Enrico Carlon
@ecarlon.bsky.social
Professor @KU Leuven, Statistical and Computational Physics, Interested in DNA (Statistical)-mechanics, Chromatin Structure, Biomolecular Condensates
Left X-Twitter on Nov. 2024 - building up a new community here!
Left X-Twitter on Nov. 2024 - building up a new community here!
Congratulations to Giandomenico Vanore on being awarded a PhD Fellowship by @fwovlaanderen.bsky.social
He will conduct his doctoral research under my supervision on the project “Understanding the structure of interphase chromosomes.”
#statistical_physics #polymers #chromatin #MD_simulations
He will conduct his doctoral research under my supervision on the project “Understanding the structure of interphase chromosomes.”
#statistical_physics #polymers #chromatin #MD_simulations
November 4, 2025 at 3:01 PM
Congratulations to Giandomenico Vanore on being awarded a PhD Fellowship by @fwovlaanderen.bsky.social
He will conduct his doctoral research under my supervision on the project “Understanding the structure of interphase chromosomes.”
#statistical_physics #polymers #chromatin #MD_simulations
He will conduct his doctoral research under my supervision on the project “Understanding the structure of interphase chromosomes.”
#statistical_physics #polymers #chromatin #MD_simulations
Reposted by Enrico Carlon
Working on biosensors? Don’t miss this MDPI webinar introducing thermal biosensing via the heat-transfer method (HTM) — a simple yet powerful way to detect biomolecular interactions and monitor cells.
Pioneers of HTM will share their insights!
#Biosensors #HTM
More info: sciforum.net/event/Sensor...
Pioneers of HTM will share their insights!
#Biosensors #HTM
More info: sciforum.net/event/Sensor...
October 8, 2025 at 12:16 PM
Working on biosensors? Don’t miss this MDPI webinar introducing thermal biosensing via the heat-transfer method (HTM) — a simple yet powerful way to detect biomolecular interactions and monitor cells.
Pioneers of HTM will share their insights!
#Biosensors #HTM
More info: sciforum.net/event/Sensor...
Pioneers of HTM will share their insights!
#Biosensors #HTM
More info: sciforum.net/event/Sensor...
🧬 Seminar Alert!
Join us next Friday 17 Oct. for “Mechanics, Dynamics and Shape in Oocytes” by Dr. Bart Vos — a deep dive into how physical forces and cell mechanics shape early development.
Discover the emerging field of mechanobiology, where physics meets life.
Join us next Friday 17 Oct. for “Mechanics, Dynamics and Shape in Oocytes” by Dr. Bart Vos — a deep dive into how physical forces and cell mechanics shape early development.
Discover the emerging field of mechanobiology, where physics meets life.
October 14, 2025 at 4:20 PM
🧬 Seminar Alert!
Join us next Friday 17 Oct. for “Mechanics, Dynamics and Shape in Oocytes” by Dr. Bart Vos — a deep dive into how physical forces and cell mechanics shape early development.
Discover the emerging field of mechanobiology, where physics meets life.
Join us next Friday 17 Oct. for “Mechanics, Dynamics and Shape in Oocytes” by Dr. Bart Vos — a deep dive into how physical forces and cell mechanics shape early development.
Discover the emerging field of mechanobiology, where physics meets life.
Interest in pursuing a PhD/postdoctoral position in experimental Condensed Matter Physics with applications to biological systems? Don’t miss this opportunity from the "Small Biosystems Lab" felixritortlab.com UBarcelona which combines statistical physics with single-molecule experimental techniques
October 14, 2025 at 8:58 AM
Interest in pursuing a PhD/postdoctoral position in experimental Condensed Matter Physics with applications to biological systems? Don’t miss this opportunity from the "Small Biosystems Lab" felixritortlab.com UBarcelona which combines statistical physics with single-molecule experimental techniques
New preprint! With Takahiro Sakaue we studied an active polymer dynamics focusing on the mean-square displacement of a monomer. We show that the MSD can be described by a simple compounding formula linking an isolated monomer MSD with tension propagation along the chain -
arxiv.org/abs/2510.07949
arxiv.org/abs/2510.07949
Compounding formula approach to chromatin and active polymer dynamics
Active polymers are ubiquitous in nature, and often kicked by persistent noises that break detailed balance. In order to capture the out-of-equilibrium dynamics of such active polymers, we propose a s...
arxiv.org
October 12, 2025 at 4:03 PM
New preprint! With Takahiro Sakaue we studied an active polymer dynamics focusing on the mean-square displacement of a monomer. We show that the MSD can be described by a simple compounding formula linking an isolated monomer MSD with tension propagation along the chain -
arxiv.org/abs/2510.07949
arxiv.org/abs/2510.07949
Traveling back after an exciting three days meeting of the MeChaNiSM Doctoral Network @mechanism-network.bsky.social - Thanks to all students, PIs and supporting staff for these intense days of scientific discussions about our projects on DNA/RNA mechanics. www.chalmers.se/en/projects/...
MeChaNiSM
Mechanical Characterization of Nucleic acids using Single Molecule techniques
www.chalmers.se
October 10, 2025 at 12:10 PM
Traveling back after an exciting three days meeting of the MeChaNiSM Doctoral Network @mechanism-network.bsky.social - Thanks to all students, PIs and supporting staff for these intense days of scientific discussions about our projects on DNA/RNA mechanics. www.chalmers.se/en/projects/...
New preprint out! We investigate DNA kinks using biased all-atom MD simulations, in collaboration with Arianna Fassino and Aderik Voorspoels @aderikvoorspoels.bsky.social, as part of the EU-funded Doctoral Network MeChaNiSM @mechanism-network.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Inferring DNA kinkability from biased MD simulations
In several biological processes, such as looping, supercoiling and DNA-protein interactions, DNA is subject to very strong deformations. While coarse-grained models often approximate DNA as a smoothly...
www.biorxiv.org
September 14, 2025 at 6:51 AM
New preprint out! We investigate DNA kinks using biased all-atom MD simulations, in collaboration with Arianna Fassino and Aderik Voorspoels @aderikvoorspoels.bsky.social, as part of the EU-funded Doctoral Network MeChaNiSM @mechanism-network.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Enrico Carlon
📢Seminar 11 September at 12h, Faculty of Science, Seminar Room Module 5
@cienciasuam.bsky.social @uam.es
Enrico Carlon @ecarlon.bsky.social from KU Leuven
will talk about DNA mechanics beyond the twistable wormlike chain. See you there!
ifimac.uam.es/ifimac-semin...
@cienciasuam.bsky.social @uam.es
Enrico Carlon @ecarlon.bsky.social from KU Leuven
will talk about DNA mechanics beyond the twistable wormlike chain. See you there!
ifimac.uam.es/ifimac-semin...
September 4, 2025 at 8:12 AM
📢Seminar 11 September at 12h, Faculty of Science, Seminar Room Module 5
@cienciasuam.bsky.social @uam.es
Enrico Carlon @ecarlon.bsky.social from KU Leuven
will talk about DNA mechanics beyond the twistable wormlike chain. See you there!
ifimac.uam.es/ifimac-semin...
@cienciasuam.bsky.social @uam.es
Enrico Carlon @ecarlon.bsky.social from KU Leuven
will talk about DNA mechanics beyond the twistable wormlike chain. See you there!
ifimac.uam.es/ifimac-semin...
Reposted by Enrico Carlon
Applicants wanted 5:
Open position for PhD Student Studying Vitro Single-molecule Transport Across Peroxisome Mimics
careers.tudelft.nl/job/Delft-Ph...
Open position for PhD Student Studying Vitro Single-molecule Transport Across Peroxisome Mimics
careers.tudelft.nl/job/Delft-Ph...
August 22, 2025 at 8:52 AM
Applicants wanted 5:
Open position for PhD Student Studying Vitro Single-molecule Transport Across Peroxisome Mimics
careers.tudelft.nl/job/Delft-Ph...
Open position for PhD Student Studying Vitro Single-molecule Transport Across Peroxisome Mimics
careers.tudelft.nl/job/Delft-Ph...
Interesting paper by Tony Lemos and Harold Kim. DNA minicircles adopt a specific inside-out orientation. Previously predicted, now this effect has been observed in atomic force microscopy (AFM) experiments!
arxiv.org/abs/2508.15091
arxiv.org/abs/2508.15091
Visualizing Poloidal Orientation in DNA Minicircles
A short (<150 bp) double-stranded DNA (dsDNA) molecule ligated end-to-end forms a DNA minicircle. Due to sequence-dependent, nonuniform bending energetics, such a minicircle is predicted to adopt a ce...
arxiv.org
August 22, 2025 at 3:51 PM
Interesting paper by Tony Lemos and Harold Kim. DNA minicircles adopt a specific inside-out orientation. Previously predicted, now this effect has been observed in atomic force microscopy (AFM) experiments!
arxiv.org/abs/2508.15091
arxiv.org/abs/2508.15091
Enjoying this workshop on the Statistical Mechanics of polymers in Venice these days...
Great program and organization!
userswww.pd.infn.it/~orlandin/Ve...
Great program and organization!
userswww.pd.infn.it/~orlandin/Ve...
July 21, 2025 at 12:19 PM
Enjoying this workshop on the Statistical Mechanics of polymers in Venice these days...
Great program and organization!
userswww.pd.infn.it/~orlandin/Ve...
Great program and organization!
userswww.pd.infn.it/~orlandin/Ve...
New preprint! Collaboration with Andrea Bonato, Sergey Kitaev, Davide Marenduzzo and Enzo Orlandini
arxiv.org/abs/2507.00520
arxiv.org/abs/2507.00520
Topological weight and structural diversity of polydisperse chromatin loop networks
Current biophysical models for transcriptionally active chromatin view this as a polymer with sticky sites, mimicking transcription units such as promoters and enhancers which interact via the binding...
arxiv.org
July 9, 2025 at 7:42 PM
New preprint! Collaboration with Andrea Bonato, Sergey Kitaev, Davide Marenduzzo and Enzo Orlandini
arxiv.org/abs/2507.00520
arxiv.org/abs/2507.00520
Very happy that our latest publication "Statistical mechanics of multiplectoneme phases in DNA" doi.org/10.1103/Phys... was selected as Editors' Suggestion. These suggestions list "a small number of papers that the editors and referees find of particular interest, importance, or clarity". (1/4)
doi.org
April 22, 2025 at 6:43 PM
Very happy that our latest publication "Statistical mechanics of multiplectoneme phases in DNA" doi.org/10.1103/Phys... was selected as Editors' Suggestion. These suggestions list "a small number of papers that the editors and referees find of particular interest, importance, or clarity". (1/4)
A 3 year ERC-funded post-doc position in the Broedersz group of @vuamsterdam.bsky.social. Topic: Statistical physics of Chromosomes
workingat.vu.nl/vacancies/po...
workingat.vu.nl/vacancies/po...
Vacancy — Post Doc: Statistical physics of chromosomes
The Broedersz group (Theoretical physics of life) has an ERC funded opening for a 3-year Post Doc position on the statistical and dynamic organization of chromosomes.
workingat.vu.nl
April 3, 2025 at 3:25 PM
A 3 year ERC-funded post-doc position in the Broedersz group of @vuamsterdam.bsky.social. Topic: Statistical physics of Chromosomes
workingat.vu.nl/vacancies/po...
workingat.vu.nl/vacancies/po...
Reposted by Enrico Carlon
Exciting news! PoL@KUL invites you to the inaugural lecture of the International Francqui Professor 2024-25, Prof. Davide Marenduzzo (U. of Edinburgh) on Tuesday, April 29, 2025 in Leuven:
Biophysical principles of chromosome organisation
Info and registration:
fys.kuleuven.be/english/coll...
Biophysical principles of chromosome organisation
Info and registration:
fys.kuleuven.be/english/coll...
April 3, 2025 at 1:50 PM
Exciting news! PoL@KUL invites you to the inaugural lecture of the International Francqui Professor 2024-25, Prof. Davide Marenduzzo (U. of Edinburgh) on Tuesday, April 29, 2025 in Leuven:
Biophysical principles of chromosome organisation
Info and registration:
fys.kuleuven.be/english/coll...
Biophysical principles of chromosome organisation
Info and registration:
fys.kuleuven.be/english/coll...
Welcome to Arianna Fassino who has recently joined our group to start a PhD project on simulations of Nucleic Acids Mechanics. The project is part of a EU-Marie Skłodowska Curie Doctoral Network “MeChaNiSM” Mechanical Characterization of Nucleic acids - www.chalmers.se/en/projects/...
MeChaNiSM
Mechanical Characterization of Nucleic acids using Single Molecule techniques
www.chalmers.se
March 31, 2025 at 9:14 AM
Welcome to Arianna Fassino who has recently joined our group to start a PhD project on simulations of Nucleic Acids Mechanics. The project is part of a EU-Marie Skłodowska Curie Doctoral Network “MeChaNiSM” Mechanical Characterization of Nucleic acids - www.chalmers.se/en/projects/...
Reposted by Enrico Carlon
Apply now for our international Master of Science in Physics of Life @biozentrum.unibas.ch @unibasel.ch! Scholarships available.
More information: www.biozentrum.unibas.ch/education/de...
#Master #Students #Research #Physics #Mathematics #ComputerScience #Engineering #Basel #Switzerland
More information: www.biozentrum.unibas.ch/education/de...
#Master #Students #Research #Physics #Mathematics #ComputerScience #Engineering #Basel #Switzerland
March 20, 2025 at 8:10 AM
Apply now for our international Master of Science in Physics of Life @biozentrum.unibas.ch @unibasel.ch! Scholarships available.
More information: www.biozentrum.unibas.ch/education/de...
#Master #Students #Research #Physics #Mathematics #ComputerScience #Engineering #Basel #Switzerland
More information: www.biozentrum.unibas.ch/education/de...
#Master #Students #Research #Physics #Mathematics #ComputerScience #Engineering #Basel #Switzerland
Reposted by Enrico Carlon
Very pleased to share our new story on SMC complexes, a great team effort from @roisnehamelinf.bsky.social, @taschner.bsky.social in the GruberLab and James of @dnatopologylab.bsky.social We find that SMC hinge domains are ssDNA gates to facilitate obstacle bypass during DNA loop extrusion!
March 18, 2025 at 8:03 AM
Very pleased to share our new story on SMC complexes, a great team effort from @roisnehamelinf.bsky.social, @taschner.bsky.social in the GruberLab and James of @dnatopologylab.bsky.social We find that SMC hinge domains are ssDNA gates to facilitate obstacle bypass during DNA loop extrusion!
Reposted by Enrico Carlon
Now, 20+ years later, our lab revisits the hinge using the anti-plasmid SMC complex Wadjet. We show that the SMC hinge is a DNA gate—an obstacle bypass gate selective for ssDNA, used to navigate chromosomal barriers during DNA loop extrusion.
March 18, 2025 at 7:56 AM
Now, 20+ years later, our lab revisits the hinge using the anti-plasmid SMC complex Wadjet. We show that the SMC hinge is a DNA gate—an obstacle bypass gate selective for ssDNA, used to navigate chromosomal barriers during DNA loop extrusion.
Reposted by Enrico Carlon
Yet another preprint from the lab—this one is personal. During my PhD, I ended up working on the cohesin SMC hinge, showing its role in sister chromatid cohesion and proposing it as a DNA entry gate in the SMC ring. But the details have remained mysterious and controversial.
March 18, 2025 at 7:55 AM
Yet another preprint from the lab—this one is personal. During my PhD, I ended up working on the cohesin SMC hinge, showing its role in sister chromatid cohesion and proposing it as a DNA entry gate in the SMC ring. But the details have remained mysterious and controversial.
Reposted by Enrico Carlon
Hinge bypass can explain some otherwise-difficult to explain observations made by colleagues using single molecule imaging and by simulating chromosome folding. DNA loop-extruding SMC complexes turn out to be even a bit more wonderful.
March 18, 2025 at 7:57 AM
Hinge bypass can explain some otherwise-difficult to explain observations made by colleagues using single molecule imaging and by simulating chromosome folding. DNA loop-extruding SMC complexes turn out to be even a bit more wonderful.
Reposted by Enrico Carlon
Awesome teamwork and important initial insights from @drhonsworth.bsky.social @roisnehamelinf.bsky.social @taschner.bsky.social with great additions from Madhu @dnatopologylab.bsky.social and James. See for yourself at: www.biorxiv.org/content/10.1...
The SMC Hinge is a Selective Gate for Obstacle Bypass
DNA loop-extruding SMC complexes play vital roles in genome maintenance and DNA immunity. However, the ability of these ring-shaped DNA motors to navigate large DNA-bound obstacles, such as DNA/RNA po...
www.biorxiv.org
March 18, 2025 at 7:57 AM
Awesome teamwork and important initial insights from @drhonsworth.bsky.social @roisnehamelinf.bsky.social @taschner.bsky.social with great additions from Madhu @dnatopologylab.bsky.social and James. See for yourself at: www.biorxiv.org/content/10.1...
Reposted by Enrico Carlon
Our new review on how the #chromatin domain is formed in the cell is now available @Curr Opin Struct Biol.📄✨
We critically discuss the domain formation mechanism from a physical perspective, including #phase-separation and #condensation.
📥 Free-download link:
authors.elsevier.com/a/1keGn,LqAr...
We critically discuss the domain formation mechanism from a physical perspective, including #phase-separation and #condensation.
📥 Free-download link:
authors.elsevier.com/a/1keGn,LqAr...
February 20, 2025 at 11:15 AM
Our new review on how the #chromatin domain is formed in the cell is now available @Curr Opin Struct Biol.📄✨
We critically discuss the domain formation mechanism from a physical perspective, including #phase-separation and #condensation.
📥 Free-download link:
authors.elsevier.com/a/1keGn,LqAr...
We critically discuss the domain formation mechanism from a physical perspective, including #phase-separation and #condensation.
📥 Free-download link:
authors.elsevier.com/a/1keGn,LqAr...
Just published in J Chem Phys @aip.bsky.social special issue on "Chromatin Structure and Dynamics". I will tell more on this work in a future post. Collaboration with @lremini.bsky.social, M. Segers and A. Parmeggiani.
doi.org/10.1063/5.02...
doi.org/10.1063/5.02...
Inferring interphase chromosomal structure from multiplexed fluorescence in situ hybridization data: A unified picture from human and mouse cells
We analyze multiplexed fluorescence in situ hybridization (m-FISH) data for human and mouse cell lines. The m-FISH technique uses fluorescently-labeled single-s
doi.org
February 5, 2025 at 1:17 PM
Just published in J Chem Phys @aip.bsky.social special issue on "Chromatin Structure and Dynamics". I will tell more on this work in a future post. Collaboration with @lremini.bsky.social, M. Segers and A. Parmeggiani.
doi.org/10.1063/5.02...
doi.org/10.1063/5.02...
Reposted by Enrico Carlon
Is chromatin ordered or disordered? It all depends on the linker DNA length.
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
December 24, 2024 at 9:48 AM
Is chromatin ordered or disordered? It all depends on the linker DNA length.
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets
Check our latest work with Mike Rosen and Sy Redding. We explore how changes in linker DNA length (as small as 1 bp) fine-tune chromatin structure, between order and disorder, and the properties of chromatin droplets