John Novembre
@jnovembre.bsky.social
Population geneticist, University of Chicago
Reposted by John Novembre
The 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs:
probgen2026.github.io
Please help spread the news.
probgen2026.github.io
Please help spread the news.
Home - ProbGen 2026
Your Site Description
probgen2026.github.io
June 6, 2025 at 5:52 PM
The 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs:
probgen2026.github.io
Please help spread the news.
probgen2026.github.io
Please help spread the news.
Excited for our publication on how the geographic scale of a sample affects the discovery of rare, deleterious variants to be out this week. With a mix of theory, simulation, and data analysis, we show when samples are narrow vs broad, the number of variants discovered and their frequencies change
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
June 5, 2025 at 5:55 PM
Excited for our publication on how the geographic scale of a sample affects the discovery of rare, deleterious variants to be out this week. With a mix of theory, simulation, and data analysis, we show when samples are narrow vs broad, the number of variants discovered and their frequencies change
Reposted by John Novembre
New work by Andy Dahl and Michal Sadowski on using GxE to study genetics of drug response now out in Cell Genomics www.cell.com/cell-genomic...
Characterizing the genetic architecture of drug response using gene-context interaction methods
Sadowski et al. propose a framework to study the genetics of response to commonly prescribed drugs in large biobanks. They quantify the heritability of response to statins, metformin, warfarin, and methotrexate, and identify associated genes. Their analysis also shows the importance of accounting for drug use in genetic risk prediction.
www.cell.com
December 4, 2024 at 8:46 PM
New work by Andy Dahl and Michal Sadowski on using GxE to study genetics of drug response now out in Cell Genomics www.cell.com/cell-genomic...
Check it out - PhD student @maggiesteiner.bsky.social's nice thread and link to our new preprint on how sample design, in terms of how geographically narrow vs broad a sample is, impacts the discovery/SFS of deleterious variants.
Excited to share a new preprint with @jnovembre.bsky.social ! We use a combination of population genetic theory, simulation, and data analysis to ask: how does study design in genetic studies (including biobanks) impact the discovery of rare, deleterious variants?
Study design and the sampling of deleterious rare variants in biobank-scale datasets https://www.biorxiv.org/content/10.1101/2024.12.02.626424v1
December 4, 2024 at 6:02 PM
Check it out - PhD student @maggiesteiner.bsky.social's nice thread and link to our new preprint on how sample design, in terms of how geographically narrow vs broad a sample is, impacts the discovery/SFS of deleterious variants.
#ASHG24 - Check out our new methods to reveal population structure through time -- poster 3026F presented today by Ahmed Selim from the lab!
November 8, 2024 at 9:06 PM
#ASHG24 - Check out our new methods to reveal population structure through time -- poster 3026F presented today by Ahmed Selim from the lab!
#ASHG24 make your way to today’s Novembre lab posters 3015 (label free reference matching, @LukeAnderTroc) 3016 (rare variant discovery, @maggiecsteiner ) and 4041 (impacts of multigeneration shared environments, @mkiravn) to see some great science!
November 6, 2024 at 10:17 PM
#ASHG24 make your way to today’s Novembre lab posters 3015 (label free reference matching, @LukeAnderTroc) 3016 (rare variant discovery, @maggiecsteiner ) and 4041 (impacts of multigeneration shared environments, @mkiravn) to see some great science!
Come join us! UChicago Human Genetics has an open broad computational faculty search (with an emphasis on probabilistic machine learning). First round of application review will begin ~October 15th. apply.interfolio.com/149891 EOE/Vet/Disability.
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 18, 2024 at 12:13 PM
Come join us! UChicago Human Genetics has an open broad computational faculty search (with an emphasis on probabilistic machine learning). First round of application review will begin ~October 15th. apply.interfolio.com/149891 EOE/Vet/Disability.
Reposted by John Novembre
Allele ages provide limited information about the strength of negative selection https://www.biorxiv.org/content/10.1101/2024.08.06.606888v1
Allele ages provide limited information about the strength of negative selection https://www.biorxiv.org/content/10.1101/2024.08.06.606888v1
For many problems in population genetics, it is useful to characterize the distribution of fitness e
www.biorxiv.org
August 7, 2024 at 3:31 AM
Allele ages provide limited information about the strength of negative selection https://www.biorxiv.org/content/10.1101/2024.08.06.606888v1
Reposted by John Novembre
Just reposting James Kitchens blog post on pedigrees and the coalescent. As I'm using the R shiny he made for teaching again this year
james-kitchens.com/blog/why-are...
james-kitchens.com/blog/why-are...
Why Are There So Many Gene Trees?
In evolutionary biology, we often think about the phylogeny of a group, the underlying relationships between the samples. When the comparison is of species (particularly those that are distantly relat...
james-kitchens.com
November 20, 2023 at 4:47 AM
Just reposting James Kitchens blog post on pedigrees and the coalescent. As I'm using the R shiny he made for teaching again this year
james-kitchens.com/blog/why-are...
james-kitchens.com/blog/why-are...