Kara Margolis
@karapedsgastrodoc.bsky.social
Pediatric gastroenterologist and physician scientist; Director of the NYU Pain Research Center; gut-brain enthusiast, especially when it comes to mood and neurobehavior.
Reposted by Kara Margolis
Shoutouts to @nyupainresearch.bsky.social @vabraira.bsky.social @dr-lupo.bsky.social @sdavidson.bsky.social @karapedsgastrodoc.bsky.social for helping organize!
Excited to announce the first NYC Area Pain meetup being hosted at NYU. Come connect with other pain researchers and learn about the advances being made by early career researchers.
RSVP: luma.com/m5zwchlt?tk=...
Still accepting submissions for lightening talks, reach out if interested.
RSVP: luma.com/m5zwchlt?tk=...
Still accepting submissions for lightening talks, reach out if interested.
November 5, 2025 at 6:35 PM
Shoutouts to @nyupainresearch.bsky.social @vabraira.bsky.social @dr-lupo.bsky.social @sdavidson.bsky.social @karapedsgastrodoc.bsky.social for helping organize!
Reposted by Kara Margolis
New research reveals that the gut can sense microbial flagellin via TLR5-expressing neuropod cells, triggering PYY release & reducing feeding through a gut–brain neural circuit—independent of microbiota or immune cues.
@karapedsgastrodoc.bsky.social
🔗 www.nature.com/articles/s41...
@karapedsgastrodoc.bsky.social
🔗 www.nature.com/articles/s41...
A gut sense for a microbial pattern regulates feeding - Nature
A study reveals a gut–brain sensory pathway through which the microbial component flagellin activates neuropod cells in the colon to signal the brain and reduce feeding in mice.
www.nature.com
July 24, 2025 at 8:51 PM
New research reveals that the gut can sense microbial flagellin via TLR5-expressing neuropod cells, triggering PYY release & reducing feeding through a gut–brain neural circuit—independent of microbiota or immune cues.
@karapedsgastrodoc.bsky.social
🔗 www.nature.com/articles/s41...
@karapedsgastrodoc.bsky.social
🔗 www.nature.com/articles/s41...
@chalysthalee.bsky.social did an amazing job presenting at the ISSR! Such a well-deserved travel award and so proud to have her representing the lab!!
Just back from a great week in Vienna for #ISSR2025. I am grateful for the travel award and the opportunity to share my work. Big thanks to @karapedsgastrodoc.bsky.social and Mike Gershon for their steady support in the lab and my career. Loved connecting with 5-HT researchers from around the world!
July 22, 2025 at 12:58 PM
@chalysthalee.bsky.social did an amazing job presenting at the ISSR! Such a well-deserved travel award and so proud to have her representing the lab!!
Reposted by Kara Margolis
A new study shows that food structure plays a key role in determining which gut hormones are released.
@karapedsgastrodoc.bsky.social
#GLP1 #GutBrainAxis #FoodStructure #Type2Diabetes #ImperialCollege
📖 Nature Metabolism
www.nature.com/articles/s42...
@karapedsgastrodoc.bsky.social
#GLP1 #GutBrainAxis #FoodStructure #Type2Diabetes #ImperialCollege
📖 Nature Metabolism
www.nature.com/articles/s42...
Upper-gastrointestinal tract metabolite profile regulates glycaemic and satiety responses to meals with contrasting structure: a pilot study - Nature Metabolism
In this randomized crossover pilot study, the authors collected human gastrointestinal digesta using a unique intubation technique to compare how meals with contrasting cellular structures affect post...
www.nature.com
June 24, 2025 at 8:32 PM
A new study shows that food structure plays a key role in determining which gut hormones are released.
@karapedsgastrodoc.bsky.social
#GLP1 #GutBrainAxis #FoodStructure #Type2Diabetes #ImperialCollege
📖 Nature Metabolism
www.nature.com/articles/s42...
@karapedsgastrodoc.bsky.social
#GLP1 #GutBrainAxis #FoodStructure #Type2Diabetes #ImperialCollege
📖 Nature Metabolism
www.nature.com/articles/s42...
Reposted by Kara Margolis
🩸 A new blood test (WBAIL-2) detects gluten-triggered IL-2 release, offering a non-invasive, accurate way to diagnose celiac disease, even in patients on a gluten-free diet! 🌾❌
Game-changer for gut health.
sciencedirect.com/science/arti...
#guthealthmatters #WBAIL2
@karapedsgastrodoc.bsky.social
Game-changer for gut health.
sciencedirect.com/science/arti...
#guthealthmatters #WBAIL2
@karapedsgastrodoc.bsky.social
Blood-based T Cell Diagnosis of Celiac Disease
Current diagnosis of celiac disease (CeD) is inaccurate in patients following a gluten-free diet (GFD). Blood-based diagnostics targeting gluten-speci…
sciencedirect.com
June 20, 2025 at 3:46 PM
🩸 A new blood test (WBAIL-2) detects gluten-triggered IL-2 release, offering a non-invasive, accurate way to diagnose celiac disease, even in patients on a gluten-free diet! 🌾❌
Game-changer for gut health.
sciencedirect.com/science/arti...
#guthealthmatters #WBAIL2
@karapedsgastrodoc.bsky.social
Game-changer for gut health.
sciencedirect.com/science/arti...
#guthealthmatters #WBAIL2
@karapedsgastrodoc.bsky.social
Reposted by Kara Margolis
Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior.
buff.ly/caKMGY3
buff.ly/caKMGY3
buff.ly
June 11, 2025 at 5:25 PM
Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior.
buff.ly/caKMGY3
buff.ly/caKMGY3
Reposted by Kara Margolis
How bad will it be? Catastrophic.
Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come.
But, this is the WH's *proposed* budget.
Speak up now before it is too late.
(inflation adjusted $-s below)
Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come.
But, this is the WH's *proposed* budget.
Speak up now before it is too late.
(inflation adjusted $-s below)
May 31, 2025 at 2:50 AM
Reposted by Kara Margolis
🎤 BLINK AND YOU'LL MISS IT: FLASH TALKS AT THE 5TH ANNUAL AMPIRS! ⚡ This year’s Flash Talks were a whirlwind of brilliance 🎤one mic, infinite insight. And WOW, did our presenters deliver! 👏PRC representing! #PRCpride #violetpride #NYUDental #nyuniversity
May 30, 2025 at 10:23 PM
🎤 BLINK AND YOU'LL MISS IT: FLASH TALKS AT THE 5TH ANNUAL AMPIRS! ⚡ This year’s Flash Talks were a whirlwind of brilliance 🎤one mic, infinite insight. And WOW, did our presenters deliver! 👏PRC representing! #PRCpride #violetpride #NYUDental #nyuniversity
Reposted by Kara Margolis
Round two- ding ding! 🥊 Time for an AMPIRS photo dump that’ll knock your lanyard off 😎🚨poster session 2 coming in 🤳📸 picture perfect!👌
May 31, 2025 at 12:38 AM
Round two- ding ding! 🥊 Time for an AMPIRS photo dump that’ll knock your lanyard off 😎🚨poster session 2 coming in 🤳📸 picture perfect!👌
Reposted by Kara Margolis
Reposted by Kara Margolis
Curtains down on AMPIRS! Dr. Nigel Bunnett, our MPB Chair, brought it home with closing remarks. Huge thanks to our amazing sponsors and a special shoutout to MPB for hosting AMPIRS & Welcoming the Pain Research Center into the fun! And now… cue the real research question: Wheres happy hour? 🍹😄
May 31, 2025 at 2:17 AM
Curtains down on AMPIRS! Dr. Nigel Bunnett, our MPB Chair, brought it home with closing remarks. Huge thanks to our amazing sponsors and a special shoutout to MPB for hosting AMPIRS & Welcoming the Pain Research Center into the fun! And now… cue the real research question: Wheres happy hour? 🍹😄
Reposted by Kara Margolis
New study! Aging and nerve injury cause senescent neurons in the peripheral nervous system, driving increased pain; targeting these cells could offer a new pain treatment especially in older adults.
@vivtawfik-mdphd.bsky.social
@karapedsgastrodoc.bsky.social
www.nature.com/articles/s41...
@vivtawfik-mdphd.bsky.social
@karapedsgastrodoc.bsky.social
www.nature.com/articles/s41...
Aging and injury drive neuronal senescence in the dorsal root ganglia - Nature Neuroscience
The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.
www.nature.com
May 29, 2025 at 1:44 PM
New study! Aging and nerve injury cause senescent neurons in the peripheral nervous system, driving increased pain; targeting these cells could offer a new pain treatment especially in older adults.
@vivtawfik-mdphd.bsky.social
@karapedsgastrodoc.bsky.social
www.nature.com/articles/s41...
@vivtawfik-mdphd.bsky.social
@karapedsgastrodoc.bsky.social
www.nature.com/articles/s41...
Reposted by Kara Margolis
IL-18 signaling in epithelial-derived enterochromaffin cells plays a pivotal role in injury response and stem cell activation in the mouse intestine #gutresearch #epithelialcells #IL18 #stemcells
@karapedsgastrodoc.bsky.social
www.pnas.org/doi/10.1073/...
@karapedsgastrodoc.bsky.social
www.pnas.org/doi/10.1073/...
The IL-18 receptor is expressed on murine small-intestinal enterochromaffin cells and executes a recovery program upon injury | PNAS
Upon injury, epithelial-derived IL-18 is released and induces an inflammatory response
in underlying IL18R1+ lamina propria cells. Notably, Il18r1 ...
www.pnas.org
May 29, 2025 at 8:49 PM
IL-18 signaling in epithelial-derived enterochromaffin cells plays a pivotal role in injury response and stem cell activation in the mouse intestine #gutresearch #epithelialcells #IL18 #stemcells
@karapedsgastrodoc.bsky.social
www.pnas.org/doi/10.1073/...
@karapedsgastrodoc.bsky.social
www.pnas.org/doi/10.1073/...
Reposted by Kara Margolis
@karapedsgastrodoc.bsky.social @margolislabnyu.bsky.social @amergastroassn.bsky.social PRC Website: dental.nyu.edu/research/pai... Margolis Lab: dental.nyu.edu/faculty/mole...
NYU Pain Research Center
dental.nyu.edu
May 21, 2025 at 6:48 PM
Reposted by Kara Margolis
Yes! Your taste buds do talk to your brain🧠! Thank you Dr. Nirupa Chaudhari for a fantastic talk! #brain #NYUdentistry #PRC
May 22, 2025 at 6:01 PM
Yes! Your taste buds do talk to your brain🧠! Thank you Dr. Nirupa Chaudhari for a fantastic talk! #brain #NYUdentistry #PRC
Reposted by Kara Margolis
May 22, 2025 at 9:51 PM
Reposted by Kara Margolis
A new study with Dr. Yi Ye as a co-author "Associations of Pain, Anxiety, and Depressive Symptoms With Sleep Outcomes in Patients with Head and Neck Squamous Cell Carcinoma: A Cross-Sectional Observational Study" #Pain #Anxiety #Depression #HNSCC onlinelibrary.wiley.com/doi/full/10....
Associations of Pain, Anxiety, and Depressive Symptoms With Sleep Outcomes in Patients With Head and Neck Squamous Cell Carcinoma: A Cross‐Sectional Observational Study
Background This exploratory cross-sectional observational study sought to characterize sleep quality and evaluate its association with sociodemographic, clinicopathological, behavioral, and psycholo...
onlinelibrary.wiley.com
May 27, 2025 at 1:59 PM
A new study with Dr. Yi Ye as a co-author "Associations of Pain, Anxiety, and Depressive Symptoms With Sleep Outcomes in Patients with Head and Neck Squamous Cell Carcinoma: A Cross-Sectional Observational Study" #Pain #Anxiety #Depression #HNSCC onlinelibrary.wiley.com/doi/full/10....
Reposted by Kara Margolis
Green light for pain relief! 🟢 Researchers found green light therapy reduced osteoarthritis pain in rats, via analgesic endolipids engaging the endocannabinoid system. #PainResearch #GreenLight #Osteoarthritis journals.lww.com/pain/fulltex...
Visual exposure to green light therapy reduces knee joint... : PAIN
cytokines in the cerebrospinal fluid. The present study assessed the effect of green light therapy (GLT) on joint pain in a rat model of osteoarthritis (OA) and investigated the role of endolipids. Ma...
journals.lww.com
May 27, 2025 at 6:32 PM
Green light for pain relief! 🟢 Researchers found green light therapy reduced osteoarthritis pain in rats, via analgesic endolipids engaging the endocannabinoid system. #PainResearch #GreenLight #Osteoarthritis journals.lww.com/pain/fulltex...
Reposted by Kara Margolis
May 29, 2025 at 1:31 PM
Reposted by Kara Margolis
🚨Sound the alarm- it’s an AMPIRS photo dump! 🚨Poster Session 1 brought the heat 🔥 Big shoutout to our amazing PRC members who rocked their posters! #NYUDental #nyuniversity #AMPIRS #Painresearchcenter
May 30, 2025 at 4:39 PM
🚨Sound the alarm- it’s an AMPIRS photo dump! 🚨Poster Session 1 brought the heat 🔥 Big shoutout to our amazing PRC members who rocked their posters! #NYUDental #nyuniversity #AMPIRS #Painresearchcenter
Reposted by Kara Margolis
#PRC Highlight: Happy Flash back Friday! Flashing Back to Cinco De Mayo! 💃🕺🏼🪇 MPB Tea Time always celebrating in style! #PRCpride #teatime #🫖 #cincodemayo #flashbackfridays #thankyou #PRC
May 17, 2025 at 2:58 AM
#PRC Highlight: Happy Flash back Friday! Flashing Back to Cinco De Mayo! 💃🕺🏼🪇 MPB Tea Time always celebrating in style! #PRCpride #teatime #🫖 #cincodemayo #flashbackfridays #thankyou #PRC
Reposted by Kara Margolis
New research reveals prolactin as a driver of stress-induced post-surgery pain in women. Blocking prolactin shows promise for better pain management & reduced opioid use! #PostoperativePain #Prolactin #PainResearch www.pnas.org/doi/10.1073/...
A prolactin-targeting antibody to prevent stress-induced peripheral nociceptor sensitization and female postoperative pain | PNAS
Scheduled surgeries elicit stress in many patients. Levels of preoperative stress,
anxiety, and female gender are known risk factors for increased ...
www.pnas.org
May 20, 2025 at 4:39 PM
New research reveals prolactin as a driver of stress-induced post-surgery pain in women. Blocking prolactin shows promise for better pain management & reduced opioid use! #PostoperativePain #Prolactin #PainResearch www.pnas.org/doi/10.1073/...
Reposted by Kara Margolis
Great talk given to the PRC PRIMED Club by guest speaker Manon Bohic on Spinal Oxytocin Modulates Touch Reward and Pain Relief Through Shared Dorsal Horn Circuits. Manon Bohic is a research associate at Rutgers University.👏 #Thankyou for the visit! #SpinalDorsal #PRC #womeninscience
May 20, 2025 at 5:28 PM
Great talk given to the PRC PRIMED Club by guest speaker Manon Bohic on Spinal Oxytocin Modulates Touch Reward and Pain Relief Through Shared Dorsal Horn Circuits. Manon Bohic is a research associate at Rutgers University.👏 #Thankyou for the visit! #SpinalDorsal #PRC #womeninscience
Reposted by Kara Margolis
💡 A promising non-opioid strategy—SBI-810 reduces pain, opioid reward, withdrawal, and constipation through selective β-arrestin-2 signaling www.sciencedirect.com/science/arti...
Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain
G-protein-biased agonists have been shown to enhance opioid analgesia by circumventing β-arrestin-2 (βarr2) signaling. We previously reported that SBI…
www.sciencedirect.com
May 20, 2025 at 6:30 PM
💡 A promising non-opioid strategy—SBI-810 reduces pain, opioid reward, withdrawal, and constipation through selective β-arrestin-2 signaling www.sciencedirect.com/science/arti...
Reposted by Kara Margolis
A big shoutout to Nikhil Sharma for joining our MPB Seminar Series! 🙌 @nyupainresearch.bsky.social loved your fascinating deep dive into the enteric nervous system and its connection with peripheral sensory & autonomic ganglia. 👨🔬🧠✨ #Neuroscience #PainResearch #MPBSeminar
May 20, 2025 at 7:02 PM
A big shoutout to Nikhil Sharma for joining our MPB Seminar Series! 🙌 @nyupainresearch.bsky.social loved your fascinating deep dive into the enteric nervous system and its connection with peripheral sensory & autonomic ganglia. 👨🔬🧠✨ #Neuroscience #PainResearch #MPBSeminar