Evan Irving-Pease
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evanirvingpease.bsky.social
Evan Irving-Pease
@evanirvingpease.bsky.social
PI at the Big Data Institute, University of Oxford
Royal Society University Research Fellow
aDNA | Complex Traits | Selection | Disease | Domestication
🇦🇺🇬🇧💀🧬🦠🐕
Pinned
Delighted to see our paper characterising the inbreeding history of dogs and wolves over the past 10,000 years published this week in @pnas.org. Work led by the excellent @katiabou.bsky.social, and co-supervised by me, Laurent Frantz and Fernando Racimo www.pnas.org/doi/10.1073/...
Reposted by Evan Irving-Pease
The story the evolution of height in populations of Europe has been a bit of rollercoaster, veering between natural selection or admixture with populations who had a higher genetic propensity to be taller by chance. This preprint goes back to natural selection...

www.biorxiv.org/content/10.6...
www.biorxiv.org
February 3, 2026 at 12:28 PM
Reposted by Evan Irving-Pease
Why are Dutch people so tall? This has been a long-standing debate in genetics, with earlier studies questioned due to unaccounted for confounding. Great to be involved in a new study (link below) using within-family GWAS; we confirm that height has been under positive selection.
February 2, 2026 at 12:29 PM
Reposted by Evan Irving-Pease
A new study from Anthropic finds that gains in coding efficiency when relying on AI assistance did did not meet statistical significance; AI use noticeably degraded programmers’ understanding of what they were doing. Incredible.
January 30, 2026 at 11:47 PM
Reposted by Evan Irving-Pease
I had intended to post something about this new Google DeepMind paper that appeared yesterday in Nature, but the press coverage has added to what there is to say. So this is a long 🧵
www.nature.com/articles/s41...
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...
www.nature.com
January 30, 2026 at 9:47 AM
Reposted by Evan Irving-Pease
Heritability = a statistical description of sources of interindividual variation in a specific set of people under a specific set of environmental conditions. It doesn't index a fixed underlying feature of human biology. A few lines in this paper acknowledge that but its overall framing may mislead.
Heritability of intrinsic human life span is about 50% when confounding factors are addressed
How heritable is human life span? If genetic heritability is high, longevity genes can reveal aging mechanisms and inform medicine and public health. However, current estimates of heritability are low...
www.science.org
January 30, 2026 at 3:36 PM
Reposted by Evan Irving-Pease
Our work on the generalizability of polygenic scores (PGS) from the @arbelharpak.bsky.social Lab is now officially out!

We examine the accuracy of PGS predictions at the individual level. We make 3 observations that expose gaps in our understanding of PGS “portability.”

rdcu.be/e0LAr

(1/27)
Three open questions in polygenic score portability
Nature Communications - Genetic predictors of health outcomes often drop in accuracy when applied to people dissimilar to participants of large genetic studies. Here, the authors investigate the...
rdcu.be
January 26, 2026 at 11:20 PM
Reposted by Evan Irving-Pease
Cow Tools!

We have lived alongside cows for nearly 10,000 years.
We breed them and exploit them

It is now, only now, that we have discovered THEY CAN USE TOOLS

Here I describe our study

(paper) www.sciencedirect.com/science/arti... in @currentbiology.bsky.social
with @auersperga.bsky.social
January 19, 2026 at 5:26 PM
Reposted by Evan Irving-Pease
Excited to share our new preprint from the @arbelharpak.bsky.social Lab!

How do recruitment into genetic studies and study characteristics impact what we infer about the genetic bases of traits, and what are the consequences? (1/21)

www.biorxiv.org/content/10.6...
Representation in genetic studies affects inference about genetic architecture
Knowledge of a trait's "genetic architecture," namely the joint distribution of allele frequencies of causal variants and the direction and magnitude of their effects, is essential to understanding it...
www.biorxiv.org
January 14, 2026 at 7:07 PM
Reposted by Evan Irving-Pease
I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!
HLi Lab - Vacancies
Openings
hlilab.github.io
January 14, 2026 at 3:44 PM
Reposted by Evan Irving-Pease
While stories of singular DNA changes that drove evolution of human brain/behaviour remain seductive, advances across multiple fields of biology cast doubt on such simplistic narratives of our origins. A new paper from my lab shows how biobanks may speak to this fundamental question.🧪
Explainer🧵👇1/n
Evaluating the effects of archaic protein-altering variants in living human adults
Promise and pitfalls of using large biobanks to study impacts of archaic protein-coding variants in living humans.
www.science.org
December 18, 2025 at 1:51 PM
Reposted by Evan Irving-Pease
I've spent all day struggling to write a single page of a popular science article. I bang away at a word processor; give up; start diagramming on paper. Take some notes; draft a few sentences in pen; return to the computer...and very slowly I figure out what I was trying to say in the first place.
December 16, 2025 at 11:41 PM
Reposted by Evan Irving-Pease
Lovely to work with @blevinske.bsky.social, @paleogenomics.bsky.social & Verena Schuenemann on " Ancient DNA insights into diverse pathogens and their hosts"! Read it at rdcu.be/eSVPN
Ancient DNA insights into diverse pathogens and their hosts
Nature Reviews Genetics - Ancient DNA techniques are being applied to study increasingly diverse pathogens of the past. The authors review the latest insights into pathogen–host coevolution,...
rdcu.be
December 3, 2025 at 6:04 PM
Reposted by Evan Irving-Pease
Our new ancient DNA paper has just been published!
We present 28 new genomes from southern Africa - several of them high-coverage whole genomes.
Exciting to be moving towards population-level representation of ancient southern African genetic diversity!

www.nature.com/articles/s41...
Homo sapiens-specific evolution unveiled by ancient southern African genomes - Nature
The genomes of 28 ancient southern African individuals dated to between 10,200 and 150 years before present offer insights into the evolution of Homo sapiens.
www.nature.com
December 3, 2025 at 4:42 PM
Reposted by Evan Irving-Pease
Our paper in the PNAS Special Feature on 🐕 is out!
We demonstrated the accuracy of imputing ancient canid genomes, looked at inbreeding levels over the past 10,000 years and found genomic regions resistant to ROH which were enriched for immunity and chemosensory genes.
www.pnas.org/doi/10.1073/...
Imputation of ancient canid genomes reveals inbreeding history over the past 10,000 years | PNAS
The multi-millennia-long history between dogs and humans has placed them at the forefront of archaeological and genomic research. Despite ongoing e...
www.pnas.org
December 1, 2025 at 11:00 AM
Reposted by Evan Irving-Pease
What's that? 5 ancient doggy papers in 10 days is too many dogs?

Can I interest you in some cats?

Perhaps a complete retelling of cat domestication, dispersal, and replacement across Eurasia?

As you wish!

Science
www.science.org/doi/10.1126/...

Cell Genomics
www.cell.com/cell-genomic...
The dispersal of domestic cats from North Africa to Europe around 2000 years ago
The domestic cat (Felis catus) descends from the African wildcat Felis lybica lybica. Its global distribution alongside humans testifies to its successful adaptation to anthropogenic environments. Unc...
www.science.org
November 28, 2025 at 12:40 PM
Reposted by Evan Irving-Pease
A PNAS Special Feature exclusively about dogs? Woof!
Here are 3 of the 8 that we were involved with. Congrats to @lachiescarsbrook.bsky.social & @undeaddandy.bsky.social
Dingoes!
www.pnas.org/doi/10.1073/...
German Shepherds!
www.pnas.org/doi/10.1073/...
Imputation!
www.pnas.org/doi/10.1073/...
Imputation of ancient canid genomes reveals inbreeding history over the past 10,000 years | PNAS
The multi-millennia-long history between dogs and humans has placed them at the forefront of archaeological and genomic research. Despite ongoing e...
www.pnas.org
November 25, 2025 at 12:41 PM
Reposted by Evan Irving-Pease
🚨 PNAS Special Feature 2 🐕

We used ancient DNA and dietary isotopes to show that landscape modification and the introduction of European dogs impacted dingo populations across Australia.

🔗 Full paper here: www.pnas.org/doi/10.1073/...
November 24, 2025 at 9:22 PM
Reposted by Evan Irving-Pease
🚨 PNAS Special Feature 🐕

We analysed genomes of historical German Shepherds to reveal how bottlenecks linked to WWII and the use of popular sires led to significant declines in genomic health. We also found an early 20th century wolf-dog hybrid!

🔗 Full paper here: www.pnas.org/doi/10.1073/...
November 24, 2025 at 9:10 PM
Reposted by Evan Irving-Pease
Our paper is out! Although wolves and dogs can interbreed and produce fertile offspring, hybridization between the two is rare. We found that most dogs today have low but detectable levels of post-domestication wolf ancestry that has shaped their evolution in human environments. tinyurl.com/yt4x4r7n
A legacy of genetic entanglement with wolves shapes modern dogs | PNAS
Dogs evolved through interactions between people and gray wolves during the Late Pleistocene and have been ubiquitous in human societies ever since...
www.pnas.org
November 25, 2025 at 2:42 AM
Reposted by Evan Irving-Pease
The invention of agriculture (around 9,000 years ago) spurred the rise of early states? NO. Our research www.nature.com/articles/s41... (with @drqueue.bsky.social) in @nathumbehav.nature.com supports an alternative theory that States almost invariably formed in societies that grew cereal grains.
State formation across cultures and the role of grain, intensive agriculture, taxation and writing - Nature Human Behaviour
Opie and Atkinson conduct a global phylogenetic analysis of 868 cultures and find evidence indicating that cereal grain cultivation, not agricultural surplus, drove state formation. Their findings als...
www.nature.com
November 25, 2025 at 10:11 AM
Very thankful to the @royalsociety.org for the opportunity to start my own research group at the Big Data Institute, @ndm.ox.ac.uk, as a Royal Society University Research Fellow! royalsociety.org/news/2025/11...
Exceptional researchers awarded early career fellowships worth more than £83 million | Royal Society
A new cohort of exceptional researchers at have been awarded funding through the Royal Society’s early career schemes, the University Research Fellowship (URF), Dorothy Hodgkin Fellowship (DHF) and Ne...
royalsociety.org
November 25, 2025 at 11:50 AM
Delighted to see our paper characterising the inbreeding history of dogs and wolves over the past 10,000 years published this week in @pnas.org. Work led by the excellent @katiabou.bsky.social, and co-supervised by me, Laurent Frantz and Fernando Racimo www.pnas.org/doi/10.1073/...
November 25, 2025 at 11:08 AM
Reposted by Evan Irving-Pease
We are recruiting!

If you like evolutionary biology, microbial genomics, and host-pathogen interactions we have a PhD opening at @ugiatucl.bsky.social using population-scale metagenomics to map global phage diversity and uncover evolutionary signatures that could point to new antimicrobials.
November 24, 2025 at 10:50 AM
Reposted by Evan Irving-Pease
⏰ The clock is ticking❗

LESS THAN 10 DAYS LEFT to submit your abstracts (30th Nov).

Do it here👉 icp2026.palaeogenomics.org/abstracts/

Many of you are asking for the registration fees 💸. We are still working out the details, but we estimate 400-500€ for regular attendees and 300-400€ for students.
Abstracts – International Conference on Palaeogenomics 2026
icp2026.palaeogenomics.org
November 21, 2025 at 11:39 AM