Drice Challal
dricechallal.bsky.social
Drice Challal
@dricechallal.bsky.social
Gene regulation, RNA, RBP
Assistant Professor, Université Paris Cité, EGM - IBPC, CNRS
Pinned
Thrilled to see our story now out at @naturecomms.bsky.social
A shared adventure with Estelle Leroy and Mathieu Rougemaille @i2bcparissaclay.bsky.social, and with the precious help of the @palancadelab.bsky.social
Such a tiny RNA with such a wide range of functions
www.nature.com/articles/s41...
Reposted by Drice Challal
🚨 New preprint! 🚨
We just dropped our latest work on RNA-binding proteins and sporulation in B. subtilis! Turns out, the RBP landscape gets a major remix during sporulation 👀. Check it out here 👉 www.biorxiv.org/content/10.1...
#RBP #RNA #sporulation #Bacillus #microbiology @lcbofficiel.bsky.social
Remodeling of RNA-Binding Proteome and RNA-mediated regulation as a new layer of control of sporulation
Sporulation allows certain bacteria to survive extreme conditions for extended periods posing challenges to public health and food safety. Transcriptional level of regulation relying on σ factors has ...
www.biorxiv.org
April 15, 2025 at 9:27 AM
Reposted by Drice Challal
I am thrilled to share this new preprint from our lab!
We find (>800!) 30S binding sites in hundreds of 5'UTRs, but also new dynamic steps of translation initiation.
www.biorxiv.org/content/10.1...
Congrats to all co-authors at the RNA control of gene expression lab, IBPC CNRS
(Thread, 1/6)
30S-seq redefines the bacterial Ribosome Binding Site
The translation initiation step is rate limiting for the efficiency of gene expression in all organisms. However, the mechanism of ribosome recruitment to mRNA start sites strikingly differs between e...
www.biorxiv.org
April 6, 2025 at 7:53 AM
Thrilled to see our story now out at @naturecomms.bsky.social
A shared adventure with Estelle Leroy and Mathieu Rougemaille @i2bcparissaclay.bsky.social, and with the precious help of the @palancadelab.bsky.social
Such a tiny RNA with such a wide range of functions
www.nature.com/articles/s41...
April 5, 2025 at 10:11 AM
Reposted by Drice Challal
Happy to share our genetic toolkit designed to make your gene editing (life) easier, faster and very efficient!

Also suitable to build saturated chromosomal variant libraries using oligo-recombineering with extra short homology arms!

www.biorxiv.org/content/10.1...
March 21, 2025 at 7:06 AM
Merci beaucoup for your precious contribution to this work !

@I2BCParisSaclay

x.com/ASadylab/statu…
March 22, 2025 at 11:08 AM
My main Ph.D project on the role of General Regulatory Factors in protecting promoters from ectopic and divergent transcription initiation is now available. So enthusiastic to finally see the result of this great adventure with @DomenicoLibri @LabLibri
@MolecularCell

x.com/MolecularCell/…
March 22, 2025 at 11:08 AM