Emma M. Groarke
@emmamgroarke.bsky.social
🇮🇪 Hematologist @ NHLBI. #BMF #SAA, #Telomere Biology Disorders, #VEXAS, #MDS. Views are my own. #HemeSky
Pleased to see our work looking at the impact of cytokine derived therapies / steroids on hematologic progression in #VEXAS led by Benjamin Turturice & Peter Grayson now published in @ard.eular.org www.sciencedirect.com/science/arti...
July 1, 2025 at 2:08 PM
Pleased to see our work looking at the impact of cytokine derived therapies / steroids on hematologic progression in #VEXAS led by Benjamin Turturice & Peter Grayson now published in @ard.eular.org www.sciencedirect.com/science/arti...
Excited to see our NHLBI work on infections and immunodeficiency in patients with #telomere biology disorders now published @bloodjournal.bsky.social >1/3 had significant infection history & nearly 1/2 t-lymphopenia. Fernando Catto & Fernanda Gutierrez-Rodrigues. ashpublications.org/blood/articl...
June 25, 2025 at 8:37 PM
Excited to see our NHLBI work on infections and immunodeficiency in patients with #telomere biology disorders now published @bloodjournal.bsky.social >1/3 had significant infection history & nearly 1/2 t-lymphopenia. Fernando Catto & Fernanda Gutierrez-Rodrigues. ashpublications.org/blood/articl...
Reposted by Emma M. Groarke
I’m delighted to share our latest work on severe aplastic anaemia, published in Nature Communications. Using advanced single-cell approaches to dissect immune-mediated marrow failure before and after immunotherapy.
A great collaboration with NIH. www.nature.com/articles/s41...
A great collaboration with NIH. www.nature.com/articles/s41...
Human autoimmunity at single cell resolution in aplastic anemia before and after effective immunotherapy - Nature Communications
The transcriptional phenotype of immune cells associated with severe aplastic anaemia (SAA) may change post immunotherapy. Here the authors analyse single cell transcriptomics of hematopoietic and imm...
www.nature.com
June 7, 2025 at 6:07 AM
I’m delighted to share our latest work on severe aplastic anaemia, published in Nature Communications. Using advanced single-cell approaches to dissect immune-mediated marrow failure before and after immunotherapy.
A great collaboration with NIH. www.nature.com/articles/s41...
A great collaboration with NIH. www.nature.com/articles/s41...
Excited to share our NHLBI work led by Alice Wu in collaboration with @kingscollegelondon.bsky.social published in @natcomms.nature.com using scRNAseq and CyTOF to explore pathophysiology of immune #aplasticanemia pre and post IST. www.nature.com/articles/s41...
May 30, 2025 at 8:07 PM
Excited to share our NHLBI work led by Alice Wu in collaboration with @kingscollegelondon.bsky.social published in @natcomms.nature.com using scRNAseq and CyTOF to explore pathophysiology of immune #aplasticanemia pre and post IST. www.nature.com/articles/s41...
Excited to share our NHLBI group’s latest work, led by post-doc Hiroki Mizumaki, looking at the role of the adaptive and innate immune system in #VEXAS in @natcomms.nature.com www.nature.com/articles/s41... Bhavisha Patel Fernanda Gutierrez-Rodrigues Neal S Young
May 21, 2025 at 12:11 PM
Excited to share our NHLBI group’s latest work, led by post-doc Hiroki Mizumaki, looking at the role of the adaptive and innate immune system in #VEXAS in @natcomms.nature.com www.nature.com/articles/s41... Bhavisha Patel Fernanda Gutierrez-Rodrigues Neal S Young
Congrats to FRENVEX for their study on azacitadine in #VEXAS led by Thibault Comont in @bloodjournal.bsky.social Confirmed inflammatory & hematologic responses in >50%. Molecular responses in >2/3rds! Toxicity common especially in first 3 cycles. ashpublications.org/blood/articl...
May 19, 2025 at 1:28 PM
Congrats to FRENVEX for their study on azacitadine in #VEXAS led by Thibault Comont in @bloodjournal.bsky.social Confirmed inflammatory & hematologic responses in >50%. Molecular responses in >2/3rds! Toxicity common especially in first 3 cycles. ashpublications.org/blood/articl...
The NIH goslings making an appearance this spring 🌸🪿
May 9, 2025 at 1:39 AM
The NIH goslings making an appearance this spring 🌸🪿
New multi center phase 2 study in @bloodadvances.bsky.social looking again at the role of eltrombopag in pediatric #SAA - overall underwhelming in the treatment naive setting. Possible role in relapsed/refractory though very low numbers ashpublications.org/bloodadvance...
May 7, 2025 at 5:32 PM
New multi center phase 2 study in @bloodadvances.bsky.social looking again at the role of eltrombopag in pediatric #SAA - overall underwhelming in the treatment naive setting. Possible role in relapsed/refractory though very low numbers ashpublications.org/bloodadvance...
Reposted by Emma M. Groarke
In a new editorial, Dr. Mary Frances McMullin explores the scientific foundations and clinical implications of a study on variant EPO and erythrocytosis. Read the editorial: nej.md/3YmAnNU
@qubelfastofficial.bsky.social #MedSky #Hematology
@qubelfastofficial.bsky.social #MedSky #Hematology
April 30, 2025 at 10:01 PM
In a new editorial, Dr. Mary Frances McMullin explores the scientific foundations and clinical implications of a study on variant EPO and erythrocytosis. Read the editorial: nej.md/3YmAnNU
@qubelfastofficial.bsky.social #MedSky #Hematology
@qubelfastofficial.bsky.social #MedSky #Hematology
Reposted by Emma M. Groarke
Both clonal hematopoiesis of indeterminate potential (CHIP) and cancer are more common with age. When they coexist in the same patient, CHIP cells may migrate to the tumor and have an adverse effect on overall survival. Full study results: nej.md/3EnzMVu
#MedSky #Hematology
#MedSky #Hematology
April 27, 2025 at 1:21 PM
Both clonal hematopoiesis of indeterminate potential (CHIP) and cancer are more common with age. When they coexist in the same patient, CHIP cells may migrate to the tumor and have an adverse effect on overall survival. Full study results: nej.md/3EnzMVu
#MedSky #Hematology
#MedSky #Hematology
Happy birthday to the OG NHLBI #BMFsm team! Dr. Neal S Young, staff scientist Dr. Sachiko Kajigaya and research nurse Olga Rios who have spent the last few decades at the NIH driving a clinical and translational research program which has led to astonishing progress in #SAA and other marrow failures
April 16, 2025 at 3:59 AM
Happy birthday to the OG NHLBI #BMFsm team! Dr. Neal S Young, staff scientist Dr. Sachiko Kajigaya and research nurse Olga Rios who have spent the last few decades at the NIH driving a clinical and translational research program which has led to astonishing progress in #SAA and other marrow failures
Very nice paper published in @natmedicine.bsky.social from the 🇮🇹 San Raffaele group showing upregulation of inflammatory and senescence markers in #VEXAS HSPCs with exhaustion of surrounding wild type cells. www.nature.com/articles/s41...
April 15, 2025 at 7:10 PM
Very nice paper published in @natmedicine.bsky.social from the 🇮🇹 San Raffaele group showing upregulation of inflammatory and senescence markers in #VEXAS HSPCs with exhaustion of surrounding wild type cells. www.nature.com/articles/s41...
Excited to see this work on #clonalhematopoiesis in #telomere disorders led by @daria-babushok.bsky.social @pennmedicine.bsky.social in @jclinical-invest.bsky.social - ATM mutations commonly observed. ATM-dependent DDR from telomere dysfunction key in disease pathogenesis www.jci.org/articles/vie...
April 7, 2025 at 6:38 PM
Excited to see this work on #clonalhematopoiesis in #telomere disorders led by @daria-babushok.bsky.social @pennmedicine.bsky.social in @jclinical-invest.bsky.social - ATM mutations commonly observed. ATM-dependent DDR from telomere dysfunction key in disease pathogenesis www.jci.org/articles/vie...
Looking for public comments on the @ash.hematology.org #AplasticAnemia guidelines - see here! www.hematology.org/education/cl...
April 3, 2025 at 5:44 PM
Looking for public comments on the @ash.hematology.org #AplasticAnemia guidelines - see here! www.hematology.org/education/cl...
Gene therapy for #telomere biology disorders 🧬! Report of first 2 patients @nejm.org evidence by Kas Myers using vector to increase expression of ZSCAN4 to elongate telomeres. Some TL elongation in HSPCs but low numbers. Will be interested to see more data! evidence.nejm.org/doi/pdf/10.1...
March 28, 2025 at 3:47 PM
Gene therapy for #telomere biology disorders 🧬! Report of first 2 patients @nejm.org evidence by Kas Myers using vector to increase expression of ZSCAN4 to elongate telomeres. Some TL elongation in HSPCs but low numbers. Will be interested to see more data! evidence.nejm.org/doi/pdf/10.1...
Excited to see our NHLBI work just published in @bloodadvances.bsky.social showing the negative effects of HLA alloimmunization in #SAA patients treated with immunosuppression. Lead by our former fellow Jibran Durrani now at UMiami ashpublications.org/bloodadvance... #BMFsm
March 23, 2025 at 10:55 PM
Excited to see our NHLBI work just published in @bloodadvances.bsky.social showing the negative effects of HLA alloimmunization in #SAA patients treated with immunosuppression. Lead by our former fellow Jibran Durrani now at UMiami ashpublications.org/bloodadvance... #BMFsm
Congrats to our former NHLBI @petermaccc.bsky.social fellow
Ashvind Prabahran who led this work looking at the immune features of megakaryocytes in #BMFsm just published in @bloodadvances.bsky.social 👇 ashpublications.org/bloodadvance... #SAA
Ashvind Prabahran who led this work looking at the immune features of megakaryocytes in #BMFsm just published in @bloodadvances.bsky.social 👇 ashpublications.org/bloodadvance... #SAA
March 23, 2025 at 10:45 PM
Congrats to our former NHLBI @petermaccc.bsky.social fellow
Ashvind Prabahran who led this work looking at the immune features of megakaryocytes in #BMFsm just published in @bloodadvances.bsky.social 👇 ashpublications.org/bloodadvance... #SAA
Ashvind Prabahran who led this work looking at the immune features of megakaryocytes in #BMFsm just published in @bloodadvances.bsky.social 👇 ashpublications.org/bloodadvance... #SAA
Reposted by Emma M. Groarke
The #CCCTAA at #ASH24. Look for important international collaborative studies on #telomere biology disorders in the near future. @teamtelomere.bsky.social is a key partner.
Reach out to join the Clinical Care Consortium of Telomere Associated Ailments 🧬 #teamscience
Reach out to join the Clinical Care Consortium of Telomere Associated Ailments 🧬 #teamscience
December 7, 2024 at 10:18 PM
The #CCCTAA at #ASH24. Look for important international collaborative studies on #telomere biology disorders in the near future. @teamtelomere.bsky.social is a key partner.
Reach out to join the Clinical Care Consortium of Telomere Associated Ailments 🧬 #teamscience
Reach out to join the Clinical Care Consortium of Telomere Associated Ailments 🧬 #teamscience
Happy Christmas to all from Ireland! 🇮🇪 🎄
December 26, 2024 at 4:38 PM
Happy Christmas to all from Ireland! 🇮🇪 🎄
Congrats to @jamesnolan.bsky.social (now at @pmresearch-uhn.bsky.social) on his #ASH24 abstract achievement award for his PhD research @tcddublin.bsky.social! @adrianbracken.bsky.social 🇮🇪🇨🇦 @ash-hematology.bsky.social #Lmsm #ASHKudos
December 10, 2024 at 5:49 PM
Congrats to @jamesnolan.bsky.social (now at @pmresearch-uhn.bsky.social) on his #ASH24 abstract achievement award for his PhD research @tcddublin.bsky.social! @adrianbracken.bsky.social 🇮🇪🇨🇦 @ash-hematology.bsky.social #Lmsm #ASHKudos
Beautiful view from the conference center at #ASH24 @ash-hematology.bsky.social 🌅
December 10, 2024 at 1:24 AM
Beautiful view from the conference center at #ASH24 @ash-hematology.bsky.social 🌅
Congrats to Denis O’Keeffe from
UHL for presenting the result of the 🇮🇪ish collaborative TILLIRI study - looking at #VTE prophylaxis in lower limb injuries. @ash-hematology.bsky.social #ASH24 @fniainle.bsky.social
UHL for presenting the result of the 🇮🇪ish collaborative TILLIRI study - looking at #VTE prophylaxis in lower limb injuries. @ash-hematology.bsky.social #ASH24 @fniainle.bsky.social
December 9, 2024 at 11:58 PM
Congrats to Denis O’Keeffe from
UHL for presenting the result of the 🇮🇪ish collaborative TILLIRI study - looking at #VTE prophylaxis in lower limb injuries. @ash-hematology.bsky.social #ASH24 @fniainle.bsky.social
UHL for presenting the result of the 🇮🇪ish collaborative TILLIRI study - looking at #VTE prophylaxis in lower limb injuries. @ash-hematology.bsky.social #ASH24 @fniainle.bsky.social
Congrats to NHLBI‘s John Tisdale for winning the @ash-hematology.bsky.social #ASH24 Beutler Prize! #SCD #ASHKudos
December 9, 2024 at 10:08 PM
Congrats to NHLBI‘s John Tisdale for winning the @ash-hematology.bsky.social #ASH24 Beutler Prize! #SCD #ASHKudos
Former NHLBI fellow Jibran Durrani (now @miamirosenstiel.bsky.social) presenting our group’s work on complement mediated immune activation in #SAA with HLA alloimmunisation. #ASH24 @ash-hematology.bsky.social
December 9, 2024 at 7:48 AM
Former NHLBI fellow Jibran Durrani (now @miamirosenstiel.bsky.social) presenting our group’s work on complement mediated immune activation in #SAA with HLA alloimmunisation. #ASH24 @ash-hematology.bsky.social