Jelte van der Vaart
@jeltevdv.bsky.social
Postdoc 👨🏻🔬 Maurice Lab, Center for Molecular Medicine, Utrecht, The Netherlands | Peutz-Jeghers Syndrome | Adrenal cortex
Fascinated by using human representative organoid models to study (endocrine) biology and disease
Fascinated by using human representative organoid models to study (endocrine) biology and disease
Reposted by Jelte van der Vaart
Jelte van der Vaart, postdoc in our lab, has been awarded an NWO Veni grant! 🎉
He will develop human adrenal organoids to uncover how hormone producing cells change identity and function, shedding light on endocrine health.
We're so proud of his achievement and will support him along the way 😁
He will develop human adrenal organoids to uncover how hormone producing cells change identity and function, shedding light on endocrine health.
We're so proud of his achievement and will support him along the way 😁
August 13, 2025 at 11:40 AM
Jelte van der Vaart, postdoc in our lab, has been awarded an NWO Veni grant! 🎉
He will develop human adrenal organoids to uncover how hormone producing cells change identity and function, shedding light on endocrine health.
We're so proud of his achievement and will support him along the way 😁
He will develop human adrenal organoids to uncover how hormone producing cells change identity and function, shedding light on endocrine health.
We're so proud of his achievement and will support him along the way 😁
Honoured to present at the Oncode Institute Annual Meeting 2025, sharing my journey in adrenal cortex biology and organoid development from adrenocortical cancer. Grateful to the organisers for the opportunity and the inspiring discussions.
June 25, 2025 at 9:29 AM
Honoured to present at the Oncode Institute Annual Meeting 2025, sharing my journey in adrenal cortex biology and organoid development from adrenocortical cancer. Grateful to the organisers for the opportunity and the inspiring discussions.
Only 2 weeks left until I run up the Alpe d’Huez for cancer research! 🏃♂️⛰️
Training is going strong, and I’m so close to reaching my €2500 fundraising goal.
Help me get there — and support research into rare cancers like adrenocortical cancer.
💛 Donate here: www.opgevenisgeenoptie.nl/fundraisers/...
Training is going strong, and I’m so close to reaching my €2500 fundraising goal.
Help me get there — and support research into rare cancers like adrenocortical cancer.
💛 Donate here: www.opgevenisgeenoptie.nl/fundraisers/...
May 20, 2025 at 2:40 PM
Only 2 weeks left until I run up the Alpe d’Huez for cancer research! 🏃♂️⛰️
Training is going strong, and I’m so close to reaching my €2500 fundraising goal.
Help me get there — and support research into rare cancers like adrenocortical cancer.
💛 Donate here: www.opgevenisgeenoptie.nl/fundraisers/...
Training is going strong, and I’m so close to reaching my €2500 fundraising goal.
Help me get there — and support research into rare cancers like adrenocortical cancer.
💛 Donate here: www.opgevenisgeenoptie.nl/fundraisers/...
Reposted by Jelte van der Vaart
It's World Hormone Day! 🥳
The global endocrine community is joining forces today to raise awareness of the vital role of hormones in preventing and treating disease.
Help spread the word by sharing and following #BecauseHormonesMatter
www.worldhormoneday.org
The global endocrine community is joining forces today to raise awareness of the vital role of hormones in preventing and treating disease.
Help spread the word by sharing and following #BecauseHormonesMatter
www.worldhormoneday.org
April 24, 2025 at 8:39 AM
It's World Hormone Day! 🥳
The global endocrine community is joining forces today to raise awareness of the vital role of hormones in preventing and treating disease.
Help spread the word by sharing and following #BecauseHormonesMatter
www.worldhormoneday.org
The global endocrine community is joining forces today to raise awareness of the vital role of hormones in preventing and treating disease.
Help spread the word by sharing and following #BecauseHormonesMatter
www.worldhormoneday.org
🌍 Today is #RareDiseaseDay
Adrenocortical cancer affects just 1–2 per million, making research and treatment development challenging. But rare shouldn’t mean forgotten! ACC research is key to better treatments. Let’s keep pushing forward!
#AdrenocorticalCancer #RareButImportant
Adrenocortical cancer affects just 1–2 per million, making research and treatment development challenging. But rare shouldn’t mean forgotten! ACC research is key to better treatments. Let’s keep pushing forward!
#AdrenocorticalCancer #RareButImportant
February 28, 2025 at 4:07 PM
🌍 Today is #RareDiseaseDay
Adrenocortical cancer affects just 1–2 per million, making research and treatment development challenging. But rare shouldn’t mean forgotten! ACC research is key to better treatments. Let’s keep pushing forward!
#AdrenocorticalCancer #RareButImportant
Adrenocortical cancer affects just 1–2 per million, making research and treatment development challenging. But rare shouldn’t mean forgotten! ACC research is key to better treatments. Let’s keep pushing forward!
#AdrenocorticalCancer #RareButImportant
Reposted by Jelte van der Vaart
📢 Organoid enthusiast: We are preparing for the 3rd edition of OrganoidNL - April 11th!
🔥 Check amazing line up of speakers 🔥
Calvin Kuo @priscaliberali.bsky.social Nicolas Rivron, Ina Sonnen @kaikretzschmar.bsky.social Mina Gouti, and others. Be fast to register in time
amolf.nl/organoidnl-s...
🔥 Check amazing line up of speakers 🔥
Calvin Kuo @priscaliberali.bsky.social Nicolas Rivron, Ina Sonnen @kaikretzschmar.bsky.social Mina Gouti, and others. Be fast to register in time
amolf.nl/organoidnl-s...
OrganoidNL Symposium - AMOLF
OrganoidNL Symposium 2025 Friday, April 11
amolf.nl
February 14, 2025 at 1:50 PM
📢 Organoid enthusiast: We are preparing for the 3rd edition of OrganoidNL - April 11th!
🔥 Check amazing line up of speakers 🔥
Calvin Kuo @priscaliberali.bsky.social Nicolas Rivron, Ina Sonnen @kaikretzschmar.bsky.social Mina Gouti, and others. Be fast to register in time
amolf.nl/organoidnl-s...
🔥 Check amazing line up of speakers 🔥
Calvin Kuo @priscaliberali.bsky.social Nicolas Rivron, Ina Sonnen @kaikretzschmar.bsky.social Mina Gouti, and others. Be fast to register in time
amolf.nl/organoidnl-s...
Reposted by Jelte van der Vaart
Our Center for Molecular Medicine (cmmutrecht.eu) at UMC Utrecht, NL, is looking for a Principal Investigator in the field of fundamental Cancer Biology! The vacancy states tenure track level, but candidates with a more advanced career are very welcome to apply. shorturl.at/KZeYQ. Please repost!
Center for Molecular Medicine
cmmutrecht.eu
February 7, 2025 at 12:09 PM
Our Center for Molecular Medicine (cmmutrecht.eu) at UMC Utrecht, NL, is looking for a Principal Investigator in the field of fundamental Cancer Biology! The vacancy states tenure track level, but candidates with a more advanced career are very welcome to apply. shorturl.at/KZeYQ. Please repost!
Reposted by Jelte van der Vaart
✨ New #Review ✨
@madelonmaurice.bsky.social & Stephane Angers discuss the newest insights on #WntSignalling with a focus on biogenesis & transport of Wnts and Wnt receptor complex activation.
👉 go.nature.com/42ynuU0
@madelonmaurice.bsky.social & Stephane Angers discuss the newest insights on #WntSignalling with a focus on biogenesis & transport of Wnts and Wnt receptor complex activation.
👉 go.nature.com/42ynuU0
Mechanistic insights into Wnt–β-catenin pathway activation and signal transduction - Nature Reviews Molecular Cell Biology
Wnt–β-catenin signalling regulates stem cell renewal, development and tissue homeostasis. In this Review, the authors examine recent findings concerning Wnt protein production, receptor activation and...
go.nature.com
January 28, 2025 at 7:43 AM
✨ New #Review ✨
@madelonmaurice.bsky.social & Stephane Angers discuss the newest insights on #WntSignalling with a focus on biogenesis & transport of Wnts and Wnt receptor complex activation.
👉 go.nature.com/42ynuU0
@madelonmaurice.bsky.social & Stephane Angers discuss the newest insights on #WntSignalling with a focus on biogenesis & transport of Wnts and Wnt receptor complex activation.
👉 go.nature.com/42ynuU0
Reposted by Jelte van der Vaart
📣January is #AdrenalCancerAwarenessMonth
Let’s talk about #AdrenoCorticalCarcinoma to fight it together! #ACC #AdrenalCancer #CureACC #EndoSky #MedSky @amenduk.bsky.social
Let’s talk about #AdrenoCorticalCarcinoma to fight it together! #ACC #AdrenalCancer #CureACC #EndoSky #MedSky @amenduk.bsky.social
January 25, 2025 at 8:30 AM
📣January is #AdrenalCancerAwarenessMonth
Let’s talk about #AdrenoCorticalCarcinoma to fight it together! #ACC #AdrenalCancer #CureACC #EndoSky #MedSky @amenduk.bsky.social
Let’s talk about #AdrenoCorticalCarcinoma to fight it together! #ACC #AdrenalCancer #CureACC #EndoSky #MedSky @amenduk.bsky.social
Reposted by Jelte van der Vaart
Pre-print Alert! 📢
Proud to share our insights on WNT7B driving pancreatic cancer progression. Sprangers et al uses organoids to show that WNT7B employs short-range signaling driving tumor growth and mediate a shift of PDAC cells towards a more aggressive phenotype
www.biorxiv.org/content/10.1...
Proud to share our insights on WNT7B driving pancreatic cancer progression. Sprangers et al uses organoids to show that WNT7B employs short-range signaling driving tumor growth and mediate a shift of PDAC cells towards a more aggressive phenotype
www.biorxiv.org/content/10.1...
WNT7B drives a program for pancreatic cancer subtype switching and progression
Hyperactivation of WNT signaling is a well-established hallmark of cancer. Various epithelial cancers express high levels of WNT7B and WNT10A that are not commonly expressed during tissue homeostasis,...
www.biorxiv.org
December 22, 2024 at 8:30 PM
Pre-print Alert! 📢
Proud to share our insights on WNT7B driving pancreatic cancer progression. Sprangers et al uses organoids to show that WNT7B employs short-range signaling driving tumor growth and mediate a shift of PDAC cells towards a more aggressive phenotype
www.biorxiv.org/content/10.1...
Proud to share our insights on WNT7B driving pancreatic cancer progression. Sprangers et al uses organoids to show that WNT7B employs short-range signaling driving tumor growth and mediate a shift of PDAC cells towards a more aggressive phenotype
www.biorxiv.org/content/10.1...
Reposted by Jelte van der Vaart
Excited about our pre-print on AXIN1 mutations in HCC!
We found that AXIN1 mutations drive low but physiologically relevant levels of Wnt/β-catenin signaling, while being permissive to YAP/TAZ activation. This helps explain why mutations in AXIN1 and β-catenin are linked to distinct HCC subtypes.
We found that AXIN1 mutations drive low but physiologically relevant levels of Wnt/β-catenin signaling, while being permissive to YAP/TAZ activation. This helps explain why mutations in AXIN1 and β-catenin are linked to distinct HCC subtypes.
Hepatocellular carcinoma-associated AXIN1 mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signaling https://www.biorxiv.org/content/10.1101/2024.11.28.625941v1
Hepatocellular carcinoma-associated AXIN1 mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signaling https://www.biorxiv.org/content/10.1101/2024.11.28.625941v1
In healthy cells, AXIN1 organizes assembly of a large destruction complex that mediates proteolysis
www.biorxiv.org
December 8, 2024 at 4:17 PM
Excited about our pre-print on AXIN1 mutations in HCC!
We found that AXIN1 mutations drive low but physiologically relevant levels of Wnt/β-catenin signaling, while being permissive to YAP/TAZ activation. This helps explain why mutations in AXIN1 and β-catenin are linked to distinct HCC subtypes.
We found that AXIN1 mutations drive low but physiologically relevant levels of Wnt/β-catenin signaling, while being permissive to YAP/TAZ activation. This helps explain why mutations in AXIN1 and β-catenin are linked to distinct HCC subtypes.
Scientists are fleeing Twitter and joining forces on BlueSky 🦋. Interested in seeing your (departmental) colleagues of the Center for Molecular Medicine, Utrecht? Join the CMM starter pack
go.bsky.app/N5aWHZ2
go.bsky.app/N5aWHZ2
CMM starterpack
Join the conversation
go.bsky.app
December 6, 2024 at 8:23 AM
Scientists are fleeing Twitter and joining forces on BlueSky 🦋. Interested in seeing your (departmental) colleagues of the Center for Molecular Medicine, Utrecht? Join the CMM starter pack
go.bsky.app/N5aWHZ2
go.bsky.app/N5aWHZ2
Reposted by Jelte van der Vaart
#Organoid research starter pack.
I didn't find many researchers from the field yet, please comment/text me to be added!
go.bsky.app/RmXgs6d
I didn't find many researchers from the field yet, please comment/text me to be added!
go.bsky.app/RmXgs6d
November 24, 2024 at 8:32 AM
#Organoid research starter pack.
I didn't find many researchers from the field yet, please comment/text me to be added!
go.bsky.app/RmXgs6d
I didn't find many researchers from the field yet, please comment/text me to be added!
go.bsky.app/RmXgs6d