Emma M. Groarke
@emmamgroarke.bsky.social
🇮🇪 Hematologist @ NHLBI. #BMF #SAA, #Telomere Biology Disorders, #VEXAS, #MDS. Views are my own. #HemeSky
Pleased to see our work looking at the impact of cytokine derived therapies / steroids on hematologic progression in #VEXAS led by Benjamin Turturice & Peter Grayson now published in @ard.eular.org www.sciencedirect.com/science/arti...
July 1, 2025 at 2:08 PM
Pleased to see our work looking at the impact of cytokine derived therapies / steroids on hematologic progression in #VEXAS led by Benjamin Turturice & Peter Grayson now published in @ard.eular.org www.sciencedirect.com/science/arti...
Excited to see our NHLBI work on infections and immunodeficiency in patients with #telomere biology disorders now published @bloodjournal.bsky.social >1/3 had significant infection history & nearly 1/2 t-lymphopenia. Fernando Catto & Fernanda Gutierrez-Rodrigues. ashpublications.org/blood/articl...
June 25, 2025 at 8:37 PM
Excited to see our NHLBI work on infections and immunodeficiency in patients with #telomere biology disorders now published @bloodjournal.bsky.social >1/3 had significant infection history & nearly 1/2 t-lymphopenia. Fernando Catto & Fernanda Gutierrez-Rodrigues. ashpublications.org/blood/articl...
Excited to share our NHLBI work led by Alice Wu in collaboration with @kingscollegelondon.bsky.social published in @natcomms.nature.com using scRNAseq and CyTOF to explore pathophysiology of immune #aplasticanemia pre and post IST. www.nature.com/articles/s41...
May 30, 2025 at 8:07 PM
Excited to share our NHLBI work led by Alice Wu in collaboration with @kingscollegelondon.bsky.social published in @natcomms.nature.com using scRNAseq and CyTOF to explore pathophysiology of immune #aplasticanemia pre and post IST. www.nature.com/articles/s41...
Excited to share our NHLBI group’s latest work, led by post-doc Hiroki Mizumaki, looking at the role of the adaptive and innate immune system in #VEXAS in @natcomms.nature.com www.nature.com/articles/s41... Bhavisha Patel Fernanda Gutierrez-Rodrigues Neal S Young
May 21, 2025 at 12:11 PM
Excited to share our NHLBI group’s latest work, led by post-doc Hiroki Mizumaki, looking at the role of the adaptive and innate immune system in #VEXAS in @natcomms.nature.com www.nature.com/articles/s41... Bhavisha Patel Fernanda Gutierrez-Rodrigues Neal S Young
Congrats to FRENVEX for their study on azacitadine in #VEXAS led by Thibault Comont in @bloodjournal.bsky.social Confirmed inflammatory & hematologic responses in >50%. Molecular responses in >2/3rds! Toxicity common especially in first 3 cycles. ashpublications.org/blood/articl...
May 19, 2025 at 1:28 PM
Congrats to FRENVEX for their study on azacitadine in #VEXAS led by Thibault Comont in @bloodjournal.bsky.social Confirmed inflammatory & hematologic responses in >50%. Molecular responses in >2/3rds! Toxicity common especially in first 3 cycles. ashpublications.org/blood/articl...
The NIH goslings making an appearance this spring 🌸🪿
May 9, 2025 at 1:39 AM
The NIH goslings making an appearance this spring 🌸🪿
New multi center phase 2 study in @bloodadvances.bsky.social looking again at the role of eltrombopag in pediatric #SAA - overall underwhelming in the treatment naive setting. Possible role in relapsed/refractory though very low numbers ashpublications.org/bloodadvance...
May 7, 2025 at 5:32 PM
New multi center phase 2 study in @bloodadvances.bsky.social looking again at the role of eltrombopag in pediatric #SAA - overall underwhelming in the treatment naive setting. Possible role in relapsed/refractory though very low numbers ashpublications.org/bloodadvance...
Happy birthday to the OG NHLBI #BMFsm team! Dr. Neal S Young, staff scientist Dr. Sachiko Kajigaya and research nurse Olga Rios who have spent the last few decades at the NIH driving a clinical and translational research program which has led to astonishing progress in #SAA and other marrow failures
April 16, 2025 at 3:59 AM
Happy birthday to the OG NHLBI #BMFsm team! Dr. Neal S Young, staff scientist Dr. Sachiko Kajigaya and research nurse Olga Rios who have spent the last few decades at the NIH driving a clinical and translational research program which has led to astonishing progress in #SAA and other marrow failures
Very nice paper published in @natmedicine.bsky.social from the 🇮🇹 San Raffaele group showing upregulation of inflammatory and senescence markers in #VEXAS HSPCs with exhaustion of surrounding wild type cells. www.nature.com/articles/s41...
April 15, 2025 at 7:10 PM
Very nice paper published in @natmedicine.bsky.social from the 🇮🇹 San Raffaele group showing upregulation of inflammatory and senescence markers in #VEXAS HSPCs with exhaustion of surrounding wild type cells. www.nature.com/articles/s41...
Excited to see this work on #clonalhematopoiesis in #telomere disorders led by @daria-babushok.bsky.social @pennmedicine.bsky.social in @jclinical-invest.bsky.social - ATM mutations commonly observed. ATM-dependent DDR from telomere dysfunction key in disease pathogenesis www.jci.org/articles/vie...
April 7, 2025 at 6:38 PM
Excited to see this work on #clonalhematopoiesis in #telomere disorders led by @daria-babushok.bsky.social @pennmedicine.bsky.social in @jclinical-invest.bsky.social - ATM mutations commonly observed. ATM-dependent DDR from telomere dysfunction key in disease pathogenesis www.jci.org/articles/vie...
Looking for public comments on the @ash.hematology.org #AplasticAnemia guidelines - see here! www.hematology.org/education/cl...
April 3, 2025 at 5:44 PM
Looking for public comments on the @ash.hematology.org #AplasticAnemia guidelines - see here! www.hematology.org/education/cl...
Gene therapy for #telomere biology disorders 🧬! Report of first 2 patients @nejm.org evidence by Kas Myers using vector to increase expression of ZSCAN4 to elongate telomeres. Some TL elongation in HSPCs but low numbers. Will be interested to see more data! evidence.nejm.org/doi/pdf/10.1...
March 28, 2025 at 3:47 PM
Gene therapy for #telomere biology disorders 🧬! Report of first 2 patients @nejm.org evidence by Kas Myers using vector to increase expression of ZSCAN4 to elongate telomeres. Some TL elongation in HSPCs but low numbers. Will be interested to see more data! evidence.nejm.org/doi/pdf/10.1...
Excited to see our NHLBI work just published in @bloodadvances.bsky.social showing the negative effects of HLA alloimmunization in #SAA patients treated with immunosuppression. Lead by our former fellow Jibran Durrani now at UMiami ashpublications.org/bloodadvance... #BMFsm
March 23, 2025 at 10:55 PM
Excited to see our NHLBI work just published in @bloodadvances.bsky.social showing the negative effects of HLA alloimmunization in #SAA patients treated with immunosuppression. Lead by our former fellow Jibran Durrani now at UMiami ashpublications.org/bloodadvance... #BMFsm
Congrats to our former NHLBI @petermaccc.bsky.social fellow
Ashvind Prabahran who led this work looking at the immune features of megakaryocytes in #BMFsm just published in @bloodadvances.bsky.social 👇 ashpublications.org/bloodadvance... #SAA
Ashvind Prabahran who led this work looking at the immune features of megakaryocytes in #BMFsm just published in @bloodadvances.bsky.social 👇 ashpublications.org/bloodadvance... #SAA
March 23, 2025 at 10:45 PM
Congrats to our former NHLBI @petermaccc.bsky.social fellow
Ashvind Prabahran who led this work looking at the immune features of megakaryocytes in #BMFsm just published in @bloodadvances.bsky.social 👇 ashpublications.org/bloodadvance... #SAA
Ashvind Prabahran who led this work looking at the immune features of megakaryocytes in #BMFsm just published in @bloodadvances.bsky.social 👇 ashpublications.org/bloodadvance... #SAA
Happy Christmas to all from Ireland! 🇮🇪 🎄
December 26, 2024 at 4:38 PM
Happy Christmas to all from Ireland! 🇮🇪 🎄
Congrats to @jamesnolan.bsky.social (now at @pmresearch-uhn.bsky.social) on his #ASH24 abstract achievement award for his PhD research @tcddublin.bsky.social! @adrianbracken.bsky.social 🇮🇪🇨🇦 @ash-hematology.bsky.social #Lmsm #ASHKudos
December 10, 2024 at 5:49 PM
Congrats to @jamesnolan.bsky.social (now at @pmresearch-uhn.bsky.social) on his #ASH24 abstract achievement award for his PhD research @tcddublin.bsky.social! @adrianbracken.bsky.social 🇮🇪🇨🇦 @ash-hematology.bsky.social #Lmsm #ASHKudos
Beautiful view from the conference center at #ASH24 @ash-hematology.bsky.social 🌅
December 10, 2024 at 1:24 AM
Beautiful view from the conference center at #ASH24 @ash-hematology.bsky.social 🌅
Congrats to Denis O’Keeffe from
UHL for presenting the result of the 🇮🇪ish collaborative TILLIRI study - looking at #VTE prophylaxis in lower limb injuries. @ash-hematology.bsky.social #ASH24 @fniainle.bsky.social
UHL for presenting the result of the 🇮🇪ish collaborative TILLIRI study - looking at #VTE prophylaxis in lower limb injuries. @ash-hematology.bsky.social #ASH24 @fniainle.bsky.social
December 9, 2024 at 11:58 PM
Congrats to Denis O’Keeffe from
UHL for presenting the result of the 🇮🇪ish collaborative TILLIRI study - looking at #VTE prophylaxis in lower limb injuries. @ash-hematology.bsky.social #ASH24 @fniainle.bsky.social
UHL for presenting the result of the 🇮🇪ish collaborative TILLIRI study - looking at #VTE prophylaxis in lower limb injuries. @ash-hematology.bsky.social #ASH24 @fniainle.bsky.social
Congrats to NHLBI‘s John Tisdale for winning the @ash-hematology.bsky.social #ASH24 Beutler Prize! #SCD #ASHKudos
December 9, 2024 at 10:08 PM
Congrats to NHLBI‘s John Tisdale for winning the @ash-hematology.bsky.social #ASH24 Beutler Prize! #SCD #ASHKudos
Former NHLBI fellow Jibran Durrani (now @miamirosenstiel.bsky.social) presenting our group’s work on complement mediated immune activation in #SAA with HLA alloimmunisation. #ASH24 @ash-hematology.bsky.social
December 9, 2024 at 7:48 AM
Former NHLBI fellow Jibran Durrani (now @miamirosenstiel.bsky.social) presenting our group’s work on complement mediated immune activation in #SAA with HLA alloimmunisation. #ASH24 @ash-hematology.bsky.social
Check out my NHLBI colleague Bhavisha Patel‘s poster reporting our work in patient reported outcomes in #VEXAS. Patients reported high symptom burden. #ASH24 @ash-hematology.bsky.social
December 9, 2024 at 7:43 AM
Check out my NHLBI colleague Bhavisha Patel‘s poster reporting our work in patient reported outcomes in #VEXAS. Patients reported high symptom burden. #ASH24 @ash-hematology.bsky.social
Amazing talk from our NHLBI fellow Nick Lee presenting long-term results from our high-dose Danazol protocol for patients with #TBD. #ASH24 @ash-hematology.bsky.social
December 8, 2024 at 5:58 PM
Amazing talk from our NHLBI fellow Nick Lee presenting long-term results from our high-dose Danazol protocol for patients with #TBD. #ASH24 @ash-hematology.bsky.social
Check out our former NHLBI fellow (now at @miamirosenstiel.bsky.social!) JibranDurrani’s #ASH24 poster looking at more selective JAKi in our immune BMF model. @ash-hematology.bsky.social #BMFsm
December 8, 2024 at 3:49 PM
Check out our former NHLBI fellow (now at @miamirosenstiel.bsky.social!) JibranDurrani’s #ASH24 poster looking at more selective JAKi in our immune BMF model. @ash-hematology.bsky.social #BMFsm
Meeting with my Irish 🇮🇪 contingent at #ASH24! @ash-hematology.bsky.social Nina Orfali and Paul Browne
December 8, 2024 at 6:52 AM
Meeting with my Irish 🇮🇪 contingent at #ASH24! @ash-hematology.bsky.social Nina Orfali and Paul Browne