Jordi Xiol
@jordixiol.bsky.social
Science, history, and drug development | https://vineyardbooks.substack.com/
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Jordi Xiol
@jordixiol.bsky.social
· May 9
Adam and Eve Existed: They Created the Genetic Code
How did life on Earth begin? Recent scientific advances suggest that all living forms are descended from a single gene that existed around 4 billion years ago. This gene encoded for two proteins that ...
www.vineyardbooks.blog
How did life on Earth begin?
Recent scientific advances suggest that all living beings are descended from a single gene that appeared around 4 billion years ago.
New blog post
Adam and Eve Existed: They Created the Genetic Code
www.vineyardbooks.blog/p/adam-and-e...
Recent scientific advances suggest that all living beings are descended from a single gene that appeared around 4 billion years ago.
New blog post
Adam and Eve Existed: They Created the Genetic Code
www.vineyardbooks.blog/p/adam-and-e...
Reposted by Jordi Xiol
Nobel Prizes by country and year.
The dominance of Germany is striking every time. Before 1933, that is. And the utter dominance of America (and the UK) after 1945.
The dominance of Germany is striking every time. Before 1933, that is. And the utter dominance of America (and the UK) after 1945.
March 28, 2025 at 3:22 PM
Nobel Prizes by country and year.
The dominance of Germany is striking every time. Before 1933, that is. And the utter dominance of America (and the UK) after 1945.
The dominance of Germany is striking every time. Before 1933, that is. And the utter dominance of America (and the UK) after 1945.
Reposted by Jordi Xiol
"In a minefield of glitchy AI search and social media, Wikipedia becomes one of the most reliable places on the internet"
Read more, via CNN Business ➡️ edition.cnn.com/2025/01/14/b...
Read more, via CNN Business ➡️ edition.cnn.com/2025/01/14/b...
March 28, 2025 at 10:51 PM
"In a minefield of glitchy AI search and social media, Wikipedia becomes one of the most reliable places on the internet"
Read more, via CNN Business ➡️ edition.cnn.com/2025/01/14/b...
Read more, via CNN Business ➡️ edition.cnn.com/2025/01/14/b...
Nobody's talking about the fact that some anonymous hero included Jeffrey Goldberg in that Signal group chat. Lighting the way
March 27, 2025 at 7:58 AM
Nobody's talking about the fact that some anonymous hero included Jeffrey Goldberg in that Signal group chat. Lighting the way
GSK allegedly just tipped the feds that Pfizer intentionally delayed releasing its Covid vaccine Phase 3 data until after the 2020 election.
A very risky move by GSK that could seriously backfire, regardless of whether the accusation is true
www.wsj.com/health/pharm...
A very risky move by GSK that could seriously backfire, regardless of whether the accusation is true
www.wsj.com/health/pharm...
Exclusive | U.S. Prosecutors Probe Tip About Timing of Pfizer Vaccine
The inquiry is looking into a politically explosive suggestion that Pfizer delayed announcing a successful vaccine against Covid-19 until after the election that Trump lost to Biden.
www.wsj.com
March 26, 2025 at 10:23 PM
GSK allegedly just tipped the feds that Pfizer intentionally delayed releasing its Covid vaccine Phase 3 data until after the 2020 election.
A very risky move by GSK that could seriously backfire, regardless of whether the accusation is true
www.wsj.com/health/pharm...
A very risky move by GSK that could seriously backfire, regardless of whether the accusation is true
www.wsj.com/health/pharm...
🎙️Podcast
1957 - La URSS lanza el satélite Sputnik y desata la carrera espacial con Estados Unidos
2025 - DeepSeek revela la competitividad de China en inteligencia artificial
Momento DeepSeek: En este episodio analizamos el auge de China en clave biotech
open.spotify.com/episode/63Vj...
1957 - La URSS lanza el satélite Sputnik y desata la carrera espacial con Estados Unidos
2025 - DeepSeek revela la competitividad de China en inteligencia artificial
Momento DeepSeek: En este episodio analizamos el auge de China en clave biotech
open.spotify.com/episode/63Vj...
E10 - Momento DeepSeek en Biotech
PÍLDORAS de BIOTECH · Episode
open.spotify.com
March 19, 2025 at 12:06 PM
🎙️Podcast
1957 - La URSS lanza el satélite Sputnik y desata la carrera espacial con Estados Unidos
2025 - DeepSeek revela la competitividad de China en inteligencia artificial
Momento DeepSeek: En este episodio analizamos el auge de China en clave biotech
open.spotify.com/episode/63Vj...
1957 - La URSS lanza el satélite Sputnik y desata la carrera espacial con Estados Unidos
2025 - DeepSeek revela la competitividad de China en inteligencia artificial
Momento DeepSeek: En este episodio analizamos el auge de China en clave biotech
open.spotify.com/episode/63Vj...
Reposted by Jordi Xiol
A dark read from a biotech investor. Some important themes here about prioritizing shareholders substack.com/inbox/post/1...
How Biotech was broken & how to fix it!
Over the past five years, biotech investors have endured a challenging period, and industry’s struggles are evident.
substack.com
March 18, 2025 at 10:54 AM
A dark read from a biotech investor. Some important themes here about prioritizing shareholders substack.com/inbox/post/1...
"We were badly misled about Covid". TLDR, it's about a potential lab origin. Some serious soul-searching to be done on this topic by the scientific community
www.nytimes.com/2025/03/16/o...
www.nytimes.com/2025/03/16/o...
Opinion | We Were Badly Misled About Covid
The same dangerous mistakes. The same lack of candor.
www.nytimes.com
March 16, 2025 at 1:34 PM
"We were badly misled about Covid". TLDR, it's about a potential lab origin. Some serious soul-searching to be done on this topic by the scientific community
www.nytimes.com/2025/03/16/o...
www.nytimes.com/2025/03/16/o...
Roche pays $1.65B upfront to co-develop Zealand Pharma's long-acting amylin agonist for obesity. The deal includes a total consideration of $5.3B and the two companies will split profits evenly in Europe and the US
Danish biotech has been on fire lately
$ZEAL
www.globenewswire.com/news-release...
Danish biotech has been on fire lately
$ZEAL
www.globenewswire.com/news-release...
Zealand Pharma and Roche enter collaboration and license agreement to co-develop and co-commercialize petrelintide as a future foundational therapy for people with overweight and obesity
Company announcement – No. 4 / 2025 Zealand Pharma and Roche enter collaboration and license agreement to co-develop and co-commercialize petrelintide as...
www.globenewswire.com
March 12, 2025 at 7:49 AM
Roche pays $1.65B upfront to co-develop Zealand Pharma's long-acting amylin agonist for obesity. The deal includes a total consideration of $5.3B and the two companies will split profits evenly in Europe and the US
Danish biotech has been on fire lately
$ZEAL
www.globenewswire.com/news-release...
Danish biotech has been on fire lately
$ZEAL
www.globenewswire.com/news-release...
Now there's talk of a recession and the stock market is crashing. Does anyone still question that the Democrats' problem with the economy is one of communication?
A deja vu from the campaign disaster in 2016: having a great economy but letting everyone believe it’s in shambles
March 10, 2025 at 2:36 PM
Now there's talk of a recession and the stock market is crashing. Does anyone still question that the Democrats' problem with the economy is one of communication?
You are not rewriting the genetic code, John Evans, you are rewriting the genetic sequence. The genetic code has been the same since life can call itself life
$BEAM
$BEAM
March 10, 2025 at 11:54 AM
You are not rewriting the genetic code, John Evans, you are rewriting the genetic sequence. The genetic code has been the same since life can call itself life
$BEAM
$BEAM
$MLYS announces positive topline data from two pivotal trials in uncontrolled or resistant hypertension. The primary endpoint was met in both
#portfolio
ir.mineralystx.com/news-events/...
#portfolio
ir.mineralystx.com/news-events/...
Mineralys Therapeutics Announces Positive Topline Results from Launch-HTN and Advance-HTN Pivotal Trials of Lorundrostat for the Treatment of Uncontrolled or Resistant Hypertension
– Launch-HTN met its primary endpoint with lorundrostat 50 mg dose achieving a 16.9 mmHg reduction in systolic blood pressure, and a 9.1…...
ir.mineralystx.com
March 10, 2025 at 11:12 AM
$MLYS announces positive topline data from two pivotal trials in uncontrolled or resistant hypertension. The primary endpoint was met in both
#portfolio
ir.mineralystx.com/news-events/...
#portfolio
ir.mineralystx.com/news-events/...
$BEAM positive Ph1/2 data in Alpha-1 Antitrypsin Deficiency, the paradigmatic indication for a base editing approach given that neither a KO nor gene therapy would be sufficient
They also priced a $500M offering behind closed doors, this will be controversial
www.globenewswire.com/news-release...
They also priced a $500M offering behind closed doors, this will be controversial
www.globenewswire.com/news-release...
Beam Therapeutics Announces Positive Initial Data for BEAM-302 in the Phase 1/2 Trial in Alpha-1 Antitrypsin Deficiency (AATD), Demonstrating First Ever Clinical Genetic Correction of a Disease-causin...
Single Dose of BEAM-302 Led to Durable, Dose-dependent Increases in Total and Functional Alpha-1 Antitrypsin (AAT), Production of Corrected M-AAT, and...
www.globenewswire.com
March 10, 2025 at 10:58 AM
$BEAM positive Ph1/2 data in Alpha-1 Antitrypsin Deficiency, the paradigmatic indication for a base editing approach given that neither a KO nor gene therapy would be sufficient
They also priced a $500M offering behind closed doors, this will be controversial
www.globenewswire.com/news-release...
They also priced a $500M offering behind closed doors, this will be controversial
www.globenewswire.com/news-release...
Reposted by Jordi Xiol
Are the longevity crowd barking up the wrong tree because they have mistaken the chicken for the egg?
Evidence that epigenetic 'clocks' are driven by somatic mutations www.nature.com/articles/s43...
#biosky
Evidence that epigenetic 'clocks' are driven by somatic mutations www.nature.com/articles/s43...
#biosky
Somatic mutation as an explanation for epigenetic aging - Nature Aging
Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive remodeling ...
www.nature.com
March 10, 2025 at 10:48 AM
Are the longevity crowd barking up the wrong tree because they have mistaken the chicken for the egg?
Evidence that epigenetic 'clocks' are driven by somatic mutations www.nature.com/articles/s43...
#biosky
Evidence that epigenetic 'clocks' are driven by somatic mutations www.nature.com/articles/s43...
#biosky
The Monsanto acquisition probably ranks as the worst ever by a pharma company
Bayer as a whole is now worth less than what it paid for Monsanto, and litigation is putting the company in financial distress. All karma for not having bought small biotech instead :)
endpts.com/bayer-eyes-c...
Bayer as a whole is now worth less than what it paid for Monsanto, and litigation is putting the company in financial distress. All karma for not having bought small biotech instead :)
endpts.com/bayer-eyes-c...
Bayer eyes capital raise as it grapples with Monsanto cases
Bayer is asking shareholders to authorize a potential equity offer that would allow it to quickly raise billions of euros to deal with ongoing Monsanto litigation.
endpts.com
March 8, 2025 at 9:53 AM
The Monsanto acquisition probably ranks as the worst ever by a pharma company
Bayer as a whole is now worth less than what it paid for Monsanto, and litigation is putting the company in financial distress. All karma for not having bought small biotech instead :)
endpts.com/bayer-eyes-c...
Bayer as a whole is now worth less than what it paid for Monsanto, and litigation is putting the company in financial distress. All karma for not having bought small biotech instead :)
endpts.com/bayer-eyes-c...
CytomX/Amgen discontinue masked EGFR T Cell Engager
It seems intuitively hard to get to therapeutic exposures if both sides of the bispecific antibody are masked. More encouraging data with Janux' PSMA bispecific where only CD3 arm is masked
$CTMX $AMGN $JANX $VIR
ir.cytomx.com/news-release...
It seems intuitively hard to get to therapeutic exposures if both sides of the bispecific antibody are masked. More encouraging data with Janux' PSMA bispecific where only CD3 arm is masked
$CTMX $AMGN $JANX $VIR
ir.cytomx.com/news-release...
CytomX Therapeutics Announces 2024 Financial Results and Provides Business Update | CytomX Therapeutics, Inc.
- Continued progress with lead program, CX-2051 (EpCAM PROBODY ® Topo-1 ADC), in Phase 1a study in advanced colorectal cancer with initial Phase 1a clinical data to be presented in 1H 2025 - - CX-801 (PROBODY ® Interferon-alpha 2b) Phase 1a translational data in advanced melanoma expected in 2H
ir.cytomx.com
March 7, 2025 at 10:23 AM
CytomX/Amgen discontinue masked EGFR T Cell Engager
It seems intuitively hard to get to therapeutic exposures if both sides of the bispecific antibody are masked. More encouraging data with Janux' PSMA bispecific where only CD3 arm is masked
$CTMX $AMGN $JANX $VIR
ir.cytomx.com/news-release...
It seems intuitively hard to get to therapeutic exposures if both sides of the bispecific antibody are masked. More encouraging data with Janux' PSMA bispecific where only CD3 arm is masked
$CTMX $AMGN $JANX $VIR
ir.cytomx.com/news-release...
Giving GPT 4.5 a try and the reasoning capacity is getting scary. Where did the people who said that LLMs were just statistical parrots go?
March 5, 2025 at 7:28 PM
Giving GPT 4.5 a try and the reasoning capacity is getting scary. Where did the people who said that LLMs were just statistical parrots go?
Dry powder for European biotech: Sofinnova Partners raises €1.2B to fuel the next wave of life sciences innovation
sofinnovapartners.com/news/sofinno...
sofinnovapartners.com/news/sofinno...
Sofinnova Partners raises €1.2 billion to fuel the next wave of life sciences innovation — Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm in life sciences, specializing in healthcare and sustainability. Based in Paris, London and Milan, the firm brings together a team of prof...
sofinnovapartners.com
March 4, 2025 at 7:36 AM
Dry powder for European biotech: Sofinnova Partners raises €1.2B to fuel the next wave of life sciences innovation
sofinnovapartners.com/news/sofinno...
sofinnovapartners.com/news/sofinno...
"Coalition of the willing" is the new way Europe needs to operate on everything, not just geopolitics. Just get together the countries who agree on something, and get it done
www.theguardian.com/world/2025/m...
www.theguardian.com/world/2025/m...
Orbán problem pushes EU towards ‘coalitions of the willing’ on Ukraine
As crisis talks loom, Trump and the bloc’s own populist spoilers have driven it away from its old quest for unanimity
www.theguardian.com
March 2, 2025 at 10:32 PM
"Coalition of the willing" is the new way Europe needs to operate on everything, not just geopolitics. Just get together the countries who agree on something, and get it done
www.theguardian.com/world/2025/m...
www.theguardian.com/world/2025/m...
Are European labs seeing an uptick in high-quality postdoc applications? Just curious
February 28, 2025 at 9:05 PM
Are European labs seeing an uptick in high-quality postdoc applications? Just curious
Stem cell therapy in epilepsy: an interview with Jonathon Parker, investigator in Neurona Therapeutic’s pioneering trial
#portfolio
www.neurologylive.com/view/stem-ce...
#portfolio
www.neurologylive.com/view/stem-ce...
Stem Cells in Epilepsy: Innovations and Challenges in Neurosurgical Treatment
Jonathon Parker, MD, PhD, an assistant professor of neurosurgery and neuroscience at Mayo Clinic Arizona, provided commentary on the promise and roadblocks behind stem cell approaches in epilepsy.
www.neurologylive.com
February 27, 2025 at 8:18 PM
Stem cell therapy in epilepsy: an interview with Jonathon Parker, investigator in Neurona Therapeutic’s pioneering trial
#portfolio
www.neurologylive.com/view/stem-ce...
#portfolio
www.neurologylive.com/view/stem-ce...
Are low-resolution images in a corporate deck a red flag? yes/no
February 27, 2025 at 4:16 PM
Are low-resolution images in a corporate deck a red flag? yes/no
John Stewart slices his hand while talking drug pricing
The biopharma sector needs to fight the common misconception that drug development is funded by taxpayer money. Basic research and development are both equally necessary, but they're very different things
www.dailykos.com/stories/2025...
The biopharma sector needs to fight the common misconception that drug development is funded by taxpayer money. Basic research and development are both equally necessary, but they're very different things
www.dailykos.com/stories/2025...
Jon Stewart’s DOGE rage draws blood—literally
“Daily Show” host Jon Stewart accidentally sliced his hand during his opening monologue on Monday night. The incident happened as Stewart worked himself up over the horse manure being tossed ...
www.dailykos.com
February 26, 2025 at 7:59 AM
John Stewart slices his hand while talking drug pricing
The biopharma sector needs to fight the common misconception that drug development is funded by taxpayer money. Basic research and development are both equally necessary, but they're very different things
www.dailykos.com/stories/2025...
The biopharma sector needs to fight the common misconception that drug development is funded by taxpayer money. Basic research and development are both equally necessary, but they're very different things
www.dailykos.com/stories/2025...
Reposted by Jordi Xiol
