Co-abundance analysis of 938 healthy individuals uncovers how host factors shape gut microbiome interactions, highlighting a core set of 200 impacted genera and additional factor-specific interactions. @ggspasteur.bsky.social

www.nature.com/articles/s42...

We are happy to share a new paper from our lab:
The influence of environment on bacterial co-abundance in the gut microbiomes of healthy human individuals www.nature.com/articles/s42...
which investigates environmental effects on microbiome interactions, using our previously published tool MANOCCA.

🧬👩‍🏫 Today, in our Journal Club, we discussed this preprint about multi-trait GWAS finemapping by Matthew Stephens’ Lab

Yuxin Zou et al. Fast and flexible joint fine-mapping of multiple traits via the Sum of Single Effects model

🧬 New multi-trait genetic paper on asthma heterogeneity from Emmanuelle Bouzigon's lab and lead by Raphaël Vernet in the Journal of Allergy and Clinical Immunology

Unraveling shared genetics across asthma subtypes and 81 asthma-related traits

🔗 doi.org/10.1016/j.ja...

A new collaborative work with our colleagues from HealthFex! Unraveling shared genetics across asthma subtypes and 81 asthma-related traits - www.jacionline.org/article/S009...

📰Journal club
Our team discussed “Leveraging the local genetic structure for trans-ancestry association mapping” (Xiao et al., AJHG 2022), which introduces LOG-TRAM, a method that boosts statistical power in underrepresented populations by using local genetic architecture. doi.org/10.1016/j.aj...

Peer review is not quite dead but it’s on life support and the current model of scientific publishing is a burning platform. healthydebate.ca/2025/06/topi...

📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41...

Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.

This long-shot paper aimed to assess whether common GWAS pipelines are reaching their limits for prediction purposes. The review process was lengthy and painful. We're curious to see how it will fly! All comments are welcome! www.cell.com/hgg-advances...

Nice! Add a special relatedness matrix for cross-chromosome correlations to estimate the extra heritability due to assortative mating. Much larger contribution for educational attainment than for fluid IQ.

www.nature.com/articles/s41...

For today's journal club, we discussed the LHC-MR (Latent Heritable Confounder MR, rdcu.be/emhYv) paper from @zkutalik.bsky.social group. The study propose a new method to model concordant horizontal pleitropy thus accounting for confounding effect.

We're hiring Pioneer Fellow Postdocs!!

Join us at the Pioneer Centre for SMARTbiomed to develop innovative methods in epidemiology, biostatistics, and statistical genetics, working with big biomedical data.

international.au.dk/about/profil...

#StatGen #Epi #Postdoc #SMARTbiomed

A new study from the lab in collaboration with Michael J Cho from BWH investigating COPD subtypes using multi-trait genetics!
www.sciencedirect.com/science/arti...

Glad to be part of this collaborative piece investigating how genetic effect changes with age!

iovs.arvojournals.org/article.aspx...

Thanks to Les Treilles Fondation (www.fondationdestreilles.com) for hosting us for a wonderful retreat to discuss causal inference in genetics with Charles Assad, Brielin Brown, @judithabk6.bsky.social, Anne Rovsing, Matti Pirinen,Marie Verbanck,Xiang Zhou,Chiara Sabatti, and Sriram Sankararaman...

📢Our unit is opening a postdoc position! All candidates interested in working in the field of Statistical Genetics in the thriving Institut Pasteur Paris campus are welcome to apply !!!
For details please check here: research.pasteur.fr/en/job/postd...