Charikleia Karageorgiou (Clio)
@evobioclio.bsky.social
Postdoc at @UBuffalo | Gokcumen Lab
Evolution, structural variants and population genetics.
PhD from @uab.cat | Inversion polymorphism.
https://biolevol.github.io/
Evolution, structural variants and population genetics.
PhD from @uab.cat | Inversion polymorphism.
https://biolevol.github.io/
Pinned
Reconstruction of the human amylase locus reveals ancient duplications seeding modern-day variation
Previous studies suggested that the copy number of the human salivary amylase gene, AMY1, correlates with starch-rich diets. However, evolutionary analyses are hampered by the absence of accurate, seq...
www.science.org
The typeset version of our article, "Reconstruction of the human amylase locus reveals ancient duplications seeding modern-day variation", is now online. This thread will provide an overview of how gene duplications have shaped modern variation in the amylase locus.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Charikleia Karageorgiou (Clio)
Another announcement! 📣 Our work on hybrid incompatibility in cohesin protection in 🐭oocytes is published!! Congrats Warif El Yakoubi and Eddie Pan!!🎉 We found hybrids with cohesion errors in two distinct genus.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Hybrid female sterility due to cohesin protection errors in mouse oocytes
Misregulation of chromosome cohesion during female meiosis serves as a reproductive isolating barrier in mice.
www.science.org
February 7, 2026 at 12:51 AM
Another announcement! 📣 Our work on hybrid incompatibility in cohesin protection in 🐭oocytes is published!! Congrats Warif El Yakoubi and Eddie Pan!!🎉 We found hybrids with cohesion errors in two distinct genus.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Charikleia Karageorgiou (Clio)
New research in #GENETICS identifies chromosome number and mean chromosome size as practical proxies for genome-wide recombination rate by analyzing genetic map data from 73 insect species and 157 monocentric flowering plants. buff.ly/L4O68V5
February 3, 2026 at 7:03 PM
New research in #GENETICS identifies chromosome number and mean chromosome size as practical proxies for genome-wide recombination rate by analyzing genetic map data from 73 insect species and 157 monocentric flowering plants. buff.ly/L4O68V5
Reposted by Charikleia Karageorgiou (Clio)
Time for a thread on our Christmas preprint “Origin and evolution of acrocentric chromosomes in human and great apes”. I had so much fun with this project and paper. It will be hard to summarize in a thread, but I’ll try www.biorxiv.org/content/10.6... [1/21]
February 2, 2026 at 2:58 PM
Time for a thread on our Christmas preprint “Origin and evolution of acrocentric chromosomes in human and great apes”. I had so much fun with this project and paper. It will be hard to summarize in a thread, but I’ll try www.biorxiv.org/content/10.6... [1/21]
Reposted by Charikleia Karageorgiou (Clio)
New tool from @alexsweeten.bsky.social to find and classify all your satellites: "AniAnn's: alignment-free annotation of tandem repeat arrays using fast average nucleotide identity estimates"
📄 www.biorxiv.org/content/10.6...
📦 github.com/marbl/anianns
📄 www.biorxiv.org/content/10.6...
📦 github.com/marbl/anianns
January 29, 2026 at 1:05 PM
New tool from @alexsweeten.bsky.social to find and classify all your satellites: "AniAnn's: alignment-free annotation of tandem repeat arrays using fast average nucleotide identity estimates"
📄 www.biorxiv.org/content/10.6...
📦 github.com/marbl/anianns
📄 www.biorxiv.org/content/10.6...
📦 github.com/marbl/anianns
Reposted by Charikleia Karageorgiou (Clio)
The performance of genetic-constraint metrics varies significantly across the human noncoding genome https://www.biorxiv.org/content/10.64898/2026.01.28.701168v1
January 29, 2026 at 7:32 AM
The performance of genetic-constraint metrics varies significantly across the human noncoding genome https://www.biorxiv.org/content/10.64898/2026.01.28.701168v1
Reposted by Charikleia Karageorgiou (Clio)
New review out in Nat Rev Genet: Emergence & evolution of protein-coding de novo genes by Erich and Lars Eicholt @lacholt.bsky.social. How non-coding DNA becomes translated, persists or is lost in populations, and can yield structured/functional proteins—plus methods & open questions! rdcu.be/e09SM
Emergence and evolution of protein-coding de novo genes
Nature Reviews Genetics - De novo gene evolution entails the birth of new genes from previously non-coding DNA. In this Review, Bornberg-Bauer and Eicholt overview how protein-coding de novo genes...
rdcu.be
January 28, 2026 at 6:19 PM
New review out in Nat Rev Genet: Emergence & evolution of protein-coding de novo genes by Erich and Lars Eicholt @lacholt.bsky.social. How non-coding DNA becomes translated, persists or is lost in populations, and can yield structured/functional proteins—plus methods & open questions! rdcu.be/e09SM
Reposted by Charikleia Karageorgiou (Clio)
Excited to announce our latest publication in reporting evidence for three (3!) new whole genome duplications (WGDs) in yeasts. Scientists have often wondered why WGD is so rare in fungi, it turns out we may just not have been looking hard enough! 🧪 🍄 🧬
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Discovery of additional ancient genome duplications in yeasts
Whole-genome duplication (WGD) has had profound macroevolutionary impacts on diverse lineages,1,2 preceding adaptive radiations in vertebrates,3,4,5 t…
www.sciencedirect.com
January 28, 2026 at 5:49 PM
Excited to announce our latest publication in reporting evidence for three (3!) new whole genome duplications (WGDs) in yeasts. Scientists have often wondered why WGD is so rare in fungi, it turns out we may just not have been looking hard enough! 🧪 🍄 🧬
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Charikleia Karageorgiou (Clio)
We hope this little guide and review of the recent literature on SVs will be useful for the community in #ecology #evolution #genomics #PopGen.
Great lead by Kat!!
Great lead by Kat!!
New review!
Theory & a practical guide to structural variants in popgen🧬
Many thanks to my co-authors: @rebekahoomen.bsky.social
@annatigano.bsky.social @marenwellenreuther.bsky.social @janawold.bsky.social @dlfield.bsky.social @clairemerot.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
Theory & a practical guide to structural variants in popgen🧬
Many thanks to my co-authors: @rebekahoomen.bsky.social
@annatigano.bsky.social @marenwellenreuther.bsky.social @janawold.bsky.social @dlfield.bsky.social @clairemerot.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
A Beginner's Guide to Structural Variants in Eco‐Evolutionary Population Genomics
Whole-genome sequencing (WGS) has greatly expanded researchers' ability to study structural variants (SVs), that is, the variation in the presence, number, orientation or position of a DNA sequence. ....
onlinelibrary.wiley.com
January 28, 2026 at 7:04 AM
We hope this little guide and review of the recent literature on SVs will be useful for the community in #ecology #evolution #genomics #PopGen.
Great lead by Kat!!
Great lead by Kat!!
Reposted by Charikleia Karageorgiou (Clio)
A new extreme of meiotic evolution:
✔️ 𝗻𝗼 crossovers
✔️ 𝗻𝗼 gene conversion
✔️ 𝗻𝗼𝗿𝗺𝗮𝗹 meiosis & fertility
Sex mimics clonality without becoming asexual, in the holocentric multicellular eukaryote 𝘙𝘩𝘺𝘯𝘤𝘩𝘰𝘴𝘱𝘰𝘳𝘢 𝘵𝘦𝘯𝘶𝘪𝘴.
more about it:
www.biorxiv.org/content/10.6...
✔️ 𝗻𝗼 crossovers
✔️ 𝗻𝗼 gene conversion
✔️ 𝗻𝗼𝗿𝗺𝗮𝗹 meiosis & fertility
Sex mimics clonality without becoming asexual, in the holocentric multicellular eukaryote 𝘙𝘩𝘺𝘯𝘤𝘩𝘰𝘴𝘱𝘰𝘳𝘢 𝘵𝘦𝘯𝘶𝘪𝘴.
more about it:
www.biorxiv.org/content/10.6...
January 27, 2026 at 10:57 AM
A new extreme of meiotic evolution:
✔️ 𝗻𝗼 crossovers
✔️ 𝗻𝗼 gene conversion
✔️ 𝗻𝗼𝗿𝗺𝗮𝗹 meiosis & fertility
Sex mimics clonality without becoming asexual, in the holocentric multicellular eukaryote 𝘙𝘩𝘺𝘯𝘤𝘩𝘰𝘴𝘱𝘰𝘳𝘢 𝘵𝘦𝘯𝘶𝘪𝘴.
more about it:
www.biorxiv.org/content/10.6...
✔️ 𝗻𝗼 crossovers
✔️ 𝗻𝗼 gene conversion
✔️ 𝗻𝗼𝗿𝗺𝗮𝗹 meiosis & fertility
Sex mimics clonality without becoming asexual, in the holocentric multicellular eukaryote 𝘙𝘩𝘺𝘯𝘤𝘩𝘰𝘴𝘱𝘰𝘳𝘢 𝘵𝘦𝘯𝘶𝘪𝘴.
more about it:
www.biorxiv.org/content/10.6...
Reposted by Charikleia Karageorgiou (Clio)
Meiotic drive has long been considered as a genetic curiosity. Genomic "footprints" suggest otherwise.
Check out our new review doi.org/10.1093/molb..., a cross-taxa synthesis arguing that recurrent drive is a pervasive and underappreciated force in genome evolution.
Check out our new review doi.org/10.1093/molb..., a cross-taxa synthesis arguing that recurrent drive is a pervasive and underappreciated force in genome evolution.
The Evolutionary Genomics of Meiotic Drive
Abstract. Meiotic drivers are selfish genetic elements that gain transmission advantages by distorting equal, Mendelian segregation. For decades, biologist
doi.org
January 27, 2026 at 2:14 PM
Meiotic drive has long been considered as a genetic curiosity. Genomic "footprints" suggest otherwise.
Check out our new review doi.org/10.1093/molb..., a cross-taxa synthesis arguing that recurrent drive is a pervasive and underappreciated force in genome evolution.
Check out our new review doi.org/10.1093/molb..., a cross-taxa synthesis arguing that recurrent drive is a pervasive and underappreciated force in genome evolution.
Reposted by Charikleia Karageorgiou (Clio)
Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk.
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
Common variation in meiosis genes shapes human recombination and aneuploidy - Nature
Analysis of data from pre-implantation genetic testing sheds light on the genetic basis of meiotic-origin aneuploidy, the leading cause of human pregnancy loss, identifying common genetic variants ass...
www.nature.com
January 21, 2026 at 9:14 PM
Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk.
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
Reposted by Charikleia Karageorgiou (Clio)
📢 Three new #bioRxiv preprints from our team on holocentric chromosomes.
Together, they connect centromere repeat evolution, karyotype dynamics, and meiotic recombination outcomes, revealing how holocentric genomes evolve and function. 🧬👇
Together, they connect centromere repeat evolution, karyotype dynamics, and meiotic recombination outcomes, revealing how holocentric genomes evolve and function. 🧬👇
January 21, 2026 at 2:45 PM
📢 Three new #bioRxiv preprints from our team on holocentric chromosomes.
Together, they connect centromere repeat evolution, karyotype dynamics, and meiotic recombination outcomes, revealing how holocentric genomes evolve and function. 🧬👇
Together, they connect centromere repeat evolution, karyotype dynamics, and meiotic recombination outcomes, revealing how holocentric genomes evolve and function. 🧬👇
Reposted by Charikleia Karageorgiou (Clio)
Pangenome analysis reveals the evolutionary dynamics of repeat-based holocentromeres https://www.biorxiv.org/content/10.64898/2026.01.17.700053v1
January 19, 2026 at 2:32 AM
Pangenome analysis reveals the evolutionary dynamics of repeat-based holocentromeres https://www.biorxiv.org/content/10.64898/2026.01.17.700053v1
Reposted by Charikleia Karageorgiou (Clio)
Breast milk isn't just nutrition – it delivers live bacterial strains that colonize the infant gut and persist for months.
Happy to share our new paper, where we used metagenomics to track bacterial strains between 195 mother-infant pairs over the first 6 months of life:
doi.org/10.1038/s414...
Happy to share our new paper, where we used metagenomics to track bacterial strains between 195 mother-infant pairs over the first 6 months of life:
doi.org/10.1038/s414...
Assembly of the infant gut microbiome and resistome are linked to bacterial strains in mother’s milk - Nature Communications
Here, with metagenomic analyses on longitudinal samples collected from 195 mother-infant pairs, the authors show that the breast milk microbiome contributes to infant gut assembly through bacterial st...
doi.org
January 18, 2026 at 8:35 PM
Breast milk isn't just nutrition – it delivers live bacterial strains that colonize the infant gut and persist for months.
Happy to share our new paper, where we used metagenomics to track bacterial strains between 195 mother-infant pairs over the first 6 months of life:
doi.org/10.1038/s414...
Happy to share our new paper, where we used metagenomics to track bacterial strains between 195 mother-infant pairs over the first 6 months of life:
doi.org/10.1038/s414...
Reposted by Charikleia Karageorgiou (Clio)
Registration for the 2026 NY Area Population Genetics meeting is now open, at events.simonsfoundation.org/e0mEoL?rt=8k.... Registration is free but required; if you are submitting an abstract, note that the deadline is *January 30th*.
January 14, 2026 at 9:37 PM
Registration for the 2026 NY Area Population Genetics meeting is now open, at events.simonsfoundation.org/e0mEoL?rt=8k.... Registration is free but required; if you are submitting an abstract, note that the deadline is *January 30th*.
Reposted by Charikleia Karageorgiou (Clio)
Representation in genetic studies affects inference about genetic architecture https://www.biorxiv.org/content/10.64898/2026.01.12.699135v1
January 13, 2026 at 11:32 PM
Representation in genetic studies affects inference about genetic architecture https://www.biorxiv.org/content/10.64898/2026.01.12.699135v1
Reposted by Charikleia Karageorgiou (Clio)
Characterising the detectable and invisible fractions of genomic loci under balancing selection https://www.biorxiv.org/content/10.64898/2026.01.13.698512v1
January 13, 2026 at 1:32 PM
Characterising the detectable and invisible fractions of genomic loci under balancing selection https://www.biorxiv.org/content/10.64898/2026.01.13.698512v1
Reposted by Charikleia Karageorgiou (Clio)
Want to study the genomics of repeated adaptation with data from hundreds of species? New funding for non-Canadians @ grad or postdoc level. Internal competition at UCalgary with very short deadline so please get in touch ASAP!!
sshrc-crsh.canada.ca/en/funding/o...
sshrc-crsh.canada.ca/en/funding/o...
January 9, 2026 at 6:41 PM
Want to study the genomics of repeated adaptation with data from hundreds of species? New funding for non-Canadians @ grad or postdoc level. Internal competition at UCalgary with very short deadline so please get in touch ASAP!!
sshrc-crsh.canada.ca/en/funding/o...
sshrc-crsh.canada.ca/en/funding/o...
Reposted by Charikleia Karageorgiou (Clio)
Targeted Chromosomal Sequencing of Wild Bonobos Identifies a Genetically Distinct Subpopulation East of the Lomami River https://www.biorxiv.org/content/10.64898/2026.01.08.698381v1
January 9, 2026 at 2:46 PM
Targeted Chromosomal Sequencing of Wild Bonobos Identifies a Genetically Distinct Subpopulation East of the Lomami River https://www.biorxiv.org/content/10.64898/2026.01.08.698381v1
Reposted by Charikleia Karageorgiou (Clio)
Postdoc position call @univie.ac.at - happy to host projects related to introgression, great ape genomics, and more!
careers.univie.ac.at/en/postdoc/e...
careers.univie.ac.at/en/postdoc/e...
careers.univie.ac.at
January 9, 2026 at 11:42 AM
Postdoc position call @univie.ac.at - happy to host projects related to introgression, great ape genomics, and more!
careers.univie.ac.at/en/postdoc/e...
careers.univie.ac.at/en/postdoc/e...
Reposted by Charikleia Karageorgiou (Clio)
Global patterns of natural selection inferred using ancient DNA https://www.biorxiv.org/content/10.64898/2026.01.07.697984v1
January 8, 2026 at 10:32 AM
Global patterns of natural selection inferred using ancient DNA https://www.biorxiv.org/content/10.64898/2026.01.07.697984v1
Reposted by Charikleia Karageorgiou (Clio)
🎉 New year, NEW PREPRINT!
Bacteria exhibit astonishing genetic diversity, but where do new genes come from?
My best friend Arya Kaul (/labmate in the @baym lab) investigates how advantageous deletions can spawn new genes - "deletion-born fusions." 🧵:
Bacteria exhibit astonishing genetic diversity, but where do new genes come from?
My best friend Arya Kaul (/labmate in the @baym lab) investigates how advantageous deletions can spawn new genes - "deletion-born fusions." 🧵:
Novel genes arise from genomic deletions across the bacterial tree of life https://www.biorxiv.org/content/10.64898/2026.01.05.697752v1
January 6, 2026 at 4:09 PM
🎉 New year, NEW PREPRINT!
Bacteria exhibit astonishing genetic diversity, but where do new genes come from?
My best friend Arya Kaul (/labmate in the @baym lab) investigates how advantageous deletions can spawn new genes - "deletion-born fusions." 🧵:
Bacteria exhibit astonishing genetic diversity, but where do new genes come from?
My best friend Arya Kaul (/labmate in the @baym lab) investigates how advantageous deletions can spawn new genes - "deletion-born fusions." 🧵:
New review from @gokcumenlab.bsky.social led by Petar Pajic on VNTRs. If you’re interested in VNTRs, this is a very nice synthesis.
academic.oup.com/gbe/article/...
academic.oup.com/gbe/article/...
Evolutionary Balancing of Genetic Consequence and Innovation in Mammals Through Variable Number Tandem Repeats
Abstract. Understanding genomic function has historically relied on sequence conservation across evolutionary time. However, advances in genomics have reve
academic.oup.com
January 8, 2026 at 1:27 PM
New review from @gokcumenlab.bsky.social led by Petar Pajic on VNTRs. If you’re interested in VNTRs, this is a very nice synthesis.
academic.oup.com/gbe/article/...
academic.oup.com/gbe/article/...