Quinn Lee
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jquinnlee.bsky.social
Quinn Lee
@jquinnlee.bsky.social
Navigation & memory researcher
CIHR Postdoctoral Fellow @ McGill University
Incoming Assistant Professor @ University of Alberta (starting July 2025)
Accepting graduate student applications to start Fall 2025: https://sites.psych.ualberta.ca/NMSLab
Pinned
Psyched that my postdoc work w @markbrandonlab.bsky.social + @atkeinath.bsky.social is now in Neuron! TL/DR: remapping in CA1 has a representational structure that is reliable across brains, and we use this representation to test models of cognitive maps.
#NeuroSky #NeuroAI 🧪🧠

tinyurl.com/4juhmad8
Identifying representational structure in CA1 to benchmark theoretical models of cognitive mapping
Decades of theoretical and empirical work have suggested the hippocampus instantiates some form of a cognitive map. Yet, tests of competing theories h…
tinyurl.com
Reposted by Quinn Lee
Trans rights are human rights.

Fresh work incoming: Here we quantitatively compare the representational geometry of mouse CA1 and human spatial memory during environmental deformations. Briefest TLDR: Human memory looks like a change-resistant version of mouse CA1.

www.biorxiv.org/cgi/content/...
Change-resistance distinguishes the representational geometries of human spatial memory and mouse CA1 in deformed environments
Prior work has highlighted qualitative similarities between the neural instantiations of cognitive maps in rodents and memory-guided navigation in humans, suggesting a conservation of representational...
www.biorxiv.org
July 15, 2025 at 5:11 PM
Reposted by Quinn Lee
Thrilled to announce I'll be starting my own neuro-theory lab, as an Assistant Professor at @yaleneuro.bsky.social @wutsaiyale.bsky.social this Fall!

My group will study offline learning in the sleeping brain: how neural activity self-organizes during sleep and the computations it performs. 🧵
June 23, 2025 at 3:55 PM
Reposted by Quinn Lee
Excited to share the sequel to our 2022 paper! In this follow-up, we show that the stable head direction (HD) signals we reported in blind mice rely on stereo olfaction—that is, the comparison of odor info. between the two nostrils.

Link: www.nature.com/articles/s41...

🧵highlights below
Stereo olfaction underlies stable coding of head direction in blind mice - Nature Communications
Stereo olfaction involves comparing odor differences between the two nostrils. Here, using neuronal recordings and a behavioral test, the authors demonstrate that blind mice use stereo olfaction to fo...
www.nature.com
April 15, 2025 at 6:26 AM
Reposted by Quinn Lee
BTSP, but not STDP, can account for place field changes in hippocampus, out in Nature Neuroscience today:

www.nature.com/articles/s41...

🧠📈 🧪
Synaptic plasticity rules driving representational shifting in the hippocampus - Nature Neuroscience
Madar et al. report that behavioral timescale synaptic plasticity (BTSP), not spike-timing-dependent plasticity, explains heterogeneous place fields shifting in the hippocampus. The probability of BTS...
www.nature.com
April 8, 2025 at 12:49 PM
The dataset and code for our recent paper in Neuron (tinyurl.com/yc48d6vr) is online now!
The data is available on Zenodo (zenodo.org/records/1486...) and code on Github (github.com/jquinnlee/ge...). Big thanks to @markbrandonlab.bsky.social and @atkeinath.bsky.social on this effort! #neuroskyence 🧠
Mouse CA1 Calcium Imaging and Behavioural Dataset in 3x3 Geometric Morph Paradigm
The following dataset was collected by Dr. J. Quinn Lee, Dr. Alexandra T. Keinath, and Erica Cianfarano in the laboratory of Dr. Mark P. Brandon. All methods and details are described in the original ...
zenodo.org
April 8, 2025 at 9:45 PM
Reposted by Quinn Lee
Looking forward to seeing you all in Montreal this week 🧠🧠🧠
Use #cosyne2025 so we can 👀 what you're up to!!
March 26, 2025 at 6:15 PM
Reposted by Quinn Lee
1/ Our paper appeared in @Nature today! www.nature.com/articles/s41... w/ Fiete Lab and @khonamikail.bsky.social .
Explains emergence of multiple grid cell modules, w/ excellent match to data! Novel mechanism for applying across vast systems from development to ecosystems. 🧵👇
Global modules robustly emerge from local interactions and smooth gradients - Nature
The principle of peak selection is described, by which local interactions and smooth gradients drive self-organization of discrete global modules.
www.nature.com
February 19, 2025 at 11:20 PM
Reposted by Quinn Lee
Position open for Director of Research Innovation & Operations at Concordia as part of the Abundant Intelligences (www.indigenous-ai.net/abundant/) project, which seeks to reshape AI with indigenous insights:

www.kbrs.ca/Career/17387...

Please share!!!

🧪 #MLSky
Director of Research Innovation & Operations (DRIO) – Abundant Intelligences
Application deadline: March 21, 2025
www.kbrs.ca
February 12, 2025 at 3:01 PM
Reposted by Quinn Lee
Very pleased to share our recent work, in which we use LLMs for automated discovery of interpretable models of animal behavior 🪰🐀🕵️‍♀️ that take the form of Python programs 🐍

See below for a summary of key results by
@pcastr.bsky.social!
Can LLMs be used to discover interpretable models of human and animal behavior?🤔

Turns out: yes!

Thrilled to share our latest preprint where we used FunSearch to automatically discover symbolic cognitive models of behavior.
1/12
February 11, 2025 at 12:52 PM
Reposted by Quinn Lee
It's finally out!

Visual experience orthogonalizes visual cortical responses

Training in a visual task changes V1 tuning curves in odd ways. This effect is explained by a simple convex transformation. It orthogonalizes the population, making it easier to decode.

10.1016/j.celrep.2025.115235
February 2, 2025 at 9:59 AM
Reposted by Quinn Lee
American science and medicine has been thrown into chaos and uncertainty over the past week. Here are some stories to get up to speed. 1/12
January 28, 2025 at 3:58 AM
Reposted by Quinn Lee
Eleanor Maguire, who died 4 January at age 54, pioneered the famous London taxi-driver study and naturalistic approaches for studying spatial and episodic memory in people.

By @callimcflurry.bsky.social

www.thetransmitter.org/memory/remem...
Remembering Eleanor Maguire, ‘trailblazer’ of human memory
Maguire, mastermind of the famous London taxi-driver study, broadened the field and championed the importance of spatial representations in memory.
www.thetransmitter.org
January 10, 2025 at 10:07 PM
Reposted by Quinn Lee
Stellar new work lead by the inimitable James Whittington in Neuron that develops a new theory unifying episodic and working memory and explains diverse hippocampal and prefrontal data: www.cell.com/neuron/fullt... w/Will Dorrell, @behrenstimb.bsky.social Mohamedy El Gaby
A tale of two algorithms: Structured slots explain prefrontal sequence memory and are unified with hippocampal cognitive maps
The algorithm of the prefrontal working memory system on sequence memory tasks is not well understood, whereas it is well understood for the hippocampal episodic memory system. This work shows a mathematical duality between working and episodic sequence memory. This leads to a computational understanding of sequence working memory—as structured activity slots. This theory algorithmically explains recurrent neural network (RNN) and prefrontal representations during sequence memory tasks.
www.cell.com
December 6, 2024 at 6:47 PM
New brief report now out in Hippocampus! We used functional molecular imaging to ask if activity sparsity in the hippocampus (dorsal to ventral DG, CA3 and CA1) depends on memory task performed. Turns out the pattern is identical across tasks! onlinelibrary.wiley.com/doi/10.1002/...
#NeuroSky 🧠🧪
Sparsity of Population Activity in the Hippocampus Is Task‐Invariant Across the Trisynaptic Circuit and Dorsoventral Axis
Evidence from neurophysiological and genetic studies demonstrates that activity sparsity—the proportion of neurons that are active at a given time in a population—systematically varies across the can...
onlinelibrary.wiley.com
December 2, 2024 at 2:35 PM
Reposted by Quinn Lee
Our latest preprint has landed www.biorxiv.org/content/10.1...
Fantastic work from @laurenb29.bsky.social and Will de Cothi showing how many of the cell types associated with subiculum (e.g. boundary vector cells, corner cells) can be understood as successor features. TLDR: SUB not CA1 is the SR
Unifying Subicular Function: A Predictive Map Approach
The successor representation has emerged as a powerful model for understanding mammalian navigation and memory; explaining the spatial coding properties of hippocampal place cells and entorhinal grid ...
www.biorxiv.org
November 26, 2024 at 12:21 PM
Wicked new pre-print from @atkeinath.bsky.social
More evidence for a unifying predictive framework of cognitive mapping in the mouse brain! Also first time I have seen reliable between subject differences in maps over protracted time. Nicely done!!
Super excited to share our first preprint of work from the lab! We monitor and manipulate the CA1 representation of mice exploring a multicompartment environment to contrast geometric vs. predictive theories of cognitive mapping.

TLDR: All signs point to a predictive theory!

tinyurl.com/yeyv5p3x
Idiosyncratic navigation determines mouse CA1 representational structure in a multicompartment environment
Organisms from mice to humans rely on cognitive maps instantiated by the hippocampal formation to flexibly and efficiently navigate the world. Traditional theories of cognitive mapping posit that thes...
tinyurl.com
November 29, 2024 at 2:48 PM
Reposted by Quinn Lee
The Dept. of Computing Science at the University of Alberta is hiring! The new hires in AI will be nominated for a Canada CIFAR AI Chair. We have 3 TT positions:

AI/ML/DL Theory: apps.ualberta.ca/careers/post...
AI + SWE: apps.ualberta.ca/careers/post...
Systems: apps.ualberta.ca/careers/post...
November 27, 2024 at 3:07 PM
Reposted by Quinn Lee
What are the brain’s “real” tuning curves?

Our new preprint "SIMPL: Scalable and hassle-free optimisation of neural representations from behaviour” argues that existing techniques for latent variable discovery are lacking.

We suggest a much simpl-er way to do things.
1/21🧵
November 25, 2024 at 1:39 PM
Reposted by Quinn Lee
How can biology teach us to design better AI?🤔
Our new paper, w Mike @drmichaellevin.bsky.social "Bio-inspired AI: Integrating Biological Complexity," explores how biological principles like adaptability, context-dependence, and hierarchical processing can inspire the next generation of AI.
🧵👇1/n
November 26, 2024 at 3:35 PM
Reposted by Quinn Lee
Want to be part of the NeuroAI community CSHL ?

Applications are open for outstanding graduate students in Artificial Intelligence to spend the summer at CSHL as NeuroAI Interns.

Deadline: Dec 10th, 2024. Please spread the word!

www.schooljobs.com/careers/cshl...

@cshlaboratory.bsky.social
November 21, 2024 at 10:01 PM
Psyched that my postdoc work w @markbrandonlab.bsky.social + @atkeinath.bsky.social is now in Neuron! TL/DR: remapping in CA1 has a representational structure that is reliable across brains, and we use this representation to test models of cognitive maps.
#NeuroSky #NeuroAI 🧪🧠

tinyurl.com/4juhmad8
Identifying representational structure in CA1 to benchmark theoretical models of cognitive mapping
Decades of theoretical and empirical work have suggested the hippocampus instantiates some form of a cognitive map. Yet, tests of competing theories h…
tinyurl.com
November 22, 2024 at 6:58 PM
Reposted by Quinn Lee
Huge congrats to @karyna-mi.bsky.social for her paper published today in Science! She found that the hippocampus is really important for a key strategy we use to make decisions called hidden state inference! 🧪 🧠https://www.science.org/doi/10.1126/science.adq5874 1/7
Hidden state inference requires abstract contextual representations in the ventral hippocampus
The ability to use subjective, latent contextual representations to influence decision-making is crucial for everyday life. The hippocampus is hypothesized to bind together otherwise abstract combinat...
www.science.org
November 22, 2024 at 1:20 PM
Reposted by Quinn Lee
Our new paper in @natureportfolio.bsky.social shows entorhinal grid cells adapt their representations to a new environment in one-shot and derives a model that fuses landmarks & motion to *predict* the detailed grid rep *before* the mouse enters the new environment! www.nature.com/articles/s41...
One-shot entorhinal maps enable flexible navigation in novel environments - Nature
How the navigational system of the brain constructs spatial maps that require both rapid changes and representational accuracy is explored.
www.nature.com
November 21, 2024 at 9:57 PM