Hannah Hrncir
@hannahhrncir.bsky.social
Lover of cell identity and tissue homeostasis • Emory BCDB in @graczlab.bsky.social • she/her •
Preprint out now (@graczlab.bsky.social): doi.org/10.1101/2025...
We establish a 3D imaging (iDISCO/light sheet microscopy) + analysis pipeline to quantify intrahepatic bile duct (IHBD) architecture during homeostasis and liver injury — in both mice and humans. 🧵 1/8
We establish a 3D imaging (iDISCO/light sheet microscopy) + analysis pipeline to quantify intrahepatic bile duct (IHBD) architecture during homeostasis and liver injury — in both mice and humans. 🧵 1/8
Quantitative 3D imaging of mouse and human intrahepatic bile ducts in homeostasis and liver injury
Intrahepatic bile ducts (IHBDs) form a complex hierarchical network essential for liver function. Remodeling and expansion of this network during ductular reaction (DR) is a hallmark of liver disease ...
doi.org
April 25, 2025 at 9:43 PM
Preprint out now (@graczlab.bsky.social): doi.org/10.1101/2025...
We establish a 3D imaging (iDISCO/light sheet microscopy) + analysis pipeline to quantify intrahepatic bile duct (IHBD) architecture during homeostasis and liver injury — in both mice and humans. 🧵 1/8
We establish a 3D imaging (iDISCO/light sheet microscopy) + analysis pipeline to quantify intrahepatic bile duct (IHBD) architecture during homeostasis and liver injury — in both mice and humans. 🧵 1/8
Reposted by Hannah Hrncir
We are thrilled to release one of the first cookbooks about scientists! Over 120 scientists profiles and recipes
@labculturebites.bsky.social
@labculturebites.bsky.social
April 21, 2025 at 4:10 PM
We are thrilled to release one of the first cookbooks about scientists! Over 120 scientists profiles and recipes
@labculturebites.bsky.social
@labculturebites.bsky.social
Reposted by Hannah Hrncir
CONGRATS to @hannahhrncir.bsky.social, who successfully defended her PhD on Friday! 🥳 A major milestone for the lab and a tour de force of liver research from Dr. Hrncir. Her next stop is the Caron Lab at UNC (@unc-cbp.bsky.social). Very proud of all Hannah accomplished in a short 5yrs!
April 6, 2025 at 10:11 PM
CONGRATS to @hannahhrncir.bsky.social, who successfully defended her PhD on Friday! 🥳 A major milestone for the lab and a tour de force of liver research from Dr. Hrncir. Her next stop is the Caron Lab at UNC (@unc-cbp.bsky.social). Very proud of all Hannah accomplished in a short 5yrs!
Reposted by Hannah Hrncir
#standupforscience2025 at Georgia State Capitol in Atlanta 🧬🔬✊
March 7, 2025 at 8:51 PM
#standupforscience2025 at Georgia State Capitol in Atlanta 🧬🔬✊
Microscopy meeting alert! I’ll be presenting on low (overall morphology) and high (single cell) resolution 3D imaging+analysis using iDISCO at the SEMS meeting May 14-16 in Columbia, SC. If you’re also a microscopy enthusiast register here: southeasternmicroscopy.org/2024-meeting...
2025 Meeting – SEMS
southeasternmicroscopy.org
February 17, 2025 at 4:01 PM
Microscopy meeting alert! I’ll be presenting on low (overall morphology) and high (single cell) resolution 3D imaging+analysis using iDISCO at the SEMS meeting May 14-16 in Columbia, SC. If you’re also a microscopy enthusiast register here: southeasternmicroscopy.org/2024-meeting...
Out now in @naturecomms.bsky.social! In @graczlab.bsky.social, I’ve had the freedom to ‘follow the science’. Here, I pursued a key interest of mine which is understanding how cells organize to form functional tissues. We found distinct regulation between intrahepatic bile ductules and bile ducts.
Some good news: @hannahhrncir.bsky.social ‘s primary PhD paper is finally online! This study lays the groundwork for a lot of technical and conceptual things the lab is currently working on, including light sheet microscopy for imaging entire biliary trees in mouse liver: rdcu.be/d90Br 1/4
Sox9 inhibits Activin A to promote biliary maturation and branching morphogenesis
Nature Communications - The bile ducts of the liver form a network of large ducts and small ductules, though how they are patterned remains unclear. Hrncir et al. show that Sox9 is required for the...
rdcu.be
February 17, 2025 at 2:13 PM
Out now in @naturecomms.bsky.social! In @graczlab.bsky.social, I’ve had the freedom to ‘follow the science’. Here, I pursued a key interest of mine which is understanding how cells organize to form functional tissues. We found distinct regulation between intrahepatic bile ductules and bile ducts.
Reposted by Hannah Hrncir
Some good news: @hannahhrncir.bsky.social ‘s primary PhD paper is finally online! This study lays the groundwork for a lot of technical and conceptual things the lab is currently working on, including light sheet microscopy for imaging entire biliary trees in mouse liver: rdcu.be/d90Br 1/4
Sox9 inhibits Activin A to promote biliary maturation and branching morphogenesis
Nature Communications - The bile ducts of the liver form a network of large ducts and small ductules, though how they are patterned remains unclear. Hrncir et al. show that Sox9 is required for the...
rdcu.be
February 16, 2025 at 7:30 PM
Some good news: @hannahhrncir.bsky.social ‘s primary PhD paper is finally online! This study lays the groundwork for a lot of technical and conceptual things the lab is currently working on, including light sheet microscopy for imaging entire biliary trees in mouse liver: rdcu.be/d90Br 1/4
Some fun imaging using iDISCO and spinning disk confocal microscopy 📸
Among all the bad news about science, I had to share some beautiful new imaging of the mouse liver from @hannahhrncir.bsky.social in my lab. CEACAM1 (red) and Sox9EGFP (green).
February 11, 2025 at 2:10 AM
Some fun imaging using iDISCO and spinning disk confocal microscopy 📸
Reposted by Hannah Hrncir
If you are female PhD faculty in #GIresearch ( #basicscience or #translational), we invite you to join WINGS, Women Innovating in Gastrointestinal Science, a community for career development, mentorship & networking. Please fill out the form on our website and RT! bit.ly/4fHBWfj #GISky #Gastrosky
WINGS | edelblumlab
Women Innovating in Gastrointestinal Science is a group of basic & translational GI researchers that provides a community to connect, empower and inspire female faculty.
www.edelblumlab.com
January 6, 2025 at 9:29 PM
If you are female PhD faculty in #GIresearch ( #basicscience or #translational), we invite you to join WINGS, Women Innovating in Gastrointestinal Science, a community for career development, mentorship & networking. Please fill out the form on our website and RT! bit.ly/4fHBWfj #GISky #Gastrosky
Science + construction paper 🙌
New lab decor, courtesy of @hannahhrncir.bsky.social and @kkanak.bsky.social !
Most of the meme references had to be explained to me 👴🏻🫠
Most of the meme references had to be explained to me 👴🏻🫠
January 13, 2025 at 6:52 PM
Science + construction paper 🙌
Reposted by Hannah Hrncir
Even though there are great #devbio and #biophysics starter packs, I felt #morphogenesis & #organogenesis was missing as a subfield :D
Far from complete or full. Tell me if you want to be added!
go.bsky.app/PB6s8PQ
Far from complete or full. Tell me if you want to be added!
go.bsky.app/PB6s8PQ
November 19, 2024 at 7:14 PM
Even though there are great #devbio and #biophysics starter packs, I felt #morphogenesis & #organogenesis was missing as a subfield :D
Far from complete or full. Tell me if you want to be added!
go.bsky.app/PB6s8PQ
Far from complete or full. Tell me if you want to be added!
go.bsky.app/PB6s8PQ
Reposted by Hannah Hrncir
@hannahhrncir.bsky.social shows that Sox9 is essential for development of small bile ductules in the liver: www.biorxiv.org/content/10.1...
Sox9 links biliary maturation to branching morphogenesis
Branching morphogenesis couples cellular differentiation with development of tissue architecture. Intrahepatic bile duct (IHBD) morphogenesis is initiated with biliary epithelial cell (BEC) specificat...
www.biorxiv.org
November 14, 2024 at 12:33 AM
@hannahhrncir.bsky.social shows that Sox9 is essential for development of small bile ductules in the liver: www.biorxiv.org/content/10.1...
Reposted by Hannah Hrncir
Some Gracz Lab members are joining the great migration to Bluesky! Welcome to @hannahhrncir.bsky.social and @nicjanto.bsky.social. Both are 4th year PhD students with awesome manuscripts currently in revisions!
November 14, 2024 at 12:33 AM
Some Gracz Lab members are joining the great migration to Bluesky! Welcome to @hannahhrncir.bsky.social and @nicjanto.bsky.social. Both are 4th year PhD students with awesome manuscripts currently in revisions!