Jeremy Ducharme
@jbducharme.bsky.social
Post-doc at the University of Florida studying regulation of muscle mass and cancer associated muscle pathology.
Reposted by Jeremy Ducharme
🧪 Really cool new #circadian paper looking at the role of the liver clock in inter-organ crosstalk with muscle during Cachexia "Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia": Cell www.cell.com/cell/fulltex...
Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia
Cancer-induced liver changes promote body wasting through secreted factors, with circadian
regulators and hepatokines being important contributors to cancer cachexia.
www.cell.com
July 22, 2025 at 5:29 PM
🧪 Really cool new #circadian paper looking at the role of the liver clock in inter-organ crosstalk with muscle during Cachexia "Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia": Cell www.cell.com/cell/fulltex...
Reposted by Jeremy Ducharme
Muscle samples from patients with pancreatic cancer inform on muscle wasting—
@andyjudge24.bsky.social and team reveal that complement activation contributes to skeletal muscle pathology in PDAC cachexia.
Full report: buff.ly/ZKft1gx
@andyjudge24.bsky.social and team reveal that complement activation contributes to skeletal muscle pathology in PDAC cachexia.
Full report: buff.ly/ZKft1gx
June 24, 2025 at 1:20 PM
Muscle samples from patients with pancreatic cancer inform on muscle wasting—
@andyjudge24.bsky.social and team reveal that complement activation contributes to skeletal muscle pathology in PDAC cachexia.
Full report: buff.ly/ZKft1gx
@andyjudge24.bsky.social and team reveal that complement activation contributes to skeletal muscle pathology in PDAC cachexia.
Full report: buff.ly/ZKft1gx
Reposted by Jeremy Ducharme
Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia
Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia
Ducharme et al. investigate the impact and crosstalk between cancer and FoxP1 on the skeletal-muscle circadian transcriptome that mediates time-of-day-dependent biological functions. They reveal cancer/disease-specific functions of FoxP1 in the disruption and reprograming of the skeletal-muscle circadian transcriptome, which may contribute to cancer-induced muscle loss.
dlvr.it
May 16, 2025 at 2:38 PM
Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia
Reposted by Jeremy Ducharme
Cancer induced FoxP1 expression in muscle reprograms muscle clock output. Why does this matter? By co-opting normal clock output, FoxP1 is disrupting homeostatic pathways important for muscle health. We posit that this clock disruption could be a factor contributing to cachectic outcomes.
May 11, 2025 at 5:21 PM
Cancer induced FoxP1 expression in muscle reprograms muscle clock output. Why does this matter? By co-opting normal clock output, FoxP1 is disrupting homeostatic pathways important for muscle health. We posit that this clock disruption could be a factor contributing to cachectic outcomes.
Reposted by Jeremy Ducharme
Its taken a few years but finally had science fun collaborating with @andyjudge24.bsky.social, @sarahjudge.bsky.social and the talented postdoc @jbducharme.bsky.social with support from Miguel Gutierrez-Monreal. Cancer and the muscle clock. 1/ www.cell.com/cell-reports...
Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia
Ducharme et al. investigate the impact and crosstalk between cancer and FoxP1 on the
skeletal-muscle circadian transcriptome that mediates time-of-day-dependent biological
functions. They reveal cance...
www.cell.com
May 11, 2025 at 5:18 PM
Its taken a few years but finally had science fun collaborating with @andyjudge24.bsky.social, @sarahjudge.bsky.social and the talented postdoc @jbducharme.bsky.social with support from Miguel Gutierrez-Monreal. Cancer and the muscle clock. 1/ www.cell.com/cell-reports...
Come tune in next week to the CCS Trainee Talks to hear some of our recent work in the Judge Lab! Zoom registration link is on the CCS website.
The Education Committee of the @CancerCachexia Society invites you to our Trainee Talks on April 9 at 12:00 pm EDT. Seminars are open to everyone, please share!
See cancercachexiasociety.org for link.
See cancercachexiasociety.org for link.
April 2, 2025 at 10:36 PM
Come tune in next week to the CCS Trainee Talks to hear some of our recent work in the Judge Lab! Zoom registration link is on the CCS website.
Reposted by Jeremy Ducharme
A great opening session of speakers on the topic of cancer cachexia at the Advances in Skeletal Muscle Biology (ASMB) conference at UFMyology, which included the CMR's Prof Paul Gregorevic
March 20, 2025 at 2:51 AM
A great opening session of speakers on the topic of cancer cachexia at the Advances in Skeletal Muscle Biology (ASMB) conference at UFMyology, which included the CMR's Prof Paul Gregorevic
Reposted by Jeremy Ducharme
Ablation of satellite cell-specific clock gene, Bmal1, alters force production, muscle damage, and repair following contractile-induced injury
faseb.onlinelibrary.wiley.com/doi/10.1096/...
faseb.onlinelibrary.wiley.com/doi/10.1096/...
Ablation of satellite cell‐specific clock gene, Bmal1, alters force production, muscle damage, and repair following contractile‐induced injury
Ablation of SC-Bmal1 lowered force production and altered the magnitude of muscle damage/repair and SC myogenic progression following eccentric contractile injury.
faseb.onlinelibrary.wiley.com
January 15, 2025 at 7:41 PM
Ablation of satellite cell-specific clock gene, Bmal1, alters force production, muscle damage, and repair following contractile-induced injury
faseb.onlinelibrary.wiley.com/doi/10.1096/...
faseb.onlinelibrary.wiley.com/doi/10.1096/...
Reposted by Jeremy Ducharme
So proud of all the lab for their hard work, some of which they shared at #SCWDConference. Dr. Ducharme even brought home the Young Investigator Award 🙌🏼 Congrats Jeremy
December 8, 2024 at 9:08 PM
So proud of all the lab for their hard work, some of which they shared at #SCWDConference. Dr. Ducharme even brought home the Young Investigator Award 🙌🏼 Congrats Jeremy
Reposted by Jeremy Ducharme
The 8th Cancer Cachexia Conference will be hosted in Turin Italy, Sept 25-27, 2025
November 18, 2024 at 8:48 PM
The 8th Cancer Cachexia Conference will be hosted in Turin Italy, Sept 25-27, 2025