Justin Cotney
@justincotney.bsky.social
Father, scientist, tech geek
Reposted by Justin Cotney
A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo
www.nature.com/articles/s41...
www.nature.com/articles/s41...
DNA-guided transcription factor interactions extend human gene regulatory code - Nature
A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...
www.nature.com
April 9, 2025 at 4:51 PM
A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Happy to present the first preprint from my lab after relocating @CHOP_Research @ChildrensPhila Here we describe gene expression at the single cell level across major milestones of human and mouse development. preprint here: https://buff.ly/3PFWNoG
January 21, 2025 at 9:38 PM
Happy to present the first preprint from my lab after relocating @CHOP_Research @ChildrensPhila Here we describe gene expression at the single cell level across major milestones of human and mouse development. preprint here: https://buff.ly/3PFWNoG
Reposted by Justin Cotney
Impressive study from Alex Stark lab identifying 3 new types of silencer elements in Drosophila
New TF binds a particular isolated motif in non-accessible sites to recruit G9a. Deletion of these elements can lead to upregulation of nearby gene
www.sciencedirect.com/science/arti...
New TF binds a particular isolated motif in non-accessible sites to recruit G9a. Deletion of these elements can lead to upregulation of nearby gene
www.sciencedirect.com/science/arti...
November 20, 2024 at 9:34 PM
Impressive study from Alex Stark lab identifying 3 new types of silencer elements in Drosophila
New TF binds a particular isolated motif in non-accessible sites to recruit G9a. Deletion of these elements can lead to upregulation of nearby gene
www.sciencedirect.com/science/arti...
New TF binds a particular isolated motif in non-accessible sites to recruit G9a. Deletion of these elements can lead to upregulation of nearby gene
www.sciencedirect.com/science/arti...