Sandeep Gupta
@guptalabuofa.bsky.social
Assistant Professor@ UofAlberta, Canada. Neurobiologist, stem cell scientist, mentor
Pinned
Sandeep Gupta
@guptalabuofa.bsky.social
· Oct 10
first lab meeting of the Gupta lab! very fun start. We are building functional stern cell models to investigate neural disorders like autism.
Reposted by Sandeep Gupta
Still think brain regions don’t exist? That everything is everywhere? That cell types don’t matter and that everything is a dynamical phase portrait?
Wrong.
Interconnected brain modules exist at the level of fine grained transcriptomics. www.nature.com/articles/s41...
Wrong.
Interconnected brain modules exist at the level of fine grained transcriptomics. www.nature.com/articles/s41...
Whole-cortex in situ sequencing reveals input-dependent area identity - Nature
BARseq interrogates the expression of 104 cell-type marker genes in 10.3 million cells over nine mouse forebrain hemispheres to reveal the role of peripheral inputs on cortical area development.
www.nature.com
November 6, 2025 at 12:39 PM
Still think brain regions don’t exist? That everything is everywhere? That cell types don’t matter and that everything is a dynamical phase portrait?
Wrong.
Interconnected brain modules exist at the level of fine grained transcriptomics. www.nature.com/articles/s41...
Wrong.
Interconnected brain modules exist at the level of fine grained transcriptomics. www.nature.com/articles/s41...
Reposted by Sandeep Gupta
Development that lasts a life time. Check out the 2025 special issue of @dev-journal.bsky.social on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
journals.biologists.com/dev/issue/15...
journals.biologists.com/dev/issue/15...
Volume 152 Issue 20 | Development | The Company of Biologists
journals.biologists.com
November 5, 2025 at 8:54 AM
Development that lasts a life time. Check out the 2025 special issue of @dev-journal.bsky.social on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
journals.biologists.com/dev/issue/15...
journals.biologists.com/dev/issue/15...
what an ending with iNeurons by Dr. Carol Schuurmans. it was a great experience witnessing cutting-edge stem cell research in Canada. Next Vancouver! #TMM2025
That’s a wrap for #TMM2025 in Ottawa! 🎉
Highlights included:
✨ SCN’s Celebration of Research Excellence
💡 Plenaries on stem cell therapies
🔬 Christine Mummery’s keynote
🧬 Open symposia on cardiac & neuronal regeneration
Thanks to all sponsors and participants—see you next year in Vancouver!
Highlights included:
✨ SCN’s Celebration of Research Excellence
💡 Plenaries on stem cell therapies
🔬 Christine Mummery’s keynote
🧬 Open symposia on cardiac & neuronal regeneration
Thanks to all sponsors and participants—see you next year in Vancouver!
November 5, 2025 at 10:50 PM
what an ending with iNeurons by Dr. Carol Schuurmans. it was a great experience witnessing cutting-edge stem cell research in Canada. Next Vancouver! #TMM2025
Reposted by Sandeep Gupta
ISSCR & Stem Cell Network are seeking nominations to form a working group of early career scientists & senior trainees in stem cell & regenerative medicine research who will provide perspectives on global workforce development. Nominations are due 5 December. Learn more 👉https://ow.ly/j8uY50Xnlzc
The ISSCR and Stem Cell Network Launch Global Regenerative Medicine Workforce Development Initiative — International Society for Stem Cell Research
The International Society for Stem Cell Research (ISSCR) and the Stem Cell Network (SCN) are pleased to partner to lead a joint initiative and a global conversation on workforce development in regenerative medicine. Through this collaboration, the organizations will examine current challenges and op
ow.ly
November 5, 2025 at 7:30 PM
ISSCR & Stem Cell Network are seeking nominations to form a working group of early career scientists & senior trainees in stem cell & regenerative medicine research who will provide perspectives on global workforce development. Nominations are due 5 December. Learn more 👉https://ow.ly/j8uY50Xnlzc
Gupta Lab's image of stem cell- derived neuroepithelium is displayed at #TMM2025. didn't win though 😭 congratulations to all the winners, beautiful pics of wonderful world of stem cells.
November 5, 2025 at 3:15 PM
Gupta Lab's image of stem cell- derived neuroepithelium is displayed at #TMM2025. didn't win though 😭 congratulations to all the winners, beautiful pics of wonderful world of stem cells.
great start of day 3 at #TMM2025 with a talk by Neurona therapeutic on major advances in epilepsy treatment with stem cell- derived interneurons! things are getting excited!
November 5, 2025 at 3:08 PM
great start of day 3 at #TMM2025 with a talk by Neurona therapeutic on major advances in epilepsy treatment with stem cell- derived interneurons! things are getting excited!
Reposted by Sandeep Gupta
Great coverage by @thetransmissions.bsky.social of our latest preprint: adding new evidence (and a hint of controversy 🙂) to the E/I imbalance debate in autism
👇👇
www.thetransmitter.org/spectrum/ram...
👇👇
www.thetransmitter.org/spectrum/ram...
Ramping up cortical activity in early life sparks autism-like behaviors in mice
The findings add fuel to the long-running debate over how an imbalance in excitatory and inhibitory signaling contributes to the autism.
www.thetransmitter.org
November 4, 2025 at 10:59 AM
Great coverage by @thetransmissions.bsky.social of our latest preprint: adding new evidence (and a hint of controversy 🙂) to the E/I imbalance debate in autism
👇👇
www.thetransmitter.org/spectrum/ram...
👇👇
www.thetransmitter.org/spectrum/ram...
great day-2 morning at #TMM2025, listening to an amazing story from Dr. Cristina Nostro, finding roles of macrophages in hsc- derived islet cell differentiation that can revolutionize future diabetes treatments. Huge congratulations to Dr. Nostro for receiving TMM2025 Till & McCulloch prize!
November 4, 2025 at 4:39 PM
great day-2 morning at #TMM2025, listening to an amazing story from Dr. Cristina Nostro, finding roles of macrophages in hsc- derived islet cell differentiation that can revolutionize future diabetes treatments. Huge congratulations to Dr. Nostro for receiving TMM2025 Till & McCulloch prize!
very interesting talk by Ross Fitzsimmons from @ucalgary.bsky.social on raindeer antler regeneration and lessons for regenerative biology.
November 3, 2025 at 7:50 PM
very interesting talk by Ross Fitzsimmons from @ucalgary.bsky.social on raindeer antler regeneration and lessons for regenerative biology.
excited to hear some cool science! #TMM2025
🧬 #TMM2025 KEYNOTE ALERT!
Meet Professor Christine Mummery — known for advancing #StemCell and organ-on-chip technologies to transform #HeartDisease research and drug safety testing. 🔬
📍 Ottawa, ON
📅 Nov 3–5, 2025
🎟️ Early bird registration is now open — register today!
🔗 www.tillandmcculloch.ca
Meet Professor Christine Mummery — known for advancing #StemCell and organ-on-chip technologies to transform #HeartDisease research and drug safety testing. 🔬
📍 Ottawa, ON
📅 Nov 3–5, 2025
🎟️ Early bird registration is now open — register today!
🔗 www.tillandmcculloch.ca
November 3, 2025 at 7:19 AM
excited to hear some cool science! #TMM2025
Reposted by Sandeep Gupta
🎉 #ICYMI: New speakers announced for #TMM2025!
Join us in Ottawa to hear from Dr. Maria Cristina Nostro, 2025 Till & McCulloch Award recipient, and Brandon Murareanu, Drew Lyall Award winner, as they share groundbreaking #RegenerativeMedicine research. 🔬
Don’t miss it. ➡️ www.tillandmcculloch.ca
Join us in Ottawa to hear from Dr. Maria Cristina Nostro, 2025 Till & McCulloch Award recipient, and Brandon Murareanu, Drew Lyall Award winner, as they share groundbreaking #RegenerativeMedicine research. 🔬
Don’t miss it. ➡️ www.tillandmcculloch.ca
October 20, 2025 at 2:13 PM
🎉 #ICYMI: New speakers announced for #TMM2025!
Join us in Ottawa to hear from Dr. Maria Cristina Nostro, 2025 Till & McCulloch Award recipient, and Brandon Murareanu, Drew Lyall Award winner, as they share groundbreaking #RegenerativeMedicine research. 🔬
Don’t miss it. ➡️ www.tillandmcculloch.ca
Join us in Ottawa to hear from Dr. Maria Cristina Nostro, 2025 Till & McCulloch Award recipient, and Brandon Murareanu, Drew Lyall Award winner, as they share groundbreaking #RegenerativeMedicine research. 🔬
Don’t miss it. ➡️ www.tillandmcculloch.ca
Reposted by Sandeep Gupta
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
www.biorxiv.org
October 26, 2025 at 5:15 PM
Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇
www.biorxiv.org/content/10.1...
Reposted by Sandeep Gupta
And the open access article in Science
#ReproSky 🧪 #ReproMed #ObGynSky
www.science.org/doi/10.1126/...
#ReproSky 🧪 #ReproMed #ObGynSky
www.science.org/doi/10.1126/...
Comparative analysis of human and mouse ovaries across age
The mouse is a tractable model for human ovarian biology, however its utility is limited by incomplete understanding of how transcription and signaling differ interspecifically and with age. We compar...
www.science.org
October 26, 2025 at 6:49 PM
And the open access article in Science
#ReproSky 🧪 #ReproMed #ObGynSky
www.science.org/doi/10.1126/...
#ReproSky 🧪 #ReproMed #ObGynSky
www.science.org/doi/10.1126/...
Reposted by Sandeep Gupta
A hearty Denisovan stew ripe with stories of mixing and more mixing, even with a third more ‘archaic’ hominid.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A high-coverage genome from a 200,000-year-old Denisovan
Denisovans, an extinct sister group of Neandertals who lived in Eastern Eurasia during the Middle and Late Pleistocene, are known only from a handful of skeletal remains and limited genetic data, incl...
www.biorxiv.org
October 20, 2025 at 7:07 PM
A hearty Denisovan stew ripe with stories of mixing and more mixing, even with a third more ‘archaic’ hominid.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sandeep Gupta
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Reposted by Sandeep Gupta
I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Staff Scientist
About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...
embl.wd103.myworkdayjobs.com
October 10, 2025 at 7:30 AM
I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
first lab meeting of the Gupta lab! very fun start. We are building functional stern cell models to investigate neural disorders like autism.
October 10, 2025 at 3:56 AM
first lab meeting of the Gupta lab! very fun start. We are building functional stern cell models to investigate neural disorders like autism.
Reposted by Sandeep Gupta
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
The functional landscape of the human ubiquitinome
Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...
www.biorxiv.org
October 9, 2025 at 7:07 AM
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
Reposted by Sandeep Gupta
At a time when there is so much discourse and rhetoric against disability, some thoughts here from a few months ago: www.thespec.com/opinion/cont...
Valuing disability and difference in society
Those sitting at the decision-making and policy tables are far removed from the day-to-day experience of children, youth and their families.
www.thespec.com
October 6, 2025 at 8:02 PM
At a time when there is so much discourse and rhetoric against disability, some thoughts here from a few months ago: www.thespec.com/opinion/cont...
Reposted by Sandeep Gupta
I know the news is tough right now.
So take a moment and soak in the gorgeousness & promise of the science that led to this year’s Nobel Prize in Medicine & Physiology.
WOW.
www.nytimes.com/2025/10/06/h...
So take a moment and soak in the gorgeousness & promise of the science that led to this year’s Nobel Prize in Medicine & Physiology.
WOW.
www.nytimes.com/2025/10/06/h...
Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems
www.nytimes.com
October 7, 2025 at 2:13 AM
I know the news is tough right now.
So take a moment and soak in the gorgeousness & promise of the science that led to this year’s Nobel Prize in Medicine & Physiology.
WOW.
www.nytimes.com/2025/10/06/h...
So take a moment and soak in the gorgeousness & promise of the science that led to this year’s Nobel Prize in Medicine & Physiology.
WOW.
www.nytimes.com/2025/10/06/h...
Reposted by Sandeep Gupta
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
October 6, 2025 at 1:02 PM
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reposted by Sandeep Gupta
Dense longitudinal neuroimaging reveals individual brain change trajectories: Trends in Cognitive Sciences www.cell.com/trends/cogni...
Dense longitudinal neuroimaging reveals individual brain change trajectories
Longitudinal measurements of brain structure and function are critical for understanding
how humans change over time. Traditional longitudinal approaches sample sparsely across
large windows of time t...
www.cell.com
October 7, 2025 at 10:50 AM
Dense longitudinal neuroimaging reveals individual brain change trajectories: Trends in Cognitive Sciences www.cell.com/trends/cogni...
Reposted by Sandeep Gupta
I am going to repost our job ad because we are not getting many applicants!
Like anywhere, there are pros and cons, so if you have questions just DM or email me.
#academicjobs #neuroskyence #neuroethology #academicsky
Like anywhere, there are pros and cons, so if you have questions just DM or email me.
#academicjobs #neuroskyence #neuroethology #academicsky
For anyone on the neuroscience job market, our ads are up. We are looking for anyone working in systems neuroscience of animals to join us in southern Alberta 🇨🇦
#academicsky #neuroskyence #neuroethology #academicjobs #Canada
neurojobs.sfn.org/job/39049/as...
#academicsky #neuroskyence #neuroethology #academicjobs #Canada
neurojobs.sfn.org/job/39049/as...
Assistant Professor (Neuroscience, Tenure Track) - Lethbridge (City), Alberta (CA) job with University of Lethbridge | 39049
Assistant Professor (tenure track) of the Department of Neuroscience at the University of Lethbridge, Alberta, Canada
neurojobs.sfn.org
October 7, 2025 at 1:33 AM
I am going to repost our job ad because we are not getting many applicants!
Like anywhere, there are pros and cons, so if you have questions just DM or email me.
#academicjobs #neuroskyence #neuroethology #academicsky
Like anywhere, there are pros and cons, so if you have questions just DM or email me.
#academicjobs #neuroskyence #neuroethology #academicsky