@jacobtref.bsky.social
blog.jacobtrefethen.com
Managing Director, Coefficient Giving
science!
Managing Director, Coefficient Giving
science!
Pinned
This year Demis Hassabis predicted AI could cure all disease in a decade.
But other scientists like Claus Wilke & Derek Lowe say biology is far more complex, or progress will be limited by clinical trials & economics.
In a new 4hr podcast episode of *Hard Drugs*, we answer: Will AI solve medicine?
But other scientists like Claus Wilke & Derek Lowe say biology is far more complex, or progress will be limited by clinical trials & economics.
In a new 4hr podcast episode of *Hard Drugs*, we answer: Will AI solve medicine?
Will AI solve medicine?
spotify.link
Will AI solve medicine?
We decided to be as definitive as is possible in 2025. That meant going long, through the drug development process
Sections
1. Clashing worldviews
2. Drug discovery
3. Models
4. Efficacy
5. Safety
6. Manufacturing & healthcare
7. Funding
8. Trust & ambition
Hope you enjoy!
We decided to be as definitive as is possible in 2025. That meant going long, through the drug development process
Sections
1. Clashing worldviews
2. Drug discovery
3. Models
4. Efficacy
5. Safety
6. Manufacturing & healthcare
7. Funding
8. Trust & ambition
Hope you enjoy!
Reposted
*30 minutes in*
**....people infected with the virus have about 500 quadrillion particles of viral surface proteins circulating in the antibodies during an infection.**
Jacob: That's...that's a lot. I am no mathematician. 🤣
**....people infected with the virus have about 500 quadrillion particles of viral surface proteins circulating in the antibodies during an infection.**
Jacob: That's...that's a lot. I am no mathematician. 🤣
So far this is the Hard Drugs episode I personally learned most from while recording. Some holiday listening for those of you traveling this week (I’m headed to the airport in 30 mins…).
Fun to record 8 episodes this year. With that, signing off for 2025! ✌️
Fun to record 8 episodes this year. With that, signing off for 2025! ✌️
The hepatitis B vaccine is amazing.
It was the first viral protein subunit vaccine, the first recombinant vaccine, AND the first vaccine to prevent a type of cancer.
That's right: we've had a cancer vaccine for over 40 years.
Our new three-hour episode of Hard Drugs is all about it:
It was the first viral protein subunit vaccine, the first recombinant vaccine, AND the first vaccine to prevent a type of cancer.
That's right: we've had a cancer vaccine for over 40 years.
Our new three-hour episode of Hard Drugs is all about it:
December 24, 2025 at 10:56 AM
*30 minutes in*
**....people infected with the virus have about 500 quadrillion particles of viral surface proteins circulating in the antibodies during an infection.**
Jacob: That's...that's a lot. I am no mathematician. 🤣
**....people infected with the virus have about 500 quadrillion particles of viral surface proteins circulating in the antibodies during an infection.**
Jacob: That's...that's a lot. I am no mathematician. 🤣
Reposted
If you have a long drive or flight coming up, I recommend our latest Hard Drugs episode!
The story of developing the hep B vaccine is wild, and it was very fun to record. This episode also contains the most swearing.
The story of developing the hep B vaccine is wild, and it was very fun to record. This episode also contains the most swearing.
The hepatitis B vaccine is amazing.
It was the first viral protein subunit vaccine, the first recombinant vaccine, AND the first vaccine to prevent a type of cancer.
That's right: we've had a cancer vaccine for over 40 years.
Our new three-hour episode of Hard Drugs is all about it:
It was the first viral protein subunit vaccine, the first recombinant vaccine, AND the first vaccine to prevent a type of cancer.
That's right: we've had a cancer vaccine for over 40 years.
Our new three-hour episode of Hard Drugs is all about it:
The first cancer vaccine
open.spotify.com
December 23, 2025 at 10:45 AM
If you have a long drive or flight coming up, I recommend our latest Hard Drugs episode!
The story of developing the hep B vaccine is wild, and it was very fun to record. This episode also contains the most swearing.
The story of developing the hep B vaccine is wild, and it was very fun to record. This episode also contains the most swearing.
So far this is the Hard Drugs episode I personally learned most from while recording. Some holiday listening for those of you traveling this week (I’m headed to the airport in 30 mins…).
Fun to record 8 episodes this year. With that, signing off for 2025! ✌️
Fun to record 8 episodes this year. With that, signing off for 2025! ✌️
The hepatitis B vaccine is amazing.
It was the first viral protein subunit vaccine, the first recombinant vaccine, AND the first vaccine to prevent a type of cancer.
That's right: we've had a cancer vaccine for over 40 years.
Our new three-hour episode of Hard Drugs is all about it:
It was the first viral protein subunit vaccine, the first recombinant vaccine, AND the first vaccine to prevent a type of cancer.
That's right: we've had a cancer vaccine for over 40 years.
Our new three-hour episode of Hard Drugs is all about it:
The first cancer vaccine
open.spotify.com
December 22, 2025 at 6:07 PM
So far this is the Hard Drugs episode I personally learned most from while recording. Some holiday listening for those of you traveling this week (I’m headed to the airport in 30 mins…).
Fun to record 8 episodes this year. With that, signing off for 2025! ✌️
Fun to record 8 episodes this year. With that, signing off for 2025! ✌️
Reposted
Big new blogpost!
My guide to data visualization, which includes a very long table of contents, tons of charts, and more.
--> Why data visualization matters and how to make charts more effective, clear, transparent, and sometimes, beautiful.
www.scientificdiscovery.dev/p/salonis-gu...
My guide to data visualization, which includes a very long table of contents, tons of charts, and more.
--> Why data visualization matters and how to make charts more effective, clear, transparent, and sometimes, beautiful.
www.scientificdiscovery.dev/p/salonis-gu...
December 9, 2025 at 8:28 PM
Big new blogpost!
My guide to data visualization, which includes a very long table of contents, tons of charts, and more.
--> Why data visualization matters and how to make charts more effective, clear, transparent, and sometimes, beautiful.
www.scientificdiscovery.dev/p/salonis-gu...
My guide to data visualization, which includes a very long table of contents, tons of charts, and more.
--> Why data visualization matters and how to make charts more effective, clear, transparent, and sometimes, beautiful.
www.scientificdiscovery.dev/p/salonis-gu...
Reposted
I appreciated the reflection on how insane 18th and 19th century science seemed. What do you mean you put a dog's brain into a rabbit's brain? Wait, you are carefully observing a sealed dead eel?
Imagine you lived in the 18th century.
Smallpox kills 1 in 3 cases. Yet you can’t culture pathogens, don’t know germ theory, and have no idea what a virus is. How would you invent a vaccine?
In a new episode of HARD DRUGS, we trace the history of vaccines!
Smallpox kills 1 in 3 cases. Yet you can’t culture pathogens, don’t know germ theory, and have no idea what a virus is. How would you invent a vaccine?
In a new episode of HARD DRUGS, we trace the history of vaccines!
The history of vaccines
open.spotify.com
November 27, 2025 at 12:49 PM
I appreciated the reflection on how insane 18th and 19th century science seemed. What do you mean you put a dog's brain into a rabbit's brain? Wait, you are carefully observing a sealed dead eel?
Reposted
THIS is what I need no more ryan lizza and so forth etc
Imagine you lived in the 18th century.
Smallpox kills 1 in 3 cases. Yet you can’t culture pathogens, don’t know germ theory, and have no idea what a virus is. How would you invent a vaccine?
In a new episode of HARD DRUGS, we trace the history of vaccines!
Smallpox kills 1 in 3 cases. Yet you can’t culture pathogens, don’t know germ theory, and have no idea what a virus is. How would you invent a vaccine?
In a new episode of HARD DRUGS, we trace the history of vaccines!
The history of vaccines
open.spotify.com
November 27, 2025 at 11:32 AM
THIS is what I need no more ryan lizza and so forth etc
Attenuation Is All You Need (Well, inactivation too)
We cover the invention of 20 vaccines from the 1700s through 1970. Technology (smallpox vaccine) preceding scientific understanding (germ theory), then speeding up once theory established from experiments (maggots…) & new tools made (agar plates)
We cover the invention of 20 vaccines from the 1700s through 1970. Technology (smallpox vaccine) preceding scientific understanding (germ theory), then speeding up once theory established from experiments (maggots…) & new tools made (agar plates)
Imagine you lived in the 18th century.
Smallpox kills 1 in 3 cases. Yet you can’t culture pathogens, don’t know germ theory, and have no idea what a virus is. How would you invent a vaccine?
In a new episode of HARD DRUGS, we trace the history of vaccines!
Smallpox kills 1 in 3 cases. Yet you can’t culture pathogens, don’t know germ theory, and have no idea what a virus is. How would you invent a vaccine?
In a new episode of HARD DRUGS, we trace the history of vaccines!
The history of vaccines
open.spotify.com
November 26, 2025 at 8:25 PM
Attenuation Is All You Need (Well, inactivation too)
We cover the invention of 20 vaccines from the 1700s through 1970. Technology (smallpox vaccine) preceding scientific understanding (germ theory), then speeding up once theory established from experiments (maggots…) & new tools made (agar plates)
We cover the invention of 20 vaccines from the 1700s through 1970. Technology (smallpox vaccine) preceding scientific understanding (germ theory), then speeding up once theory established from experiments (maggots…) & new tools made (agar plates)
Reposted
Some news: Open Philanthropy is now Coefficient Giving! Our mission is unchanged but the new name reflects our growing work with other donors to multiply the impact of their giving.
🧵 on our work to make philanthropy a more efficient "market" and plans going forward:
🧵 on our work to make philanthropy a more efficient "market" and plans going forward:
November 18, 2025 at 3:07 PM
Some news: Open Philanthropy is now Coefficient Giving! Our mission is unchanged but the new name reflects our growing work with other donors to multiply the impact of their giving.
🧵 on our work to make philanthropy a more efficient "market" and plans going forward:
🧵 on our work to make philanthropy a more efficient "market" and plans going forward:
Reposted
Some amazing jobs here! Our science and global health R&D team works on funding breakthroughs for neglected, high mortality/morbidity diseases and does a ton of great and interesting work -- see job links in Jacob's thread!
🚨 Hiring scientists to help give away money 🚨
At Open Philanthropy, we have given away $600M in biomedical research since 2016. Now, we're expanding the team to do more.
We're hiring:
* Up to 3 Senior Program Associates
* Program Officer in strep A
Remote OK, salaries in links! (Thread below)
At Open Philanthropy, we have given away $600M in biomedical research since 2016. Now, we're expanding the team to do more.
We're hiring:
* Up to 3 Senior Program Associates
* Program Officer in strep A
Remote OK, salaries in links! (Thread below)
Hiring scientists to give away money
At Open Philanthropy, we have given away $600 million in biomedical research since 2016. That funding has supported the work of thousands of scientists across hundreds of universities, nonprofits, and...
blog.jacobtrefethen.com
November 12, 2025 at 1:55 AM
Some amazing jobs here! Our science and global health R&D team works on funding breakthroughs for neglected, high mortality/morbidity diseases and does a ton of great and interesting work -- see job links in Jacob's thread!
🚨 Hiring scientists to help give away money 🚨
At Open Philanthropy, we have given away $600M in biomedical research since 2016. Now, we're expanding the team to do more.
We're hiring:
* Up to 3 Senior Program Associates
* Program Officer in strep A
Remote OK, salaries in links! (Thread below)
At Open Philanthropy, we have given away $600M in biomedical research since 2016. Now, we're expanding the team to do more.
We're hiring:
* Up to 3 Senior Program Associates
* Program Officer in strep A
Remote OK, salaries in links! (Thread below)
Hiring scientists to give away money
At Open Philanthropy, we have given away $600 million in biomedical research since 2016. That funding has supported the work of thousands of scientists across hundreds of universities, nonprofits, and...
blog.jacobtrefethen.com
November 12, 2025 at 1:11 AM
🚨 Hiring scientists to help give away money 🚨
At Open Philanthropy, we have given away $600M in biomedical research since 2016. Now, we're expanding the team to do more.
We're hiring:
* Up to 3 Senior Program Associates
* Program Officer in strep A
Remote OK, salaries in links! (Thread below)
At Open Philanthropy, we have given away $600M in biomedical research since 2016. Now, we're expanding the team to do more.
We're hiring:
* Up to 3 Senior Program Associates
* Program Officer in strep A
Remote OK, salaries in links! (Thread below)
Reposted
MFW my co-host @jacobtref.bsky.social is telling me all about the drug development pipeline.
October 29, 2025 at 4:24 PM
MFW my co-host @jacobtref.bsky.social is telling me all about the drug development pipeline.
Reposted
Welp @scientificdiscovery.dev and Jacob are back again, Will AI Cure Disease? By the end of the 4.5 hours you'll be significantly older and might find out!
www.worksinprogress.news/p/will-ai-so...?
www.worksinprogress.news/p/will-ai-so...?
Will AI solve medicine?
Some say AI will solve medicine within a decade. Others believe biology is far more complex than people imagine and AI will hit the limits of clinical trials and economics. Who's right?
www.worksinprogress.news
October 29, 2025 at 2:36 PM
Welp @scientificdiscovery.dev and Jacob are back again, Will AI Cure Disease? By the end of the 4.5 hours you'll be significantly older and might find out!
www.worksinprogress.news/p/will-ai-so...?
www.worksinprogress.news/p/will-ai-so...?
Will AI solve medicine?
We decided to be as definitive as is possible in 2025. That meant going long, through the drug development process
Sections
1. Clashing worldviews
2. Drug discovery
3. Models
4. Efficacy
5. Safety
6. Manufacturing & healthcare
7. Funding
8. Trust & ambition
Hope you enjoy!
We decided to be as definitive as is possible in 2025. That meant going long, through the drug development process
Sections
1. Clashing worldviews
2. Drug discovery
3. Models
4. Efficacy
5. Safety
6. Manufacturing & healthcare
7. Funding
8. Trust & ambition
Hope you enjoy!
This year Demis Hassabis predicted AI could cure all disease in a decade.
But other scientists like Claus Wilke & Derek Lowe say biology is far more complex, or progress will be limited by clinical trials & economics.
In a new 4hr podcast episode of *Hard Drugs*, we answer: Will AI solve medicine?
But other scientists like Claus Wilke & Derek Lowe say biology is far more complex, or progress will be limited by clinical trials & economics.
In a new 4hr podcast episode of *Hard Drugs*, we answer: Will AI solve medicine?
Will AI solve medicine?
spotify.link
October 29, 2025 at 5:30 PM
Will AI solve medicine?
We decided to be as definitive as is possible in 2025. That meant going long, through the drug development process
Sections
1. Clashing worldviews
2. Drug discovery
3. Models
4. Efficacy
5. Safety
6. Manufacturing & healthcare
7. Funding
8. Trust & ambition
Hope you enjoy!
We decided to be as definitive as is possible in 2025. That meant going long, through the drug development process
Sections
1. Clashing worldviews
2. Drug discovery
3. Models
4. Efficacy
5. Safety
6. Manufacturing & healthcare
7. Funding
8. Trust & ambition
Hope you enjoy!
Reposted
Apparently some people think I'm AI generated, because... I don't blink enough
October 19, 2025 at 7:21 AM
Apparently some people think I'm AI generated, because... I don't blink enough
Reposted
Tune in to find out:
- how to go from hallucinated cat pictures to hallucinated proteins
- whether @jacobtref.bsky.social can do photosynthesis
- whether we can make tiny protein straws for tardigrades to drink from
- how to go from hallucinated cat pictures to hallucinated proteins
- whether @jacobtref.bsky.social can do photosynthesis
- whether we can make tiny protein straws for tardigrades to drink from
New episode of Hard Drugs!
What if you could design a protein never seen in nature?
Scientists are using new AI tools like RFDiffusion, AlphaFold & ProteinMPNN to hallucinate novel proteins to solve problems nature hasn't.
@jacobtref.bsky.social & I talk about the art of protein design 🧑🎨
What if you could design a protein never seen in nature?
Scientists are using new AI tools like RFDiffusion, AlphaFold & ProteinMPNN to hallucinate novel proteins to solve problems nature hasn't.
@jacobtref.bsky.social & I talk about the art of protein design 🧑🎨
The art of protein design with AI
YouTube video by Works in Progress
www.youtube.com
October 17, 2025 at 10:30 PM
Tune in to find out:
- how to go from hallucinated cat pictures to hallucinated proteins
- whether @jacobtref.bsky.social can do photosynthesis
- whether we can make tiny protein straws for tardigrades to drink from
- how to go from hallucinated cat pictures to hallucinated proteins
- whether @jacobtref.bsky.social can do photosynthesis
- whether we can make tiny protein straws for tardigrades to drink from
Our most practical episode yet for people who want to dabble in biotech
As of 2022, you can hallucinate protein structures using AI similar to Midjourney (RFDiffusion) -> create amino acid strings for them (ProteinMPNN) -> validate with AlphaFold
Biology becomes engineering…
As of 2022, you can hallucinate protein structures using AI similar to Midjourney (RFDiffusion) -> create amino acid strings for them (ProteinMPNN) -> validate with AlphaFold
Biology becomes engineering…
New episode of Hard Drugs!
What if you could design a protein never seen in nature?
Scientists are using new AI tools like RFDiffusion, AlphaFold & ProteinMPNN to hallucinate novel proteins to solve problems nature hasn't.
@jacobtref.bsky.social & I talk about the art of protein design 🧑🎨
What if you could design a protein never seen in nature?
Scientists are using new AI tools like RFDiffusion, AlphaFold & ProteinMPNN to hallucinate novel proteins to solve problems nature hasn't.
@jacobtref.bsky.social & I talk about the art of protein design 🧑🎨
The art of protein design with AI
YouTube video by Works in Progress
www.youtube.com
October 15, 2025 at 5:02 PM
Our most practical episode yet for people who want to dabble in biotech
As of 2022, you can hallucinate protein structures using AI similar to Midjourney (RFDiffusion) -> create amino acid strings for them (ProteinMPNN) -> validate with AlphaFold
Biology becomes engineering…
As of 2022, you can hallucinate protein structures using AI similar to Midjourney (RFDiffusion) -> create amino acid strings for them (ProteinMPNN) -> validate with AlphaFold
Biology becomes engineering…
Reposted
Cool episode on how AI can help us design new proteins (e.g., for vaccines).
I’d heard of AlphaFold before, but not of ProteinMPNN. You feed a protein structure into PMPNN & generate possible sequences of amino acids. And then you feed those into AlphaFold to check whether they’d fold up that way!
I’d heard of AlphaFold before, but not of ProteinMPNN. You feed a protein structure into PMPNN & generate possible sequences of amino acids. And then you feed those into AlphaFold to check whether they’d fold up that way!
New episode of HARD DRUGS!
AlphaFold, ProteinMPNN & other AI tools are transforming biology and drug design.
But how do they work? What can’t they do? And can we use them to make a vaccine against Strep A for the very first time?
In this episode, Jacob and I talk about hacking proteins with AI.
AlphaFold, ProteinMPNN & other AI tools are transforming biology and drug design.
But how do they work? What can’t they do? And can we use them to make a vaccine against Strep A for the very first time?
In this episode, Jacob and I talk about hacking proteins with AI.
Hacking proteins with AI
open.spotify.com
October 2, 2025 at 6:28 AM
Cool episode on how AI can help us design new proteins (e.g., for vaccines).
I’d heard of AlphaFold before, but not of ProteinMPNN. You feed a protein structure into PMPNN & generate possible sequences of amino acids. And then you feed those into AlphaFold to check whether they’d fold up that way!
I’d heard of AlphaFold before, but not of ProteinMPNN. You feed a protein structure into PMPNN & generate possible sequences of amino acids. And then you feed those into AlphaFold to check whether they’d fold up that way!
Hearing a lot about AI designing drugs, but not sure what specifically that means?
Ever wonder how AlphaFold works, or what practical problems it helps with?
How rattan daybeds can hold their own in a modern home?
This episode is for you!
Ever wonder how AlphaFold works, or what practical problems it helps with?
How rattan daybeds can hold their own in a modern home?
This episode is for you!
New episode of HARD DRUGS!
AlphaFold, ProteinMPNN & other AI tools are transforming biology and drug design.
But how do they work? What can’t they do? And can we use them to make a vaccine against Strep A for the very first time?
In this episode, Jacob and I talk about hacking proteins with AI.
AlphaFold, ProteinMPNN & other AI tools are transforming biology and drug design.
But how do they work? What can’t they do? And can we use them to make a vaccine against Strep A for the very first time?
In this episode, Jacob and I talk about hacking proteins with AI.
Hacking proteins with AI
open.spotify.com
October 1, 2025 at 5:34 PM
Hearing a lot about AI designing drugs, but not sure what specifically that means?
Ever wonder how AlphaFold works, or what practical problems it helps with?
How rattan daybeds can hold their own in a modern home?
This episode is for you!
Ever wonder how AlphaFold works, or what practical problems it helps with?
How rattan daybeds can hold their own in a modern home?
This episode is for you!
Reposted
every time i feel bad about writing long essays / blog posts i think, no. what would saloni and jacob do.
September 28, 2025 at 9:40 AM
every time i feel bad about writing long essays / blog posts i think, no. what would saloni and jacob do.
Reposted
The reviews are in!
"I heard it just now! So good 😊" – my mom
"Just listened to the new insulin episode and loved it." – @rossaokod.bsky.social
"you should have added 5 more minutes on how early researchers checked for the sweetness of animal urine..." – @pseudoerasmus.bsky.social
"I heard it just now! So good 😊" – my mom
"Just listened to the new insulin episode and loved it." – @rossaokod.bsky.social
"you should have added 5 more minutes on how early researchers checked for the sweetness of animal urine..." – @pseudoerasmus.bsky.social
New podcast episode of HARD DRUGS!
A hundred years ago, insulin was scraped from pig pancreases.
Today, it’s made by bacteria in giant tanks.
In this episode, we cover 100 years of insulin … in 15 minutes!
A hundred years ago, insulin was scraped from pig pancreases.
Today, it’s made by bacteria in giant tanks.
In this episode, we cover 100 years of insulin … in 15 minutes!
100 years of insulin in 15 minutes
open.spotify.com
September 17, 2025 at 5:01 PM
The reviews are in!
"I heard it just now! So good 😊" – my mom
"Just listened to the new insulin episode and loved it." – @rossaokod.bsky.social
"you should have added 5 more minutes on how early researchers checked for the sweetness of animal urine..." – @pseudoerasmus.bsky.social
"I heard it just now! So good 😊" – my mom
"Just listened to the new insulin episode and loved it." – @rossaokod.bsky.social
"you should have added 5 more minutes on how early researchers checked for the sweetness of animal urine..." – @pseudoerasmus.bsky.social
Reposted
1/3 As someone diagnosed as Type 1 in 1976, I can remember beginning on porcine insulin (bovine was another alternative). The first "human" insulin I had was actually enzymatically modified porcine. I started with glass syringes, with exchangeable all metal needles, stored in methylated spirit.
September 16, 2025 at 7:42 PM
1/3 As someone diagnosed as Type 1 in 1976, I can remember beginning on porcine insulin (bovine was another alternative). The first "human" insulin I had was actually enzymatically modified porcine. I started with glass syringes, with exchangeable all metal needles, stored in methylated spirit.
Last episode: an introduction to what proteins are
This episode: proteins can be medicines!
Insulin is a protein. 104 years ago, no one with diabetes had been injected with it, then came insulin from animals, then came bioreactors...
This episode: proteins can be medicines!
Insulin is a protein. 104 years ago, no one with diabetes had been injected with it, then came insulin from animals, then came bioreactors...
New podcast episode of HARD DRUGS!
A hundred years ago, insulin was scraped from pig pancreases.
Today, it’s made by bacteria in giant tanks.
In this episode, we cover 100 years of insulin … in 15 minutes!
A hundred years ago, insulin was scraped from pig pancreases.
Today, it’s made by bacteria in giant tanks.
In this episode, we cover 100 years of insulin … in 15 minutes!
100 years of insulin in 15 minutes
open.spotify.com
September 16, 2025 at 6:19 PM
Last episode: an introduction to what proteins are
This episode: proteins can be medicines!
Insulin is a protein. 104 years ago, no one with diabetes had been injected with it, then came insulin from animals, then came bioreactors...
This episode: proteins can be medicines!
Insulin is a protein. 104 years ago, no one with diabetes had been injected with it, then came insulin from animals, then came bioreactors...
Reposted
Saloni and Jacob have a natural way to make everything sound like it’s the coolest thing in the world, so naturally I’m now all on board of the protein train 🚂
NEW EPISODE of HARD DRUGS!
“5 hours is too long!” some of you said after our first episode. So our second episode is 20 minutes 🤭
@jacobtref.bsky.social and I explore the world of proteins: how proteins fold into complex shapes, why complexity matters, how crowded and dynamic a cell really is.
“5 hours is too long!” some of you said after our first episode. So our second episode is 20 minutes 🤭
@jacobtref.bsky.social and I explore the world of proteins: how proteins fold into complex shapes, why complexity matters, how crowded and dynamic a cell really is.
Proteins: Weird blobs that do important things
open.spotify.com
September 4, 2025 at 4:35 AM
Saloni and Jacob have a natural way to make everything sound like it’s the coolest thing in the world, so naturally I’m now all on board of the protein train 🚂
AI for protein design won a Nobel Prize last year. Are new protein drugs to cure diseases on their way?
This episode introduces what proteins are. You can listen to it on its own, or as the first plank of us answering that question. Subscribe in a podcast app for future planks!
This episode introduces what proteins are. You can listen to it on its own, or as the first plank of us answering that question. Subscribe in a podcast app for future planks!
NEW EPISODE of HARD DRUGS!
“5 hours is too long!” some of you said after our first episode. So our second episode is 20 minutes 🤭
@jacobtref.bsky.social and I explore the world of proteins: how proteins fold into complex shapes, why complexity matters, how crowded and dynamic a cell really is.
“5 hours is too long!” some of you said after our first episode. So our second episode is 20 minutes 🤭
@jacobtref.bsky.social and I explore the world of proteins: how proteins fold into complex shapes, why complexity matters, how crowded and dynamic a cell really is.
Proteins: Weird blobs that do important things
open.spotify.com
September 3, 2025 at 6:23 PM
AI for protein design won a Nobel Prize last year. Are new protein drugs to cure diseases on their way?
This episode introduces what proteins are. You can listen to it on its own, or as the first plank of us answering that question. Subscribe in a podcast app for future planks!
This episode introduces what proteins are. You can listen to it on its own, or as the first plank of us answering that question. Subscribe in a podcast app for future planks!
Over the weekend I published an essay series on a question I've been thinking about for a while:
What does AI progress mean for medical progress?
It starts with this 500 word piece. If you want more after that, there are 10,000 words of forking paths:
blog.jacobtrefethen.com/ai-progress-...
What does AI progress mean for medical progress?
It starts with this 500 word piece. If you want more after that, there are 10,000 words of forking paths:
blog.jacobtrefethen.com/ai-progress-...
What does AI progress mean for medical progress?
Rapid AI progress does not automatically mean rapid medical progress. If the point of AI progress is human flourishing, we must make other complementary investments too. Even with extremely powerful A...
blog.jacobtrefethen.com
August 5, 2025 at 8:47 PM
Over the weekend I published an essay series on a question I've been thinking about for a while:
What does AI progress mean for medical progress?
It starts with this 500 word piece. If you want more after that, there are 10,000 words of forking paths:
blog.jacobtrefethen.com/ai-progress-...
What does AI progress mean for medical progress?
It starts with this 500 word piece. If you want more after that, there are 10,000 words of forking paths:
blog.jacobtrefethen.com/ai-progress-...