Isabelle Rosso
@irosso.bsky.social
Psychologist / neuroscientist. @HarvardMed
& @McLeanHospital. PTSD & trauma. #academictwitter, #WomenInSTEM. Views mine.
& @McLeanHospital. PTSD & trauma. #academictwitter, #WomenInSTEM. Views mine.
How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions: Trends in Neurosciences www.cell.com/trends/neuro...
How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions
The brain constantly generates predictions based on one’s knowledge of the world,
as captured in memory. When these predictions are in error, our knowledge base must
be revised to remain relevant. Her...
www.cell.com
October 7, 2025 at 2:27 AM
How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions: Trends in Neurosciences www.cell.com/trends/neuro...
Reposted by Isabelle Rosso
In reporting this piece on the new trial for a Huntington's treatment, I was struck by one thing in particular:
The joy.
One of my sources wept for joy. He has spent his entire career studying this disease, he said it was the happiest day. www.sciencenews.org/article/hunt...
The joy.
One of my sources wept for joy. He has spent his entire career studying this disease, he said it was the happiest day. www.sciencenews.org/article/hunt...
Huntington's progression slowed by experimental gene therapy
An experimental gene therapy slowed Huntington’s by up to 75 percent in a small clinical trial. While not a cure, it may give patients longer lives.
www.sciencenews.org
September 26, 2025 at 5:58 PM
In reporting this piece on the new trial for a Huntington's treatment, I was struck by one thing in particular:
The joy.
One of my sources wept for joy. He has spent his entire career studying this disease, he said it was the happiest day. www.sciencenews.org/article/hunt...
The joy.
One of my sources wept for joy. He has spent his entire career studying this disease, he said it was the happiest day. www.sciencenews.org/article/hunt...
Reposted by Isabelle Rosso
✨My first science feature is out in Chemical & Engineering News!✨
I interviewed and wrote about Dr. Shana V. Stoddard, a brilliant disabled scientist changing STEM.
Disabled scientists deserve visibility and celebration.
cen.acs.org/synthesis/me...
#DisabledInSTEM #SciComm #RepresentationMatters
I interviewed and wrote about Dr. Shana V. Stoddard, a brilliant disabled scientist changing STEM.
Disabled scientists deserve visibility and celebration.
cen.acs.org/synthesis/me...
#DisabledInSTEM #SciComm #RepresentationMatters
Shana V. Stoddard: How to create an environment for all science students to succeed
Grad student <b>Alyssa T. Paparella</b> talks with this computational biochemist about adjusting work styles and leaning on community
cen.acs.org
September 20, 2025 at 4:55 PM
✨My first science feature is out in Chemical & Engineering News!✨
I interviewed and wrote about Dr. Shana V. Stoddard, a brilliant disabled scientist changing STEM.
Disabled scientists deserve visibility and celebration.
cen.acs.org/synthesis/me...
#DisabledInSTEM #SciComm #RepresentationMatters
I interviewed and wrote about Dr. Shana V. Stoddard, a brilliant disabled scientist changing STEM.
Disabled scientists deserve visibility and celebration.
cen.acs.org/synthesis/me...
#DisabledInSTEM #SciComm #RepresentationMatters
Reposted by Isabelle Rosso
Join us in Congratulating the 2025 ACNP Travel Award Class! 🙌🎉
August 8, 2025 at 1:01 PM
Join us in Congratulating the 2025 ACNP Travel Award Class! 🙌🎉
Reposted by Isabelle Rosso
In case you missed this yesterday…..
NIH will only accept six applications per PI per calendar year. drugmonkey.wordpress.com/2025/07/17/n...
NIH will only accept six applications per PI per calendar year.
NIH has issued NOT-OD-25-132 Supporting Fairness and Originality in NIH Research Applications which informs us that NIH will only accept six new, renewal, resubmission, or revision applications fro…
drugmonkey.wordpress.com
July 18, 2025 at 3:41 PM
In case you missed this yesterday…..
Reposted by Isabelle Rosso
First paper from my lab @upenn.edu (open access) @ Biological Psychiatry w/ @emilyrperkins.bsky.social +@keananjoyner.bsky.social
We discuss the need to falsify theories of biology predicting syndromes vs. syndromes in ways that allow both to be true 🧵1/10
authors.elsevier.com/sd/article/S...
We discuss the need to falsify theories of biology predicting syndromes vs. syndromes in ways that allow both to be true 🧵1/10
authors.elsevier.com/sd/article/S...
June 28, 2025 at 2:53 PM
First paper from my lab @upenn.edu (open access) @ Biological Psychiatry w/ @emilyrperkins.bsky.social +@keananjoyner.bsky.social
We discuss the need to falsify theories of biology predicting syndromes vs. syndromes in ways that allow both to be true 🧵1/10
authors.elsevier.com/sd/article/S...
We discuss the need to falsify theories of biology predicting syndromes vs. syndromes in ways that allow both to be true 🧵1/10
authors.elsevier.com/sd/article/S...
Reposted by Isabelle Rosso
Finally getting to post the thread on this, and excited to force you all to read some of the new work from our group on trying to understand if traumatic stress might impact reactivity to basic stimuli.
Or, honestly, where we asked “what if we just flash a checkerboard at trauma survivors?” 1/🧵
Or, honestly, where we asked “what if we just flash a checkerboard at trauma survivors?” 1/🧵
🆕 in DPN from our EB member @nateurneuro.bsky.social, @brainstorm12.bsky.social & @irosso.bsky.social et al:
Traumatic stress alters neural reactivity to visual stimulation
www.nature.com/articles/s44...
Traumatic stress alters neural reactivity to visual stimulation
www.nature.com/articles/s44...
Traumatic stress alters neural reactivity to visual stimulation - NPP—Digital Psychiatry and Neuroscience
This study investigated if exposure to traumatic stress altered brain activity to basic visual stimulation. The authors found that recent trauma survivors showed altered activity within the visual cor...
www.nature.com
May 27, 2025 at 8:40 PM
Finally getting to post the thread on this, and excited to force you all to read some of the new work from our group on trying to understand if traumatic stress might impact reactivity to basic stimuli.
Or, honestly, where we asked “what if we just flash a checkerboard at trauma survivors?” 1/🧵
Or, honestly, where we asked “what if we just flash a checkerboard at trauma survivors?” 1/🧵
Reposted by Isabelle Rosso
🆕 in DPN from our EB member @nateurneuro.bsky.social, @brainstorm12.bsky.social & @irosso.bsky.social et al:
Traumatic stress alters neural reactivity to visual stimulation
www.nature.com/articles/s44...
Traumatic stress alters neural reactivity to visual stimulation
www.nature.com/articles/s44...
Traumatic stress alters neural reactivity to visual stimulation - NPP—Digital Psychiatry and Neuroscience
This study investigated if exposure to traumatic stress altered brain activity to basic visual stimulation. The authors found that recent trauma survivors showed altered activity within the visual cor...
www.nature.com
May 21, 2025 at 1:11 PM
🆕 in DPN from our EB member @nateurneuro.bsky.social, @brainstorm12.bsky.social & @irosso.bsky.social et al:
Traumatic stress alters neural reactivity to visual stimulation
www.nature.com/articles/s44...
Traumatic stress alters neural reactivity to visual stimulation
www.nature.com/articles/s44...
Reposted by Isabelle Rosso
Social Buffering of Posttraumatic Stress Disorder: Longitudinal Effects and Neural Mediators - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging www.biologicalpsychiatrycnni.org/article/S245...
Social Buffering of Posttraumatic Stress Disorder: Longitudinal Effects and Neural Mediators
Posttraumatic stress disorder (PTSD) is a well-characterized psychiatric disorder
that features changes in mood and arousal following traumatic events. Previous animal
and human studies of social supp...
www.biologicalpsychiatrycnni.org
May 7, 2025 at 3:27 PM
Social Buffering of Posttraumatic Stress Disorder: Longitudinal Effects and Neural Mediators - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging www.biologicalpsychiatrycnni.org/article/S245...
California sets an example to follow. @warren.senate.gov @markey.senate.gov
Wow. Cali is leading the way. Again.
SB 829 would create a new state agency, the California Institute for Scientific Research, to fund research in biomedicine, public health, climate, oceanography, coastal ecosystems sd11.senate.ca.gov/news/trump-g...
May 3, 2025 at 5:34 PM
California sets an example to follow. @warren.senate.gov @markey.senate.gov
Reposted by Isabelle Rosso
This piece by an anonymous NIH insider spells it out:
*Slow science spending as much as possible, ignore existing commitments
*Present the failure to spend as a "savings"
*House GOP leadership will make cuts permanent with rescission/tax cut
donmoynihan.substack.com/p/the-nih-bu...
*Slow science spending as much as possible, ignore existing commitments
*Present the failure to spend as a "savings"
*House GOP leadership will make cuts permanent with rescission/tax cut
donmoynihan.substack.com/p/the-nih-bu...
The NIH budget is on a fast track to disaster
An NIH insider explains what Republicans are likely to do next, and what we can do
donmoynihan.substack.com
May 2, 2025 at 1:17 AM
This piece by an anonymous NIH insider spells it out:
*Slow science spending as much as possible, ignore existing commitments
*Present the failure to spend as a "savings"
*House GOP leadership will make cuts permanent with rescission/tax cut
donmoynihan.substack.com/p/the-nih-bu...
*Slow science spending as much as possible, ignore existing commitments
*Present the failure to spend as a "savings"
*House GOP leadership will make cuts permanent with rescission/tax cut
donmoynihan.substack.com/p/the-nih-bu...
How delays in issuing NIH funds may create the appearance of a budget 'surplus' that becomes justification to cut the NIH budget. @statnews.com #neuroskyence
🚨 This MUST READ essay and call to action spells out, in very clear terms, how the Trump administration could get away with slashing the NIH budget. NIH scientists and Dems in congress need to read and understand it. This is where we win or lose the battle to save the NIH and US science. 🧪 🧠 🧬 🔊
The NIH budget is on a fast track to disaster
An NIH insider explains what Republicans are likely to do next, and what we can do
donmoynihan.substack.com
April 28, 2025 at 3:17 PM
How delays in issuing NIH funds may create the appearance of a budget 'surplus' that becomes justification to cut the NIH budget. @statnews.com #neuroskyence
Reposted by Isabelle Rosso
𝗛𝗼𝘄 𝘀𝗵𝗼𝘂𝗹𝗱 𝘄𝗲 𝗱𝗲𝗳𝗶𝗻𝗲 𝗮𝗻𝗱 𝗱𝗲𝘁𝗲𝗿𝗺𝗶𝗻𝗲 𝗮 𝗯𝗿𝗮𝗶𝗻 𝗿𝗲𝗴𝗶𝗼𝗻'𝘀 𝗶𝗺𝗽𝗼𝗿𝘁𝗮𝗻𝗰𝗲?
We introduce the idea of "importance" in terms of the extent to which a region's signals steer/contribute to brain dynamics as a function of brain state.
Work by @codejoydo.bsky.social
elifesciences.org/reviewed-pre...
We introduce the idea of "importance" in terms of the extent to which a region's signals steer/contribute to brain dynamics as a function of brain state.
Work by @codejoydo.bsky.social
elifesciences.org/reviewed-pre...
Brain dynamics and spatiotemporal trajectories during threat processing
elifesciences.org
April 27, 2025 at 5:17 PM
𝗛𝗼𝘄 𝘀𝗵𝗼𝘂𝗹𝗱 𝘄𝗲 𝗱𝗲𝗳𝗶𝗻𝗲 𝗮𝗻𝗱 𝗱𝗲𝘁𝗲𝗿𝗺𝗶𝗻𝗲 𝗮 𝗯𝗿𝗮𝗶𝗻 𝗿𝗲𝗴𝗶𝗼𝗻'𝘀 𝗶𝗺𝗽𝗼𝗿𝘁𝗮𝗻𝗰𝗲?
We introduce the idea of "importance" in terms of the extent to which a region's signals steer/contribute to brain dynamics as a function of brain state.
Work by @codejoydo.bsky.social
elifesciences.org/reviewed-pre...
We introduce the idea of "importance" in terms of the extent to which a region's signals steer/contribute to brain dynamics as a function of brain state.
Work by @codejoydo.bsky.social
elifesciences.org/reviewed-pre...
Reposted by Isabelle Rosso
#TobRegSky #PedSky #MedSky #EpiSky #policysky #polisky #neuroskyence #neurosci #PainResearch #addictionsci 🧪🛟
Queen's University in Canada starts program to admit "doctoral students whose offers from top U.S. schools have been rescinded or who are reconsidering their acceptance to a U.S. school ..."
Queen's University in Canada starts program to admit "doctoral students whose offers from top U.S. schools have been rescinded or who are reconsidering their acceptance to a U.S. school ..."
Some good news for a change–Queen's has set aside funds to assist any students who have lost their visa status in the US and are looking to continue their graduate studies. Please share widely.
www.queensu.ca/grad-postdoc...
www.queensu.ca/grad-postdoc...
Queen’s Special U.S. Doctoral Recruitment Initiative | School of Graduate Studies and Postdoctoral AffairsDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown arrowDown...
Queen’s University is a globally engaged, research-intensive institution dedicated to attracting and supporting exceptional PhD students who will significantly advance our research mission.
www.queensu.ca
April 27, 2025 at 2:33 AM
#TobRegSky #PedSky #MedSky #EpiSky #policysky #polisky #neuroskyence #neurosci #PainResearch #addictionsci 🧪🛟
Queen's University in Canada starts program to admit "doctoral students whose offers from top U.S. schools have been rescinded or who are reconsidering their acceptance to a U.S. school ..."
Queen's University in Canada starts program to admit "doctoral students whose offers from top U.S. schools have been rescinded or who are reconsidering their acceptance to a U.S. school ..."
Reposted by Isabelle Rosso
Please consider making a public comment opposing the possibility of making NIH directors, program officers, and other staff (e.g. SRO, GMS) political appointees. This only took me ~90 seconds. Please repost. Thanks 👍
The notice and COMMENT PERIOD OPENED TODAY AND CLOSES MAY 23.
Anyone who would like to register an objection or comment should go to this page and click on the green “public comment” button at the top:
www.federalregister.gov/documents/20...
6/n
Anyone who would like to register an objection or comment should go to this page and click on the green “public comment” button at the top:
www.federalregister.gov/documents/20...
6/n
Improving Performance, Accountability and Responsiveness in the Civil Service
The Office of Personnel Management (OPM) is proposing a rule to increase career employee accountability. Agency supervisors report great difficulty removing employees for poor performance or misconduc...
www.federalregister.gov
April 23, 2025 at 6:50 PM
Please consider making a public comment opposing the possibility of making NIH directors, program officers, and other staff (e.g. SRO, GMS) political appointees. This only took me ~90 seconds. Please repost. Thanks 👍
Reposted by Isabelle Rosso
Acting Institute Directors named at NIH
Jeffrey Taubenberger, Ph.D. NIAID (Influenza)
Carolyn Hutter, Ph.D. NHGRI (Genetics, epidemiology)
Alison Cernich, Ph.D. NICHD (Rehab medicine)
Monica Webb Hooper, Ph.D. NIMHD (Cancer disparities)
Courtney Aklin, Ph.D. NINR (Clinical Psych)
1/n
Jeffrey Taubenberger, Ph.D. NIAID (Influenza)
Carolyn Hutter, Ph.D. NHGRI (Genetics, epidemiology)
Alison Cernich, Ph.D. NICHD (Rehab medicine)
Monica Webb Hooper, Ph.D. NIMHD (Cancer disparities)
Courtney Aklin, Ph.D. NINR (Clinical Psych)
1/n
April 25, 2025 at 5:45 PM
Acting Institute Directors named at NIH
Jeffrey Taubenberger, Ph.D. NIAID (Influenza)
Carolyn Hutter, Ph.D. NHGRI (Genetics, epidemiology)
Alison Cernich, Ph.D. NICHD (Rehab medicine)
Monica Webb Hooper, Ph.D. NIMHD (Cancer disparities)
Courtney Aklin, Ph.D. NINR (Clinical Psych)
1/n
Jeffrey Taubenberger, Ph.D. NIAID (Influenza)
Carolyn Hutter, Ph.D. NHGRI (Genetics, epidemiology)
Alison Cernich, Ph.D. NICHD (Rehab medicine)
Monica Webb Hooper, Ph.D. NIMHD (Cancer disparities)
Courtney Aklin, Ph.D. NINR (Clinical Psych)
1/n
Reposted by Isabelle Rosso
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
the word alert is in a purple circle
ALT: the word alert is in a purple circle
media.tenor.com
April 23, 2025 at 6:03 PM
ACTION ITEM-----ACTION ITEM
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Implementation of Schedule F
This is what a lot of us have been worried about.
This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.
BUT THERE IS A COMMENT PERIOD...
1/n
Reposted by Isabelle Rosso
We're hiring! The Shackman Lab is hiring a full-time postbac RA for the 2025-26 academic year. This is fabulous opportunity to learn, work, and play with us in the DMV before heading off to graduate school. shackmanlab.org/studycoordin...
Study Coordinator: Full-time Paid Postbaccalaureate Research Assistant | ShackmanLab
shackmanlab.org
April 21, 2025 at 2:46 PM
We're hiring! The Shackman Lab is hiring a full-time postbac RA for the 2025-26 academic year. This is fabulous opportunity to learn, work, and play with us in the DMV before heading off to graduate school. shackmanlab.org/studycoordin...
Reposted by Isabelle Rosso
Just heard @erc.europa.eu will increase funding for grantees relocating to #Europe. Researchers based in the US or elsewhere in the world, can apply for €1 million beyond the usual max amount to set up a lab or #research team, if scientifically justified. Now to be €2 million.
🧪 #grants #academic
🧪 #grants #academic
April 18, 2025 at 8:21 AM
Just heard @erc.europa.eu will increase funding for grantees relocating to #Europe. Researchers based in the US or elsewhere in the world, can apply for €1 million beyond the usual max amount to set up a lab or #research team, if scientifically justified. Now to be €2 million.
🧪 #grants #academic
🧪 #grants #academic
Reposted by Isabelle Rosso
Non-response to treatment is common for patients with PTSD. The lowest non-response rates is found for trauma-focused treatments, but even the non-response rates for these treatments is substantial. onlinelibrary.wiley.com/doi/10.1155/...
Prevalence and Predictors of Nonresponse to Psychological Treatment for PTSD: A Meta‐Analysis
Background. Although highly efficacious psychological treatments for posttraumatic stress disorder (PTSD) exist, there is evidence that first-line psychological treatment approaches leave a substanti...
onlinelibrary.wiley.com
April 15, 2025 at 11:15 AM
Non-response to treatment is common for patients with PTSD. The lowest non-response rates is found for trauma-focused treatments, but even the non-response rates for these treatments is substantial. onlinelibrary.wiley.com/doi/10.1155/...
Reposted by Isabelle Rosso
You look at science (or at least talk of it) as some sort of demoralizing invention of man, something apart from real life, and which must be cautiously guarded and kept separate from everyday existence. But science and everyday life cannot and should not be separated.
Rosalind Franklin (to father)
Rosalind Franklin (to father)
April 1, 2025 at 11:18 AM
You look at science (or at least talk of it) as some sort of demoralizing invention of man, something apart from real life, and which must be cautiously guarded and kept separate from everyday existence. But science and everyday life cannot and should not be separated.
Rosalind Franklin (to father)
Rosalind Franklin (to father)
Bravo les Français, et en particulier l’Université d’Aix-Marseille. C’est bien pensé.
15 American scientists working in climate, health & astrophysics to be brought to the University of Aix-Marseille , under a 3-year "Safe Place for Science".
Europe positions itself to reverse the decades-long transatlantic brain drain.
🧪
www.theguardian.com/commentisfre...
Europe positions itself to reverse the decades-long transatlantic brain drain.
🧪
www.theguardian.com/commentisfre...
A French university is offering ‘scientific asylum’ for US talent. The brain drain has started | Alexander Hurst
The Trump administration is cutting funding, while specifically targeting institutions like Columbia. No wonder academics want out, says Guardian Europe columnist Alexander Hurst
www.theguardian.com
March 24, 2025 at 12:12 PM
Bravo les Français, et en particulier l’Université d’Aix-Marseille. C’est bien pensé.
Reposted by Isabelle Rosso
The administration is removing phone support for Soc Security recipients. Making it more difficult for seniors to get their checks. It’s a back door way to cut SS benefits. Horrific.
If you know anyone who is impacted, please help them get online to get their benefits approved
If you know anyone who is impacted, please help them get online to get their benefits approved
benefit.me
March 19, 2025 at 5:40 PM
The administration is removing phone support for Soc Security recipients. Making it more difficult for seniors to get their checks. It’s a back door way to cut SS benefits. Horrific.
If you know anyone who is impacted, please help them get online to get their benefits approved
If you know anyone who is impacted, please help them get online to get their benefits approved
Reposted by Isabelle Rosso
In exciting news (for me), we demonstrate a structural covariance network of early visual cortex previously identified in recent trauma survivors is associated with PTSD symptoms in a mega-analysis of the ENIGMA-PTSD dataset.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup.
Background: Identifying robust neural signatures of posttraumatic stress disorder (PTSD) symptoms is important to facilitate precision psychiatry and help in understanding and treatment of the disorde...
www.medrxiv.org
March 20, 2025 at 12:20 AM
In exciting news (for me), we demonstrate a structural covariance network of early visual cortex previously identified in recent trauma survivors is associated with PTSD symptoms in a mega-analysis of the ENIGMA-PTSD dataset.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...