New preprint from our group! We propose SHAPES, a set of metrics to quantify the distributional coverage of generative models of protein structures with embeddings at different structural hierarchies and quantify undersampling / extrapolation behaviors.

Checkout out these two bombshell papers from @possuhuanglab.bsky.social @stanfordmedicine.bsky.social, computational design of antigen-specific binders to MHC-I or -II, with applications to next gen targeted therapeutics 🤯

This is a clever way to use synthetic biology: taking a toxin that overactivate the immune system (superantigen), rationally modify its core components and transform it into a platform of immunotherapy agents.
Congratulations to @haotiandu.bsky.social and @possuhuanglab.bsky.social on the 2 papers!

Excited to share that TRACeR stories are out🙌