Swarnabh Bhattacharya
@iamzico.bsky.social
Stem cell researcher | Organoids | Computational biology | Postdoc | Ramesh Shivdasani Lab | Dana-Farber Cancer Institute | Harvard Medical School | Ph.D @Shalom-Feuerstein Lab | Technion IIT
Pinned
Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell
Bhattacharya et al. delineate chromatin and mRNA dynamics of intestinal secretory
differentiation. They demonstrate that goblet and Paneth cells are phenotypic variants
of a facile signal-responsive A...
dlvr.it
I am excited to share my latest Postdoctoral work @cp-cellstemcell.bsky.social @cellpress.bsky.social (dlvr.it/TK2Fzl), in which we reveal that goblet and Paneth cells aren’t fixed lineages but represent dynamic states influenced by local cues. Here's a walkthrough of what we found (🧵)....
There are many ways to make your voice heard and participate in all that #ISSCR2026 has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more! invt.io/1bxbhh15upf @ISSCR.org
Join me at the ISSCR 2026 Annual Meeting!
Register now
invt.io
November 5, 2025 at 4:02 PM
There are many ways to make your voice heard and participate in all that #ISSCR2026 has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more! invt.io/1bxbhh15upf @ISSCR.org
Reposted by Swarnabh Bhattacharya
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Thrilled to be selected as an #ISSCR2026 Ambassador! The @isscr.org 2026 Annual Meeting will take place in Montréal, Canada on 8-11 July 2026 & features 4 days of scientific sessions with talks from global researchers! Explore the scientific program and the ways to participate. invt.io/1bxb53avp9c
I'm an ISSCR 2026 Ambassador, join me!
Register now
invt.io
October 20, 2025 at 9:07 PM
Thrilled to be selected as an #ISSCR2026 Ambassador! The @isscr.org 2026 Annual Meeting will take place in Montréal, Canada on 8-11 July 2026 & features 4 days of scientific sessions with talks from global researchers! Explore the scientific program and the ways to participate. invt.io/1bxb53avp9c
Reposted by Swarnabh Bhattacharya
Catch up on Development presents… webinar on gut development
Check out the talks of Surojit Sural @surojitsural.bsky.social & Swarnabh Bhattacharya @iamzico.bsky.social
Also, register for our upcoming #DevPres on 15 October: us02web.zoom.us/webinar/regi...
thenode.biologists.com/catch-up-on-...
Check out the talks of Surojit Sural @surojitsural.bsky.social & Swarnabh Bhattacharya @iamzico.bsky.social
Also, register for our upcoming #DevPres on 15 October: us02web.zoom.us/webinar/regi...
thenode.biologists.com/catch-up-on-...
Catch up on Development presents… webinar on gut development - the Node
Our September webinar featured three early-career researchers working on gut development. Here, we share the talks from Surojit Sural (Columbia University) and Swarnabh Bhattacharya (Dana-Farber Cance...
thenode.biologists.com
October 8, 2025 at 12:46 PM
Catch up on Development presents… webinar on gut development
Check out the talks of Surojit Sural @surojitsural.bsky.social & Swarnabh Bhattacharya @iamzico.bsky.social
Also, register for our upcoming #DevPres on 15 October: us02web.zoom.us/webinar/regi...
thenode.biologists.com/catch-up-on-...
Check out the talks of Surojit Sural @surojitsural.bsky.social & Swarnabh Bhattacharya @iamzico.bsky.social
Also, register for our upcoming #DevPres on 15 October: us02web.zoom.us/webinar/regi...
thenode.biologists.com/catch-up-on-...
Reposted by Swarnabh Bhattacharya
Our next #DevPres webinar focusses on gut development with talks from Surojit Sural @surojitsural.bsky.social, Swarnabh Bhattacharya @iamzico.bsky.social and Brittany Edens, chaired by Alex Eve @amjeve.bsky.social.
📆 17 September, 15:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
📆 17 September, 15:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
September 4, 2025 at 10:37 AM
Our next #DevPres webinar focusses on gut development with talks from Surojit Sural @surojitsural.bsky.social, Swarnabh Bhattacharya @iamzico.bsky.social and Brittany Edens, chaired by Alex Eve @amjeve.bsky.social.
📆 17 September, 15:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
📆 17 September, 15:00 BST (UTC+1)
Register here: us02web.zoom.us/webinar/regi...
Thanks to @rkzwick.bsky.social for writing this excellent preview and thoughtful discussion on our recent article @cp-cellstemcell.bsky.social (t.co/TkDxt1b3DH)
Online Now! To play Paneth or goblet: Shapeshifting secretory cells read the room #stemcells
To play Paneth or goblet: Shapeshifting secretory cells read the room
(Cell Stem Cell 32, 861–863; June 5, 2025)
dlvr.it
June 27, 2025 at 9:30 PM
Thanks to @rkzwick.bsky.social for writing this excellent preview and thoughtful discussion on our recent article @cp-cellstemcell.bsky.social (t.co/TkDxt1b3DH)
Honored to receive a Pilot & Feasibility grant (P30 DK034854) from the Harvard Digestive Disease Center to explore cellular plasticity and the epigenetic drivers of inflammatory bowel disease. Excited to uncover new insights into IBD pathogenesis!
June 9, 2025 at 1:08 AM
Honored to receive a Pilot & Feasibility grant (P30 DK034854) from the Harvard Digestive Disease Center to explore cellular plasticity and the epigenetic drivers of inflammatory bowel disease. Excited to uncover new insights into IBD pathogenesis!
I’m thrilled to have our work—“Intestinal secretory differentiation reflects niche-driven phenotypic plasticity of a common signal-responsive terminal cell” (dlvr.it/TK2Fzl) featured in the Preview of this issue of @cp-cellstemcell.bsky.social!
To play Paneth or goblet: Shapeshifting secretory cells read the room
The intestinal secretory lineage is thought to comprise four distinct cell types derived
from one Atoh1+ progenitor, but the mechanisms that distinguish Paneth and goblet
cells are unclear. Bhattachar...
www.cell.com
June 7, 2025 at 1:33 AM
I’m thrilled to have our work—“Intestinal secretory differentiation reflects niche-driven phenotypic plasticity of a common signal-responsive terminal cell” (dlvr.it/TK2Fzl) featured in the Preview of this issue of @cp-cellstemcell.bsky.social!
Reposted by Swarnabh Bhattacharya
Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9
A thread 🧵 1/9
Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications
Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...
www.nature.com
April 28, 2025 at 10:49 AM
Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9
A thread 🧵 1/9
Reposted by Swarnabh Bhattacharya
Check out this exciting preprint from @aznarbenitahlab.bsky.social discovering a new mode of crosstalk between YAP and the circadian regulator BMAL1. Congrats @juliabonjoch.bsky.social and @guiomarsolanas.bsky.social for fantastic work and thank you for the fun collaboration!
Hi Bluesky community:)
Our new manuscript is now available as a preprint!⛅️
biorxiv.org/content/10.1...
1/ Here, we describe a novel BMAL1-YAP complex in epidermal cells, which is hijacked during ageing to control the expression of up-regulated inflammation genes through enhancer binding.🧵
Our new manuscript is now available as a preprint!⛅️
biorxiv.org/content/10.1...
1/ Here, we describe a novel BMAL1-YAP complex in epidermal cells, which is hijacked during ageing to control the expression of up-regulated inflammation genes through enhancer binding.🧵
BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis
Ageing is characterised by persistent low-grade inflammation that is linked to impaired tissue homeostasis and functionality. However, the molecular mechanisms driving age-associated inflammation rema...
biorxiv.org
April 23, 2025 at 7:32 PM
Check out this exciting preprint from @aznarbenitahlab.bsky.social discovering a new mode of crosstalk between YAP and the circadian regulator BMAL1. Congrats @juliabonjoch.bsky.social and @guiomarsolanas.bsky.social for fantastic work and thank you for the fun collaboration!
Reposted by Swarnabh Bhattacharya
Online Now! Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell #stemcells
Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell
Bhattacharya et al. delineate chromatin and mRNA dynamics of intestinal secretory differentiation. They demonstrate that goblet and Paneth cells are phenotypic variants of a facile signal-responsive ATOH1+ cell type and that goblet and Paneth cis-elements and the canonical genes they control interconvert upon modulation of Wnt and BMP signals.
dlvr.it
April 8, 2025 at 11:36 PM
Online Now! Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell #stemcells
I am excited to share my latest Postdoctoral work @cp-cellstemcell.bsky.social @cellpress.bsky.social (dlvr.it/TK2Fzl), in which we reveal that goblet and Paneth cells aren’t fixed lineages but represent dynamic states influenced by local cues. Here's a walkthrough of what we found (🧵)....
Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell
Bhattacharya et al. delineate chromatin and mRNA dynamics of intestinal secretory
differentiation. They demonstrate that goblet and Paneth cells are phenotypic variants
of a facile signal-responsive A...
dlvr.it
April 8, 2025 at 4:43 PM
I am excited to share my latest Postdoctoral work @cp-cellstemcell.bsky.social @cellpress.bsky.social (dlvr.it/TK2Fzl), in which we reveal that goblet and Paneth cells aren’t fixed lineages but represent dynamic states influenced by local cues. Here's a walkthrough of what we found (🧵)....
Reposted by Swarnabh Bhattacharya
Different fibroblast subtypes propel spatially defined ileal inflammation through TNFR1 signaling in murine ileitis @naturecomms.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 28, 2025 at 7:19 PM
Different fibroblast subtypes propel spatially defined ileal inflammation through TNFR1 signaling in murine ileitis @naturecomms.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Swarnabh Bhattacharya
Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis
www.science.org/doi/10.1126/...
@nbgolovchenko.bsky.social @sciimmunology.bsky.social @edelblumlab.bsky.social
www.science.org/doi/10.1126/...
@nbgolovchenko.bsky.social @sciimmunology.bsky.social @edelblumlab.bsky.social
March 21, 2025 at 6:31 PM
Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis
www.science.org/doi/10.1126/...
@nbgolovchenko.bsky.social @sciimmunology.bsky.social @edelblumlab.bsky.social
www.science.org/doi/10.1126/...
@nbgolovchenko.bsky.social @sciimmunology.bsky.social @edelblumlab.bsky.social
Reposted by Swarnabh Bhattacharya
Vagal pathway activation links chronic stress to decline in intestinal stem cell function @cp-cellstemcell.bsky.social
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
March 21, 2025 at 7:08 PM
Vagal pathway activation links chronic stress to decline in intestinal stem cell function @cp-cellstemcell.bsky.social
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Reposted by Swarnabh Bhattacharya
🔦Spotlight of Peter Dempsey, @brumbaugh-lab.bsky.social et al paper: Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells by @iamzico.bsky.social and Ramesh Shivdasani at @danafarber.bsky.social http://dlvr.it/TJfVRZ
March 20, 2025 at 9:01 PM
🔦Spotlight of Peter Dempsey, @brumbaugh-lab.bsky.social et al paper: Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells by @iamzico.bsky.social and Ramesh Shivdasani at @danafarber.bsky.social http://dlvr.it/TJfVRZ
It was fun to write this Spotlight article @cp-cellchembiol.bsky.social on the recent NCB paper (rdcu.be/eayN3) by @brumbaugh-lab.bsky.social & Dempsey labs, revealing how epigenetic fluidity drives phenotypic malleability in the intestinal epithelium. www.sciencedirect.com/science/arti...
March 20, 2025 at 3:30 PM
It was fun to write this Spotlight article @cp-cellchembiol.bsky.social on the recent NCB paper (rdcu.be/eayN3) by @brumbaugh-lab.bsky.social & Dempsey labs, revealing how epigenetic fluidity drives phenotypic malleability in the intestinal epithelium. www.sciencedirect.com/science/arti...
Reposted by Swarnabh Bhattacharya
Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...
Measuring and manipulating mechanical forces during development - Nature Cell Biology
This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...
www.nature.com
March 10, 2025 at 1:33 PM
Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...
Reposted by Swarnabh Bhattacharya
📣Funded #PhDposition! – Pls RT!
Looking for a passionate PhD student to explore cellular crosstalk in #TumorMicroenvironment combining #organoids #scRNAseq &high-res imaging.
Join us @VetmeduniVienna in a vibrant research environment!
#CancerResearch #PhD
👉 euraxess.ec.europa.eu/jobs/302158
Looking for a passionate PhD student to explore cellular crosstalk in #TumorMicroenvironment combining #organoids #scRNAseq &high-res imaging.
Join us @VetmeduniVienna in a vibrant research environment!
#CancerResearch #PhD
👉 euraxess.ec.europa.eu/jobs/302158
January 3, 2025 at 1:10 PM
📣Funded #PhDposition! – Pls RT!
Looking for a passionate PhD student to explore cellular crosstalk in #TumorMicroenvironment combining #organoids #scRNAseq &high-res imaging.
Join us @VetmeduniVienna in a vibrant research environment!
#CancerResearch #PhD
👉 euraxess.ec.europa.eu/jobs/302158
Looking for a passionate PhD student to explore cellular crosstalk in #TumorMicroenvironment combining #organoids #scRNAseq &high-res imaging.
Join us @VetmeduniVienna in a vibrant research environment!
#CancerResearch #PhD
👉 euraxess.ec.europa.eu/jobs/302158
Reposted by Swarnabh Bhattacharya
A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...
Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration
Tissue regeneration relies on the ability of cells to undergo de novo patterning. While tissue patterning has been viewed as the transition from initially identical un-patterned cells to an arrangemen...
biorxiv.org
January 15, 2025 at 5:32 PM
A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...
Reposted by Swarnabh Bhattacharya
Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: rdcu.be/d5AEc
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!
H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium
Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...
rdcu.be
January 10, 2025 at 5:22 AM
Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: rdcu.be/d5AEc
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!
Reposted by Swarnabh Bhattacharya
New research in @nature.com led by Ramesh A. Shivdasani, MD, PhD, of @danafarber.bsky.social gives insight into how intestinal tumors develop. https://go.nature.com/42cMksp
January 9, 2025 at 3:30 PM
New research in @nature.com led by Ramesh A. Shivdasani, MD, PhD, of @danafarber.bsky.social gives insight into how intestinal tumors develop. https://go.nature.com/42cMksp
Reposted by Swarnabh Bhattacharya
Crypt density and recruited enhancers underlie intestinal tumor initiation
@Nature
www.nature.com/articles/s41...
@Nature
www.nature.com/articles/s41...
January 9, 2025 at 1:38 AM
Crypt density and recruited enhancers underlie intestinal tumor initiation
@Nature
www.nature.com/articles/s41...
@Nature
www.nature.com/articles/s41...
New Publication Alert from Shivdasani Lab!! 🚨🚨
Adenomas don’t form just because of Apc mutations—they require cooperation between mutant intestinal crypts. Congratulations to Liam and all the authors! Thrilled to be part of this fantastic study! @nature.com
rdcu.be/d5DQh
Adenomas don’t form just because of Apc mutations—they require cooperation between mutant intestinal crypts. Congratulations to Liam and all the authors! Thrilled to be part of this fantastic study! @nature.com
rdcu.be/d5DQh
Crypt density and recruited enhancers underlie intestinal tumour initiation - Nature
Nature - Crypt density and recruited enhancers underlie intestinal tumour initiation
www.nature.com
January 8, 2025 at 10:41 PM
New Publication Alert from Shivdasani Lab!! 🚨🚨
Adenomas don’t form just because of Apc mutations—they require cooperation between mutant intestinal crypts. Congratulations to Liam and all the authors! Thrilled to be part of this fantastic study! @nature.com
rdcu.be/d5DQh
Adenomas don’t form just because of Apc mutations—they require cooperation between mutant intestinal crypts. Congratulations to Liam and all the authors! Thrilled to be part of this fantastic study! @nature.com
rdcu.be/d5DQh
Reposted by Swarnabh Bhattacharya
Cool study from @katemiro.bsky.social and @dfachinetti.bsky.social labs showing how chromosome abnormalities activate p53 through nuclear envelope stress 🤩 Congrats to all!
Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin
January 8, 2025 at 12:23 PM
Cool study from @katemiro.bsky.social and @dfachinetti.bsky.social labs showing how chromosome abnormalities activate p53 through nuclear envelope stress 🤩 Congrats to all!