Karin Purshouse
@karinpurshouse.bsky.social
Med Onc Doc/Researcher. Former @USUKFulbright @EcatTrack #oncology #glioblastoma 🇬🇧🇩🇪 Chair @onctrainees. @CSO_Scotland Clin Lecturer
Reposted by Karin Purshouse
To advance our knowledge about the role of ecDNAs in cancer, it would be helpful if people could at least acknowledge that not everyone concludes that ecDNAs form "hubs" in the nucleus.
pubmed.ncbi.nlm.nih.gov/40972571/
pubmed.ncbi.nlm.nih.gov/41237767/
pubmed.ncbi.nlm.nih.gov/36476408/
pubmed.ncbi.nlm.nih.gov/40972571/
pubmed.ncbi.nlm.nih.gov/41237767/
pubmed.ncbi.nlm.nih.gov/36476408/
Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription - PubMed
Extrachromosomal, circular DNA (ecDNA) is a prevalent oncogenic alteration in cancer genomes, often associated with aggressive tumor behavior and poor patient outcome. While previous studies proposed a chromatin-based mobile enhancer model for ecDNA-driven oncogenesis, its precise mechanism and impa …
pubmed.ncbi.nlm.nih.gov
November 18, 2025 at 12:05 PM
To advance our knowledge about the role of ecDNAs in cancer, it would be helpful if people could at least acknowledge that not everyone concludes that ecDNAs form "hubs" in the nucleus.
pubmed.ncbi.nlm.nih.gov/40972571/
pubmed.ncbi.nlm.nih.gov/41237767/
pubmed.ncbi.nlm.nih.gov/36476408/
pubmed.ncbi.nlm.nih.gov/40972571/
pubmed.ncbi.nlm.nih.gov/41237767/
pubmed.ncbi.nlm.nih.gov/36476408/
aacrjournals.org/cancerdiscov...
How ecDNA adapt to therapeutics 👇👇👇
Delighted to make a small contribution to this important study, congratulations to all involved 🎉
How ecDNA adapt to therapeutics 👇👇👇
Delighted to make a small contribution to this important study, congratulations to all involved 🎉
Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers
AbstractExtrachromosomal DNA (ecDNA) amplification enhances intercellular oncogene dosage variability and accelerates tumor evolution by violating foundational principles of genetic inheritance throug...
aacrjournals.org
August 12, 2025 at 9:14 AM
aacrjournals.org/cancerdiscov...
How ecDNA adapt to therapeutics 👇👇👇
Delighted to make a small contribution to this important study, congratulations to all involved 🎉
How ecDNA adapt to therapeutics 👇👇👇
Delighted to make a small contribution to this important study, congratulations to all involved 🎉
Reposted by Karin Purshouse
I am excited, our collaborative work on tumours driven by ecDNA amplified MYCN and the underlying copy-number dependent fitness landscape just came out in Cancer Discovery @aacrjournals.bsky.social.
@anton-henssen.bsky.social @cancergrand.bsky.social
aacrjournals.org/cancerdiscov...
@anton-henssen.bsky.social @cancergrand.bsky.social
aacrjournals.org/cancerdiscov...
Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers
AbstractExtrachromosomal DNA (ecDNA) amplification enhances intercellular oncogene dosage variability and accelerates tumor evolution by violating foundational principles of genetic inheritance throug...
aacrjournals.org
August 8, 2025 at 10:22 AM
I am excited, our collaborative work on tumours driven by ecDNA amplified MYCN and the underlying copy-number dependent fitness landscape just came out in Cancer Discovery @aacrjournals.bsky.social.
@anton-henssen.bsky.social @cancergrand.bsky.social
aacrjournals.org/cancerdiscov...
@anton-henssen.bsky.social @cancergrand.bsky.social
aacrjournals.org/cancerdiscov...
Ah what a couple of days! And what a bunch of people 😍
This Symposium was very much a team effort but I'm delighted to be handing over the @notchonctrainees.bsky.social Chair-ing reigns to the fabulous Mary Denholm, who is already well wizened to the role, with Alfred So our new VC 🎉
This Symposium was very much a team effort but I'm delighted to be handing over the @notchonctrainees.bsky.social Chair-ing reigns to the fabulous Mary Denholm, who is already well wizened to the role, with Alfred So our new VC 🎉
NOTCH UK - The National Oncology Trainee Collaborative for Healt
@notchonctrainees.bsky.social
· Mar 25
That’s a wrap for #NOTCH2025 our 5th Annual Research Symposium!
Thank you to all of our delegates, sponsors, and speakers for providing education and inspiration for all current and future oncology researchers! 💫
We look forward to hosting you again next year! 🥳
Thank you to all of our delegates, sponsors, and speakers for providing education and inspiration for all current and future oncology researchers! 💫
We look forward to hosting you again next year! 🥳
March 25, 2025 at 7:06 PM
Ah what a couple of days! And what a bunch of people 😍
This Symposium was very much a team effort but I'm delighted to be handing over the @notchonctrainees.bsky.social Chair-ing reigns to the fabulous Mary Denholm, who is already well wizened to the role, with Alfred So our new VC 🎉
This Symposium was very much a team effort but I'm delighted to be handing over the @notchonctrainees.bsky.social Chair-ing reigns to the fabulous Mary Denholm, who is already well wizened to the role, with Alfred So our new VC 🎉
Reposted by Karin Purshouse
Thank you to all delegates who have already registered. We are here to welcome you throughout the day!
Say hello to our Board Members Dharrsshini and Mariam 👋
#NOTCH2025
Say hello to our Board Members Dharrsshini and Mariam 👋
#NOTCH2025
March 24, 2025 at 9:52 AM
Thank you to all delegates who have already registered. We are here to welcome you throughout the day!
Say hello to our Board Members Dharrsshini and Mariam 👋
#NOTCH2025
Say hello to our Board Members Dharrsshini and Mariam 👋
#NOTCH2025
Honestly watching the memes about #Minah from #thetraitors having her named spelled incorrectly is like having flashbacks from every day of my life.
It's Karin with an 'i'!!!
WITH AN 'I'!!!
Thank you for listening to my TED talk 😊
It's Karin with an 'i'!!!
WITH AN 'I'!!!
Thank you for listening to my TED talk 😊
January 25, 2025 at 8:46 PM
Honestly watching the memes about #Minah from #thetraitors having her named spelled incorrectly is like having flashbacks from every day of my life.
It's Karin with an 'i'!!!
WITH AN 'I'!!!
Thank you for listening to my TED talk 😊
It's Karin with an 'i'!!!
WITH AN 'I'!!!
Thank you for listening to my TED talk 😊
Reposted by Karin Purshouse
Apply as Transition Fellow in Brain Tumour Research @edinburghuni.bsky.social and @ucl.ac.uk !
📢 Develop your independent research programme
💡 Collaborate with world-class experts
for info contact Steven Pollard, Simona Parrinello, Vincenzo D'Angiolella
#ResearchJobs #BrainCancer #CareerOpportunity
📢 Develop your independent research programme
💡 Collaborate with world-class experts
for info contact Steven Pollard, Simona Parrinello, Vincenzo D'Angiolella
#ResearchJobs #BrainCancer #CareerOpportunity
January 14, 2025 at 11:05 AM
Apply as Transition Fellow in Brain Tumour Research @edinburghuni.bsky.social and @ucl.ac.uk !
📢 Develop your independent research programme
💡 Collaborate with world-class experts
for info contact Steven Pollard, Simona Parrinello, Vincenzo D'Angiolella
#ResearchJobs #BrainCancer #CareerOpportunity
📢 Develop your independent research programme
💡 Collaborate with world-class experts
for info contact Steven Pollard, Simona Parrinello, Vincenzo D'Angiolella
#ResearchJobs #BrainCancer #CareerOpportunity
So happy to share the latest study from NOTCH led by Dr Karen Mactier from @NHS_Lothian @UofGlasgow, looking at UK-wide practice in managing a rare cancer, uterine sarcoma
👇👇👇
pubmed.ncbi.nlm.nih.gov/39725428/
👇👇👇
pubmed.ncbi.nlm.nih.gov/39725428/
TOURISM study (Treatment Outcomes in UteRIne SarcoMa): a 10-year retrospective evaluation of practice in the UK - PubMed
Our data highlight the diversity in patient management in uterine sarcoma and a marked survival advantage for patients diagnosed with stage I disease. These data highlight the importance of a multidis...
pubmed.ncbi.nlm.nih.gov
January 6, 2025 at 10:06 AM
So happy to share the latest study from NOTCH led by Dr Karen Mactier from @NHS_Lothian @UofGlasgow, looking at UK-wide practice in managing a rare cancer, uterine sarcoma
👇👇👇
pubmed.ncbi.nlm.nih.gov/39725428/
👇👇👇
pubmed.ncbi.nlm.nih.gov/39725428/
Reposted by Karin Purshouse
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
November 25, 2024 at 12:38 PM
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/