to have played a small role in this project - congrats to lead/corr authors Oliver, Benjamin, and Markus!
www.nature.com/articles/s41...
#alphafold #evolution #genomics
Reposted by Kentsis Research Group
Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵
Design principles of cell-state-specific enhancers in hematopoiesis
Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread
dual activator-repressor function of transcription factors (TFs) and enables the model-guided
design of cell-state-sp...
www.cell.com
May 8, 2025 at 4:07 PM
Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵
Supporting medical science in the USA - The Lancet www.thelancet.com/journals/lan...
Supporting medical science in the USA
The pursuit of rigorous medical science is not compatible with capitulation to government
demands aimed at weaponising and eroding science. On April 14, Edwin R Martin Jr,
the Trump-appointed interim ...
www.thelancet.com
April 25, 2025 at 10:55 PM
Supporting medical science in the USA - The Lancet www.thelancet.com/journals/lan...
What would the National Cancer Act look like today? Bravo Kevin Cullen! Act! cancerletter.com/guest-editor...
What would Mary do? Trump’s actions call for Lasker-style advocacy - The Cancer Letter
A diagnosis of cancer brings with it fear and uncertainty. Changes proposed by the Trump administration pose a grave new risk to those who suffer from cancer today or will suffer from cancer in the fu...
cancerletter.com
April 20, 2025 at 7:37 PM
What would the National Cancer Act look like today? Bravo Kevin Cullen! Act! cancerletter.com/guest-editor...
Reposted by Kentsis Research Group
New in @naturecomms.bsky.social: MSK's @kentsisresearch.bsky.social & collaborators identified a rare population of stem cells responsible for disease persistence & therapy resistance in acute myeloid leukemia (#AML), which could help improve treatment strategies: www.nature.com/articles/s41...
April 4, 2025 at 1:49 PM
New in @naturecomms.bsky.social: MSK's @kentsisresearch.bsky.social & collaborators identified a rare population of stem cells responsible for disease persistence & therapy resistance in acute myeloid leukemia (#AML), which could help improve treatment strategies: www.nature.com/articles/s41...
A new KRG study led by Sumiko Takao @naturecomms.bsky.social uncovers how epigenetic mechanisms control human leukemia stem cells (LSCs) that fuel therapy resistance in AML. www.nature.com/articles/s41...
Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance - Nature Communications
Acute myeloid leukemia (AML) arise from mutations of stem and progenitor cells. Here, authors identify a quiescent, label-retaining cell population in AML patient specimens that have tumor-initiation ...
www.nature.com
April 3, 2025 at 6:47 PM
A new KRG study led by Sumiko Takao @naturecomms.bsky.social uncovers how epigenetic mechanisms control human leukemia stem cells (LSCs) that fuel therapy resistance in AML. www.nature.com/articles/s41...
A little lab fun
March 22, 2025 at 11:59 AM
A little lab fun
Reposted by Kentsis Research Group
I am thrilled to share our story online at @cellpress.bsky.social . Big thanks to all authors: Zhiping, Bill, @lubanlab.bsky.social, Keith & bluesky-less!
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
March 9, 2025 at 2:35 AM
I am thrilled to share our story online at @cellpress.bsky.social . Big thanks to all authors: Zhiping, Bill, @lubanlab.bsky.social, Keith & bluesky-less!
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
After many years of explaining trainees how to review scientific manuscripts well, I've summarized them here: docs.google.com/document/d/1...
KRG tips on how to review scientific papers
KRG tips on how to review scientific papers well Alex Kentsis, 2025 General approach Read the entire manuscript, including the methods and supplemental files. Note the quality of the data, and whet...
docs.google.com
March 14, 2025 at 7:05 PM
After many years of explaining trainees how to review scientific manuscripts well, I've summarized them here: docs.google.com/document/d/1...
Reposted by Kentsis Research Group
Telomeric transposons are pervasive in linear bacterial genomes | Science www.science.org/doi/10.1126/...
Telomeric transposons are pervasive in linear bacterial genomes
Eukaryotes have linear DNA and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. Here we identify several families of independently evolved telomeric tr...
www.science.org
March 6, 2025 at 8:02 PM
Telomeric transposons are pervasive in linear bacterial genomes | Science www.science.org/doi/10.1126/...
New book out: Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults alexkentsis.net/book-develop...
Book: Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults - Kentsis Research Group at Memorial Sloan Kettering Cancer Center
We are pleased to announce the publication of Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults. The subject of this book deals with cancers that affect children a...
alexkentsis.net
March 5, 2025 at 1:57 PM
New book out: Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults alexkentsis.net/book-develop...
Join us as a Research Technician in the Kentsis Lab externaltalent-mskcc.icims.com/jobs/83429/r...
Memorial Sloan Kettering Cancer Center Careers
Let’s change the way the world treats cancer
Our multi-disciplinary teams work together to provide exceptional patient care, develop innovative research, and deliver outstanding educational programs.
externaltalent-mskcc.icims.com
February 8, 2025 at 7:23 PM
Join us as a Research Technician in the Kentsis Lab externaltalent-mskcc.icims.com/jobs/83429/r...
Wow! Unlikely contamination because of isotope distributions and racemic mixture. Wow! www.nature.com/articles/s41...
Abundant ammonia and nitrogen-rich soluble organic matter in samples from asteroid (101955) Bennu - Nature Astronomy
Rocks and dust from the asteroid Bennu contain some of the molecular building blocks of life on Earth, such as amino acids and nucleobases. They also carry ammonia that formed billions of years ago in...
www.nature.com
January 30, 2025 at 6:52 PM
Wow! Unlikely contamination because of isotope distributions and racemic mixture. Wow! www.nature.com/articles/s41...
Looking forward to the CCRI Symposium on Cancer Epigenetics next week: ccri.at/st-anna-ccri...
St. Anna CCRI Symposium 2025 - St. Anna CCRI
We are excited to invite you to the St. Anna CCRI Symposium on Cancer Epigenetics, taking place on January 24th, 2025. As the only research institute in central Europe dedicated exclusively to childho...
ccri.at
January 17, 2025 at 5:47 PM
Looking forward to the CCRI Symposium on Cancer Epigenetics next week: ccri.at/st-anna-ccri...
Come to #KSPrecisionOnc25 and hear @yaniv.kazansky present the latest on rational epigenetic and synthetic combination therapies for sarcomas: www.keystonesymposia.org/conferences/...
Precision Oncology: Emerging Technologies & Implementation | Keystone Symposia
Join us at the Keystone Symposia on Precision Oncology: Emerging Technologies & Implementation, January 2025, in Breckenridge, with field leaders!
www.keystonesymposia.org
January 13, 2025 at 12:21 AM
Come to #KSPrecisionOnc25 and hear @yaniv.kazansky present the latest on rational epigenetic and synthetic combination therapies for sarcomas: www.keystonesymposia.org/conferences/...
Here is a recent #MSKKids lecture
@mskcancercenter.bsky.social: Toward a unified theory of why young people develop cancer ☛ alexkentsis.net/wp-content/u...
@mskcancercenter.bsky.social: Toward a unified theory of why young people develop cancer ☛ alexkentsis.net/wp-content/u...
January 11, 2025 at 9:47 PM
Here is a recent #MSKKids lecture
@mskcancercenter.bsky.social: Toward a unified theory of why young people develop cancer ☛ alexkentsis.net/wp-content/u...
@mskcancercenter.bsky.social: Toward a unified theory of why young people develop cancer ☛ alexkentsis.net/wp-content/u...