Douglas W. Houston
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dhouston.bsky.social
Douglas W. Houston
@dhouston.bsky.social
Developmental Biologist. Professor, #UIowa
Director, Developmental Studies Hybridoma Bank,
@dshb-antibodies.bsky.social
Views my own
Reposted by Douglas W. Houston
🔎 Spotted in @natbiotech.nature.com!
Researchers from @hubrechtinstitute.bsky.social, among others, used DSHB's anti-integrin-β1 [AIIB2] mAb in a study on how an antibody derivative (scTS2/16) enhances human epithelial organoid growth.

📄 tinyurl.com/yu36mt6m

🧫 dshb.biology.uiowa.edu/AIIB2
November 10, 2025 at 8:18 PM
Thanks to the folks at @HCRimaging for their nifty HCR HiFi encoders: "quantitative signal amplification of
1˚ antibodies for same-isotype multiplexing"
🔑@DSHB_antibodies can be tagged as supernatant, allowing mulplx wo/purification --> here are 2 trusted IgG1s used together
November 7, 2025 at 12:29 AM
Reposted by Douglas W. Houston
Nice highlight of new genome paper. ❤️ emphasis on leadership of ECR Potamomics team members @kylemcelroy.bsky.social @chelseahiggins.bsky.social @jsharbro.bsky.social Genome Duplication in a New Zealand Snail Holds Clues for the Persistence of (A)sexual Reproduction: academic.oup.com/gbe/article/...
Highlight: Genome Duplication in a New Zealand Snail Holds Clues for the Persistence of (A)sexual Reproduction
Why does sexual reproduction persist in so many species? This is a fundamental question in biology that, remarkably, remains a mystery. Sexual reproduction
academic.oup.com
November 6, 2025 at 3:07 PM
Reposted by Douglas W. Houston
I am so proud & happy to see our Potamo genome assembly finally out there in the world! The process ended up being way more challenging than expected, but for some really cool reasons. ❤️🐌🧬
TLDR: Surprise! A VERY recent WGD.
academic.oup.com/gbe/article/...
Photo: C. Böck, ILIM, Mondsee, Austria)
November 5, 2025 at 4:50 PM
Reposted by Douglas W. Houston
How do four-eyed fish see above & underwater? 🌤️🌊 Our new preprint reveals how Anableps rewired its retina for dual vision- evolution at work 👁️👁️ Kudos to @perezlouise.bsky.social @josanesousa.bsky.social @keylapruett.bsky.social + team!
🔗 tinyurl.com/3a8r9xy5
November 4, 2025 at 3:56 PM
Reposted by Douglas W. Houston
🔎 Spotted in #Virulence by @tandfresearch.bsky.social!
Researchers from #WSU Floyd College of Medicine used DSHB's anti-α-tubulin [AA4.3] mAb in a study on how the GCN-2 pathway triggers stress responses in C. elegans during infection.

📄 tinyurl.com/3anhfuhm

🧫 dshb.biology.uiowa.edu/AA4-3
November 4, 2025 at 9:05 PM
Reposted by Douglas W. Houston
🐸 Xenopus laevis 💚 The frog that shaped modern developmental biology! ✨ Xenopus embryos have revealed how the body axis forms, cells choose their fate, and tissues self-organize during early development 📹 Video by Bioquest Sudio and Xenbase #ModelMonday #DevBio
November 3, 2025 at 8:01 PM
Reposted by Douglas W. Houston
🔎 Spotted in The Journal of Translational Medicine!
Researchers from Sun Yat-sen University, among others, used DSHB's anti-Gingipain/P. gingivalis [61BG1.3] mAb in a study on how P. gingivalis drives cervical cancer metastasis.

📄 tinyurl.com/yzjhb6sx

🧫 dshb.biology.uiowa.edu/61BG1-3
October 28, 2025 at 2:10 AM
Reposted by Douglas W. Houston
🔎 Spotted in Molecular Genetics and Genomics!
Researchers from @ur-ctsi.bsky.social and @ucsandiego.bsky.social used DSHB's anti-HP1 [C1A9] mAb in a study on how CRIF1 suppresses tumors by opposing Ras signaling in Drosophila.

📄 tinyurl.com/4uscst5c

🧫 dshb.biology.uiowa.edu/C1A9
October 23, 2025 at 5:05 PM
Reposted by Douglas W. Houston
Hey Regen folks 👋 Excited to share that our single-nucleus RNA-seq dataset for Polypterus fin regeneration is now live at the Broad Institute portal! Dive in here: tinyurl.com/5bck22jx
Big thanks to the team for making this happen—looking forward to seeing what you all discover!
October 14, 2025 at 5:08 PM
Reposted by Douglas W. Houston
🔎 Spotted in @natcomms.nature.com!
Researchers from @uwmadison.bsky.social, among others, used DSHB's anti-MHC [MF 20] mAb in a study on how deleting ICAM-1 improves the immune resistance of stem-cell grafts.

📄 tinyurl.com/2s3pzheu

🧫 dshb.biology.uiowa.edu/MF-20
September 25, 2025 at 8:43 PM
Reposted by Douglas W. Houston
🔎 Spotted in Autophagy by @tandfresearch.bsky.social!
Researchers from #NationalTaiwanUniversity used DSHB's anti-α-Spec [3A9], anti-dlg [4F3], and anti-spitz mAbs in a study on Rab27’s role in regulating autophagy and lifespan in Drosophila.
September 23, 2025 at 3:53 PM
Novel monoclonal antibodies against the C-terminal HEAT domain of Huntingtin biorxiv.org/content/10.110…

Nice collaboration between @DSHB_antibodies , @LabScribbles and @thesgconline to make and characterize anti-HTT mAbs
https://biorxiv.org/content/10.110…
September 18, 2025 at 11:04 PM
Reposted by Douglas W. Houston
🔎 Spotted in Comparative Biochemistry & Physiology Part A!
Researchers from @umassamherst.bsky.social and @utaustin.bsky.social used DSHB's anti-NKA-α-subunit [a5] mAb in a study on how red drum larvae adapt acid excretion to survive ocean acidification.
September 18, 2025 at 6:21 PM
Reposted by Douglas W. Houston
🔎 Spotted in @mucosalimmunol.bsky.social!
Researchers from #TongjiUniversity used DSHB's anti-dlg1 [4F3] mAb in a study on how bacterial membrane vesicles suppress CREB to regulate host immunity.

📄 tinyurl.com/yc7f97wk

🧫 dshb.biology.uiowa.edu/4F3-anti-dis...
September 17, 2025 at 7:59 PM
Reposted by Douglas W. Houston
🔎 Spotted in #ScienceAdvances!
Researchers from @uni-muenster.de, #OsnabrückUniversity, and @istaresearch.bsky.social used DSHB's anti-Rab7 mAb in a study on how RabGEF complexes evolved to regulate Rab GTPases in cell trafficking.

📄 tinyurl.com/4rnzfw4k

🧫 dshb.biology.uiowa.edu/Rab7
September 12, 2025 at 8:07 PM
Reposted by Douglas W. Houston
🔎 Spotted in Proceedings B of @royalsocietypublishing.org!
Researchers from @barnard-college.bsky.social, among others, used DSHB's anti-PDF [C7] mAb in a study on how artificial night light influences fruit fly behavior across sexes and genes.
September 3, 2025 at 7:05 PM
Reposted by Douglas W. Houston
🔎 Spotted in Journal of Advanced Research!
Researchers from Heilongjiang Bayi Agricultural University used DSHB's anti-Br-C core [25E9.D7] mAb in a study on how SUMOylation switches Kr-h1 from repressing to activating Br-C during insect development.
August 20, 2025 at 3:52 AM
Move-in day at Wake Forest … our youngest is off to college!
August 20, 2025 at 8:18 PM
Reposted by Douglas W. Houston
🔎 Spotted in @plosone.org!
Researchers from #TaylorUniversity used DSHB's anti-Dlg [4F3] mAb in a study on how two myosin proteins help align wing hairs in fruit flies via the protein Gliotactin.

📄 tinyurl.com/bdfmzp77

🧫 dshb.biology.uiowa.edu/4F3-anti-dis...
August 15, 2025 at 2:01 PM
Reposted by Douglas W. Houston
🔎 Spotted in @natcomms.nature.com!
Researchers from Huazhong University of Science and Technology used 7 of DSHB's mAbs in a study on how younger gut cells can slow intestinal aging and extend lifespan in fruit flies.
August 13, 2025 at 11:05 PM
Reposted by Douglas W. Houston
🚨Only 4 days to apply!!!🚨Join the SDB SciComm Internship! Gain hands-on experience writing stories on the latest developmental biology discoveries🔬Connect with top mentors & earn $500 to attend the SDB Annual Meeting 🎉! 👉 www.sdbonline.org/science_comm... #SciComm #DevBio
August 12, 2025 at 1:29 PM
Reposted by Douglas W. Houston
🔎 Spotted in #BrainResearch by @elsevierconnect.bsky.social!
Researchers from #RussianAcademyofSciences used DSHB's anti-SV2 and anti-Na-K-Cl-cotransporter [N161/20] mAbs in a study on age-related GABA system changes in epilepsy-prone rats.
August 11, 2025 at 8:23 PM
Reposted by Douglas W. Houston
🔎 Spotted in #ScientificReports!
Researchers from University of Alabama at Birmingham used DSHB's anti-LAMP-1 [1D4B] mAb in a study on TFEB overexpression, showing it restores lysosomal function in progranulin-deficient cells.

📄 tinyurl.com/3fckjke2

🧫 dshb.biology.uiowa.edu/1D4B
August 8, 2025 at 12:17 AM
50 years later, hybridomas and monoclonal antibodies are still of "general interest" @dshb-antibodies.bsky.social
August 7, 2025 at 5:55 PM