Yi Zhu, M.D., Ph.D.
@doctoryizhu.bsky.social
PGY-2 AP/NP resident @MayoClinicPath #Neuropath #Cytopathology
Great case. Thank you for sharing!
Kicking off 2025 with my second YouTube series: Hematopathology Case Collection. The first case explores hyaline vascular Castleman Disease, stromal-rich variant with indolent T-lymphoblastic proliferation. Check it out here: youtu.be/T_1ByEJeWXM?...
Case 1. Hyaline vascular Castleman disease stromal rich variant with iTdT+ proliferation
YouTube video by Chuan Chen, MD PhD
youtu.be
January 6, 2025 at 2:09 AM
Great case. Thank you for sharing!
Reposted by Yi Zhu, M.D., Ph.D.
#PathSky 15F, thumb mass. There are no relevant positive immunostains. However, FISH for DDIT3 amplification (not rearrangement) is positive. This is an excellent example of a GLI1-amplified sarcoma. This is a great paper from the MSKCC group. pubmed.ncbi.nlm.nih.gov/38934567/
December 20, 2024 at 6:33 PM
#PathSky 15F, thumb mass. There are no relevant positive immunostains. However, FISH for DDIT3 amplification (not rearrangement) is positive. This is an excellent example of a GLI1-amplified sarcoma. This is a great paper from the MSKCC group. pubmed.ncbi.nlm.nih.gov/38934567/
Reposted by Yi Zhu, M.D., Ph.D.
#PathSky 30M, abdominal wall mass. Microcysts, bland round to spindled cells, thick-walled vessels. Positive for desmin, MyoD1, myogenin, and GFAP. Classic findings in EWSR1::PATZ1 sarcoma. Why isn’t this a fusion-positive RMS? Excellent question…https://pubmed.ncbi.nlm.nih.gov/38043789/
December 6, 2024 at 5:24 PM
#PathSky 30M, abdominal wall mass. Microcysts, bland round to spindled cells, thick-walled vessels. Positive for desmin, MyoD1, myogenin, and GFAP. Classic findings in EWSR1::PATZ1 sarcoma. Why isn’t this a fusion-positive RMS? Excellent question…https://pubmed.ncbi.nlm.nih.gov/38043789/
Reposted by Yi Zhu, M.D., Ph.D.
#PathSky Cystic leg mass, 31F. The outside pathologist thought this was probably a BFH/DF, but wasn’t sure how to explain the epithelium. This is a siderotic BFH with “adnexal induction”. You can get basically any imaginable adnexal proliferation. Siderophages are a good BFH clue.
December 5, 2024 at 4:30 PM
#PathSky Cystic leg mass, 31F. The outside pathologist thought this was probably a BFH/DF, but wasn’t sure how to explain the epithelium. This is a siderotic BFH with “adnexal induction”. You can get basically any imaginable adnexal proliferation. Siderophages are a good BFH clue.
Reposted by Yi Zhu, M.D., Ph.D.
Example of how BK nephropathy can be easily missed due to sampling. Dense inflammation only seen in deep medulla in this sample. Cortex unremarkable. Striking viral inclusions visualized. SV40 IHC positive. #renalpath #nephrology #pathsky
December 4, 2024 at 5:32 PM
Example of how BK nephropathy can be easily missed due to sampling. Dense inflammation only seen in deep medulla in this sample. Cortex unremarkable. Striking viral inclusions visualized. SV40 IHC positive. #renalpath #nephrology #pathsky
Reposted by Yi Zhu, M.D., Ph.D.
#PathSky 34M with a jet-black mass next to the seminal vesicle. Melanoma? A very occasional psammoma body was present, and expression of PRKAR1A was completely lost. Malignant melanotic nerve sheath tumor (previously “melanotic schwannoma”) in an unusual location.
December 4, 2024 at 4:57 PM
#PathSky 34M with a jet-black mass next to the seminal vesicle. Melanoma? A very occasional psammoma body was present, and expression of PRKAR1A was completely lost. Malignant melanotic nerve sheath tumor (previously “melanotic schwannoma”) in an unusual location.
Reposted by Yi Zhu, M.D., Ph.D.
Autolysis versus ATN in autopsy kidney. Same kidney. Better preserved areas show thin tubular epithelial cells till sitting on basement membrane = ATN. Dethatched lining tubular epithelial cells falling into lumen = autolysis/can't assess. #renalpath #pathsky #nephrology #autopsypath
December 4, 2024 at 5:02 PM
Autolysis versus ATN in autopsy kidney. Same kidney. Better preserved areas show thin tubular epithelial cells till sitting on basement membrane = ATN. Dethatched lining tubular epithelial cells falling into lumen = autolysis/can't assess. #renalpath #pathsky #nephrology #autopsypath
Reposted by Yi Zhu, M.D., Ph.D.
#PathSky Solid and cystic mass next to the liver in a 50F with no relevant hx or other masses. Once you think of it, extraspinal myxopapillary ependymoma in a rather odd location seems a good fit. Why not, right?
December 2, 2024 at 7:34 PM
#PathSky Solid and cystic mass next to the liver in a 50F with no relevant hx or other masses. Once you think of it, extraspinal myxopapillary ependymoma in a rather odd location seems a good fit. Why not, right?
Reposted by Yi Zhu, M.D., Ph.D.
December 3, 2024 at 4:08 AM
Reposted by Yi Zhu, M.D., Ph.D.
#PathSky Hand mass, 32M. Bland spindle cell tumor with collagen trapping- just an FH, right? Also some less bland epithelioid areas. This is a predominantly spindled epithelioid sarcoma- “modulation” from epithelioid to spindled cells is an under appreciated morphological hallmark. See Comment.
November 22, 2024 at 2:48 PM
#PathSky Hand mass, 32M. Bland spindle cell tumor with collagen trapping- just an FH, right? Also some less bland epithelioid areas. This is a predominantly spindled epithelioid sarcoma- “modulation” from epithelioid to spindled cells is an under appreciated morphological hallmark. See Comment.
Reposted by Yi Zhu, M.D., Ph.D.
#PathSky
Scalp mass, 33M. Just a nice example of soft tissue Rosai-Dorfman disease. I think this low power “pale->pink->blue” look is a good low power clue. In addition to S100 protein, Karen Rech’s group here at Mayo have shown OCT2 to be valuable in this dx. pubmed.ncbi.nlm.nih.gov/33177341/
Scalp mass, 33M. Just a nice example of soft tissue Rosai-Dorfman disease. I think this low power “pale->pink->blue” look is a good low power clue. In addition to S100 protein, Karen Rech’s group here at Mayo have shown OCT2 to be valuable in this dx. pubmed.ncbi.nlm.nih.gov/33177341/
November 21, 2024 at 8:08 PM
#PathSky
Scalp mass, 33M. Just a nice example of soft tissue Rosai-Dorfman disease. I think this low power “pale->pink->blue” look is a good low power clue. In addition to S100 protein, Karen Rech’s group here at Mayo have shown OCT2 to be valuable in this dx. pubmed.ncbi.nlm.nih.gov/33177341/
Scalp mass, 33M. Just a nice example of soft tissue Rosai-Dorfman disease. I think this low power “pale->pink->blue” look is a good low power clue. In addition to S100 protein, Karen Rech’s group here at Mayo have shown OCT2 to be valuable in this dx. pubmed.ncbi.nlm.nih.gov/33177341/
Reposted by Yi Zhu, M.D., Ph.D.
I haven’t seen a #pathsky starter pack yet! I’ve tried to keep up with all of the new pathologists joining, but I know I have missed many! Please tag yourselves/others below and I will follow them and add them 😁 @kmirza.bsky.social @clilleymd.bsky.social @brettkurpiel.bsky.social go.bsky.app/6bWDSjT
November 13, 2024 at 9:03 PM
I haven’t seen a #pathsky starter pack yet! I’ve tried to keep up with all of the new pathologists joining, but I know I have missed many! Please tag yourselves/others below and I will follow them and add them 😁 @kmirza.bsky.social @clilleymd.bsky.social @brettkurpiel.bsky.social go.bsky.app/6bWDSjT
