Ellen Hanna Singleton, PhD
@ehsingleton.bsky.social
Post-doc @goteborgsuni | former post-doc @LundUniversity
| former PhD student @AlzheimerAms | cognition, imaging and fluid biomarkers in #AD | 🏴🇳🇱🇸🇪
| former PhD student @AlzheimerAms | cognition, imaging and fluid biomarkers in #AD | 🏴🇳🇱🇸🇪
Reposted by Ellen Hanna Singleton, PhD
The REAL AD team has arrived in Vienna for #ADPD2025 ! 🇦🇹🧠 ✨
We are excited to share our latest work and connect with fellow colleagues at the conference.
Come find us at our team talks and poster sessions - @michaelschoell.bsky.social, @ehsingleton.bsky.social
#EndAlz #Alzheimersresearch
We are excited to share our latest work and connect with fellow colleagues at the conference.
Come find us at our team talks and poster sessions - @michaelschoell.bsky.social, @ehsingleton.bsky.social
#EndAlz #Alzheimersresearch
March 31, 2025 at 3:09 PM
The REAL AD team has arrived in Vienna for #ADPD2025 ! 🇦🇹🧠 ✨
We are excited to share our latest work and connect with fellow colleagues at the conference.
Come find us at our team talks and poster sessions - @michaelschoell.bsky.social, @ehsingleton.bsky.social
#EndAlz #Alzheimersresearch
We are excited to share our latest work and connect with fellow colleagues at the conference.
Come find us at our team talks and poster sessions - @michaelschoell.bsky.social, @ehsingleton.bsky.social
#EndAlz #Alzheimersresearch
Reposted by Ellen Hanna Singleton, PhD
We now have a blood biomarker that is even more strongly associated with tau PET and cognitive symptoms than even p-tau217! Plasma eMTBR-tau243 will help us to understand whether cognitive impairment is likely to be related to Alzheimer's pathology. #ENDALZ
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease - Nature Medicine
Plasma eMTBR-tau243 is a specific biomarker of tau tangles in Alzheimer’s disease and enables the detecting and tracking of Alzheimer’s clinical impairment.
www.nature.com
March 31, 2025 at 2:56 PM
We now have a blood biomarker that is even more strongly associated with tau PET and cognitive symptoms than even p-tau217! Plasma eMTBR-tau243 will help us to understand whether cognitive impairment is likely to be related to Alzheimer's pathology. #ENDALZ
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ellen Hanna Singleton, PhD
it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease
www.nature.com/articles/s41...
led by Michael Heneka, published in @natrevimmunol.bsky.social today
(MANY more authors listed and linked below)
www.nature.com/articles/s41...
led by Michael Heneka, published in @natrevimmunol.bsky.social today
(MANY more authors listed and linked below)
Neuroinflammation in Alzheimer disease - Nature Reviews Immunology
This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...
www.nature.com
December 10, 2024 at 3:03 AM
it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease
www.nature.com/articles/s41...
led by Michael Heneka, published in @natrevimmunol.bsky.social today
(MANY more authors listed and linked below)
www.nature.com/articles/s41...
led by Michael Heneka, published in @natrevimmunol.bsky.social today
(MANY more authors listed and linked below)
Reposted by Ellen Hanna Singleton, PhD
@zimmerneurolab.bsky.social debut here in 🦋 with an autoradiographic head-to-head study comparing tau PET tracers in the postmortem brain tissue 👇
📄 In a new study just published in the Journal of Nuclear Medicine, our PhD student #AntonioAliaga, in collaboration with #Prof.PedroRosa-Neto's team, evaluated the binding properties of tau radiotracers in postmortem human brain tissue in the context of AD. 👇 1/n jnm.snmjournals.org/content/earl...
Comparison Between Brain and Cerebellar Autoradiography Using [18F]Flortaucipir, [18F]MK6240, and [18F]PI2620 in Postmortem Human Brain Tissue
Our objective was to evaluate the in vitro binding properties of [18F]flortaucipir, 6-(fluoro-18F)-3-(1 H -pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]MK6240), and 2-(2-([18F]fluoro)pyridin-4...
jnm.snmjournals.org
November 25, 2024 at 6:34 PM
@zimmerneurolab.bsky.social debut here in 🦋 with an autoradiographic head-to-head study comparing tau PET tracers in the postmortem brain tissue 👇
Reposted by Ellen Hanna Singleton, PhD
Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP
doi.org/10.1007/s004...
doi.org/10.1007/s004...
Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies - Acta Neuropathologica
Tau PET has attracted increasing interest as an imaging biomarker for 4-repeat (4R)-tauopathy progressive supranuclear palsy (PSP). However, the translation of in vitro 4R-tau binding to in vivo tau P...
doi.org
November 25, 2024 at 5:59 PM
Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP
doi.org/10.1007/s004...
doi.org/10.1007/s004...