Fletcher Lab
@fletcherlabucb.bsky.social
Bioengineering, Biophysics, Computational Biology and Molecular and Cell Biology. Account run by students/post-docs.
Lab website: https://fletchlab.berkeley.edu/
Lab website: https://fletchlab.berkeley.edu/
Pinned
Fletcher Lab
@fletcherlabucb.bsky.social
· Nov 21
Lab: Why aren't we on Bluesky?
Dan: Umm. I don't follow Bluesky.
Lab: But the rest of the world does. Scientists too.
Dan: I see. What's your point?
Lab: We should be on Bluesky. And join scientific discussions.
Dan: I'm more the silent type.
Lab: We'll run it.
Dan: Go for it!
Dan: Umm. I don't follow Bluesky.
Lab: But the rest of the world does. Scientists too.
Dan: I see. What's your point?
Lab: We should be on Bluesky. And join scientific discussions.
Dan: I'm more the silent type.
Lab: We'll run it.
Dan: Go for it!
October 21, 2025 at 6:14 AM
Reposted by Fletcher Lab
Our team is developing portable digital microscopes that harness AI to automatically detect parasitic infections.
This shows great potential to help public health programs expand access to affordable disease screening in low-resource settings.
Link: tinyurl.com/4bazch67
This shows great potential to help public health programs expand access to affordable disease screening in low-resource settings.
Link: tinyurl.com/4bazch67
October 14, 2025 at 11:51 AM
Our team is developing portable digital microscopes that harness AI to automatically detect parasitic infections.
This shows great potential to help public health programs expand access to affordable disease screening in low-resource settings.
Link: tinyurl.com/4bazch67
This shows great potential to help public health programs expand access to affordable disease screening in low-resource settings.
Link: tinyurl.com/4bazch67
Check out Siddhansh (@sid592.bsky.social) presentation at the 4th Physics of Life Symposium hosted by the #CZBiohubSF. youtu.be/b7G5wyE6iyo?...
2025 Physics of Life Symposium: Siddhansh Agarwal
YouTube video by Chan Zuckerberg Biohub Network
youtu.be
September 22, 2025 at 3:56 PM
Check out Siddhansh (@sid592.bsky.social) presentation at the 4th Physics of Life Symposium hosted by the #CZBiohubSF. youtu.be/b7G5wyE6iyo?...
Happy Postdoc Appreciation Week to all of our postdocs! #PostdocAppreciationWeek
September 17, 2025 at 9:52 PM
Happy Postdoc Appreciation Week to all of our postdocs! #PostdocAppreciationWeek
Congratulations Kira for passing your qualifying exam!
August 27, 2025 at 10:39 PM
Congratulations Kira for passing your qualifying exam!
Take a look at our newest published article in PLOS NTD: doi.org/10.1371/jour... #schistosomiasis #ML #diagnostics
Multi-contrast machine learning improves schistosomiasis diagnostic performance
Author summary Schistosomiasis is a neglected tropical disease that impacts hundreds of millions of people worldwide. Patients with Schistosoma haematobium shed parasite eggs in their urine, which can...
doi.org
August 13, 2025 at 11:21 PM
Take a look at our newest published article in PLOS NTD: doi.org/10.1371/jour... #schistosomiasis #ML #diagnostics
Check out our most recent published paper in @natcomms.nature.com about the effects of cell surface crowding in cell-cell fusion: rdcu.be/ezCOF
Cell surface crowding is a tunable energetic barrier to cell-cell fusion
Nature Communications - Cell-cell fusion is fundamental to physiological processes such as muscle formation and viral infection. Here, the authors show that the proteins embedded on the plasma...
rdcu.be
August 7, 2025 at 12:58 AM
Check out our most recent published paper in @natcomms.nature.com about the effects of cell surface crowding in cell-cell fusion: rdcu.be/ezCOF
Check out this talk by one of our amazing postdocs, Deepak! youtu.be/ErE3f5iyPio
2025 Interdisciplinary Science Summit Showcase Talk: Deepak Krishnamurthy
YouTube video by Schmidt Science Fellows
youtu.be
August 5, 2025 at 4:48 PM
Check out this talk by one of our amazing postdocs, Deepak! youtu.be/ErE3f5iyPio
Had fun at the MBL Physiology Course in Woods Hole!
Chunzi, Elizabeth & Kira led creative rotations:
• Trogocytosis is a mi(gh)t-y way to transfer
• Sync(ytium) or Swim: Which fusogen will reign supreme?
• Mucin Impossible: Eat up or get lost
Chunzi, Elizabeth & Kira led creative rotations:
• Trogocytosis is a mi(gh)t-y way to transfer
• Sync(ytium) or Swim: Which fusogen will reign supreme?
• Mucin Impossible: Eat up or get lost
July 25, 2025 at 9:42 PM
Had fun at the MBL Physiology Course in Woods Hole!
Chunzi, Elizabeth & Kira led creative rotations:
• Trogocytosis is a mi(gh)t-y way to transfer
• Sync(ytium) or Swim: Which fusogen will reign supreme?
• Mucin Impossible: Eat up or get lost
Chunzi, Elizabeth & Kira led creative rotations:
• Trogocytosis is a mi(gh)t-y way to transfer
• Sync(ytium) or Swim: Which fusogen will reign supreme?
• Mucin Impossible: Eat up or get lost
Welcome to our new BioE Ph.D. students, Smiti and Michael Anne! @smitim.bsky.social
June 27, 2025 at 9:20 PM
Welcome to our new BioE Ph.D. students, Smiti and Michael Anne! @smitim.bsky.social
Congratulations Caitlin!!
Congratulations to the eight recipients of the 2025 Dr. Eddie Méndez Scholar Award! This award recognizes outstanding early-career scientists from underrepresented backgrounds who are studying cancer, infectious diseases and basic sciences. Learn more: bit.ly/4jWvT8O
June 19, 2025 at 12:41 PM
Congratulations Caitlin!!
Come to the Annual Fletcher Lab Artshow on Friday May 9th, 2025! We host this event yearly as an opportunity for folks to display their artwork, come together with wine and cheese, and admire artwork!
April 21, 2025 at 8:15 PM
Come to the Annual Fletcher Lab Artshow on Friday May 9th, 2025! We host this event yearly as an opportunity for folks to display their artwork, come together with wine and cheese, and admire artwork!
Come explore and be amazed on April 12 and 13 at the @exploratorium.bsky.social. This event is based upon work supported by the Center for Cellular Construction. #microscopy #Magnified
April 9, 2025 at 8:59 PM
Come explore and be amazed on April 12 and 13 at the @exploratorium.bsky.social. This event is based upon work supported by the Center for Cellular Construction. #microscopy #Magnified
Congratulations to both Jared and Andres for passing their qualifying exams
April 1, 2025 at 10:50 PM
Congratulations to both Jared and Andres for passing their qualifying exams
The NTDscope is a portable brightfield, darkfield, and fluorescence microscope used for the diagnosis of neglected tropical diseases (NTDs). Check out our latest preprint: www.medrxiv.org/content/10.1...
March 28, 2025 at 5:37 PM
The NTDscope is a portable brightfield, darkfield, and fluorescence microscope used for the diagnosis of neglected tropical diseases (NTDs). Check out our latest preprint: www.medrxiv.org/content/10.1...
Reposted by Fletcher Lab
🌟Say hello to Dan Fletcher @fletcherlabucb.bsky.social, a bioengineer renowned for developing novel experimental approaches and microscopy tools with far-reaching impacts on our understanding of infectious diseases, immunology, and cancer biology. 1/
March 27, 2025 at 6:01 PM
🌟Say hello to Dan Fletcher @fletcherlabucb.bsky.social, a bioengineer renowned for developing novel experimental approaches and microscopy tools with far-reaching impacts on our understanding of infectious diseases, immunology, and cancer biology. 1/
Reposted by Fletcher Lab
preLights in cell biology (Feb 2025)
This article lists the recent @prelights.bsky.social posts that discuss #preprints in #cellbio. Featured #preLight by @fadelvalle.bsky.social covering work on macrophage trogocytosis from @fletcherlabucb.bsky.social.
journals.biologists.com/jcs/article/...
This article lists the recent @prelights.bsky.social posts that discuss #preprints in #cellbio. Featured #preLight by @fadelvalle.bsky.social covering work on macrophage trogocytosis from @fletcherlabucb.bsky.social.
journals.biologists.com/jcs/article/...
preLights in cell biology (February 2025)
This article includes recent preLights posts that discuss preprints in the field of cell biology.Target cell tension regulates macrophage trogocytosis by Caitlin E. Cornell et al.Read the preLight.Vis...
journals.biologists.com
March 10, 2025 at 9:43 AM
preLights in cell biology (Feb 2025)
This article lists the recent @prelights.bsky.social posts that discuss #preprints in #cellbio. Featured #preLight by @fadelvalle.bsky.social covering work on macrophage trogocytosis from @fletcherlabucb.bsky.social.
journals.biologists.com/jcs/article/...
This article lists the recent @prelights.bsky.social posts that discuss #preprints in #cellbio. Featured #preLight by @fadelvalle.bsky.social covering work on macrophage trogocytosis from @fletcherlabucb.bsky.social.
journals.biologists.com/jcs/article/...
Some lab members and friends attended the #StandupforScience protest.
March 8, 2025 at 12:31 AM
Some lab members and friends attended the #StandupforScience protest.
Reposted by Fletcher Lab
“We have a role to play in making the world a better place.”
Thank you to #RhodesScholar Professor Dan Fletcher for hosting our partners Schmidt Science Fellows at UC, Berkeley for another year as part of the Science Leadership Program.
@fletcherlabucb.bsky.social 📷 @claudinegossett.bsky.social
Thank you to #RhodesScholar Professor Dan Fletcher for hosting our partners Schmidt Science Fellows at UC, Berkeley for another year as part of the Science Leadership Program.
@fletcherlabucb.bsky.social 📷 @claudinegossett.bsky.social
February 19, 2025 at 11:43 AM
“We have a role to play in making the world a better place.”
Thank you to #RhodesScholar Professor Dan Fletcher for hosting our partners Schmidt Science Fellows at UC, Berkeley for another year as part of the Science Leadership Program.
@fletcherlabucb.bsky.social 📷 @claudinegossett.bsky.social
Thank you to #RhodesScholar Professor Dan Fletcher for hosting our partners Schmidt Science Fellows at UC, Berkeley for another year as part of the Science Leadership Program.
@fletcherlabucb.bsky.social 📷 @claudinegossett.bsky.social
Reposted by Fletcher Lab
Fun story from the Fletcher lab showing that surface crowding is a major impediment to cell-cell fusion and myoblasts reduce their surface crowding to improve fusion!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 17, 2024 at 2:22 AM
Fun story from the Fletcher lab showing that surface crowding is a major impediment to cell-cell fusion and myoblasts reduce their surface crowding to improve fusion!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Fletcher Lab
This supports the idea that target cell's biophysical properties regulate the decision to trogocytose instead of phagocytose, as Caitlin Cornell @fletcherlabucb.bsky.social proposed in their recent preprint: doi.org/10.1101/2024.12.02.626490
Target cell tension regulates macrophage trogocytosis
Macrophages are known to engulf small membrane fragments, or trogocytose, target cells and pathogens, rather than fully phagocytose them. However, little is known about what causes macrophages to choo...
doi.org
February 10, 2025 at 5:58 PM
This supports the idea that target cell's biophysical properties regulate the decision to trogocytose instead of phagocytose, as Caitlin Cornell @fletcherlabucb.bsky.social proposed in their recent preprint: doi.org/10.1101/2024.12.02.626490
Check out our latest preprint where we show how you can improve automated detection of schistosomiasis by using images of multiple contrasts (brightfield and darkfield) acquired on a mobile microscope! www.medrxiv.org/content/10.1...
February 3, 2025 at 8:59 PM
Check out our latest preprint where we show how you can improve automated detection of schistosomiasis by using images of multiple contrasts (brightfield and darkfield) acquired on a mobile microscope! www.medrxiv.org/content/10.1...
Happy Lunar New Year! We hope the Lunar New Year brings you much health and happiness. #HappyLunarNewYear2025
January 29, 2025 at 10:33 PM
Happy Lunar New Year! We hope the Lunar New Year brings you much health and happiness. #HappyLunarNewYear2025
Check out our most recent paper about a previously under-appreciated crowding barrier to cell-cell fusion. www.biorxiv.org/content/10.1...
Cell surface crowding is a tunable biophysical barrier to cell-cell fusion
Cell-cell fusion is fundamental to developmental processes such as muscle formation, as well as to viral infections that cause pathological syncytia. An essential step in fusion is close membrane appo...
www.biorxiv.org
January 8, 2025 at 9:00 PM
Check out our most recent paper about a previously under-appreciated crowding barrier to cell-cell fusion. www.biorxiv.org/content/10.1...
Felipe (@fadelvalle.bsky.social) did a fantastic job summarizing the main points and asking intriguing questions for our future next steps. Check it out!
Feeling tense? Macrophages sense that!
Macrophages prefer to "nibble" (trogocytose) soft targets and "engulf" (phagocytose) stiff ones. Stiffness matters for immune responses! #preprint #FletcherLab
Check out the #preLight written by @fadelvalle.bsky.social
prelights.biologists.com/highlights/t...
Macrophages prefer to "nibble" (trogocytose) soft targets and "engulf" (phagocytose) stiff ones. Stiffness matters for immune responses! #preprint #FletcherLab
Check out the #preLight written by @fadelvalle.bsky.social
prelights.biologists.com/highlights/t...
Target cell tension regulates macrophage trogocytosis - preLights
Feeling tense? Macrophages sense that! Macrophages prefer to "nibble" (trogocytose) soft targets and "engulf" (phagocytose) stiff ones. Stiffness matters for immune responses!
prelights.biologists.com
January 6, 2025 at 7:00 PM
Felipe (@fadelvalle.bsky.social) did a fantastic job summarizing the main points and asking intriguing questions for our future next steps. Check it out!