Paulo Navarro-Costa
@germcells.bsky.social
Group leader studying reproduction and infertility | Quality Assurance Manager | Invited Assistant Professor | Perennial outsider | DIY aesthete 🇵🇹🇬🇧🇪🇺
Lab website: www.evorepromed.pt
Lab website: www.evorepromed.pt
Pinned
How to build a sperm cell
A shared set of old, deeply conserved genes presides over the development of sperm cells in humans, mice and fruit flies.
elifesciences.org
They said it, not us...😇 Our "fundamental" and "convincing" study on what evolution can teach us about #infertility is finally out. TL;DR? Check out this primer by @elife.bsky.social to get the lowdown on what we discovered by looking at the past of human sperm. elifesciences.org/digests/9577...
"Como podem as instituições de ensino superior afirmar que cuidam das pessoas, quando mantêm centenas de docentes num limbo contratual, sem estabilidade, sem progressão e sem reconhecimento formal do seu mérito académico?"
www.publico.pt/2025/10/19/p...
www.publico.pt/2025/10/19/p...
Saúde mental para as redes sociais, precariedade para os docentes
As universidades e politécnicos celebram a saúde mental com discursos, mas esquecem a realidade dos seus docentes, muitos presos a vínculos precários que minam o bem-estar que dizem promover.
www.publico.pt
October 19, 2025 at 7:14 AM
"Como podem as instituições de ensino superior afirmar que cuidam das pessoas, quando mantêm centenas de docentes num limbo contratual, sem estabilidade, sem progressão e sem reconhecimento formal do seu mérito académico?"
www.publico.pt/2025/10/19/p...
www.publico.pt/2025/10/19/p...
John Gurdon, yr beloved @germcells.bsky.social first and foremost scientific reference has passed away. Here's to a person who was told he couldn't make it and decided to make it on his own terms 🥂 Rest in power, John!
October 8, 2025 at 12:01 PM
John Gurdon, yr beloved @germcells.bsky.social first and foremost scientific reference has passed away. Here's to a person who was told he couldn't make it and decided to make it on his own terms 🥂 Rest in power, John!
Reposted by Paulo Navarro-Costa
Great work from Aurora's lab! 👌
🚨 New from our lab in #ScienceAdvances!
RAD21L cohesin acts as both a 3D genome architect and a transcriptional gatekeeper in the male germline. Its loss disrupts both structure and function—highlighting the tight link between genome folding and gene regulation
www.science.org/doi/10.1126/...
RAD21L cohesin acts as both a 3D genome architect and a transcriptional gatekeeper in the male germline. Its loss disrupts both structure and function—highlighting the tight link between genome folding and gene regulation
www.science.org/doi/10.1126/...
Meiotic cohesin RAD21L shapes 3D genome structure and transcription in the male germline
Deletion of the meiotic subunit RAD21L alters 3D chromatin structure and transcription in the mammalian male germ line.
www.science.org
October 2, 2025 at 11:00 AM
Great work from Aurora's lab! 👌
Semester's off to a promising start. Histology student in a Clash T-shirt asks what's my favorite Descendents record 🙌
October 1, 2025 at 4:41 PM
Semester's off to a promising start. Histology student in a Clash T-shirt asks what's my favorite Descendents record 🙌
👏👏👏 Truly well-deserved @needhibhalla.bsky.social 🏆
🎉 Congratulations to Needhi Bhalla, UC Santa Cruz (www.bhallalab.com
), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology
), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology
September 20, 2025 at 11:26 AM
👏👏👏 Truly well-deserved @needhibhalla.bsky.social 🏆
Notes on method by Hayao Miyazaki.
September 20, 2025 at 11:13 AM
Notes on method by Hayao Miyazaki.
Mais um dia normal na #Fertagus. Homem com duas crianças tem ataque de pânico em carruagem com lotação máxima excedida e ativa abertura de porta de emergência (com comboio prestes a iniciar marcha). Vai ser preciso morrer alguém para este serviço funcionar com um pingo de humanidade?
September 9, 2025 at 5:01 PM
Mais um dia normal na #Fertagus. Homem com duas crianças tem ataque de pânico em carruagem com lotação máxima excedida e ativa abertura de porta de emergência (com comboio prestes a iniciar marcha). Vai ser preciso morrer alguém para este serviço funcionar com um pingo de humanidade?
Reposted by Paulo Navarro-Costa
'Overall, the message from this survey is positive– evolutionary biologists are readily employable outside of academia, generally well-prepared for those jobs, and report high levels of satisfaction in their non-academic careers.'
#Preprint
www.biorxiv.org/content/10.1...
#Preprint
www.biorxiv.org/content/10.1...
Leaving Academia: Insights from Evolutionary Biologists on Their Career Transitions and Job Satisfaction
Many who have obtained PhDs in evolutionary biology will ultimately pursue careers that fall outside a narrow definition of an academic career. At the same time, PhD students and supervisors of PhD st...
www.biorxiv.org
September 5, 2025 at 2:02 AM
'Overall, the message from this survey is positive– evolutionary biologists are readily employable outside of academia, generally well-prepared for those jobs, and report high levels of satisfaction in their non-academic careers.'
#Preprint
www.biorxiv.org/content/10.1...
#Preprint
www.biorxiv.org/content/10.1...
Neste novo paradigma da educação, ciência e inovação, dar e devolver são conceitos fundamentais.
www.publico.pt/2025/09/05/s...
www.publico.pt/2025/09/05/s...
Reitor do Porto denuncia “pressões” para aceitar entradas ilegais em Medicina. Ministro nega
Reitor revelou ao Expresso ter sido pressionado por pessoas “influentes e com acesso ao poder”. Ministro da Educação intercedeu por alunos, mas nega pressões. Parecer deu razão ao reitor.
www.publico.pt
September 5, 2025 at 12:26 PM
Neste novo paradigma da educação, ciência e inovação, dar e devolver são conceitos fundamentais.
www.publico.pt/2025/09/05/s...
www.publico.pt/2025/09/05/s...
Só deixar isto aqui...
Comboios avariam todos os dias e utentes exigem inspeção urgente à Fertagus
Comboios avariam todos os dias e utentes exigem inspeção urgente à Fertagus
Utentes da Fertagus exigem inspeção urgente aos comboios. Avarias constantes e comboios cheios geram revolta. Governo pressionado.
www.sapo.pt
September 3, 2025 at 8:34 PM
Só deixar isto aqui...
Back in the 90s every so often I would ride this tram to go to punk rock shows in a dive bar on top of the hill. Lisbon (or whatever's left of that once fabled city) is coming apart. Peace to those who have fallen and to their loved ones 💔
Breaking News: At least 15 people are dead and 18 others injured after a popular funicular in Lisbon, the Elevador da Glória, derailed and crashed. nyti.ms/4n6YDxo
September 3, 2025 at 8:32 PM
Back in the 90s every so often I would ride this tram to go to punk rock shows in a dive bar on top of the hill. Lisbon (or whatever's left of that once fabled city) is coming apart. Peace to those who have fallen and to their loved ones 💔
Reposted by Paulo Navarro-Costa
Last week to submit your abstract! Don’t miss the chance to share your work with us at the next #POHaD GdR Symposium
@gdr-reproduction.bsky.social @juliecocquet.bsky.social #epigenetics #sperm #andrology #offspringhealth #dohad
@gdr-reproduction.bsky.social @juliecocquet.bsky.social #epigenetics #sperm #andrology #offspringhealth #dohad
📢 Save the date!
The GdR Symposium on POHaD: Paternal Origins of Health and Disease is happening Oct 16, 2025 — hybrid at Institut Cochin (Paris) & online.
📌 Free registration (required): forms.gle/TTaFbuNJmwtx...
#POHaD #Epigenetics #Reproduction
🧵1/4
The GdR Symposium on POHaD: Paternal Origins of Health and Disease is happening Oct 16, 2025 — hybrid at Institut Cochin (Paris) & online.
📌 Free registration (required): forms.gle/TTaFbuNJmwtx...
#POHaD #Epigenetics #Reproduction
🧵1/4
Registration form - POHaD GdR Symposium
By filling this form, you will confirm your registration to the upcoming POHaD hybrid Symposium taking place next October 16th, 2025. Registration is free of cost but mandatory.
Abstract submission is...
forms.gle
September 1, 2025 at 12:56 PM
Last week to submit your abstract! Don’t miss the chance to share your work with us at the next #POHaD GdR Symposium
@gdr-reproduction.bsky.social @juliecocquet.bsky.social #epigenetics #sperm #andrology #offspringhealth #dohad
@gdr-reproduction.bsky.social @juliecocquet.bsky.social #epigenetics #sperm #andrology #offspringhealth #dohad
Mas afinal é para devolvermos à sociedade ou à economia?
August 30, 2025 at 6:17 PM
Mas afinal é para devolvermos à sociedade ou à economia?
"This story shows that it is possible to establish a multibillion-dollar industry purely by letting scientists communicate their research, exchange information and share materials."
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Monoclonal antibodies revolutionized biomedical science and health care
The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing treatments.
www.nature.com
August 18, 2025 at 8:20 AM
"This story shows that it is possible to establish a multibillion-dollar industry purely by letting scientists communicate their research, exchange information and share materials."
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Peepz, it's #Tbt of that mytical #GRC on fertilization in NH. Here's the #Drosophila dream team: Yukiko Yamashita (r) and Benjamin Loppin (c), with yr beloved water boy @germcells.bsky.social on the left 😅
August 14, 2025 at 4:26 PM
Peepz, it's #Tbt of that mytical #GRC on fertilization in NH. Here's the #Drosophila dream team: Yukiko Yamashita (r) and Benjamin Loppin (c), with yr beloved water boy @germcells.bsky.social on the left 😅
À atenção do Governo de Portugal.
Science is a long game.
Translational science, or clinical medicine is only possibly because of basic science discoveries where the clinical applications are not yet known.
Also: Nobels are typically awarded for basic science… *exploratory* basic science.
True story.
Translational science, or clinical medicine is only possibly because of basic science discoveries where the clinical applications are not yet known.
Also: Nobels are typically awarded for basic science… *exploratory* basic science.
True story.
Over 20 years after Julius’s lab and mine cloned TRPM8, it is rewarding to see this science helping patients. The TRPM8 agonist Tryptyr treats dry eye by increasing tear production. A reminder that NIH-funded curiosity-driven research translates to medicines.
tryptyr.myalcon.com?gad_source=1...
tryptyr.myalcon.com?gad_source=1...
August 14, 2025 at 9:03 AM
À atenção do Governo de Portugal.
"Sutanjang was a line of division on the road that separated the incarcerated from their children. The patients were allowed to see their children once a month from a distance at this line, because of fear of infection."
hekint.org/2020/12/30/t...
hekint.org/2020/12/30/t...
The Sorokdo National Hospital of South Korea - Hektoen International
Lucy EumNew Brunswick, Canada Hansen’s disease, also known as leprosy, has historically been a highly stigmatized condition.1 For centuries it was thought to be a curse, a punishment for sin, or a her...
hekint.org
August 13, 2025 at 9:31 AM
"Sutanjang was a line of division on the road that separated the incarcerated from their children. The patients were allowed to see their children once a month from a distance at this line, because of fear of infection."
hekint.org/2020/12/30/t...
hekint.org/2020/12/30/t...
Essential reading 👇
"Seeing patients as consumers has become essential to health care organizations’ quest for greater economy, efficiency, and productivity. But neither physicians nor patients share this understanding of their interactions."
www.nejm.org/doi/full/10....
"Seeing patients as consumers has become essential to health care organizations’ quest for greater economy, efficiency, and productivity. But neither physicians nor patients share this understanding of their interactions."
www.nejm.org/doi/full/10....
A Gilded Age for Patients? The Broken Promises of Profit-Driven Medicine | NEJM
Understanding today’s corporatization of U.S. health care requires seeing it from
a historical perspective, as a process that began with a change in the business model
of care delivery in the 1920s.
www.nejm.org
August 13, 2025 at 9:27 AM
Essential reading 👇
"Seeing patients as consumers has become essential to health care organizations’ quest for greater economy, efficiency, and productivity. But neither physicians nor patients share this understanding of their interactions."
www.nejm.org/doi/full/10....
"Seeing patients as consumers has become essential to health care organizations’ quest for greater economy, efficiency, and productivity. But neither physicians nor patients share this understanding of their interactions."
www.nejm.org/doi/full/10....
Reposted by Paulo Navarro-Costa
I wrote up the financial summary for EMBO Press, which makes an effort to be transparent. The largest cost category is staff salaries (admin staff and the scientific editors). I dont know if there are mo re recent numbers, but here's 2021
www.embo.org/features/fin...
www.embo.org/features/fin...
Financial transparency at EMBO Press – Features – EMBO
Two years ago, EMBO made the EMBO Press journals’ finances public. We now provide an update on our costs of scientific publishing in 2019.
www.embo.org
August 12, 2025 at 8:34 AM
I wrote up the financial summary for EMBO Press, which makes an effort to be transparent. The largest cost category is staff salaries (admin staff and the scientific editors). I dont know if there are mo re recent numbers, but here's 2021
www.embo.org/features/fin...
www.embo.org/features/fin...
