Hauke Hillen
@haukehillen.bsky.social
Professor at the University Medical Center Göttingen & Group Leader at the MPI for Multidisciplinary Sciences
Structural biology of gene expression
https://hillenlab.uni-goettingen.de
Structural biology of gene expression
https://hillenlab.uni-goettingen.de
Pinned
Hauke Hillen
@haukehillen.bsky.social
· Jan 11
Molecular basis of human nuclear and mitochondrial tRNA 3′ processing - Nature Structural & Molecular Biology
Bhatta et al. use biochemistry and cryogenic electron microscopy to elucidate the mechanism of human tRNA 3′ processing. Their results show how mitochondria-specific subunits of RNase Z compensate for...
www.nature.com
The peer-reviewed version of our paper on human tRNA 3' processing is now published in
@naturesmb.bsky.social :
www.nature.com/articles/s41...
Many thanks to the reviewers for their constructive comments!
See also the great complementary work by the Hällberg lab: www.embopress.org/doi/full/10....
@naturesmb.bsky.social :
www.nature.com/articles/s41...
Many thanks to the reviewers for their constructive comments!
See also the great complementary work by the Hällberg lab: www.embopress.org/doi/full/10....
Reposted by Hauke Hillen
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
November 3, 2025 at 12:26 PM
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Reposted by Hauke Hillen
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Dodonova Group – Organisational principles and 3D architecture of archaeal chromatin
www.embl.org
October 15, 2025 at 10:38 AM
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Reposted by Hauke Hillen
Join us as a colleague in Göttingen!
📢 We have an opening for a tenure track assistant professor position (W1 t.t. W2) in AI in our CS dept @uni-goettingen.de, Germany.
⏰ Application deadline: Sept 19
🗣️ Please share!
uni-goettingen.de/en/697924.html
⏰ Application deadline: Sept 19
🗣️ Please share!
uni-goettingen.de/en/697924.html
W1-TT-W2 Artificial Intelligence - Georg-August-University Göttingen
Website of the Georg-August-University Göttingen
uni-goettingen.de
August 15, 2025 at 11:34 AM
Join us as a colleague in Göttingen!
Reposted by Hauke Hillen
Our story about FASTKD5 is now published at @narjournal.bsky.social It was an amazing collaboration with @haukehillen.bsky.social and Toni Barrientos’ labs.
doi.org/10.1093/nar/...
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
doi.org/10.1093/nar/...
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
FASTKD5 processes mitochondrial pre-mRNAs at noncanonical cleavage sites
Abstract. The first post-transcriptional step in mammalian mitochondrial gene expression, required for the synthesis of the 13 polypeptides encoded in mito
doi.org
July 11, 2025 at 4:14 AM
Our story about FASTKD5 is now published at @narjournal.bsky.social It was an amazing collaboration with @haukehillen.bsky.social and Toni Barrientos’ labs.
doi.org/10.1093/nar/...
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
doi.org/10.1093/nar/...
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
Join us for the 1st Symposium on Interconnections and Cross-Regulation of Gene Expression Processes this September in Göttingen! Great Lineup of international speakers and plenty of opportunities for early career researchers to present & discuss their work!
Link: sfb1565.uni-goettingen.de/symposion/
Link: sfb1565.uni-goettingen.de/symposion/
June 18, 2025 at 9:03 AM
Join us for the 1st Symposium on Interconnections and Cross-Regulation of Gene Expression Processes this September in Göttingen! Great Lineup of international speakers and plenty of opportunities for early career researchers to present & discuss their work!
Link: sfb1565.uni-goettingen.de/symposion/
Link: sfb1565.uni-goettingen.de/symposion/
We are looking for new colleagues! UMG has an open call for five (!!) new junior group leaders with the broad topic of "metabolic plasticity" - generous startup package, great infrastructure and a thriving research community in Göttingen. Click here to apply by June 30th: tinyurl.com/4hud95rn
Vorstand Forschung und Lehre -- Early Career Researchers (f/m/d) to establish and lead a Junior Research Group in the field of Metabolic Plasticity
Early Career Researchers (f/m/d) to establish and lead a Junior Research Group in the field of Metabolic Plasticity
https://umg.recruiting-portal.com/r/z123rkiwf7v6qrq/Early+Career+Researchers+fmd+to+establish+and+lead+a+Junior+Research+Group+in+the+field+of+Metabolic+Plasticity/37075/Göttingen
June 3, 2025 at 8:57 PM
We are looking for new colleagues! UMG has an open call for five (!!) new junior group leaders with the broad topic of "metabolic plasticity" - generous startup package, great infrastructure and a thriving research community in Göttingen. Click here to apply by June 30th: tinyurl.com/4hud95rn
Reposted by Hauke Hillen
Join us at the EMBO/FEBS lecture course:
The evolving role of mitochondria in metabolism
14 – 18 September 2025 | Belgrade, Serbia:
meetings.embo.org/event/25-mit...
The evolving role of mitochondria in metabolism
14 – 18 September 2025 | Belgrade, Serbia:
meetings.embo.org/event/25-mit...
The evolving role of mitochondria in metabolism
The history of mitochondria begins with their recognition as distinct cellular organelles in 1888 by Walther Flemming and the introduction of the term mitochondrion from the Greek roots meaning ‘thre…
meetings.embo.org
May 29, 2025 at 3:51 AM
Join us at the EMBO/FEBS lecture course:
The evolving role of mitochondria in metabolism
14 – 18 September 2025 | Belgrade, Serbia:
meetings.embo.org/event/25-mit...
The evolving role of mitochondria in metabolism
14 – 18 September 2025 | Belgrade, Serbia:
meetings.embo.org/event/25-mit...
Reposted by Hauke Hillen
🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
April 12, 2025 at 1:42 PM
🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
Happy to share out latest collaborative work with the groups of Ricarda Richter-Dennerlein and Peter Rehling just out in
@natcomms.nature.com. Great work led by two very talented PhD students - Franziska Finke (our lab) and Marleen Heinrichs (Richter-Dennerlein lab).
www.nature.com/articles/s41...
@natcomms.nature.com. Great work led by two very talented PhD students - Franziska Finke (our lab) and Marleen Heinrichs (Richter-Dennerlein lab).
www.nature.com/articles/s41...
Coupling of ribosome biogenesis and translation initiation in human mitochondria - Nature Communications
Mitochondrial ribosome biogenesis requires the assistance of multiple assembly factors. Here, the authors provide insights into the essential role of the GTPase MTG3 during small subunit biogenesis an...
www.nature.com
April 17, 2025 at 9:39 AM
Happy to share out latest collaborative work with the groups of Ricarda Richter-Dennerlein and Peter Rehling just out in
@natcomms.nature.com. Great work led by two very talented PhD students - Franziska Finke (our lab) and Marleen Heinrichs (Richter-Dennerlein lab).
www.nature.com/articles/s41...
@natcomms.nature.com. Great work led by two very talented PhD students - Franziska Finke (our lab) and Marleen Heinrichs (Richter-Dennerlein lab).
www.nature.com/articles/s41...
Reposted by Hauke Hillen
New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Small molecules restore mutant mitochondrial DNA polymerase activity - Nature
An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.
www.nature.com
April 9, 2025 at 4:30 PM
New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Hauke Hillen
The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @science.org 🎉
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩🎨
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩🎨
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more in this week's issue: scim.ag/3FA3Ygq
Learn more in this week's issue: scim.ag/3FA3Ygq
March 20, 2025 at 6:20 PM
The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @science.org 🎉
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩🎨
You can find the full story here www.science.org/doi/10.1126/...
@verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩🎨
The peer-revied version of our paper on the structure of the Nipah virus RNA polymerase in complex with RNA is out in @naturecomms.bsky.social. Congratulations to first-author @salafernanda.bsky.social and many thanks to the reviewers for their constructive comments!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis of Nipah virus RNA synthesis - Nature Communications
Sala et al. report the first structural snapshot of the Nipah virus RNA-dependent RNA polymerase in the actively elongating state, uncovering key mechanisms of RNA synthesis by non-segmented negative ...
www.nature.com
March 10, 2025 at 11:06 AM
The peer-revied version of our paper on the structure of the Nipah virus RNA polymerase in complex with RNA is out in @naturecomms.bsky.social. Congratulations to first-author @salafernanda.bsky.social and many thanks to the reviewers for their constructive comments!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Hauke Hillen
One enzyme, two mechanisms: A team led by @haukehillen.bsky.social from our institute and the University Medical Center Göttingen has uncovered how the 3’ ends of tRNAs are trimmed in the nucleus and mitochondria. ⬇️
www.mpinat.mpg.de/4919943/m_2503
www.mpinat.mpg.de/4919943/m_2503
February 17, 2025 at 3:00 PM
One enzyme, two mechanisms: A team led by @haukehillen.bsky.social from our institute and the University Medical Center Göttingen has uncovered how the 3’ ends of tRNAs are trimmed in the nucleus and mitochondria. ⬇️
www.mpinat.mpg.de/4919943/m_2503
www.mpinat.mpg.de/4919943/m_2503
Reposted by Hauke Hillen
Hello Bluesky, Caliskan Lab is hiring! Our new Lab in Uni Regensburg has open #ERC funded PhD and postdoctoral positions (with long term employment opportunities) in viral #RNA-protein interactions regulating #translation, #transcription, #recoding and #single-molecule-analysis #RNA
January 11, 2025 at 2:17 PM
Hello Bluesky, Caliskan Lab is hiring! Our new Lab in Uni Regensburg has open #ERC funded PhD and postdoctoral positions (with long term employment opportunities) in viral #RNA-protein interactions regulating #translation, #transcription, #recoding and #single-molecule-analysis #RNA
The peer-reviewed version of our paper on human tRNA 3' processing is now published in
@naturesmb.bsky.social :
www.nature.com/articles/s41...
Many thanks to the reviewers for their constructive comments!
See also the great complementary work by the Hällberg lab: www.embopress.org/doi/full/10....
@naturesmb.bsky.social :
www.nature.com/articles/s41...
Many thanks to the reviewers for their constructive comments!
See also the great complementary work by the Hällberg lab: www.embopress.org/doi/full/10....
Molecular basis of human nuclear and mitochondrial tRNA 3′ processing - Nature Structural & Molecular Biology
Bhatta et al. use biochemistry and cryogenic electron microscopy to elucidate the mechanism of human tRNA 3′ processing. Their results show how mitochondria-specific subunits of RNase Z compensate for...
www.nature.com
January 11, 2025 at 12:37 PM
The peer-reviewed version of our paper on human tRNA 3' processing is now published in
@naturesmb.bsky.social :
www.nature.com/articles/s41...
Many thanks to the reviewers for their constructive comments!
See also the great complementary work by the Hällberg lab: www.embopress.org/doi/full/10....
@naturesmb.bsky.social :
www.nature.com/articles/s41...
Many thanks to the reviewers for their constructive comments!
See also the great complementary work by the Hällberg lab: www.embopress.org/doi/full/10....