Janina Kupke
@janinakupke.bsky.social
#Memory #Neuroepigenetic #Engram
👩🔬 Postdoc in Molecular Engram & Memory Circuits Teams | Vrije Universiteit Amsterdam
🎓 Former Ph.D in Oliveira Lab | Heidelberg University
👩🔬 Postdoc in Molecular Engram & Memory Circuits Teams | Vrije Universiteit Amsterdam
🎓 Former Ph.D in Oliveira Lab | Heidelberg University
Reposted by Janina Kupke
🚨The paper from my postdoc in @graeffjohannes.bsky.social’s lab at @epfl-brainmind.bsky.social is out! We show that memories can be switched on and off by simply changing the « packaging » of DNA in neurons through epigenetic editing. www.nature.com/articles/s41...
Cell-type- and locus-specific epigenetic editing of memory expression - Nature Genetics
CRISPR-based epigenetic editing is used in a cell-type-specific, locus-restricted and temporally controllable manner in the adult mouse brain to modulate memory expression.
www.nature.com
October 29, 2025 at 11:11 AM
🚨The paper from my postdoc in @graeffjohannes.bsky.social’s lab at @epfl-brainmind.bsky.social is out! We show that memories can be switched on and off by simply changing the « packaging » of DNA in neurons through epigenetic editing. www.nature.com/articles/s41...
Reposted by Janina Kupke
New paper from the lab led by Ali Golbabaei. If you’re interested in systems consolidation, generalization and hippocampal neurogenesis a short 🧵 follows:
authors.elsevier.com/a/1lsO73QW8S...
authors.elsevier.com/a/1lsO73QW8S...
authors.elsevier.com
October 1, 2025 at 12:39 AM
New paper from the lab led by Ali Golbabaei. If you’re interested in systems consolidation, generalization and hippocampal neurogenesis a short 🧵 follows:
authors.elsevier.com/a/1lsO73QW8S...
authors.elsevier.com/a/1lsO73QW8S...
Reposted by Janina Kupke
Shaping the synapse through neuronal activity-regulated miRNAs
www.cell.com/trends/neuro...
www.cell.com/trends/neuro...
Shaping the synapse through neuronal activity-regulated miRNAs
The brain’s ability to adapt and support learning relies on experience-dependent synaptic
plasticity, where connections between neurons are strengthened or weakened in response
to activity. Recent res...
www.cell.com
July 15, 2025 at 1:00 PM
Shaping the synapse through neuronal activity-regulated miRNAs
www.cell.com/trends/neuro...
www.cell.com/trends/neuro...
Honoured to be awarded
Young Investigator Neuroscience Award from CHS Foundation together with my dearest David Brito for our paper in Molecular Psychiatry!
Curios about the work
⬇️⬇️⬇️ check out our paper & my 🧵 below
www.nature.com/articles/s41...
Young Investigator Neuroscience Award from CHS Foundation together with my dearest David Brito for our paper in Molecular Psychiatry!
Curios about the work
⬇️⬇️⬇️ check out our paper & my 🧵 below
www.nature.com/articles/s41...
July 14, 2025 at 3:18 PM
Honoured to be awarded
Young Investigator Neuroscience Award from CHS Foundation together with my dearest David Brito for our paper in Molecular Psychiatry!
Curios about the work
⬇️⬇️⬇️ check out our paper & my 🧵 below
www.nature.com/articles/s41...
Young Investigator Neuroscience Award from CHS Foundation together with my dearest David Brito for our paper in Molecular Psychiatry!
Curios about the work
⬇️⬇️⬇️ check out our paper & my 🧵 below
www.nature.com/articles/s41...
Reposted by Janina Kupke
🚨New paper alert! 🚨 Inactivation of the nucleus reuniens causes relapse of extinguished fear. Here we show this “circuit-induced relapse” depends on hippocampal fear memories and is mediated by hippocampal engrams. Congrats to the team!
Hippocampal ensembles regulate circuit-induced relapse of extinguished fear
Molecular Psychiatry - Hippocampal ensembles regulate circuit-induced relapse of extinguished fear
urldefense.com
May 24, 2025 at 6:35 PM
🚨New paper alert! 🚨 Inactivation of the nucleus reuniens causes relapse of extinguished fear. Here we show this “circuit-induced relapse” depends on hippocampal fear memories and is mediated by hippocampal engrams. Congrats to the team!
Reposted by Janina Kupke
Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.
rdcu.be/el18q
A short thread follows for those interested.
1/n
rdcu.be/el18q
A short thread follows for those interested.
1/n
Systems consolidation reorganizes hippocampal engram circuitry
Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...
rdcu.be
May 14, 2025 at 4:32 PM
Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.
rdcu.be/el18q
A short thread follows for those interested.
1/n
rdcu.be/el18q
A short thread follows for those interested.
1/n
Reposted by Janina Kupke
in our new lab work, we find that:
natural forgetting & induced amnesia share common impaired neural dynamics
this work was funded by multiple #NIH grants that supported students, postdocs, & the science, all with the goal of healing disorders of memory & the brain
www.cell.com/cell-reports...
natural forgetting & induced amnesia share common impaired neural dynamics
this work was funded by multiple #NIH grants that supported students, postdocs, & the science, all with the goal of healing disorders of memory & the brain
www.cell.com/cell-reports...
March 13, 2025 at 4:57 PM
in our new lab work, we find that:
natural forgetting & induced amnesia share common impaired neural dynamics
this work was funded by multiple #NIH grants that supported students, postdocs, & the science, all with the goal of healing disorders of memory & the brain
www.cell.com/cell-reports...
natural forgetting & induced amnesia share common impaired neural dynamics
this work was funded by multiple #NIH grants that supported students, postdocs, & the science, all with the goal of healing disorders of memory & the brain
www.cell.com/cell-reports...
Reposted by Janina Kupke
Excited to share our new study:
"Cold memories control whole-body thermoregulatory responses"
by @andreamunozz.bsky.social, @aaron-douglas.bsky.social & team at @tcddublin.bsky.social, in collaboration with @lydialynch.bsky.social & @drchristineannd.bsky.social
www.nature.com/articles/s41...
"Cold memories control whole-body thermoregulatory responses"
by @andreamunozz.bsky.social, @aaron-douglas.bsky.social & team at @tcddublin.bsky.social, in collaboration with @lydialynch.bsky.social & @drchristineannd.bsky.social
www.nature.com/articles/s41...
Cold memories control whole-body thermoregulatory responses - Nature
Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed betw...
www.nature.com
April 24, 2025 at 3:00 PM
Excited to share our new study:
"Cold memories control whole-body thermoregulatory responses"
by @andreamunozz.bsky.social, @aaron-douglas.bsky.social & team at @tcddublin.bsky.social, in collaboration with @lydialynch.bsky.social & @drchristineannd.bsky.social
www.nature.com/articles/s41...
"Cold memories control whole-body thermoregulatory responses"
by @andreamunozz.bsky.social, @aaron-douglas.bsky.social & team at @tcddublin.bsky.social, in collaboration with @lydialynch.bsky.social & @drchristineannd.bsky.social
www.nature.com/articles/s41...
Reposted by Janina Kupke
New paper out in Neuropsychopharmacology! 🧠
Post-learning noradrenergic activation preserves episodic-like memory by enhancing hippocampal engram reactivation.
A cellular model for why emotional memories stay vivid.
📖 rdcu.be/elfpB
📩 DM or reach out—happy to discuss.
Post-learning noradrenergic activation preserves episodic-like memory by enhancing hippocampal engram reactivation.
A cellular model for why emotional memories stay vivid.
📖 rdcu.be/elfpB
📩 DM or reach out—happy to discuss.
Posttraining noradrenergic stimulation maintains hippocampal engram reactivation and episodic-like specificity of remote memory
Neuropsychopharmacology - Posttraining noradrenergic stimulation maintains hippocampal engram reactivation and episodic-like specificity of remote memory
rdcu.be
May 9, 2025 at 8:50 AM
New paper out in Neuropsychopharmacology! 🧠
Post-learning noradrenergic activation preserves episodic-like memory by enhancing hippocampal engram reactivation.
A cellular model for why emotional memories stay vivid.
📖 rdcu.be/elfpB
📩 DM or reach out—happy to discuss.
Post-learning noradrenergic activation preserves episodic-like memory by enhancing hippocampal engram reactivation.
A cellular model for why emotional memories stay vivid.
📖 rdcu.be/elfpB
📩 DM or reach out—happy to discuss.
Check out our latest review on
Molecular and cellular mechanisms that support recent and remote memory
We highlight:
• structural and functional changes at the engram level
• hippocampal-cortical communication required for systems consolidation
doi.org/10.1016/j.nl...
Molecular and cellular mechanisms that support recent and remote memory
We highlight:
• structural and functional changes at the engram level
• hippocampal-cortical communication required for systems consolidation
doi.org/10.1016/j.nl...
April 22, 2025 at 6:59 AM
Check out our latest review on
Molecular and cellular mechanisms that support recent and remote memory
We highlight:
• structural and functional changes at the engram level
• hippocampal-cortical communication required for systems consolidation
doi.org/10.1016/j.nl...
Molecular and cellular mechanisms that support recent and remote memory
We highlight:
• structural and functional changes at the engram level
• hippocampal-cortical communication required for systems consolidation
doi.org/10.1016/j.nl...
Finally in its nice looking journal style 🤩🥳🍾
Check out our paper about DNA methylation, engram maturation and systems consolidation.
You can find a 🧵 on my previous link
bsky.app/profile/jani...
Thanks to all people involved and the journal for awarding it "Priority Communication"
Check out our paper about DNA methylation, engram maturation and systems consolidation.
You can find a 🧵 on my previous link
bsky.app/profile/jani...
Thanks to all people involved and the journal for awarding it "Priority Communication"
April 5, 2025 at 5:51 AM
Finally in its nice looking journal style 🤩🥳🍾
Check out our paper about DNA methylation, engram maturation and systems consolidation.
You can find a 🧵 on my previous link
bsky.app/profile/jani...
Thanks to all people involved and the journal for awarding it "Priority Communication"
Check out our paper about DNA methylation, engram maturation and systems consolidation.
You can find a 🧵 on my previous link
bsky.app/profile/jani...
Thanks to all people involved and the journal for awarding it "Priority Communication"
Wheeey finally out!
Ever wondered that if the reactivation status of engram cells has an effect on their structure? Yes? Then you should read this nice work!!
Congrats @pantheanemat.bsky.social @moever.bsky.social and all the rest to this nice paper!
Ever wondered that if the reactivation status of engram cells has an effect on their structure? Yes? Then you should read this nice work!!
Congrats @pantheanemat.bsky.social @moever.bsky.social and all the rest to this nice paper!
I am excited to announce that my first first-author paper is now published in a special issue on "Deciphering the memory engram” in Neurobiology of Learning and Memory in which we describe “Structural synaptic signatures of contextual memory retrieval-reactivated hippocampal engram cells".
February 19, 2025 at 4:45 PM
Wheeey finally out!
Ever wondered that if the reactivation status of engram cells has an effect on their structure? Yes? Then you should read this nice work!!
Congrats @pantheanemat.bsky.social @moever.bsky.social and all the rest to this nice paper!
Ever wondered that if the reactivation status of engram cells has an effect on their structure? Yes? Then you should read this nice work!!
Congrats @pantheanemat.bsky.social @moever.bsky.social and all the rest to this nice paper!
Memory persistence, DNA methylation, engrams& systems consolidation.
Sounds interesting?
Thread below.
Check out my latest paper and the last piece from my PhD journey @uniheidelberg.bsky.social
⬇️⬇️⬇️
www.biologicalpsychiatryjournal.com/article/S000...
Sounds interesting?
Thread below.
Check out my latest paper and the last piece from my PhD journey @uniheidelberg.bsky.social
⬇️⬇️⬇️
www.biologicalpsychiatryjournal.com/article/S000...
Hippocampal DNA methylation promotes contextual fear memory persistence by facilitating systems consolidation and cortical engram stabilization.
Long-term fear memory storage involves gradual reorganization of supporting brain
regions over time, a process termed systems consolidation. Memories initially rely
on the hippocampus but gradually sh...
www.biologicalpsychiatryjournal.com
February 10, 2025 at 6:36 PM
Memory persistence, DNA methylation, engrams& systems consolidation.
Sounds interesting?
Thread below.
Check out my latest paper and the last piece from my PhD journey @uniheidelberg.bsky.social
⬇️⬇️⬇️
www.biologicalpsychiatryjournal.com/article/S000...
Sounds interesting?
Thread below.
Check out my latest paper and the last piece from my PhD journey @uniheidelberg.bsky.social
⬇️⬇️⬇️
www.biologicalpsychiatryjournal.com/article/S000...