John Novembre
@jnovembre.bsky.social
Population geneticist, University of Chicago
This was a large collaborative piece of work with the lead efforts by student @maggiesteiner.bsky.social and former postdoc Dan Rice. It's well-timed for Maggie especially as she is defending her thesis on Monday!
June 5, 2025 at 8:46 PM
This was a large collaborative piece of work with the lead efforts by student @maggiesteiner.bsky.social and former postdoc Dan Rice. It's well-timed for Maggie especially as she is defending her thesis on Monday!
Incl. alleles that go undiscovered, the average sample frequency of alleles stays the same regardless of sampling scale. This dovetails w/ a complementary paper on deleterious variants across ancestries (also in PNAS) from Anastasia Stoylarova, @gcbias.bsky.social & @mollyprz.bsky.social
The distribution of highly deleterious variants across human ancestry groups - PubMed
A major focus of human genetics is to map severe disease mutations. Increasingly, that goal is understood as requiring huge numbers of people to be sequenced from every broadly defined genetic ancestr...
pubmed.ncbi.nlm.nih.gov
June 5, 2025 at 6:04 PM
Incl. alleles that go undiscovered, the average sample frequency of alleles stays the same regardless of sampling scale. This dovetails w/ a complementary paper on deleterious variants across ancestries (also in PNAS) from Anastasia Stoylarova, @gcbias.bsky.social & @mollyprz.bsky.social
One reason I love what come out of this project is that Dan Rice and @maggiesteiner.bsky.social got in the trenches and developed theory for a model with mutation, selection, drift, geographic dispersal, -and- uneven geographic sampling, which is remarkable simply from a modeling perspective.
December 5, 2024 at 1:28 AM
One reason I love what come out of this project is that Dan Rice and @maggiesteiner.bsky.social got in the trenches and developed theory for a model with mutation, selection, drift, geographic dispersal, -and- uneven geographic sampling, which is remarkable simply from a modeling perspective.
Thanks for sharing Dan and my condolences.
November 21, 2023 at 11:44 PM
Thanks for sharing Dan and my condolences.