George Lountos
@gt2933a.bsky.social
Scientist/Structural Biology/Crystallography/cryoEM/Travel/Georgia Tech Alumnus. Views are my own.
Reposted by George Lountos
Just out: Covalent chemical probes
Covalent chemical probes
Communications Chemistry, Published online: 29 August 2025; doi:10.1038/s42004-025-01652-6Communications Chemistry is pleased to introduce a Collection of research works focused on recent developments within the interdisciplinary field of Covalent chemical probes. Here, the Guest Editors highlight key themes and look towards the future of this research field.
bit.ly
August 29, 2025 at 5:04 PM
Just out: Covalent chemical probes
Reposted by George Lountos
How can you find consistent biological 3D structures in heavily contaminated electron microscopy data sets without using any prior knowledge? #CryoEM #SingleParticle #Reconstruction doi.org/10.1107/S205...
August 18, 2025 at 1:10 PM
How can you find consistent biological 3D structures in heavily contaminated electron microscopy data sets without using any prior knowledge? #CryoEM #SingleParticle #Reconstruction doi.org/10.1107/S205...
Our latest work on the discovery of new inhibitors of tyrosyl-DNA phosphodiesteras 1 (TDP1) is now published in Scientific Reports.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Potent β-lactam-based tyrosyl-DNA phosphodiesterase 1 inhibitors identified by a virtual screen - Scientific Reports
Scientific Reports - Potent β-lactam-based tyrosyl-DNA phosphodiesterase 1 inhibitors identified by a virtual screen
www.nature.com
July 22, 2025 at 2:42 PM
Our latest work on the discovery of new inhibitors of tyrosyl-DNA phosphodiesteras 1 (TDP1) is now published in Scientific Reports.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by George Lountos
Great Hot Structures session at #ACA2025!
ACA Etter Student Award winner Sarah Narehood, @biophyskrys.bsky.social, Nikolas Capra, Rachel Kretsch, Debanu Das, Daniel Richman
@acastructuralsci.bsky.social
ACA Etter Student Award winner Sarah Narehood, @biophyskrys.bsky.social, Nikolas Capra, Rachel Kretsch, Debanu Das, Daniel Richman
@acastructuralsci.bsky.social
July 20, 2025 at 4:17 PM
Great Hot Structures session at #ACA2025!
ACA Etter Student Award winner Sarah Narehood, @biophyskrys.bsky.social, Nikolas Capra, Rachel Kretsch, Debanu Das, Daniel Richman
@acastructuralsci.bsky.social
ACA Etter Student Award winner Sarah Narehood, @biophyskrys.bsky.social, Nikolas Capra, Rachel Kretsch, Debanu Das, Daniel Richman
@acastructuralsci.bsky.social
Reposted by George Lountos
Cong T. S. Van et al.: Probabilistic single-particle cryo-EM ab initio 3D reconstruction in SIMPLE ##CryoEM##SingleParticle##Reconstruction... ##IUCrhttps://journals.iucr.org/paper?S2059798325005686
Probabilistic single-particle cryo-EM ab initio 3D reconstruction in SIMPLE
We introduce a new approach to probabilistic multi-volume single-particle cryo-EM ab initio 3D reconstruction for simultaneous estimation of the relative particle 3D orientations and partitioning of the particles into groups with distinct structural states.
journals.iucr.org
July 9, 2025 at 12:00 AM
Cong T. S. Van et al.: Probabilistic single-particle cryo-EM ab initio 3D reconstruction in SIMPLE ##CryoEM##SingleParticle##Reconstruction... ##IUCrhttps://journals.iucr.org/paper?S2059798325005686
Activity and structure of human (d)CTP deaminase CDADC1 | PNAS www.pnas.org/doi/10.1073/...
Activity and structure of human (d)CTP deaminase CDADC1 | PNAS
Vertebrates have evolved an understudied protein termed CDADC1 (NYD-SP15) that contains
an inactive N-terminal and active C-terminal DCTD-like doma...
www.pnas.org
May 5, 2025 at 7:16 PM
Activity and structure of human (d)CTP deaminase CDADC1 | PNAS www.pnas.org/doi/10.1073/...
Reposted by George Lountos
Are you new to #CryoEM, or looking for a review of the basics?
You might enjoy our TRPV1 case study! It covers preprocessing, particle curation, refinement, and more! You can also test your skills with the advanced exercises at the end of the study.
guide.cryosparc.com/processing-d...
#CryoSPARC
You might enjoy our TRPV1 case study! It covers preprocessing, particle curation, refinement, and more! You can also test your skills with the advanced exercises at the end of the study.
guide.cryosparc.com/processing-d...
#CryoSPARC
April 16, 2025 at 10:55 AM
Are you new to #CryoEM, or looking for a review of the basics?
You might enjoy our TRPV1 case study! It covers preprocessing, particle curation, refinement, and more! You can also test your skills with the advanced exercises at the end of the study.
guide.cryosparc.com/processing-d...
#CryoSPARC
You might enjoy our TRPV1 case study! It covers preprocessing, particle curation, refinement, and more! You can also test your skills with the advanced exercises at the end of the study.
guide.cryosparc.com/processing-d...
#CryoSPARC
Reposted by George Lountos
Welcome to the participants of the 2025 #CryoEM course at Cold Spring Harbor Lab @cshlaboratory.bsky.social ! It's going to be a great 2 weeks immersed in all aspects of single particle cryoEM methods.
March 6, 2025 at 4:47 PM
Welcome to the participants of the 2025 #CryoEM course at Cold Spring Harbor Lab @cshlaboratory.bsky.social ! It's going to be a great 2 weeks immersed in all aspects of single particle cryoEM methods.
Reposted by George Lountos
Impact of the PDB on drug approvals
Open access to the PDB facilitated discovery/development of 100% of the 34 new low molecular weight, protein-targeted, antineoplastic agents approved by the US FDA 2019–2023.
Read more in Oncogene
www.nature.com/artic...
Open access to the PDB facilitated discovery/development of 100% of the 34 new low molecular weight, protein-targeted, antineoplastic agents approved by the US FDA 2019–2023.
Read more in Oncogene
www.nature.com/artic...
Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019–2023
Oncogene - Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019–2023
www.nature.com
February 26, 2025 at 5:12 PM
Impact of the PDB on drug approvals
Open access to the PDB facilitated discovery/development of 100% of the 34 new low molecular weight, protein-targeted, antineoplastic agents approved by the US FDA 2019–2023.
Read more in Oncogene
www.nature.com/artic...
Open access to the PDB facilitated discovery/development of 100% of the 34 new low molecular weight, protein-targeted, antineoplastic agents approved by the US FDA 2019–2023.
Read more in Oncogene
www.nature.com/artic...