Feline Lindhout
@felinewlindhout.bsky.social
Neurobiologist studying the molecular and cellular basis of human brain development. Postdoc @ Lancaster group, MRC-LMB in Cambridge.
Pinned
Calcium dynamics tune developmental tempo to generate evolutionarily divergent axon tract lengths
The considerably slow pace of human brain development correlates with an evolutionary increase in brain size, cell numbers, and expansion of neuronal structures, with axon tracts undergoing an even gr...
doi.org
Why is human brain development, and particularly neuron morphogenesis, so slow and how is this linked to evolution? doi.org/10.1101/2024.12.28.630576
We developed mouse brain organoid methods capturing differences to human and used these to address this. doi.org/10.1101/2024.12.21.629881
🧵 (1/n)
We developed mouse brain organoid methods capturing differences to human and used these to address this. doi.org/10.1101/2024.12.21.629881
🧵 (1/n)
Reposted by Feline Lindhout
Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons.
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
December 26, 2024 at 5:31 PM
Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons.
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Reposted by Feline Lindhout
EMBOMtg Paris May 6-9
@aydoganlab.bsky.social @jamesbriscoe.bsky.social @brunetlab.bsky.social @ebisuyamiki.bsky.social @mwdorr.bsky.social @beyerlab.bsky.social @franckp.bsky.social @janereznick.bsky.social @olmedo-lab.bsky.social @perez-carrasco.bsky.social
meetings.embo.org/event/25-dev...
@aydoganlab.bsky.social @jamesbriscoe.bsky.social @brunetlab.bsky.social @ebisuyamiki.bsky.social @mwdorr.bsky.social @beyerlab.bsky.social @franckp.bsky.social @janereznick.bsky.social @olmedo-lab.bsky.social @perez-carrasco.bsky.social
meetings.embo.org/event/25-dev...
Developmental timing across species: From mechanisms to evolutionary insights
Like choreography, development consists of a highly ordered suite of steps and transitions. Modifying developmental tempo can affect final size and composition of tissues, as well as their plasticity…
meetings.embo.org
March 29, 2025 at 3:00 PM
Reposted by Feline Lindhout
In case you missed it, check out our recent preprint on developmental timing and how slower means bigger, axons that is!
Led by the extraordinary @felinewlindhout.bsky.social
www.biorxiv.org/content/10.1...
Led by the extraordinary @felinewlindhout.bsky.social
www.biorxiv.org/content/10.1...
Calcium dynamics tune developmental tempo to generate evolutionarily divergent axon tract lengths
The considerably slow pace of human brain development correlates with an evolutionary increase in brain size, cell numbers, and expansion of neuronal structures, with axon tracts undergoing an even gr...
www.biorxiv.org
March 3, 2025 at 8:06 PM
In case you missed it, check out our recent preprint on developmental timing and how slower means bigger, axons that is!
Led by the extraordinary @felinewlindhout.bsky.social
www.biorxiv.org/content/10.1...
Led by the extraordinary @felinewlindhout.bsky.social
www.biorxiv.org/content/10.1...
A superb review with the latest insights on the Axon Initial Segment from @ameliefreal.bsky.social & Casper Hoogenraad, was a joy reading this 😀
Everything you always wanted to know about the Axon Initial Segment might be here: authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
February 14, 2025 at 6:57 PM
A superb review with the latest insights on the Axon Initial Segment from @ameliefreal.bsky.social & Casper Hoogenraad, was a joy reading this 😀
Reposted by Feline Lindhout
A valuable post to educate our peers on this #InternationalDayofWomenandGirlsinScience
Thanks @frantecol.bsky.social for putting this together.
Especially relevant for these dark days for USA science🧪
Thanks @frantecol.bsky.social for putting this together.
Especially relevant for these dark days for USA science🧪
On #InternationalDayofWomenandGirlsinScience let me remind you that we are NOWHERE NEAR parity. A few examples.
1. Women are credited less in science than men.
www.nature.com/articles/s41...
1. Women are credited less in science than men.
www.nature.com/articles/s41...
Women are credited less in science than men - Nature
The difference between the number of men and women listed as authors on scientific papers and inventors on patents is at least partly attributable to unacknowledged contributions by women scientists.
www.nature.com
February 11, 2025 at 6:39 PM
A valuable post to educate our peers on this #InternationalDayofWomenandGirlsinScience
Thanks @frantecol.bsky.social for putting this together.
Especially relevant for these dark days for USA science🧪
Thanks @frantecol.bsky.social for putting this together.
Especially relevant for these dark days for USA science🧪
Reposted by Feline Lindhout
New preprint 📣! Excited to share the result of several years of work, led by @ellylewerissa.bsky.social & @olivieroleonardi.bsky.social, in collaboration with friends @naelnadifkasri-lab.bsky.social & Giuseppe Testa. On CHD2, a chromatin remodeller, its role in evolution & development [🧵]
🧪🧠🧫🧬
🧪🧠🧫🧬
January 22, 2025 at 10:38 AM
New preprint 📣! Excited to share the result of several years of work, led by @ellylewerissa.bsky.social & @olivieroleonardi.bsky.social, in collaboration with friends @naelnadifkasri-lab.bsky.social & Giuseppe Testa. On CHD2, a chromatin remodeller, its role in evolution & development [🧵]
🧪🧠🧫🧬
🧪🧠🧫🧬
Reposted by Feline Lindhout
Okenve-Ramos, P., Gosling, R., Chojnowska-Monga, M., Gupta, K., Shields, S., Alhadyian, H., Collie, C., Gregory, E., Sanchez-Soriano, N. (2024). Neuronal ageing is promoted by the decay of the microtubule cytoskeleton. PLoS Biol, 22(3):e3002504 journals.plos.org/plosbiology/...
Neuronal ageing is promoted by the decay of the microtubule cytoskeleton
Aging is associated with structural and functional changes in neurons thought to drive motor, sensory, and cognitive impairments. Using a Drosophila model of aging, the authors report that deteriorati...
journals.plos.org
January 4, 2025 at 1:10 AM
Okenve-Ramos, P., Gosling, R., Chojnowska-Monga, M., Gupta, K., Shields, S., Alhadyian, H., Collie, C., Gregory, E., Sanchez-Soriano, N. (2024). Neuronal ageing is promoted by the decay of the microtubule cytoskeleton. PLoS Biol, 22(3):e3002504 journals.plos.org/plosbiology/...
Reposted by Feline Lindhout
We just published a thing!
In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function.
www.nature.com/articles/s41...
In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function.
www.nature.com/articles/s41...
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus - Nature Neuroscience
Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...
www.nature.com
January 7, 2025 at 10:22 AM
We just published a thing!
In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function.
www.nature.com/articles/s41...
In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function.
www.nature.com/articles/s41...
Why is human brain development, and particularly neuron morphogenesis, so slow and how is this linked to evolution? doi.org/10.1101/2024.12.28.630576
We developed mouse brain organoid methods capturing differences to human and used these to address this. doi.org/10.1101/2024.12.21.629881
🧵 (1/n)
We developed mouse brain organoid methods capturing differences to human and used these to address this. doi.org/10.1101/2024.12.21.629881
🧵 (1/n)
Calcium dynamics tune developmental tempo to generate evolutionarily divergent axon tract lengths
The considerably slow pace of human brain development correlates with an evolutionary increase in brain size, cell numbers, and expansion of neuronal structures, with axon tracts undergoing an even gr...
doi.org
December 30, 2024 at 7:45 PM
Why is human brain development, and particularly neuron morphogenesis, so slow and how is this linked to evolution? doi.org/10.1101/2024.12.28.630576
We developed mouse brain organoid methods capturing differences to human and used these to address this. doi.org/10.1101/2024.12.21.629881
🧵 (1/n)
We developed mouse brain organoid methods capturing differences to human and used these to address this. doi.org/10.1101/2024.12.21.629881
🧵 (1/n)
Excited to reconnect with old science friends and meet new ones here on Bluesky! I study human neuron development using brain organoids, other in vitro models, and lots of microscopy 🧠🔬
November 24, 2024 at 2:29 PM
Excited to reconnect with old science friends and meet new ones here on Bluesky! I study human neuron development using brain organoids, other in vitro models, and lots of microscopy 🧠🔬