Emily Edwards
@dremmye.bsky.social
British-Australian Immunologist, Rare Diseases Researcher at Monash Uni and patient advocate (AusPIPS), interested in genetics and its role in impairing immune function in #primaryimmunodeficiencies, towards improved diagnosis and treatment
#Immunology
#Immunology
Reposted by Emily Edwards
Single-Cell Multi-Omics Dissects Transcript Isoform and Immune Repertoire Dynamics in Human Immunosenescence https://www.biorxiv.org/content/10.1101/2025.11.21.689731v1
November 22, 2025 at 2:15 AM
Single-Cell Multi-Omics Dissects Transcript Isoform and Immune Repertoire Dynamics in Human Immunosenescence https://www.biorxiv.org/content/10.1101/2025.11.21.689731v1
Reposted by Emily Edwards
A PIK3delta inhibitor for ALPS:
Leniolisib reduced lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome url: rupress.org/jhi/article/...
Leniolisib reduced lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome url: rupress.org/jhi/article/...
Leniolisib reduced lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome | Journal of Human Immunity | Rockefeller University Press
Treating patients with ALPS can be challenging. This article examines the efficacy of leniolisib, a selective PI3Kδ inhibitor, in a murine model of ALPS, i
rupress.org
November 20, 2025 at 7:34 AM
A PIK3delta inhibitor for ALPS:
Leniolisib reduced lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome url: rupress.org/jhi/article/...
Leniolisib reduced lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome url: rupress.org/jhi/article/...
Reposted by Emily Edwards
Data-driven forecasting of Flu, RSV, and COVID-19 related outcomes in the United States and Canada via Hankel dynamic mode decomposition https://www.medrxiv.org/content/10.1101/2025.11.12.25339917v1
November 18, 2025 at 5:44 AM
Data-driven forecasting of Flu, RSV, and COVID-19 related outcomes in the United States and Canada via Hankel dynamic mode decomposition https://www.medrxiv.org/content/10.1101/2025.11.12.25339917v1
Reposted by Emily Edwards
Predicting long-term waning of anti-spike antibody-dependent protection against COVID-19 across diverse SARS-CoV-2 immune histories https://www.medrxiv.org/content/10.1101/2025.11.14.25340279v1
November 18, 2025 at 6:43 AM
Predicting long-term waning of anti-spike antibody-dependent protection against COVID-19 across diverse SARS-CoV-2 immune histories https://www.medrxiv.org/content/10.1101/2025.11.14.25340279v1
Reposted by Emily Edwards
Circulating biomarkers of bronchoalveolar injury help predict the need for mechanical ventilation in patients with moderate to severe COVID-19 pneumonia: a prospective cohort study https://www.medrxiv.org/content/10.1101/2025.11.16.25340358v1
November 18, 2025 at 5:43 PM
Circulating biomarkers of bronchoalveolar injury help predict the need for mechanical ventilation in patients with moderate to severe COVID-19 pneumonia: a prospective cohort study https://www.medrxiv.org/content/10.1101/2025.11.16.25340358v1
Reposted by Emily Edwards
@jengommerman.bsky.social lab investigate an animal model of progressive #MultipleSclerosis & uncover a population of anti-CD20–resistant dural B cells that remain in the brain parenchyma at disease remission rupress.org/jem/article/...
📘 In #Neuroscience 2025: rupress.org/jem/collecti...
#SfN25
📘 In #Neuroscience 2025: rupress.org/jem/collecti...
#SfN25
November 16, 2025 at 4:15 PM
@jengommerman.bsky.social lab investigate an animal model of progressive #MultipleSclerosis & uncover a population of anti-CD20–resistant dural B cells that remain in the brain parenchyma at disease remission rupress.org/jem/article/...
📘 In #Neuroscience 2025: rupress.org/jem/collecti...
#SfN25
📘 In #Neuroscience 2025: rupress.org/jem/collecti...
#SfN25
Reposted by Emily Edwards
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
November 11, 2025 at 12:52 PM
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
Proud to share our new preprint revealing how patients with inborn errors of immunity respond to 3 doses of COVID-19 vaccination. A fantastic collaboration between clinicians & scientists.
Monash University, Alfred Health, Monash Health, Burnet Institute, BD, Erasmus MC
medrxiv.org/cgi/content/...
Monash University, Alfred Health, Monash Health, Burnet Institute, BD, Erasmus MC
medrxiv.org/cgi/content/...
Third dose COVID-19 vaccination elicits immune memory in patients with inborn errors of immunity even in absence of neutralizing antibodies
Background: Immunocompromised people, including those with Inborn Errors of Immunity (IEI), are at increased risk of severe disease from viral infections. Therefore, regular booster vaccinations are r...
medrxiv.org
November 14, 2025 at 2:36 AM
Proud to share our new preprint revealing how patients with inborn errors of immunity respond to 3 doses of COVID-19 vaccination. A fantastic collaboration between clinicians & scientists.
Monash University, Alfred Health, Monash Health, Burnet Institute, BD, Erasmus MC
medrxiv.org/cgi/content/...
Monash University, Alfred Health, Monash Health, Burnet Institute, BD, Erasmus MC
medrxiv.org/cgi/content/...
Reposted by Emily Edwards
Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes @science.org @shaleklab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 23, 2025 at 6:51 PM
Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes @science.org @shaleklab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
I’m excited to share our newly published paper. Only the second report of Spleen Tyrosine Kinase (SYK) gain-of-function. We detail the clinical, immunological, and genetic features of an adult with primary immunodeficiency and autoinflammation in the Journal of Clinical Immunology:
🔗 rdcu.be/eLWFr
🔗 rdcu.be/eLWFr
Novel SYK Variant Causes Enhanced SYK Autophosphorylation and PI3K Activation in an Antibody-Deficient Patient
rdcu.be
October 22, 2025 at 7:04 PM
I’m excited to share our newly published paper. Only the second report of Spleen Tyrosine Kinase (SYK) gain-of-function. We detail the clinical, immunological, and genetic features of an adult with primary immunodeficiency and autoinflammation in the Journal of Clinical Immunology:
🔗 rdcu.be/eLWFr
🔗 rdcu.be/eLWFr
Proud to be talking at this webinar on the 8th of October alongside Ig therapy manufacturers, patients receiving therapy, clinicians and SCIg nurses.
#patientawareness
#patientawareness
Join us on 8th October in our webinar with Immune Deficiency Foundation of Australia (IDFA). Our Vice President @dremmye.bsky.social talk about what Ig is, and how this treatment aims to protect from infection. Alongside presentations on the benefits of Ig therapy!
Register here: lnkd.in/dwUj3Mec
Register here: lnkd.in/dwUj3Mec
September 17, 2025 at 5:13 AM
Proud to be talking at this webinar on the 8th of October alongside Ig therapy manufacturers, patients receiving therapy, clinicians and SCIg nurses.
#patientawareness
#patientawareness
Reposted by Emily Edwards
New content online:
Immune-cell profiling to guide stratification and treatment of patients with rheumatic diseases
Nature Reviews Rheumatology, Published online: 01 September 2025; doi:10.1038/s41584-025-01291-0In this Review article, the potential of cytometry- and single-cell RNA sequencing-based immune profiling for aiding the diagnosis and personalized treatment of rheumatic diseases is discussed.
bit.ly
September 1, 2025 at 4:01 PM
New content online:
Reposted by Emily Edwards
Genetic regulation of cell type–specific chromatin accessibility shapes immune function and disease risk @medrxivpreprint.bsky.social @anglixue.bsky.social @drjosephpowell.bsky.social
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
September 3, 2025 at 3:34 AM
Genetic regulation of cell type–specific chromatin accessibility shapes immune function and disease risk @medrxivpreprint.bsky.social @anglixue.bsky.social @drjosephpowell.bsky.social
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Emily Edwards
Shared Immune and Epigenetic Pathways in Systemic Lupus Erythematosus and Melanoma Immunotherapy: A Cross-Disease Analysis with Prognostic and Therapeutic Implications https://www.biorxiv.org/content/10.1101/2025.08.19.671053v1
August 24, 2025 at 6:15 AM
Shared Immune and Epigenetic Pathways in Systemic Lupus Erythematosus and Melanoma Immunotherapy: A Cross-Disease Analysis with Prognostic and Therapeutic Implications https://www.biorxiv.org/content/10.1101/2025.08.19.671053v1
From lab bench to Parliament House, a few weeks ago, I was proud to bring the voices of patient advocacy and rare disease research to advocate for equitable and fair access to vaccination and blood products.
With this dual lens, I added evidence-based insights to strengthen the case for change.
With this dual lens, I added evidence-based insights to strengthen the case for change.
August 15, 2025 at 5:32 AM
From lab bench to Parliament House, a few weeks ago, I was proud to bring the voices of patient advocacy and rare disease research to advocate for equitable and fair access to vaccination and blood products.
With this dual lens, I added evidence-based insights to strengthen the case for change.
With this dual lens, I added evidence-based insights to strengthen the case for change.
Reposted by Emily Edwards
Amazing new paper from @krishaurum.bsky.social and colleagues, designing novel pMHC-binders (synthetic TCRs) in silico: www.science.org/doi/10.1126/...
De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells
The recognition of intracellular antigens by CD8+ T cells through T cell receptors (TCRs) is central for adaptive immunity against infections and cancer. However, the identification of TCRs from patie...
www.science.org
July 28, 2025 at 7:41 AM
Amazing new paper from @krishaurum.bsky.social and colleagues, designing novel pMHC-binders (synthetic TCRs) in silico: www.science.org/doi/10.1126/...
Reposted by Emily Edwards
Scalable screening of ternary-code DNA methylation dynamics associated with human traits
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
July 3, 2025 at 8:43 PM
Scalable screening of ternary-code DNA methylation dynamics associated with human traits
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Reposted by Emily Edwards
Differences in immune cell profiles around the time of islet autoimmunity seroconversion in children with and without type 1 diabetes https://www.biorxiv.org/content/10.1101/2025.06.23.661117v1
June 27, 2025 at 9:15 PM
Differences in immune cell profiles around the time of islet autoimmunity seroconversion in children with and without type 1 diabetes https://www.biorxiv.org/content/10.1101/2025.06.23.661117v1
An excellent preprint offering valuable insights into the impact of CMV infection on the immune system. Three insights are important as CMV is a herpesvirus, to which over 70% of the population has been exposed.
CMV reshapes lymphoid immunity in aging: a single-cell atlas with predictive modeling https://www.biorxiv.org/content/10.1101/2025.06.24.661167v1
June 28, 2025 at 3:48 AM
An excellent preprint offering valuable insights into the impact of CMV infection on the immune system. Three insights are important as CMV is a herpesvirus, to which over 70% of the population has been exposed.
Reposted by Emily Edwards
Topical JAK inhibitor for refractory skin #inflammation in STAT1 GOF. New report from Valentina Guarnieri, Tiphaine Arlabosse, Claire Booth, and Gabriela Petrof @greatormondst.bsky.social: rupress.org/jhi/article/...
#Therapeutics #InbornErrorsOfImmunity
#Therapeutics #InbornErrorsOfImmunity
June 23, 2025 at 1:40 PM
Topical JAK inhibitor for refractory skin #inflammation in STAT1 GOF. New report from Valentina Guarnieri, Tiphaine Arlabosse, Claire Booth, and Gabriela Petrof @greatormondst.bsky.social: rupress.org/jhi/article/...
#Therapeutics #InbornErrorsOfImmunity
#Therapeutics #InbornErrorsOfImmunity
Reposted by Emily Edwards
So fabulous to see this paper out! Prof Lucy Wedderburn is a close collaborator of many researchers in our dept and this paper makes an important contribution to continued efforts to understand better ways to predict treatment response in patients with autoimmune conditions 🧬 read more below 👇
Researchers at @ucl.ac.uk's Great Ormond Street Institute for Child Health and @greatormondst.bsky.social
including Professor Lucy Wedderburn have identified a set of genes which could help predict children's response to an arthritis treatment @uclpophealthsci.bsky.social
including Professor Lucy Wedderburn have identified a set of genes which could help predict children's response to an arthritis treatment @uclpophealthsci.bsky.social
Genes may help to predict which children will respond well to arthritis treatment
A set of genes that could be used to help doctors predict which children will respond well to treatment for juvenile idiopathic arthritis (JIA) have been identified by researchers at UCL and Great Orm...
www.ucl.ac.uk
June 18, 2025 at 1:45 PM
So fabulous to see this paper out! Prof Lucy Wedderburn is a close collaborator of many researchers in our dept and this paper makes an important contribution to continued efforts to understand better ways to predict treatment response in patients with autoimmune conditions 🧬 read more below 👇
Proud to be a recipient of a seed grant from the Victorian Critical Vaccinees Collection, to investigate memory B cells in elderly individuals receiving the COVID-19 vaccine, and finding parallels with responses in immunocompromised
lnkd.in/g2FxQX5q
@MonashSTM @ErasmusMC
lnkd.in/g2FxQX5q
@MonashSTM @ErasmusMC
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
June 18, 2025 at 3:21 PM
Proud to be a recipient of a seed grant from the Victorian Critical Vaccinees Collection, to investigate memory B cells in elderly individuals receiving the COVID-19 vaccine, and finding parallels with responses in immunocompromised
lnkd.in/g2FxQX5q
@MonashSTM @ErasmusMC
lnkd.in/g2FxQX5q
@MonashSTM @ErasmusMC
I would like to share our pre-print in medRxiv. Here, we describe a novel monoallelic missense variant (c.1769G>A; p.R590Q) in the spleen tyrosine kinase (SYK) gene causing SYK gain-of-function (GOF).
A collaboration between Monash Uni, Alfred Health, Erasmus MC.
www.medrxiv.org/content/10.1...
A collaboration between Monash Uni, Alfred Health, Erasmus MC.
www.medrxiv.org/content/10.1...
Redirecting
doi.org
May 9, 2025 at 7:48 AM
I would like to share our pre-print in medRxiv. Here, we describe a novel monoallelic missense variant (c.1769G>A; p.R590Q) in the spleen tyrosine kinase (SYK) gene causing SYK gain-of-function (GOF).
A collaboration between Monash Uni, Alfred Health, Erasmus MC.
www.medrxiv.org/content/10.1...
A collaboration between Monash Uni, Alfred Health, Erasmus MC.
www.medrxiv.org/content/10.1...
This years visit to raise awarenss of Primary Immunodeficiencies as part of World Primary Immunodeficiencies Week. Thanks @DrShaneRRR for having us every year. Einstein A Go-Go – www.rrr.org.au/shared/broad... via @3RRRFM
@MonashImmunol @MonashSTM
@MonashImmunol @MonashSTM
Shared moment from Einstein A Go-Go – 27 April 2025 — Triple R 102.7FM, Melbourne Independent Radio
An episode of Einstein A Go-Go on 27 April 2025
www.rrr.org.au
April 30, 2025 at 12:30 PM
This years visit to raise awarenss of Primary Immunodeficiencies as part of World Primary Immunodeficiencies Week. Thanks @DrShaneRRR for having us every year. Einstein A Go-Go – www.rrr.org.au/shared/broad... via @3RRRFM
@MonashImmunol @MonashSTM
@MonashImmunol @MonashSTM
I'm proud to announce my promotion to Group Leader of the Primary Immunodeficiencies Group part of the Allergy and Clinical Immunology Lab in Dept Immunology, School of Translational Medicine @monashuniversity.bsky.social. We're working towards precision diagnosis & targeted treatment for patients
April 25, 2025 at 6:45 AM
I'm proud to announce my promotion to Group Leader of the Primary Immunodeficiencies Group part of the Allergy and Clinical Immunology Lab in Dept Immunology, School of Translational Medicine @monashuniversity.bsky.social. We're working towards precision diagnosis & targeted treatment for patients