E. Taylor Stone
@etaylorstone.bsky.social
Viral Immunology 🦠 | Vaccinology 💉| Nerd 🤓
Ph.D - Saint Louis University, Postdoc - HDT Bio
💙💜🩷 🧬🔬🧫📊🤖💻
Ph.D - Saint Louis University, Postdoc - HDT Bio
💙💜🩷 🧬🔬🧫📊🤖💻
Reposted by E. Taylor Stone
Collab btwn NIAID (Dr. Andrea Marzi’s lab) and HDT Bio just published! 🧪
Filovirus gold-standard VSV vax platform compared to LION/repRNA (each encoding same antigen seq) for ability to provide single-dose protection in guinea pigs against Sudan virus challenge 🧵(1/2) www.nature.com/articles/s41...
Filovirus gold-standard VSV vax platform compared to LION/repRNA (each encoding same antigen seq) for ability to provide single-dose protection in guinea pigs against Sudan virus challenge 🧵(1/2) www.nature.com/articles/s41...
Single-dose replicon RNA Sudan virus vaccine uniformly protects female guinea pigs from disease - Nature Communications
Sudan virus (SUDV) outbreaks in Uganda created public health concerns due to a lack of approved vaccines. In this study, the authors develop a repRNA SUDV vaccine and demonstrate full protection of a ...
www.nature.com
May 6, 2025 at 1:58 PM
Collab btwn NIAID (Dr. Andrea Marzi’s lab) and HDT Bio just published! 🧪
Filovirus gold-standard VSV vax platform compared to LION/repRNA (each encoding same antigen seq) for ability to provide single-dose protection in guinea pigs against Sudan virus challenge 🧵(1/2) www.nature.com/articles/s41...
Filovirus gold-standard VSV vax platform compared to LION/repRNA (each encoding same antigen seq) for ability to provide single-dose protection in guinea pigs against Sudan virus challenge 🧵(1/2) www.nature.com/articles/s41...
Reposted by E. Taylor Stone
Just published! Here we report immunogenicity and efficacy of our replicon RNA vaccine against Crimean-Congo hemorrhagic fever in a cynomolgus macaque model of #CCHFV infection. Stay tuned as we advance this candidate in clinical trials.
www.thelancet.com/journals/ebi...
www.thelancet.com/journals/ebi...
A replicating RNA vaccine confers protection against Crimean-Congo hemorrhagic fever in cynomolgus macaques
Our data demonstrate that our repNP vaccine and NP-specific antibody can protect against
CCHFV in non-human primates.
www.thelancet.com
April 15, 2025 at 1:27 AM
Just published! Here we report immunogenicity and efficacy of our replicon RNA vaccine against Crimean-Congo hemorrhagic fever in a cynomolgus macaque model of #CCHFV infection. Stay tuned as we advance this candidate in clinical trials.
www.thelancet.com/journals/ebi...
www.thelancet.com/journals/ebi...
Reposted by E. Taylor Stone
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
June 18, 2025 at 2:24 PM
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
Reposted by E. Taylor Stone
Looks like #Uganda will use #IAVI's #Ebola Sudan vaccine in a clinical trial aimed at helping to halt the country's outbreak. The trial could also provide evidence of the vaccine's efficacy. As I reported y'day, there are already doses in Uganda — 2160, in fact. www.who.int/news/item/31...
January 31, 2025 at 10:44 PM
Looks like #Uganda will use #IAVI's #Ebola Sudan vaccine in a clinical trial aimed at helping to halt the country's outbreak. The trial could also provide evidence of the vaccine's efficacy. As I reported y'day, there are already doses in Uganda — 2160, in fact. www.who.int/news/item/31...
Reposted by E. Taylor Stone
When you design a vaccine and by the time the paper comes out you’ve made three updated versions as the virus continues to evolve 😅 #influenza #RNAviruses
New paper! In collaboration with NIAID, we asked: how effective are vaccines designed against historical #H5N1 viruses in naïve mice challenged with the contemporary cattle virus? Turns out that the new isolates are different enough to warrant further evaluation of updated vaccine compositions. 🧪
Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice - Nature Communications
Here the authors show that a replicating RNA vaccine encoding the hemagglutinin (HA) of contemporary H5N1 strains confers single shot protection against lethal H5N1 challenge in mice, while an RNA enc...
www.nature.com
January 15, 2025 at 3:17 PM
When you design a vaccine and by the time the paper comes out you’ve made three updated versions as the virus continues to evolve 😅 #influenza #RNAviruses