The French Purine Club
@frenchpurine.bsky.social
The French Purine Club aims to gather researchers interested in the biology of purines, their receptors and translational outcomes. To share ideas and methods.
Reposted by The French Purine Club
Neuroscientifiques en France, on a besoin de vous !
La Société Française de Neurosciences lance un questionnaire pour dresser un panorama de notre communauté et orienter ses actions futures.
👉 10 min max : psychology.eu.qualtrics.com/jfe/form/SV_...
#neurosciences #recherche
La Société Française de Neurosciences lance un questionnaire pour dresser un panorama de notre communauté et orienter ses actions futures.
👉 10 min max : psychology.eu.qualtrics.com/jfe/form/SV_...
#neurosciences #recherche
La Société des Neurosciences a besoin de vous !
Ce questionnaire a été conçu pour évaluer votre expérience et votre relation avec la société des neurosciences. Il n'y a donc ni bonnes ni mauvaises réponses, seulement votre perspective.
psychology.eu.qualtrics.com
November 24, 2025 at 4:07 PM
Neuroscientifiques en France, on a besoin de vous !
La Société Française de Neurosciences lance un questionnaire pour dresser un panorama de notre communauté et orienter ses actions futures.
👉 10 min max : psychology.eu.qualtrics.com/jfe/form/SV_...
#neurosciences #recherche
La Société Française de Neurosciences lance un questionnaire pour dresser un panorama de notre communauté et orienter ses actions futures.
👉 10 min max : psychology.eu.qualtrics.com/jfe/form/SV_...
#neurosciences #recherche
Reposted by The French Purine Club
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 6, 2025 at 7:01 PM
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by The French Purine Club
Our editorial article published today @FrontiersIn closes the ResearchTopic: Purinergic signaling function in the #CNS in health and #diseases with 22 articles thanks to my co-editors and 145 contributing authors. #P2X #Adenosine #P2Y Front.Cell.Neurosci|
doi.org/10.3389/fncel.…
doi.org/10.3389/fncel.…
January 25, 2025 at 10:01 AM
Our editorial article published today @FrontiersIn closes the ResearchTopic: Purinergic signaling function in the #CNS in health and #diseases with 22 articles thanks to my co-editors and 145 contributing authors. #P2X #Adenosine #P2Y Front.Cell.Neurosci|
doi.org/10.3389/fncel.…
doi.org/10.3389/fncel.…
Reposted by The French Purine Club
💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF
bit.ly/4gX6njF
Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology
Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly
October 4, 2025 at 2:32 PM
💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF
bit.ly/4gX6njF
The next European #Purine Meeting will be hosted by the French Purine Club in Bordeaux in 2026 with the important support of the EU COST Presto coordinated by Prof. Elena Adinolfi.
September 9, 2025 at 3:16 PM
The next European #Purine Meeting will be hosted by the French Purine Club in Bordeaux in 2026 with the important support of the EU COST Presto coordinated by Prof. Elena Adinolfi.
The French Purine Club is present at the World Congress on Purines 🇨🇳
September 9, 2025 at 5:56 AM
The French Purine Club is present at the World Congress on Purines 🇨🇳
Reposted by The French Purine Club
A study by researchers in China introduced a new purine nucleotide prodrug targeting SARS-CoV-2.
Tested on rats, the oral drug showed strong antiviral activity, safety at high doses, and lung-targeting efficacy.
pubs.acs.org/doi/10.1021/...
Tested on rats, the oral drug showed strong antiviral activity, safety at high doses, and lung-targeting efficacy.
pubs.acs.org/doi/10.1021/...
Discovery of a 2′-α-Fluoro-2′-β-C-(fluoromethyl) Purine Nucleotide Prodrug as a Potential Oral Anti-SARS-CoV-2 Agent
A novel 2′-α-fluoro-2′-β-C-(fluoromethyl) purine nucleoside phosphoramidate prodrug 15 has been designed and synthesized to treat SARS-CoV-2 infection. The SARS-CoV-2 central replication transcription...
pubs.acs.org
January 13, 2025 at 10:03 PM
A study by researchers in China introduced a new purine nucleotide prodrug targeting SARS-CoV-2.
Tested on rats, the oral drug showed strong antiviral activity, safety at high doses, and lung-targeting efficacy.
pubs.acs.org/doi/10.1021/...
Tested on rats, the oral drug showed strong antiviral activity, safety at high doses, and lung-targeting efficacy.
pubs.acs.org/doi/10.1021/...
The French Purine Club is present at #Glia2025 #Marseille
July 9, 2025 at 11:40 AM
The French Purine Club is present at #Glia2025 #Marseille
Reposted by The French Purine Club
Members of INSERM UMR1327 Ischemia: Mohammed ELMALLAH, Marylou PICHONNIERE and Oumnia BENOUNA were pleased to present their work yesterday, at the Annual meeting of the @frenchpurine.bsky.social in Paris. A meeting enriched by relevant scientific discussions.
July 1, 2025 at 1:41 PM
Members of INSERM UMR1327 Ischemia: Mohammed ELMALLAH, Marylou PICHONNIERE and Oumnia BENOUNA were pleased to present their work yesterday, at the Annual meeting of the @frenchpurine.bsky.social in Paris. A meeting enriched by relevant scientific discussions.
Karine Massé (Université de Bordeaux, IMN CNRS UMR5293)
"Eye and kidney embryonic development regulation: Role of alkaline phosphatase alpl"
👁️🩺 Linking ALPL to organogenesis via purinergic control.
#FPC2025 #DevelopmentalBiology
"Eye and kidney embryonic development regulation: Role of alkaline phosphatase alpl"
👁️🩺 Linking ALPL to organogenesis via purinergic control.
#FPC2025 #DevelopmentalBiology
June 30, 2025 at 3:52 PM
Karine Massé (Université de Bordeaux, IMN CNRS UMR5293)
"Eye and kidney embryonic development regulation: Role of alkaline phosphatase alpl"
👁️🩺 Linking ALPL to organogenesis via purinergic control.
#FPC2025 #DevelopmentalBiology
"Eye and kidney embryonic development regulation: Role of alkaline phosphatase alpl"
👁️🩺 Linking ALPL to organogenesis via purinergic control.
#FPC2025 #DevelopmentalBiology
David Blum (INSERM UMR-S1172, Lille) -le vrai -.
"Adenosine A2A receptor in astrocytes triggers multicellular dysfunction in Alzheimer’s Disease"
🧠 From glial dysregulation to network-wide pathology and neuronal hyperexytability
#FPC2025 #AlzheimersResearch
"Adenosine A2A receptor in astrocytes triggers multicellular dysfunction in Alzheimer’s Disease"
🧠 From glial dysregulation to network-wide pathology and neuronal hyperexytability
#FPC2025 #AlzheimersResearch
June 30, 2025 at 3:46 PM
David Blum (INSERM UMR-S1172, Lille) -le vrai -.
"Adenosine A2A receptor in astrocytes triggers multicellular dysfunction in Alzheimer’s Disease"
🧠 From glial dysregulation to network-wide pathology and neuronal hyperexytability
#FPC2025 #AlzheimersResearch
"Adenosine A2A receptor in astrocytes triggers multicellular dysfunction in Alzheimer’s Disease"
🧠 From glial dysregulation to network-wide pathology and neuronal hyperexytability
#FPC2025 #AlzheimersResearch
Anne-Sophie Rolland (Lil'N'Cog, INSERM UMR-S1172, Lille)
"Newly diagnosed ALS patients may benefit from regular caffeine consumption" well her liming!
☕ Could coffee slow ALS progression?
#FPC2025 #Neurodegeneration #ALS #Neuroprotection
"Newly diagnosed ALS patients may benefit from regular caffeine consumption" well her liming!
☕ Could coffee slow ALS progression?
#FPC2025 #Neurodegeneration #ALS #Neuroprotection
June 30, 2025 at 3:27 PM
Anne-Sophie Rolland (Lil'N'Cog, INSERM UMR-S1172, Lille)
"Newly diagnosed ALS patients may benefit from regular caffeine consumption" well her liming!
☕ Could coffee slow ALS progression?
#FPC2025 #Neurodegeneration #ALS #Neuroprotection
"Newly diagnosed ALS patients may benefit from regular caffeine consumption" well her liming!
☕ Could coffee slow ALS progression?
#FPC2025 #Neurodegeneration #ALS #Neuroprotection
Solène Rimbert (ESPCI, CNRS UMR8249)
“The role of adenosine A2A receptor in the stabilisation and elimination of glutamatergic synapses”
#FPC2025 #A2a #development
“The role of adenosine A2A receptor in the stabilisation and elimination of glutamatergic synapses”
#FPC2025 #A2a #development
June 30, 2025 at 3:21 PM
Solène Rimbert (ESPCI, CNRS UMR8249)
“The role of adenosine A2A receptor in the stabilisation and elimination of glutamatergic synapses”
#FPC2025 #A2a #development
“The role of adenosine A2A receptor in the stabilisation and elimination of glutamatergic synapses”
#FPC2025 #A2a #development
Elena Dossi (Collège de France, INSERM U1050)
"Differential contribution of astroglial connexins to chronic seizures in mice and humans: a role for ATP?"
⚡ ATP as a hidden player in astroglial communication and epileptogenesis.
#FPC2025 #Neuroglia #Epilepsy #Astrocytes
"Differential contribution of astroglial connexins to chronic seizures in mice and humans: a role for ATP?"
⚡ ATP as a hidden player in astroglial communication and epileptogenesis.
#FPC2025 #Neuroglia #Epilepsy #Astrocytes
June 30, 2025 at 2:56 PM
Elena Dossi (Collège de France, INSERM U1050)
"Differential contribution of astroglial connexins to chronic seizures in mice and humans: a role for ATP?"
⚡ ATP as a hidden player in astroglial communication and epileptogenesis.
#FPC2025 #Neuroglia #Epilepsy #Astrocytes
"Differential contribution of astroglial connexins to chronic seizures in mice and humans: a role for ATP?"
⚡ ATP as a hidden player in astroglial communication and epileptogenesis.
#FPC2025 #Neuroglia #Epilepsy #Astrocytes
Sara Carracedo (Université de Bordeaux)
"P2X4 receptor modifies lysosomal properties and autophagy in microglia"
P2X4 increases lysosomal size while decreasing their number
#FPC2025 #Neuroinflammation #Microglia #Lysosomes
"P2X4 receptor modifies lysosomal properties and autophagy in microglia"
P2X4 increases lysosomal size while decreasing their number
#FPC2025 #Neuroinflammation #Microglia #Lysosomes
June 30, 2025 at 2:15 PM
Sara Carracedo (Université de Bordeaux)
"P2X4 receptor modifies lysosomal properties and autophagy in microglia"
P2X4 increases lysosomal size while decreasing their number
#FPC2025 #Neuroinflammation #Microglia #Lysosomes
"P2X4 receptor modifies lysosomal properties and autophagy in microglia"
P2X4 increases lysosomal size while decreasing their number
#FPC2025 #Neuroinflammation #Microglia #Lysosomes
Oumnia Benouna (Université de Tours)
"P2X4 modulates autophagy in renal tubular cells under ischemia-reperfusion"
🧪 New insights into P2X4's role in cell survival.
#FPC2025 #KidneyResearch #Autophagy #RenalCells
"P2X4 modulates autophagy in renal tubular cells under ischemia-reperfusion"
🧪 New insights into P2X4's role in cell survival.
#FPC2025 #KidneyResearch #Autophagy #RenalCells
June 30, 2025 at 1:44 PM
Oumnia Benouna (Université de Tours)
"P2X4 modulates autophagy in renal tubular cells under ischemia-reperfusion"
🧪 New insights into P2X4's role in cell survival.
#FPC2025 #KidneyResearch #Autophagy #RenalCells
"P2X4 modulates autophagy in renal tubular cells under ischemia-reperfusion"
🧪 New insights into P2X4's role in cell survival.
#FPC2025 #KidneyResearch #Autophagy #RenalCells
Thomas Grutter (Université de Strasbourg)
"New labeling method for revealing endogenous P2X7 at single-molecule level in BV2 microglia"
🔍 Cutting-edge imaging meets purinergic biology.
#FPC2025 #Neuroimaging #P2X7 #SingleMolecule
"New labeling method for revealing endogenous P2X7 at single-molecule level in BV2 microglia"
🔍 Cutting-edge imaging meets purinergic biology.
#FPC2025 #Neuroimaging #P2X7 #SingleMolecule
June 30, 2025 at 1:30 PM
Thomas Grutter (Université de Strasbourg)
"New labeling method for revealing endogenous P2X7 at single-molecule level in BV2 microglia"
🔍 Cutting-edge imaging meets purinergic biology.
#FPC2025 #Neuroimaging #P2X7 #SingleMolecule
"New labeling method for revealing endogenous P2X7 at single-molecule level in BV2 microglia"
🔍 Cutting-edge imaging meets purinergic biology.
#FPC2025 #Neuroimaging #P2X7 #SingleMolecule
Marylou Pichonnière (UMR1327 ISCHEMIA, Tours)
"Extracellular nanovesicles as potential biomarkers of kidney-graft function recovery"
📊 EVs as a non-invasive window into renal recovery.
#FPC2025 #Transplantation #Biomarkers #P2X4 #P2X7 #KidneyTransplantation
"Extracellular nanovesicles as potential biomarkers of kidney-graft function recovery"
📊 EVs as a non-invasive window into renal recovery.
#FPC2025 #Transplantation #Biomarkers #P2X4 #P2X7 #KidneyTransplantation
June 30, 2025 at 1:11 PM
Marylou Pichonnière (UMR1327 ISCHEMIA, Tours)
"Extracellular nanovesicles as potential biomarkers of kidney-graft function recovery"
📊 EVs as a non-invasive window into renal recovery.
#FPC2025 #Transplantation #Biomarkers #P2X4 #P2X7 #KidneyTransplantation
"Extracellular nanovesicles as potential biomarkers of kidney-graft function recovery"
📊 EVs as a non-invasive window into renal recovery.
#FPC2025 #Transplantation #Biomarkers #P2X4 #P2X7 #KidneyTransplantation
Mohammed Elmallah (Inserm UMR1327, Tours)
"Immunomodulatory effects of breast cancer MDA-MB-231- cell-derived extracellular vesicles on monocyte-derived dendritic cells: Implication of P2X4 purinergoc receptor"
#FPC2025 #PurinergicSignaling | #BreastCancer #Immunomodulation
"Immunomodulatory effects of breast cancer MDA-MB-231- cell-derived extracellular vesicles on monocyte-derived dendritic cells: Implication of P2X4 purinergoc receptor"
#FPC2025 #PurinergicSignaling | #BreastCancer #Immunomodulation
June 30, 2025 at 12:45 PM
Mohammed Elmallah (Inserm UMR1327, Tours)
"Immunomodulatory effects of breast cancer MDA-MB-231- cell-derived extracellular vesicles on monocyte-derived dendritic cells: Implication of P2X4 purinergoc receptor"
#FPC2025 #PurinergicSignaling | #BreastCancer #Immunomodulation
"Immunomodulatory effects of breast cancer MDA-MB-231- cell-derived extracellular vesicles on monocyte-derived dendritic cells: Implication of P2X4 purinergoc receptor"
#FPC2025 #PurinergicSignaling | #BreastCancer #Immunomodulation
Valérie Vouret-Craviari (IRCAN, Nice)
"Expression of purinergic checkpoints in response to treatments in lung cancers"
💡 Toward a personalized medicine including modulators of purinergic checkpoints
#FPC2025 #CancerImmunology
#PurinergicCheckpoints
"Expression of purinergic checkpoints in response to treatments in lung cancers"
💡 Toward a personalized medicine including modulators of purinergic checkpoints
#FPC2025 #CancerImmunology
#PurinergicCheckpoints
June 30, 2025 at 12:28 PM
Valérie Vouret-Craviari (IRCAN, Nice)
"Expression of purinergic checkpoints in response to treatments in lung cancers"
💡 Toward a personalized medicine including modulators of purinergic checkpoints
#FPC2025 #CancerImmunology
#PurinergicCheckpoints
"Expression of purinergic checkpoints in response to treatments in lung cancers"
💡 Toward a personalized medicine including modulators of purinergic checkpoints
#FPC2025 #CancerImmunology
#PurinergicCheckpoints
Kicking off the 3rd Annual French Purine Club Meeting in Paris,
David Blum, President of the Club, welcomes researchers to two days of cutting-edge insights on purinergic signaling in health and disease.
📍Live from ESPCI – Let the science begin!
#FPC2025
David Blum, President of the Club, welcomes researchers to two days of cutting-edge insights on purinergic signaling in health and disease.
📍Live from ESPCI – Let the science begin!
#FPC2025
June 30, 2025 at 12:19 PM
Kicking off the 3rd Annual French Purine Club Meeting in Paris,
David Blum, President of the Club, welcomes researchers to two days of cutting-edge insights on purinergic signaling in health and disease.
📍Live from ESPCI – Let the science begin!
#FPC2025
David Blum, President of the Club, welcomes researchers to two days of cutting-edge insights on purinergic signaling in health and disease.
📍Live from ESPCI – Let the science begin!
#FPC2025
📢 Scientific Program Now Live | #FPC2025
From purinergic checkpoints in cancer to ATP signaling in neurodegeneration, the 3rd Scientific Days of the French Purine Club bring cutting-edge talks across immunology, oncology & neuroscience.
📍June 30–July 1 | ESPCI Paris
From purinergic checkpoints in cancer to ATP signaling in neurodegeneration, the 3rd Scientific Days of the French Purine Club bring cutting-edge talks across immunology, oncology & neuroscience.
📍June 30–July 1 | ESPCI Paris
June 29, 2025 at 7:36 PM
📢 Scientific Program Now Live | #FPC2025
From purinergic checkpoints in cancer to ATP signaling in neurodegeneration, the 3rd Scientific Days of the French Purine Club bring cutting-edge talks across immunology, oncology & neuroscience.
📍June 30–July 1 | ESPCI Paris
From purinergic checkpoints in cancer to ATP signaling in neurodegeneration, the 3rd Scientific Days of the French Purine Club bring cutting-edge talks across immunology, oncology & neuroscience.
📍June 30–July 1 | ESPCI Paris
Reposted by The French Purine Club
Nous avons le plaisir de vous inviter aux 3ᵉ Journées Scientifiques du French Purine Club !
📅 30 juin à 14h au 1er juillet à 12h
📍 ESPCI, 10 rue Vauquelin, 75005 Paris
🔗 docs.google.com/forms/d/e/1F...
💡 Pensez aussi à votre cotisation annuelle
➡️ bit.ly/4hOcar6
Nous espérons vous y voir nombreux !
📅 30 juin à 14h au 1er juillet à 12h
📍 ESPCI, 10 rue Vauquelin, 75005 Paris
🔗 docs.google.com/forms/d/e/1F...
💡 Pensez aussi à votre cotisation annuelle
➡️ bit.ly/4hOcar6
Nous espérons vous y voir nombreux !
3e Journées Scientifiques du French Purine Club
ESPCI, 10 rue Vauquelin, 75005 Paris
docs.google.com
February 12, 2025 at 8:51 PM
Nous avons le plaisir de vous inviter aux 3ᵉ Journées Scientifiques du French Purine Club !
📅 30 juin à 14h au 1er juillet à 12h
📍 ESPCI, 10 rue Vauquelin, 75005 Paris
🔗 docs.google.com/forms/d/e/1F...
💡 Pensez aussi à votre cotisation annuelle
➡️ bit.ly/4hOcar6
Nous espérons vous y voir nombreux !
📅 30 juin à 14h au 1er juillet à 12h
📍 ESPCI, 10 rue Vauquelin, 75005 Paris
🔗 docs.google.com/forms/d/e/1F...
💡 Pensez aussi à votre cotisation annuelle
➡️ bit.ly/4hOcar6
Nous espérons vous y voir nombreux !
We stand in solidarity with the #StandUpForScience movement and with all researchers working in the United States, where academic freedom is currently being challenged.
March 7, 2025 at 2:29 AM
We stand in solidarity with the #StandUpForScience movement and with all researchers working in the United States, where academic freedom is currently being challenged.