Julie Worrell
@julieworrell.bsky.social
Research Scientist @UCD 🇮🇪 Stromal cell biology, lung injury/repair, trained immunity, infection and fibrosis #ILD #stromalimmunology #immunoSky 🫁
Interesting article 💥 Ant1 acts as as metabolic checkpoint in emphysema 💥 implications for monocyte derived macrophage infiltration 🫁 Check out our editorial here: www.atsjournals.org/doi/10.1165/... #ImmunoSky @ucd-chas.bsky.social @ucdresearch.bsky.social @yefis-immunology.bsky.social
November 6, 2025 at 7:20 PM
Interesting article 💥 Ant1 acts as as metabolic checkpoint in emphysema 💥 implications for monocyte derived macrophage infiltration 🫁 Check out our editorial here: www.atsjournals.org/doi/10.1165/... #ImmunoSky @ucd-chas.bsky.social @ucdresearch.bsky.social @yefis-immunology.bsky.social
Reposted by Julie Worrell
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 8:06 AM
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Reposted by Julie Worrell
Dear funding agencies,
I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development.
Sincerely,
Looking for basic research grants.
I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development.
Sincerely,
Looking for basic research grants.
October 14, 2025 at 7:24 PM
Dear funding agencies,
I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development.
Sincerely,
Looking for basic research grants.
I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development.
Sincerely,
Looking for basic research grants.
Reposted by Julie Worrell
This 2-part Symposium prepared jointly with @balrcommunity.bsky.social covers a huge range of research topics within the field. Don't miss this fascinating deep dive into the latest developments in lung disease.
👉 brit-thoracic.uk/WM25
#BTSWinter2025
👉 brit-thoracic.uk/WM25
#BTSWinter2025
October 6, 2025 at 12:02 PM
This 2-part Symposium prepared jointly with @balrcommunity.bsky.social covers a huge range of research topics within the field. Don't miss this fascinating deep dive into the latest developments in lung disease.
👉 brit-thoracic.uk/WM25
#BTSWinter2025
👉 brit-thoracic.uk/WM25
#BTSWinter2025
Reposted by Julie Worrell
⚠️ Half of commercial antibodies miss their target!
So how do you pick the right one for your experiment?
Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk
Tested by @ycharos.bsky.social & @oga-community.bsky.social
So how do you pick the right one for your experiment?
Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk
Tested by @ycharos.bsky.social & @oga-community.bsky.social
OGA - Only Good Antibodies Community
onlygoodantibodies.co.uk
September 29, 2025 at 6:34 PM
⚠️ Half of commercial antibodies miss their target!
So how do you pick the right one for your experiment?
Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk
Tested by @ycharos.bsky.social & @oga-community.bsky.social
So how do you pick the right one for your experiment?
Here’s the solution 👉
Antibody characterization data (all tested in KO cells) are now available at:
🔗 onlygoodantibodies.co.uk
Tested by @ycharos.bsky.social & @oga-community.bsky.social
Reposted by Julie Worrell
New #flowcytometery protocol drop from Oliver Burton.
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Optimization of the Blocking and Signal Preservation Protocol in High‐Parameter Flow Cytometry
High quality input data is the key to successful interpretation of any scientific assay. In flow cytometry, fluorescently-conjugated antibodies allow us to simultaneously measure an incredible range ...
currentprotocols.onlinelibrary.wiley.com
September 25, 2025 at 5:06 PM
New #flowcytometery protocol drop from Oliver Burton.
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
#BALR2025 🫁 @cardiffuni.bsky.social what a fantastic 3 days 👏 lovely to see everyone and to present some #fibroblast data updates 🤗 Really high standard from all #ECRs and great #flashtalks #posters #presentations. Superb keynote from @tatalab-duke.bsky.social thanks @balrcommunity.bsky.social
September 10, 2025 at 10:55 PM
#BALR2025 🫁 @cardiffuni.bsky.social what a fantastic 3 days 👏 lovely to see everyone and to present some #fibroblast data updates 🤗 Really high standard from all #ECRs and great #flashtalks #posters #presentations. Superb keynote from @tatalab-duke.bsky.social thanks @balrcommunity.bsky.social
Well done to all presenters! Excellent time keeping and a pleasure to chair this 😀 #ECR #speedyscience #scicomm @balrcommunity.bsky.social #BALR2025 🫁 🔔 only got to ring my bell once at the start of the session 😂
And now 1min flash talks at #BALR2025! It’s like speed-dating but with science, so more fun!
September 8, 2025 at 9:13 PM
Well done to all presenters! Excellent time keeping and a pleasure to chair this 😀 #ECR #speedyscience #scicomm @balrcommunity.bsky.social #BALR2025 🫁 🔔 only got to ring my bell once at the start of the session 😂
Reposted by Julie Worrell
Do you want to become part of a dynamic committee and contribute to the strategic planning of the BALR?
Apply for the open positions on our committee!
Chair
Treasurer
Communications Secretary
Publications Secretary
RSB Representative
Post-Doc Rep
More info at balr.co.uk/about
Apply for the open positions on our committee!
Chair
Treasurer
Communications Secretary
Publications Secretary
RSB Representative
Post-Doc Rep
More info at balr.co.uk/about
September 1, 2025 at 9:36 AM
Do you want to become part of a dynamic committee and contribute to the strategic planning of the BALR?
Apply for the open positions on our committee!
Chair
Treasurer
Communications Secretary
Publications Secretary
RSB Representative
Post-Doc Rep
More info at balr.co.uk/about
Apply for the open positions on our committee!
Chair
Treasurer
Communications Secretary
Publications Secretary
RSB Representative
Post-Doc Rep
More info at balr.co.uk/about
Reposted by Julie Worrell
Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age @natimmunol.nature.com @teichlab.bsky.social @donnafarber.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 13, 2025 at 6:38 PM
Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age @natimmunol.nature.com @teichlab.bsky.social @donnafarber.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Julie Worrell
Ever thought: 'If only I had 1 more day!' Well, you have not 1, but 5 more days to submit an abstract to #BALR2025!
⏰NEW abstract submission deadline: 15/08
⏰Late breaking (posters only): 25/08
⏰Registration deadline: 25/08 balr.co.uk/meetings
⏰NEW abstract submission deadline: 15/08
⏰Late breaking (posters only): 25/08
⏰Registration deadline: 25/08 balr.co.uk/meetings
August 11, 2025 at 10:40 AM
Ever thought: 'If only I had 1 more day!' Well, you have not 1, but 5 more days to submit an abstract to #BALR2025!
⏰NEW abstract submission deadline: 15/08
⏰Late breaking (posters only): 25/08
⏰Registration deadline: 25/08 balr.co.uk/meetings
⏰NEW abstract submission deadline: 15/08
⏰Late breaking (posters only): 25/08
⏰Registration deadline: 25/08 balr.co.uk/meetings
Reposted by Julie Worrell
Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge @natcomms.nature.com www.nature.com/articles/s41...
August 2, 2025 at 3:30 AM
Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge @natcomms.nature.com www.nature.com/articles/s41...
NOW in @natcomms.nature.com my postdoc work @uofgsii.bsky.social @immunememorylab.bsky.social
🫁 structual cells retain an imprint of IAV infection💪
Rapidly controlling a localized antiviral response BRFORE memory-T cells are required! rdcu.be/eyQ0F #ImmunoSky #PulmSky @wellcometrust.bsky.social
🫁 structual cells retain an imprint of IAV infection💪
Rapidly controlling a localized antiviral response BRFORE memory-T cells are required! rdcu.be/eyQ0F #ImmunoSky #PulmSky @wellcometrust.bsky.social
Lung structural cells are altered by infeluenza virus leading to rapid immune protection following re-challenge
Nature Communications - Here the authors show that lung epithelial, fibroblast, and endothelial cells retain an imprint of influenza A infection, including increased MHCI/II expression and that...
rdcu.be
August 1, 2025 at 3:46 PM
NOW in @natcomms.nature.com my postdoc work @uofgsii.bsky.social @immunememorylab.bsky.social
🫁 structual cells retain an imprint of IAV infection💪
Rapidly controlling a localized antiviral response BRFORE memory-T cells are required! rdcu.be/eyQ0F #ImmunoSky #PulmSky @wellcometrust.bsky.social
🫁 structual cells retain an imprint of IAV infection💪
Rapidly controlling a localized antiviral response BRFORE memory-T cells are required! rdcu.be/eyQ0F #ImmunoSky #PulmSky @wellcometrust.bsky.social
🌟 Immunology #PostDoc🌟 @ucd-chas.bsky.social Novel surgical innovation investigating sentinel skin flaps in acute solid organ rejection 🔬
🔗 #immunosky Apply NOW: my.corehr.com/pls/coreportal…
@britsocimm.bsky.social @yefis-immunology.bsky.social @balrcommunity.bsky.social @hrbireland.bsky.social
🔗 #immunosky Apply NOW: my.corehr.com/pls/coreportal…
@britsocimm.bsky.social @yefis-immunology.bsky.social @balrcommunity.bsky.social @hrbireland.bsky.social
https://my.corehr.com/pls/coreportal…
July 4, 2025 at 5:58 PM
🌟 Immunology #PostDoc🌟 @ucd-chas.bsky.social Novel surgical innovation investigating sentinel skin flaps in acute solid organ rejection 🔬
🔗 #immunosky Apply NOW: my.corehr.com/pls/coreportal…
@britsocimm.bsky.social @yefis-immunology.bsky.social @balrcommunity.bsky.social @hrbireland.bsky.social
🔗 #immunosky Apply NOW: my.corehr.com/pls/coreportal…
@britsocimm.bsky.social @yefis-immunology.bsky.social @balrcommunity.bsky.social @hrbireland.bsky.social
Reposted by Julie Worrell
📣Registrations and abstract submissions are OPEN for #BALR2025 in Cardiff 8-10 Sept! A stellar program and ECR awards await! Head here www.balr.co.uk/meetings to submit your abstract by 10/08 and register by 25/08!
June 23, 2025 at 5:15 PM
📣Registrations and abstract submissions are OPEN for #BALR2025 in Cardiff 8-10 Sept! A stellar program and ECR awards await! Head here www.balr.co.uk/meetings to submit your abstract by 10/08 and register by 25/08!
Reposted by Julie Worrell
🌍✨ Today is World Autoimmune & Autoinflammatory Arthritis Day! ✨🌍
Let’s come together to raise awareness of these often invisible, but life-altering diseases. 💙
📖 Read our blogs shorturl.at/rMQ4g
🎧listen to Inflammatory! podcast shorturl.at/VOSFB
#inflammatory #livebeyondIA
Let’s come together to raise awareness of these often invisible, but life-altering diseases. 💙
📖 Read our blogs shorturl.at/rMQ4g
🎧listen to Inflammatory! podcast shorturl.at/VOSFB
#inflammatory #livebeyondIA
May 20, 2025 at 11:48 AM
🌍✨ Today is World Autoimmune & Autoinflammatory Arthritis Day! ✨🌍
Let’s come together to raise awareness of these often invisible, but life-altering diseases. 💙
📖 Read our blogs shorturl.at/rMQ4g
🎧listen to Inflammatory! podcast shorturl.at/VOSFB
#inflammatory #livebeyondIA
Let’s come together to raise awareness of these often invisible, but life-altering diseases. 💙
📖 Read our blogs shorturl.at/rMQ4g
🎧listen to Inflammatory! podcast shorturl.at/VOSFB
#inflammatory #livebeyondIA
Reposted by Julie Worrell
hen it rains it pours!! What an amazing #ATS2025 for #CurePF4ALL! Nerandomilast -> ⬇️FVC decline compared to placebo in Progressive Pulmonary Fibrosis patients on antifibrotics or untreated. 👏🏼 Drs Maher, Martinez & #FibroneerILD team!!
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
May 19, 2025 at 7:20 PM
hen it rains it pours!! What an amazing #ATS2025 for #CurePF4ALL! Nerandomilast -> ⬇️FVC decline compared to placebo in Progressive Pulmonary Fibrosis patients on antifibrotics or untreated. 👏🏼 Drs Maher, Martinez & #FibroneerILD team!!
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Happy to share our new collaborative review in #ERJBreathe focusing on #ILD and recent insights into 🫁#pathogenesis @ucd-chas.bsky.social @ucdresearch.bsky.social @irishthoracicsoc.bsky.social @balrcommunity.bsky.social #ECR #PulmSky 😄 publications.ersnet.org/content/brea...
May 13, 2025 at 1:39 PM
Happy to share our new collaborative review in #ERJBreathe focusing on #ILD and recent insights into 🫁#pathogenesis @ucd-chas.bsky.social @ucdresearch.bsky.social @irishthoracicsoc.bsky.social @balrcommunity.bsky.social #ECR #PulmSky 😄 publications.ersnet.org/content/brea...
Well done to #PhD students Atia, Megan and @shforde.bsky.social who presented their exciting #respiratoryresearch 🫁 posters today @ucd-chas.bsky.social #PGRday #immunecells #UCDSoM #ILD
#womeninSTEM 👧
#womeninSTEM 👧
Energy is high here at the event! Posters are up, sessions are buzzing, and the research is next-level. 🌟
Massive respect to all our student presenters today - you’re all stars.
#LiveResearch #CHAS #GradDay @ucddublin.bsky.social @ucdresearch.bsky.social
Massive respect to all our student presenters today - you’re all stars.
#LiveResearch #CHAS #GradDay @ucddublin.bsky.social @ucdresearch.bsky.social
April 29, 2025 at 7:42 PM
Well done to #PhD students Atia, Megan and @shforde.bsky.social who presented their exciting #respiratoryresearch 🫁 posters today @ucd-chas.bsky.social #PGRday #immunecells #UCDSoM #ILD
#womeninSTEM 👧
#womeninSTEM 👧
Reposted by Julie Worrell
🎉 Happy International #DayofImmunology! 🧬💙
As we approach the end of our DOI 2025 campaign, we want to send a HUGE THANK YOU to everyone who participated in the video campaign! 🙌🎥
#ThankYouImmunology #NeuroImmunology
@iuis-online.bsky.social @yefis-immunology.bsky.social @myriamnabhan.bsky.social
As we approach the end of our DOI 2025 campaign, we want to send a HUGE THANK YOU to everyone who participated in the video campaign! 🙌🎥
#ThankYouImmunology #NeuroImmunology
@iuis-online.bsky.social @yefis-immunology.bsky.social @myriamnabhan.bsky.social
April 29, 2025 at 6:57 AM
🎉 Happy International #DayofImmunology! 🧬💙
As we approach the end of our DOI 2025 campaign, we want to send a HUGE THANK YOU to everyone who participated in the video campaign! 🙌🎥
#ThankYouImmunology #NeuroImmunology
@iuis-online.bsky.social @yefis-immunology.bsky.social @myriamnabhan.bsky.social
As we approach the end of our DOI 2025 campaign, we want to send a HUGE THANK YOU to everyone who participated in the video campaign! 🙌🎥
#ThankYouImmunology #NeuroImmunology
@iuis-online.bsky.social @yefis-immunology.bsky.social @myriamnabhan.bsky.social
Reposted by Julie Worrell
#WeekendRead! #EveryCellIsAnImmuneCell! Peng Bai Marichal &co show @ Science Immunology that endothelial cells produce TGFb to differentiate monocytes into #lung interstitial macrophages preventing aging & fibrosis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Endothelial-driven TGFβ signaling supports lung interstitial macrophage development from monocytes
Endothelial Tgfβ1 shapes the development and functional identity of lung interstitial macrophages.
www.science.org
April 27, 2025 at 2:59 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Peng Bai Marichal &co show @ Science Immunology that endothelial cells produce TGFb to differentiate monocytes into #lung interstitial macrophages preventing aging & fibrosis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Thankful for this opportunity 🙏 World Scleroderma Foundation #WSF to drive this exciting work forward 🫁 @ucd-chas.bsky.social #collaboration #stromalimmuology #SSc#SSc-ILD #pulmSky #RheumSky #ImmunoSky
March 15, 2025 at 11:53 AM
Thankful for this opportunity 🙏 World Scleroderma Foundation #WSF to drive this exciting work forward 🫁 @ucd-chas.bsky.social #collaboration #stromalimmuology #SSc#SSc-ILD #pulmSky #RheumSky #ImmunoSky
Reposted by Julie Worrell
🚨🔔 Delighted to see this piece of work from @cvrinfo.bsky.social now out in @naturemicrobiol.bsky.social ! Indeed, it really reflects what multidisciplinary team effort can be. Guess what? Spike of #SARSCoV2 is not just about antigenicity/immune evasion… doi.org/10.1038/s415...
Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic - Nature Microbiology
Systematic comparison of SARS-CoV-2 spike proteins from pre- and post-Omicron variants in cell lines, primary respiratory epithelial cells and Syrian hamsters show distinct phenotypic trajectories in ...
doi.org
January 5, 2025 at 2:43 PM
🚨🔔 Delighted to see this piece of work from @cvrinfo.bsky.social now out in @naturemicrobiol.bsky.social ! Indeed, it really reflects what multidisciplinary team effort can be. Guess what? Spike of #SARSCoV2 is not just about antigenicity/immune evasion… doi.org/10.1038/s415...
Reposted by Julie Worrell
Elegant work by Jason Cyster's group
"Our study demonstrates that the canonical chemoattractant receptor-ligand systems well-established for lymphocyte homeostatic trafficking to LNs are no longer the major contributors in the inflamed setting." #ImmunoSky
"Our study demonstrates that the canonical chemoattractant receptor-ligand systems well-established for lymphocyte homeostatic trafficking to LNs are no longer the major contributors in the inflamed setting." #ImmunoSky
Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes
Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.
www.cell.com
January 5, 2025 at 4:02 PM
Elegant work by Jason Cyster's group
"Our study demonstrates that the canonical chemoattractant receptor-ligand systems well-established for lymphocyte homeostatic trafficking to LNs are no longer the major contributors in the inflamed setting." #ImmunoSky
"Our study demonstrates that the canonical chemoattractant receptor-ligand systems well-established for lymphocyte homeostatic trafficking to LNs are no longer the major contributors in the inflamed setting." #ImmunoSky