Lasse Folkersen
@folkersen.com
CSO Nucleus Genomics
Genetics, polygenic risk scores. Previously at impute.me and Genome Center Denmark
Genetics, polygenic risk scores. Previously at impute.me and Genome Center Denmark
Very proud of this work: State of the art polygenic risk scores, and open-access even. Really hoping that this can push the field forward towards better disease prediction and prevention. The first author, Stephan, is only on X - but he did a great explainer thread there too. Check it out.
Within- and Between-Family Validation of Nine Polygenic Risk Scores Developed in 1.5 Million Individuals: Implications for IVF, Embryo Selection, and Reduction in Lifetime Disease Risk https://www.medrxiv.org/content/10.1101/2025.10.24.25338613v1
October 30, 2025 at 6:57 PM
Very proud of this work: State of the art polygenic risk scores, and open-access even. Really hoping that this can push the field forward towards better disease prediction and prevention. The first author, Stephan, is only on X - but he did a great explainer thread there too. Check it out.
Such a nice iniative.
Promoting equity in polygenic risk assessment through global collaboration www.nature.com/articles/s41... (read free: rdcu.be/dP1lC)
Promoting equity in polygenic risk assessment through global collaboration - Nature Genetics
The clinical use of current polygenic risk scores (PRSs) might widen global health disparities, as their portability to diverse groups is limited, emphasizing the need for global collaboration to…
www.nature.com
June 29, 2025 at 7:25 AM
Such a nice iniative.
Reposted by Lasse Folkersen
📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41...
Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms
tl;dr 👉 There's little/no evidence for this
Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms
tl;dr 👉 There's little/no evidence for this
May 12, 2025 at 3:49 PM
📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41...
Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms
tl;dr 👉 There's little/no evidence for this
Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms
tl;dr 👉 There's little/no evidence for this
Just doing our part for the health of the next generations:
www.youtube.com/watch?v=d4zf...
www.youtube.com/watch?v=d4zf...
Introducing: Family Planning Through Genetic Matching
YouTube video by Nucleus Genomics
www.youtube.com
March 15, 2025 at 9:17 AM
Just doing our part for the health of the next generations:
www.youtube.com/watch?v=d4zf...
www.youtube.com/watch?v=d4zf...
This aligns well with how I see the field evolving. Great to see more openness to different DNA data sources—under responsibility, of course! I see a future where both hospital and commercial DNA testing play a role in care. When high-quality data exists, it should be used!
Delighted to share our American Heart Association Scientific Statement on Direct-to-Consumer Genetic Testing for Cardiovascular Disease! www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social
March 13, 2025 at 3:23 PM
This aligns well with how I see the field evolving. Great to see more openness to different DNA data sources—under responsibility, of course! I see a future where both hospital and commercial DNA testing play a role in care. When high-quality data exists, it should be used!
Reposted by Lasse Folkersen
Given several new followers here, I'm posting the link to our Slack group "genetic genealogy science".
We post and discuss manuscripts on phasing/imputation, IBD, recombination, demographic inference, ancient DNA, ancestry/admixture, etc.
All are welcome.
join.slack.com/t/geneticgen...
We post and discuss manuscripts on phasing/imputation, IBD, recombination, demographic inference, ancient DNA, ancestry/admixture, etc.
All are welcome.
join.slack.com/t/geneticgen...
Slack
join.slack.com
November 10, 2024 at 12:21 PM
Given several new followers here, I'm posting the link to our Slack group "genetic genealogy science".
We post and discuss manuscripts on phasing/imputation, IBD, recombination, demographic inference, ancient DNA, ancestry/admixture, etc.
All are welcome.
join.slack.com/t/geneticgen...
We post and discuss manuscripts on phasing/imputation, IBD, recombination, demographic inference, ancient DNA, ancestry/admixture, etc.
All are welcome.
join.slack.com/t/geneticgen...
Since this was only announced on Twitter, I wanted to share it here as well:
Today we’re launching Nucleus Family—our biggest update yet. Family means a lot to me, and working on this has been one of the most meaningful projects I’ve been part of in a while.
Today we’re launching Nucleus Family—our biggest update yet. Family means a lot to me, and working on this has been one of the most meaningful projects I’ve been part of in a while.
February 13, 2025 at 10:44 PM
Since this was only announced on Twitter, I wanted to share it here as well:
Today we’re launching Nucleus Family—our biggest update yet. Family means a lot to me, and working on this has been one of the most meaningful projects I’ve been part of in a while.
Today we’re launching Nucleus Family—our biggest update yet. Family means a lot to me, and working on this has been one of the most meaningful projects I’ve been part of in a while.
Ok bsky you may not have heard me, but rare diseases fundraiser tm, ...at this rate X is gonna win in engagement, and like, what?!?! Neurofibromatosis not important?
my.cupids.org/fundraiser/6...
my.cupids.org/fundraiser/6...
2025 Cupid's Undie Run New York City
{{MetaTags.description}}
my.cupids.org
February 8, 2025 at 5:42 AM
Ok bsky you may not have heard me, but rare diseases fundraiser tm, ...at this rate X is gonna win in engagement, and like, what?!?! Neurofibromatosis not important?
my.cupids.org/fundraiser/6...
my.cupids.org/fundraiser/6...
I'm running in the "Cupid's Undies Run NYC" in two weeks to raise awareness and fundings for Neurofibromatosis research. Because rare-variant-genetics research matters! Fundraiser link: my.cupids.org/fundraiser/6...
2025 Cupid's Undie Run New York City
{{MetaTags.description}}
my.cupids.org
January 21, 2025 at 1:04 PM
I'm running in the "Cupid's Undies Run NYC" in two weeks to raise awareness and fundings for Neurofibromatosis research. Because rare-variant-genetics research matters! Fundraiser link: my.cupids.org/fundraiser/6...
This gem of a pop quiz from mynucleus.com shouldn't be stuck on twitter only!
January 9, 2025 at 12:27 PM
This gem of a pop quiz from mynucleus.com shouldn't be stuck on twitter only!
I really liked this commentary. It adresses the circularities in automated variant curation, but also seeks solutions. And I obviously also liked it, because it notes that we still should go beyond that simplistic "yes"/"no" bad pathogenic, good benign approach.
www.cell.com/ajhg/fulltex...
www.cell.com/ajhg/fulltex...
Toward trustable use of machine learning models of variant effects in the clinic
Machine-learning-powered predictions of the effect of genetic variants on human disease are becoming increasingly important in the clinic. In this manuscript, we lay down the core principles for their trustworthy validation and implementation and highlight four areas where current practices fall short, offering recommendations for advancing the field.
www.cell.com
December 22, 2024 at 1:21 AM
I really liked this commentary. It adresses the circularities in automated variant curation, but also seeks solutions. And I obviously also liked it, because it notes that we still should go beyond that simplistic "yes"/"no" bad pathogenic, good benign approach.
www.cell.com/ajhg/fulltex...
www.cell.com/ajhg/fulltex...
Reposted by Lasse Folkersen
Hi everyone! just wanted to re-post the psych genetic starter pack I created - now with new additions, including @pgcgenetics.bsky.social (welcome!) go.bsky.app/SkkmtMG 🥳 🧪
December 6, 2024 at 5:44 PM
Hi everyone! just wanted to re-post the psych genetic starter pack I created - now with new additions, including @pgcgenetics.bsky.social (welcome!) go.bsky.app/SkkmtMG 🥳 🧪
Help wanted: I need some notable persons from America to say I'm ok to let into their country now and then. For an O1 visa application. Please, reach out if you are (kinda) notable and currently live in the USA.
December 6, 2024 at 10:24 AM
Help wanted: I need some notable persons from America to say I'm ok to let into their country now and then. For an O1 visa application. Please, reach out if you are (kinda) notable and currently live in the USA.
Reposted by Lasse Folkersen
We are HIRING a postdoc! Are you into cardiovascular genomics? Does gene discovery and rare variants get you out of bed!? OMG, me too! Unfortunately i can't apply for this role, but YOU CAN! Come join our research lab at @garvaninstitute.bsky.social Sydney 🇦🇺 #genesky www.seek.com.au/Garvan-Insti...
a beach with a lot of people on it
ALT: a beach with a lot of people on it
media.tenor.com
December 6, 2024 at 12:22 AM
We are HIRING a postdoc! Are you into cardiovascular genomics? Does gene discovery and rare variants get you out of bed!? OMG, me too! Unfortunately i can't apply for this role, but YOU CAN! Come join our research lab at @garvaninstitute.bsky.social Sydney 🇦🇺 #genesky www.seek.com.au/Garvan-Insti...
Reposted by Lasse Folkersen
Fantastic to see this large-scale Australian trial of expanded carrier screening - identifying couples at risk of having babies with severe genetic disease, before they get pregnant - published. tl;dr we should already be doing this at population scale. www.nejm.org/doi/full/10....
Nationwide, Couple-Based Genetic Carrier Screening | NEJM
Genomic sequencing technology allows for identification of reproductive couples with
an increased chance, as compared with that in the general population, of having a
child with an autosomal recess...
www.nejm.org
November 21, 2024 at 10:17 PM
Fantastic to see this large-scale Australian trial of expanded carrier screening - identifying couples at risk of having babies with severe genetic disease, before they get pregnant - published. tl;dr we should already be doing this at population scale. www.nejm.org/doi/full/10....
Reposted by Lasse Folkersen
The Catalog isn't just a knowledgebase and source of polygenic scores, we also provide open-soruce tools to make PGS calculation easier and more reproducible! You can find our pgsc_calc tool on github (github.com/PGScatalog/p...) with extensive documentation (pgsc-calc.readthedocs.io/en/latest/).
November 26, 2024 at 12:30 PM
The Catalog isn't just a knowledgebase and source of polygenic scores, we also provide open-soruce tools to make PGS calculation easier and more reproducible! You can find our pgsc_calc tool on github (github.com/PGScatalog/p...) with extensive documentation (pgsc-calc.readthedocs.io/en/latest/).
Reposted by Lasse Folkersen
Among British Pakistani & British Bangladeshi individuals, partitioned T2D polygenic load for insulin deficiency & lipodystrophy was higher than white European individuals & predisposed to faster progression to T2D & complications www.nature.com/articles/s41... @natureportfolio.bsky.social
November 26, 2024 at 2:04 PM
Among British Pakistani & British Bangladeshi individuals, partitioned T2D polygenic load for insulin deficiency & lipodystrophy was higher than white European individuals & predisposed to faster progression to T2D & complications www.nature.com/articles/s41... @natureportfolio.bsky.social
Reposted by Lasse Folkersen
For anyone that hasn't seen it yet, Seqera recently released Seqera AI 🤖 to help convert your non-Nextflow pipelines to Nextflow, write new Nextflow workflows and write tests.
You can try it out right now at seqera.io/ask-ai/ 🚀!
My secret favorite use is to ask it to roast my pipelines 🔥😆
You can try it out right now at seqera.io/ask-ai/ 🚀!
My secret favorite use is to ask it to roast my pipelines 🔥😆
November 27, 2024 at 12:27 AM
For anyone that hasn't seen it yet, Seqera recently released Seqera AI 🤖 to help convert your non-Nextflow pipelines to Nextflow, write new Nextflow workflows and write tests.
You can try it out right now at seqera.io/ask-ai/ 🚀!
My secret favorite use is to ask it to roast my pipelines 🔥😆
You can try it out right now at seqera.io/ask-ai/ 🚀!
My secret favorite use is to ask it to roast my pipelines 🔥😆
Reposted by Lasse Folkersen
@rabaath.bsky.social explains why even after 5 years #python pandas feels clunky when coming from #Rstats: www.sumsar.net/blog/pandas-... My take is not on whether one is better than the other for the experienced, but on which one is more accessible for the inexperienced.
Why pandas feels clunky when coming from R
Five years ago I started a new role and I suddenly found myself, a
staunch R fan, having to code in Python on a daily basis. Working with
data, most of my Python work involved using
pandas, the …
www.sumsar.net
November 19, 2024 at 10:25 AM
@rabaath.bsky.social explains why even after 5 years #python pandas feels clunky when coming from #Rstats: www.sumsar.net/blog/pandas-... My take is not on whether one is better than the other for the experienced, but on which one is more accessible for the inexperienced.
Reposted by Lasse Folkersen
tidyplots
Time to say goodbye to ggplot2?😜
"a significant reduction of code complexity" vs ggplot2
cran.r-project.org/web/packages...
Jan Broder Engler bioRxiv 2024
www.biorxiv.org/content/10.1...
Time to say goodbye to ggplot2?😜
"a significant reduction of code complexity" vs ggplot2
cran.r-project.org/web/packages...
Jan Broder Engler bioRxiv 2024
www.biorxiv.org/content/10.1...
November 17, 2024 at 8:02 PM
tidyplots
Time to say goodbye to ggplot2?😜
"a significant reduction of code complexity" vs ggplot2
cran.r-project.org/web/packages...
Jan Broder Engler bioRxiv 2024
www.biorxiv.org/content/10.1...
Time to say goodbye to ggplot2?😜
"a significant reduction of code complexity" vs ggplot2
cran.r-project.org/web/packages...
Jan Broder Engler bioRxiv 2024
www.biorxiv.org/content/10.1...
Hello fellow blue sky scientist. We have a job opening for a statistical geneticists at www.mynucleus.com - feel free to DM me for details.
Nucleus
The all-in-one DNA health test.
www.mynucleus.com
November 9, 2024 at 9:50 PM
Hello fellow blue sky scientist. We have a job opening for a statistical geneticists at www.mynucleus.com - feel free to DM me for details.
What's up with the wave of bsky people now...?
October 20, 2024 at 10:49 AM
What's up with the wave of bsky people now...?
We’re thrilled at @nucleusgenomics.bsky.social to announce that we are working alongside Illumina to bring our mission of getting clinical-grade whole-genome insights to life:
illumina.com/company/news...
illumina.com/company/news...
https://illumina.com/company/news-center/feature-articles/nucleus-genomics-whole-genome-sequencing.html?utm_source=illumina&utm_id=lf-twitter…
December 13, 2023 at 3:48 PM
We’re thrilled at @nucleusgenomics.bsky.social to announce that we are working alongside Illumina to bring our mission of getting clinical-grade whole-genome insights to life:
illumina.com/company/news...
illumina.com/company/news...
#thermofisher sponsored conference on polygenic risk scores and precision medicine at SSI-Copenhagen.
December 7, 2023 at 6:40 PM
#thermofisher sponsored conference on polygenic risk scores and precision medicine at SSI-Copenhagen.