Andy DeLaitsch
@delaitsch.bsky.social
antibodies, viruses, cryo-EM -- habitually curious -- BMB graduate student at Caltech
Reposted by Andy DeLaitsch
Workflow Using a Cryogenic Coincident Fluorescence, Electron, and Ion Beam Microscope for Targeted Milling of Cells pubmed.ncbi.nlm.nih.gov/41182991/ #cryoem
November 5, 2025 at 12:54 AM
Workflow Using a Cryogenic Coincident Fluorescence, Electron, and Ion Beam Microscope for Targeted Milling of Cells pubmed.ncbi.nlm.nih.gov/41182991/ #cryoem
There's a new best-in-class HIV-1 antibody out today! Happy to have contributed to the structural characterization of this, and two other distinct VRC01-class bNAbs isolated from a single individual. www.nature.com/articles/s41...
October 6, 2025 at 8:32 PM
There's a new best-in-class HIV-1 antibody out today! Happy to have contributed to the structural characterization of this, and two other distinct VRC01-class bNAbs isolated from a single individual. www.nature.com/articles/s41...
From what I gather, CXCR4 (previously called fusin) was identified as a co-receptor for HIV nearly 30 years ago (pubmed.ncbi.nlm.nih.gov/8629022/). Nice to see a structure, and interesting to see it was done with HIV-2 gp120.
October 1, 2025 at 10:09 PM
From what I gather, CXCR4 (previously called fusin) was identified as a co-receptor for HIV nearly 30 years ago (pubmed.ncbi.nlm.nih.gov/8629022/). Nice to see a structure, and interesting to see it was done with HIV-2 gp120.
Reposted by Andy DeLaitsch
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
September 23, 2025 at 5:08 PM
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
Reposted by Andy DeLaitsch
📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
August 2, 2025 at 3:01 PM
📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Reposted by Andy DeLaitsch
If Management is the Only Way Up, We're All F'd - Rand Fishkin
sparktoro.com/blog/if-mana...
sparktoro.com/blog/if-mana...
July 24, 2025 at 3:41 PM
If Management is the Only Way Up, We're All F'd - Rand Fishkin
sparktoro.com/blog/if-mana...
sparktoro.com/blog/if-mana...
Reposted by Andy DeLaitsch
Reposted by Andy DeLaitsch
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
June 18, 2025 at 6:32 AM
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
Instant classic 🤯
Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social
March 1, 2025 at 4:49 PM
Instant classic 🤯
Reposted by Andy DeLaitsch
My first project in the @elowitzlab.bsky.social is finally out in @cellpress.bsky.social! We explore how competitive, "many-to-many" dimerization allows complex, multi-input, and cell-type-specific biochemical computations🧵↓
doi.org/10.1016/j.ce...
doi.org/10.1016/j.ce...
Redirecting
doi.org
February 26, 2025 at 2:17 AM
My first project in the @elowitzlab.bsky.social is finally out in @cellpress.bsky.social! We explore how competitive, "many-to-many" dimerization allows complex, multi-input, and cell-type-specific biochemical computations🧵↓
doi.org/10.1016/j.ce...
doi.org/10.1016/j.ce...
Reposted by Andy DeLaitsch
MISO: Microfluidic protein isolation enables single particle cryo-EM structure determination from a single cell colony https://www.biorxiv.org/content/10.1101/2025.01.10.632437v1
January 14, 2025 at 9:49 PM
MISO: Microfluidic protein isolation enables single particle cryo-EM structure determination from a single cell colony https://www.biorxiv.org/content/10.1101/2025.01.10.632437v1
Reposted by Andy DeLaitsch
RSV vaccination attempts in young children have a troubled history. Which seems to be continuing:
Infant RSV Vaccination Trouble
www.science.org
December 10, 2024 at 8:55 PM
RSV vaccination attempts in young children have a troubled history. Which seems to be continuing:
100 years ago, De Broglie published his thesis, "On the Theory of Quanta". The ideas in it catalyzed the development of electron microscopy, though Ernst Ruska was apparently unaware of De Broglie's "material waves" when he and Max Knoll first started toying with the electron microscope.
December 10, 2024 at 5:28 AM
100 years ago, De Broglie published his thesis, "On the Theory of Quanta". The ideas in it catalyzed the development of electron microscopy, though Ernst Ruska was apparently unaware of De Broglie's "material waves" when he and Max Knoll first started toying with the electron microscope.
Out now in its final form! These antibodies had us stumped for quite some time. www.nature.com/articles/s41...
Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer - npj Vaccines
npj Vaccines - Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer
www.nature.com
December 5, 2024 at 5:29 PM
Out now in its final form! These antibodies had us stumped for quite some time. www.nature.com/articles/s41...
Reposted by Andy DeLaitsch
Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 3, 2024 at 7:05 AM
Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Caltech looking nice tonight!
November 26, 2024 at 2:01 AM
Caltech looking nice tonight!