Georg Keller
@georgkeller.bsky.social
Neuroscientist studying the mechanisms of psychiatric treatments.
apredictiveprocessinglab.org
apredictiveprocessinglab.org
We think cortex might function like a JEPA. It looks like prediction errors in layer 2/3 are not computed against input (as is the idea in predictive processing), but against a representation in latent space (i.e. like in a JEPA arxiv.org/abs/2301.08243 or RPL doi.org/10.1101/2025...).
January 30, 2026 at 2:51 PM
We think cortex might function like a JEPA. It looks like prediction errors in layer 2/3 are not computed against input (as is the idea in predictive processing), but against a representation in latent space (i.e. like in a JEPA arxiv.org/abs/2301.08243 or RPL doi.org/10.1101/2025...).
Reposted by Georg Keller
Join leading scientists for a 3.5-day #LakeConference discussion on: "The Neurobiology of Mental Health" at the level of genes, cell types, organoids, circuits, networks and brain systems. Learn more & apply by January 31: https://lakeconferences.org/conf/1ed63fdb-de0c-4a56-a8b3-1f72f93d30ea
January 12, 2026 at 10:28 PM
Join leading scientists for a 3.5-day #LakeConference discussion on: "The Neurobiology of Mental Health" at the level of genes, cell types, organoids, circuits, networks and brain systems. Learn more & apply by January 31: https://lakeconferences.org/conf/1ed63fdb-de0c-4a56-a8b3-1f72f93d30ea
Reposted by Georg Keller
Join us this May to explore the biological mechanisms of mental health challenges and treatment strategies. Apply by January 31: lakeconferences.org
Home - Lake Conferences
lakeconferences.org
January 5, 2026 at 9:38 AM
Join us this May to explore the biological mechanisms of mental health challenges and treatment strategies. Apply by January 31: lakeconferences.org
Reposted by Georg Keller
1/6 New preprint 🚀 How does the cortex learn to represent things and how they move without reconstructing sensory stimuli? We developed a circuit-centric recurrent predictive learning (RPL) model based on JEPAs.
🔗 doi.org/10.1101/2025...
Led by @atenagm.bsky.social @mshalvagal.bsky.social
🔗 doi.org/10.1101/2025...
Led by @atenagm.bsky.social @mshalvagal.bsky.social
November 27, 2025 at 8:24 AM
1/6 New preprint 🚀 How does the cortex learn to represent things and how they move without reconstructing sensory stimuli? We developed a circuit-centric recurrent predictive learning (RPL) model based on JEPAs.
🔗 doi.org/10.1101/2025...
Led by @atenagm.bsky.social @mshalvagal.bsky.social
🔗 doi.org/10.1101/2025...
Led by @atenagm.bsky.social @mshalvagal.bsky.social
One of the most promising approaches to making headway in understanding the cortical algorithm that I have seen in a long time! www.biorxiv.org/content/10.1...
Understanding cortical computation through the lens of joint-embedding predictive architectures
Tracking prey or recognizing a lurking predator is as crucial for survival as anticipating their actions. To guide behavior, the brain must extract information about object identities and their dynami...
www.biorxiv.org
November 26, 2025 at 1:54 PM
One of the most promising approaches to making headway in understanding the cortical algorithm that I have seen in a long time! www.biorxiv.org/content/10.1...
Reposted by Georg Keller
In this first-person account, FMI’s senior communications manager describes taking part in an early human trial that adapts previous experiments in mice to explore how the human brain responds when visual and auditory information suddenly fall out of sync. www.fmi.ch/news-events/...
Inside the tunnel: Experiencing the brain’s response to sensory mismatches
In this first-person account, FMI’s senior communications manager describes taking part in an early human trial that adapts previous experiments in mice to explore how the human brain responds when vi...
www.fmi.ch
November 20, 2025 at 9:19 AM
In this first-person account, FMI’s senior communications manager describes taking part in an early human trial that adapts previous experiments in mice to explore how the human brain responds when visual and auditory information suddenly fall out of sync. www.fmi.ch/news-events/...
Reposted by Georg Keller
Applications are open for the #LakeConference on the Neurobiology of Mental Health in Lake Thun, Switzerland.
📆 May 17-21, 2026
🏔️ All career stages welcome
⏳ Apply by January 31, 2026
Learn more and apply: https://t.co/WcuXHdWnFa
@lakeconferences.bsky.social
📆 May 17-21, 2026
🏔️ All career stages welcome
⏳ Apply by January 31, 2026
Learn more and apply: https://t.co/WcuXHdWnFa
@lakeconferences.bsky.social
November 3, 2025 at 4:36 PM
Applications are open for the #LakeConference on the Neurobiology of Mental Health in Lake Thun, Switzerland.
📆 May 17-21, 2026
🏔️ All career stages welcome
⏳ Apply by January 31, 2026
Learn more and apply: https://t.co/WcuXHdWnFa
@lakeconferences.bsky.social
📆 May 17-21, 2026
🏔️ All career stages welcome
⏳ Apply by January 31, 2026
Learn more and apply: https://t.co/WcuXHdWnFa
@lakeconferences.bsky.social
Reposted by Georg Keller
Very much looking forward to this collaboration with @georgkeller.bsky.social at @fmiscience.bsky.social, using a cross-species approach in humans and mice to investigate the effects of antipsychotics on cortical circuit function.
FMI’s Prof. @georgkeller.bsky.social and UPK Basel’s Prof. Philip Sterzer have been awarded a 1.5 M CHF @snf-fns.ch grant to study how brain circuit changes underlie schizophrenia — bridging fundamental neuroscience and clinical research from mice to humans 🧠 www.fmi.ch/news-events/...
Understanding schizophrenia by bridging mouse and human brain circuits
FMI group leader Prof. Georg Keller and Prof. Philip Sterzer from Universitären Psychiatrischen Kliniken (UPK) Basel have jointly been awarded a Schweizerischer Nationalfonds (SNF) grant over 1.5 mill...
www.fmi.ch
October 22, 2025 at 9:15 AM
Very much looking forward to this collaboration with @georgkeller.bsky.social at @fmiscience.bsky.social, using a cross-species approach in humans and mice to investigate the effects of antipsychotics on cortical circuit function.
Reposted by Georg Keller
Join us for the second Neurobiology of Mental Health conference (May 2026) that will explore the biological mechanisms underlying mental health challenges and their treatment. Information and application on: lakeconferences.org. The deadline for applications is January 31st, 2026.
Home - Lake Conferences
lakeconferences.org
October 13, 2025 at 4:47 PM
Join us for the second Neurobiology of Mental Health conference (May 2026) that will explore the biological mechanisms underlying mental health challenges and their treatment. Information and application on: lakeconferences.org. The deadline for applications is January 31st, 2026.
Reposted by Georg Keller
Please share: Postdoc position available in a new collaborative SNSF project with @georgkeller.bsky.social at @fmiscience.bsky.social using a cross-species approach in humans and mice to investigate the cortical circuit mechanisms underlying schizophrenia. Apply at karriere.upk.ch/Postdoctoral...
Stellenangebot Postdoctoral Researcher (PostDoc m/f) 100% Translational Psychiatry Lab for 2 Years bei Universitäre Psychiatrische Kliniken Basel UPK
Forschung in Klinik für Erwachsene (UPKE)
karriere.upk.ch
October 13, 2025 at 7:02 AM
Please share: Postdoc position available in a new collaborative SNSF project with @georgkeller.bsky.social at @fmiscience.bsky.social using a cross-species approach in humans and mice to investigate the cortical circuit mechanisms underlying schizophrenia. Apply at karriere.upk.ch/Postdoctoral...
Reposted by Georg Keller
I’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 24, 2025 at 12:04 PM
I’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Georg Keller
This year's Ruth Chiquet Prize goes to @solygamagda.bsky.social, who sent a video message, for her work on how the brain detects sensory mismatches. Read more at: www.fmi.ch/news-events/...
September 17, 2025 at 8:52 AM
This year's Ruth Chiquet Prize goes to @solygamagda.bsky.social, who sent a video message, for her work on how the brain detects sensory mismatches. Read more at: www.fmi.ch/news-events/...
Reposted by Georg Keller
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
September 8, 2025 at 8:15 AM
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
I often get asked “do you think visuomotor mismatch responses are a mouse thing?” – it looks like at least humans have them as well. very excited by this!
A new preprint from our lab with @zelechowski.bsky.social & @georgkeller.bsky.social !
Using wireless EEG + VR, we recorded visuomotor mismatch responses in freely moving humans.
Huge thanks to all participants, Keller Lab members and FMI facilities!
Read more: www.biorxiv.org/content/10.1...
Using wireless EEG + VR, we recorded visuomotor mismatch responses in freely moving humans.
Huge thanks to all participants, Keller Lab members and FMI facilities!
Read more: www.biorxiv.org/content/10.1...
August 19, 2025 at 2:33 PM
I often get asked “do you think visuomotor mismatch responses are a mouse thing?” – it looks like at least humans have them as well. very excited by this!
Reposted by Georg Keller
Ditching months-long delays for fast, constructive feedback.
This interview with @solygamagda.bsky.social dives into the experience of publishing with eLife and what it could mean for a more open and efficient future in science.
This interview with @solygamagda.bsky.social dives into the experience of publishing with eLife and what it could mean for a more open and efficient future in science.
Publishing with eLife: “the future of science lies in greater transparency”
Neuroscientist Magdalena Solyga shares her latest study and her experience publishing with eLife.
buff.ly
July 21, 2025 at 3:59 PM
Ditching months-long delays for fast, constructive feedback.
This interview with @solygamagda.bsky.social dives into the experience of publishing with eLife and what it could mean for a more open and efficient future in science.
This interview with @solygamagda.bsky.social dives into the experience of publishing with eLife and what it could mean for a more open and efficient future in science.
Reposted by Georg Keller
Defending science in public we often talk about 'peer reviewed science'. But could this framing contribute to undermining trust in science and holding us back from improving the scientific process? Instead, let's talk about the work that has received the most thorough and transparent scrutiny? 🧪
July 16, 2025 at 9:34 AM
Defending science in public we often talk about 'peer reviewed science'. But could this framing contribute to undermining trust in science and holding us back from improving the scientific process? Instead, let's talk about the work that has received the most thorough and transparent scrutiny? 🧪
Reposted by Georg Keller
We’re pushing for a system that’s fairer for researchers, helping them get recognition for what, not where they publish.
Learn about our model that eliminates accept/reject decisions.
buff.ly/SCqcG4x
Learn about our model that eliminates accept/reject decisions.
buff.ly/SCqcG4x
June 17, 2025 at 8:02 PM
We’re pushing for a system that’s fairer for researchers, helping them get recognition for what, not where they publish.
Learn about our model that eliminates accept/reject decisions.
buff.ly/SCqcG4x
Learn about our model that eliminates accept/reject decisions.
buff.ly/SCqcG4x
Reposted by Georg Keller
In his new book, published today, Nachum Ulanovsky calls on the field to embrace naturalistic conditions and move away from overcontrolled experiments.
#neuroskyence
www.thetransmitter.org/systems-neur...
#neuroskyence
www.thetransmitter.org/systems-neur...
‘Natural Neuroscience,’ an excerpt
In his new book, Nachum Ulanovsky calls on the field to embrace naturalistic conditions and move away from overcontrolled experiments.
www.thetransmitter.org
April 15, 2025 at 1:11 PM
In his new book, published today, Nachum Ulanovsky calls on the field to embrace naturalistic conditions and move away from overcontrolled experiments.
#neuroskyence
www.thetransmitter.org/systems-neur...
#neuroskyence
www.thetransmitter.org/systems-neur...
Reposted by Georg Keller
How does our brain predict the future? Our review of predictive processing + research program is now on arXiv arxiv.org/abs/2504.09614
50+ neuroscientists distributed across the world worked together to create this unique community project.
50+ neuroscientists distributed across the world worked together to create this unique community project.
April 15, 2025 at 6:58 AM
How does our brain predict the future? Our review of predictive processing + research program is now on arXiv arxiv.org/abs/2504.09614
50+ neuroscientists distributed across the world worked together to create this unique community project.
50+ neuroscientists distributed across the world worked together to create this unique community project.
Reposted by Georg Keller
I just received the price, thank you so much for all your work @womeninneurouk.bsky.social !!!
March 17, 2025 at 10:57 AM
I just received the price, thank you so much for all your work @womeninneurouk.bsky.social !!!
Consistent with the work of @jeremiahycohen.bsky.social and @mishaahrens.bsky.social labs, we find that serotonin axons in mouse visual cortex appear to signal recent visuomotor uncertainty (and unlike norepinephrine axons, they have no visuomotor mismatch responses) www.biorxiv.org/content/10.1...
Activity in serotonergic axons in visuomotor areas of cortex is modulated by the recent history of visuomotor coupling
Visuomotor experience is necessary for the development of normal function of visual cortex (Attinger et al., 2017) and likely establishes a balance between movement-related predictions and sensory sig...
www.biorxiv.org
March 13, 2025 at 11:29 AM
Consistent with the work of @jeremiahycohen.bsky.social and @mishaahrens.bsky.social labs, we find that serotonin axons in mouse visual cortex appear to signal recent visuomotor uncertainty (and unlike norepinephrine axons, they have no visuomotor mismatch responses) www.biorxiv.org/content/10.1...
Just in case you - as we did - were wondering whether humans would have any of these pesky visuomotor mismatch responses certain people have seen in mice...
February 26, 2025 at 1:25 PM
Just in case you - as we did - were wondering whether humans would have any of these pesky visuomotor mismatch responses certain people have seen in mice...
Reposted by Georg Keller
Applications are open for the @lakeconferences.bsky.social on Neural Coding & Dynamics in Seattle – co-hosted with Circuit Neuroscience Basel!
📆 9/28 to 10/2
📍 Seattle, USA
🧠📈 All career stages welcomed.
Apply to attend by May 23: alleninstitute.org/events/lake-...
#LakeConference
📆 9/28 to 10/2
📍 Seattle, USA
🧠📈 All career stages welcomed.
Apply to attend by May 23: alleninstitute.org/events/lake-...
#LakeConference
Lake Conference - Neural Coding & Dynamics 2025
Join the Allen Institute and Circuit Neuroscience Basel for the Lake Conference in Seattle, Washington this September! This small conference will...
alleninstitute.org
February 25, 2025 at 11:34 PM
Applications are open for the @lakeconferences.bsky.social on Neural Coding & Dynamics in Seattle – co-hosted with Circuit Neuroscience Basel!
📆 9/28 to 10/2
📍 Seattle, USA
🧠📈 All career stages welcomed.
Apply to attend by May 23: alleninstitute.org/events/lake-...
#LakeConference
📆 9/28 to 10/2
📍 Seattle, USA
🧠📈 All career stages welcomed.
Apply to attend by May 23: alleninstitute.org/events/lake-...
#LakeConference
In @elife.bsky.social: Multimodal mismatch responses in mouse auditory cortex doi.org/10.7554/eLif...
Multimodal mismatch responses in mouse auditory cortex
Audiomotor mismatch responses in auditory cortex are amplified by concurrent visuomotor mismatches, highlighting non-hierarchical and multimodal processing of prediction errors.
doi.org
February 10, 2025 at 11:15 PM
In @elife.bsky.social: Multimodal mismatch responses in mouse auditory cortex doi.org/10.7554/eLif...
Reposted by Georg Keller
The application deadline for the Sensation and Action conference 2025 is fast approaching! Join us for an exciting set of talks and for a chance to share your ideas: www.lakeconferences.org
Home - Lake Conferences
www.lakeconferences.org
January 24, 2025 at 3:52 PM
The application deadline for the Sensation and Action conference 2025 is fast approaching! Join us for an exciting set of talks and for a chance to share your ideas: www.lakeconferences.org