Gerry Brien
@gerrybrien.bsky.social
Childhood Cancer | Chromatin Biology | Therapeutics | Outdoor Adventures
https://www.brienlab.com/
https://www.brienlab.com/
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Gerry Brien
@gerrybrien.bsky.social
· May 21
Just a few days after international DMG/DIPG day, our paper showing the importance of CBX4/PCGF4 containing cPRC1 complexes in glioma is out in @cp-molcell.bsky.social. Below is a nice synopsis of the paper by joint first author @EimearLagan.bsky.social
Reposted by Gerry Brien
Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
May 21, 2025 at 4:13 PM
Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
Reposted by Gerry Brien
Online Now: A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma Online now:
A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma
Lagan, Gannon, et al. reveal that H3K27M-DMGs depend on a specific form of cPRC1 containing CBX4 and PCGF4. H3K27M alters H3K27me3 distribution, causing increased binding of CBX4-PCGF4-cPRC1 and oncogenic gene repression. CBX4’s ability to read H3K27me3 and to form a specific cPRC1 complex with PCGF4 makes it essential in DMG.
dlvr.it
May 21, 2025 at 3:19 PM
Online Now: A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma Online now: