@jebkeiper.bsky.social
Biotech / pharma industry. Most interested in making medicines for patients that need them.
Reposted
The difference between #techbio and #biotech is hubris. Where #techbio believes biological mystery can be overcome by more data and that the underlying mechanism is unimportant, #biotech (and it's children #synbio #engbio) believes that the mechanism itself will lead to new wonders
January 24, 2025 at 6:34 AM
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My latest is an in-depth look at China's scientific rise unnerving the US biotech industry. A 🧵:
endpts.com/chinas-drug-...
endpts.com/chinas-drug-...
China's biotech boom is threatening US drugmakers' dominance
In 2019, Stanford University professor Irv Weissman and a colleague published a paper that represented a new way to target some aggressive cancers. Shortly after, they did what many researchers ...
endpts.com
January 21, 2025 at 4:21 PM
My latest is an in-depth look at China's scientific rise unnerving the US biotech industry. A 🧵:
endpts.com/chinas-drug-...
endpts.com/chinas-drug-...
January 14, 2025 at 8:52 PM
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Biotech on Bluesky get a look first.
RA Capital’s annual thoughts on how biotech can better (Semper Maior; always better). This one explore how we can elicit more candor. Some stories, too.
And tons of top-down data analyzing 2024 performance & setup for 2025.
rapport.bio/all-stories/...
RA Capital’s annual thoughts on how biotech can better (Semper Maior; always better). This one explore how we can elicit more candor. Some stories, too.
And tons of top-down data analyzing 2024 performance & setup for 2025.
rapport.bio/all-stories/...
Semper Maior: Pumping up the candor — RApport
Wouldn’t it be better if everyone in our ecosystem were candid with one another? After all, within companies it’s common to encourage everyone to speak their minds. If you see a problem, call it out;...
rapport.bio
January 11, 2025 at 7:02 PM
Biotech on Bluesky get a look first.
RA Capital’s annual thoughts on how biotech can better (Semper Maior; always better). This one explore how we can elicit more candor. Some stories, too.
And tons of top-down data analyzing 2024 performance & setup for 2025.
rapport.bio/all-stories/...
RA Capital’s annual thoughts on how biotech can better (Semper Maior; always better). This one explore how we can elicit more candor. Some stories, too.
And tons of top-down data analyzing 2024 performance & setup for 2025.
rapport.bio/all-stories/...
Reposted
Biotech on Bluesky, I’m sharing with you first.
RA Capital just launched Biotech Unveiled, a free online course our team created.
Learn at own pace. Covers fundamentals of how insurance + investment direct R&D. Essential knowledge for leaders.
racap.thinkific.com/courses/biot...
RA Capital just launched Biotech Unveiled, a free online course our team created.
Learn at own pace. Covers fundamentals of how insurance + investment direct R&D. Essential knowledge for leaders.
racap.thinkific.com/courses/biot...
Biotech Unveiled: How the Biotech Industry Works
Designed to empower biotech professionals early in their career and set them up to succeed in the broader context in which they operate, this free mini-course is full of everything you've wanted to know about biotech but didn't know who to ask.
racap.thinkific.com
January 8, 2025 at 8:04 PM
Biotech on Bluesky, I’m sharing with you first.
RA Capital just launched Biotech Unveiled, a free online course our team created.
Learn at own pace. Covers fundamentals of how insurance + investment direct R&D. Essential knowledge for leaders.
racap.thinkific.com/courses/biot...
RA Capital just launched Biotech Unveiled, a free online course our team created.
Learn at own pace. Covers fundamentals of how insurance + investment direct R&D. Essential knowledge for leaders.
racap.thinkific.com/courses/biot...
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Re-upping this reply thread from last night. Drugs don't come from nowhere, folks. And we're not ripping off the NIH, either.
I think you're describing science, IMO. Everything is atop a foundation of basic research. An example: at a previous company, I worked on a series of small-molecule inhibitors of Hormone-Sensitive Lipase, a possible target for Type II diabetes and related conditions. (1/10)
January 6, 2025 at 2:36 PM
Re-upping this reply thread from last night. Drugs don't come from nowhere, folks. And we're not ripping off the NIH, either.
Is it just me or is the biggest biotech / Pharma deal news this week going to be Centerview selling a stake?
January 6, 2025 at 6:30 PM
Is it just me or is the biggest biotech / Pharma deal news this week going to be Centerview selling a stake?
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He did it because he had a seven-year old daughter who had never seen one of his films and he wanted to make something she could see. He also said “I’m going to play this movie like I’m working with the Royal Shakespeare Company” www.gq.com/story/michae...
Michael Caine Loves 'The Muppet Christmas Carol' as Much as You Do
God bless us, every one! But especially Michael Caine.
www.gq.com
December 26, 2024 at 2:56 AM
He did it because he had a seven-year old daughter who had never seen one of his films and he wanted to make something she could see. He also said “I’m going to play this movie like I’m working with the Royal Shakespeare Company” www.gq.com/story/michae...
Reposted
New York Times
‘Six Childhood Scourges We’ve Forgotten About, Thanks to Vaccines
Most Americans, including doctors, have no memory of the devastating diseases that routinely threatened children until the 1960s.’
‘Six Childhood Scourges We’ve Forgotten About, Thanks to Vaccines
Most Americans, including doctors, have no memory of the devastating diseases that routinely threatened children until the 1960s.’
Six Childhood Scourges We’ve Forgotten About, Thanks to Vaccines
Most Americans, including doctors, have no memory of the devastating diseases that routinely threatened children until the 1960s.
www.nytimes.com
December 13, 2024 at 1:57 PM
New York Times
‘Six Childhood Scourges We’ve Forgotten About, Thanks to Vaccines
Most Americans, including doctors, have no memory of the devastating diseases that routinely threatened children until the 1960s.’
‘Six Childhood Scourges We’ve Forgotten About, Thanks to Vaccines
Most Americans, including doctors, have no memory of the devastating diseases that routinely threatened children until the 1960s.’
Kudos to both Vijay and Vineeta!
Scoop with @kylelahucik.bsky.social and @drewsnews.bsky.social: There's a changing of the guards atop a16z's health and biotech team. Vijay Pande is handing over the reins to Vineeta Agarwala as he prepares for a larger role involving AI in healthcare. endpts.com/vijay-pande-...
Exclusive: Vijay Pande hands a16z biotech leadership to Vineeta Agarwala, moves to AI role
The biotech and life sciences team at a16z is getting a new leader, as founding investor Vijay Pande moves into a role focused on artificial intelligence and its healthcare applications, Endpoints New...
endpts.com
December 9, 2024 at 9:31 PM
Kudos to both Vijay and Vineeta!
@lisamjarvis.bsky.social’s editorial on the shocking murder of UnitedHealth Insurance’s CEO is a must read, and masterclass on balanced perspectives. The health insurance “industry” has a basic economic principle incompatible with others in the ecosystem. Collect premiums, don’t pay claims.
Can the public's rage over our broken health care system, which boiled over in response to the fatal shooting of UnitedHealth Group executive Brian Thompson, be channeled into anything productive? Some thoughts on this week's events. (gift link):
The Health Insurance Industry Is Broken. Don’t Let It Break Us.
The ghoulish reaction to the slaying of UnitedHealth's Brian Thompson reflects frustration over a failed and unfair system.
www.bloomberg.com
December 7, 2024 at 4:44 PM
@lisamjarvis.bsky.social’s editorial on the shocking murder of UnitedHealth Insurance’s CEO is a must read, and masterclass on balanced perspectives. The health insurance “industry” has a basic economic principle incompatible with others in the ecosystem. Collect premiums, don’t pay claims.
Read further and found this alternative suggested by the strike organizers. Yoink!!
December 7, 2024 at 3:18 AM
Read further and found this alternative suggested by the strike organizers. Yoink!!
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@dereklowe.bsky.social honing in on the same bottom line message from @wpwalters.bsky.social @prof-ajay-jain.bsky.social
it's so true and hits so hard:
it's so true and hits so hard:
December 6, 2024 at 8:57 PM
@dereklowe.bsky.social honing in on the same bottom line message from @wpwalters.bsky.social @prof-ajay-jain.bsky.social
it's so true and hits so hard:
it's so true and hits so hard:
Reposted
Between the earthquake/tsuanmi scare, the UnitedHealthcare shooting and the South Korea martial law stuff this week, it feels like Bluesky is getting more and more critical mass around breaking events that made Twitter so sticky and useful.
December 6, 2024 at 12:29 AM
Between the earthquake/tsuanmi scare, the UnitedHealthcare shooting and the South Korea martial law stuff this week, it feels like Bluesky is getting more and more critical mass around breaking events that made Twitter so sticky and useful.
Reposted
You may not understand why, but the healthcare insurance and PBM contracts YOU have signed for Tesla, SpaceX , @X, along with CEOs of other big companies , have more impact on healthcare costs and quality of care in this country, than anything you can do with DOGE
December 5, 2024 at 9:59 PM
You may not understand why, but the healthcare insurance and PBM contracts YOU have signed for Tesla, SpaceX , @X, along with CEOs of other big companies , have more impact on healthcare costs and quality of care in this country, than anything you can do with DOGE
Reposted
DiffDock, a new diffusion-based ligand docking program, made s big splash earlier this year. But it’s apparently not all it’s claimed to be:
Computational Care
www.science.org
December 6, 2024 at 5:01 PM
DiffDock, a new diffusion-based ligand docking program, made s big splash earlier this year. But it’s apparently not all it’s claimed to be:
Reposted
Sometimes the combination of arrogance and ignorance is breathtaking. Yes, US health care has high admin costs; that's because it relies so much on private insurers. Govt-run health insurance has much lower overhead
December 6, 2024 at 11:49 AM
Sometimes the combination of arrogance and ignorance is breathtaking. Yes, US health care has high admin costs; that's because it relies so much on private insurers. Govt-run health insurance has much lower overhead
@lifescivc.bsky.social blog on Atlas Venture's recent fundraising is a master class in biotech venture capital financial metrics. A must read.
lifescivc.com/2024/12/atla...
lifescivc.com/2024/12/atla...
Atlas XIV And Reflections On The VC Math Problem - LifeSciVC
Today we announced the closing of Atlas Venture Fund XIV, a $450M investment vehicle focused exclusively on early stage biotech investing. With the closing of Fund XIV, we’re privileged to be able to ...
lifescivc.com
December 5, 2024 at 4:40 PM
@lifescivc.bsky.social blog on Atlas Venture's recent fundraising is a master class in biotech venture capital financial metrics. A must read.
lifescivc.com/2024/12/atla...
lifescivc.com/2024/12/atla...
I’ve worked with Ramy for years, and I completely agree that the overhype doesn’t help make medicines any faster. AI is a great tool, it’s not a solution in and of itself.
Farid's hot takes contradict many dogmas in the AI #drugdesign industry:
That attaching the workhorse of the wet lab to the #AI cart will make it go; that designing small molecule drugs with AI will work at all; that all of the startups purporting to use AI are actually telling the truth.
🩺🖥️🧪💊
That attaching the workhorse of the wet lab to the #AI cart will make it go; that designing small molecule drugs with AI will work at all; that all of the startups purporting to use AI are actually telling the truth.
🩺🖥️🧪💊
December 4, 2024 at 1:26 PM
I’ve worked with Ramy for years, and I completely agree that the overhype doesn’t help make medicines any faster. AI is a great tool, it’s not a solution in and of itself.
Reposted
The fight between Eli Lilly and Novo Nordisk over the booming obesity drug market is intensifying now that manufacturing has ramped up. This Lilly-sponsored study is one jab.
Eli Lilly’s Zepbound Beats Novo Nordisk’s Wegovy in First Head-to-Head Study
People who took Zepbound lost 17 pounds more on average after 72 weeks of treatment than those who were given Novo Nordisk’s drug.
www.wsj.com
December 4, 2024 at 12:04 PM
The fight between Eli Lilly and Novo Nordisk over the booming obesity drug market is intensifying now that manufacturing has ramped up. This Lilly-sponsored study is one jab.
This whole thread. The beauty of this platform…
Atoms are binary. They are either intended to be hydrogen or helium. We can't just scrap this worldview just because of a handful of exceptions
November 30, 2024 at 9:34 PM
This whole thread. The beauty of this platform…
Reposted
Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera | Collaboration with @georgwinter.bsky.social and Kristin Riching labs. Now published in Journal of the American Chemical Society @acsjacs.bsky.social pubs.acs.org/doi/10.1021/...
Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera
Proteolysis targeting chimera (PROTAC) degraders are typically bifunctional with one E3 ligase ligand connected to one target protein ligand via a linker. While augmented valency has been shown with t...
pubs.acs.org
November 30, 2024 at 4:35 PM
Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera | Collaboration with @georgwinter.bsky.social and Kristin Riching labs. Now published in Journal of the American Chemical Society @acsjacs.bsky.social pubs.acs.org/doi/10.1021/...