David A Muller
@davidamuller.bsky.social
"Learning more and more about less and less"
Materials Physics and Electron Microscopy at Cornell (he/him)
https://muller.research.engineering.cornell.edu/
Materials Physics and Electron Microscopy at Cornell (he/him)
https://muller.research.engineering.cornell.edu/
Pinned
David A Muller
@davidamuller.bsky.social
· Apr 23
Dose-Efficient Cryo-Electron Microscopy for Thick Samples using Tilt-Corrected Scanning Transmission Electron Microscopy, Demonstrated on Cells and Single Particles
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
#cryoEM Lena and I started working on this project almost 10 years ago, with @ktspoth and then Yue taking data. Lena passed away before she could finish the paper, even as other groups were finding it very useful. With Yue and friends we finally got something out! www.biorxiv.org/content/10.1...
While Cornell has field theorists, we also have practitioners
November 10, 2025 at 7:45 PM
While Cornell has field theorists, we also have practitioners
Imaging hydrogen atoms with ptychography
Hydrogen, the universe’s most abundant atom, is also the hardest to see in solids. Using electron ptychography, we directly reveals hydrogen’s hidden structures inside metals, as reported in our JACS paper (pubs.acs.org/doi/10.1021/...).
@davidamuller.bsky.social
@jacs.acspublications.org
@davidamuller.bsky.social
@jacs.acspublications.org
October 10, 2025 at 7:15 PM
Imaging hydrogen atoms with ptychography
Jim West's group taught us everything we know about building ultra-quiet rooms
SPARK sighting at @possible-futures.bsky.social!
Less than two weeks till it's available at a bookstore near you!
Share the story of Jim West and his invention of the microphone we all use today on Zoom, phones 🎤
Preorder here: bit.ly/SPARKbk
#WomeninSTEM 🧪
#SciArt
#Booksky
#Science
#Blacksky
Less than two weeks till it's available at a bookstore near you!
Share the story of Jim West and his invention of the microphone we all use today on Zoom, phones 🎤
Preorder here: bit.ly/SPARKbk
#WomeninSTEM 🧪
#SciArt
#Booksky
#Science
#Blacksky
October 8, 2025 at 4:50 PM
Jim West's group taught us everything we know about building ultra-quiet rooms
#cryoEM 🧪⚛️ Lena’s paper on imaging thick biological sections with STEM is finally published! We started this work almost 10 years ago. After Lena passed in 2023, I spent much of my sabbatical working with Yue and Steve to wrap this up. Also learned a lot about TEM vs STEM dose efficiency
Tilt-corrected bright-field scanning transmission electron microscopy (tcBF-STEM) offers enhanced contrast and dose efficiency for cryo-EM in thick biological specimens.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dose-efficient cryo-electron microscopy for thick samples using tilt- corrected scanning transmission electron microscopy - Nature Methods
Tilt-corrected bright-field scanning transmission electron microscopy offers enhanced cryogenic electron microscopy contrast and substantial improvement in dose efficiency for thick samples such as bacterial cells and large organelles, while still being able to perform single-particle analysis.
www.nature.com
September 24, 2025 at 7:36 AM
#cryoEM 🧪⚛️ Lena’s paper on imaging thick biological sections with STEM is finally published! We started this work almost 10 years ago. After Lena passed in 2023, I spent much of my sabbatical working with Yue and Steve to wrap this up. Also learned a lot about TEM vs STEM dose efficiency
Some good news 🧪⚛️
August 28, 2025 at 12:37 AM
Some good news 🧪⚛️
Our new zippy ptychography code, PtyRAD is now out in print. 3D Multislice reconstructions that used to take a day, now can be done in about an hour!
🧪⚛️ #ptycho
paper and install links:
academic.oup.com/mam/article/...
🧪⚛️ #ptycho
paper and install links:
academic.oup.com/mam/article/...
PtyRAD: A High-Performance and Flexible Ptychographic Reconstruction Framework with Automatic Differentiation
Abstract. Electron ptychography has recently achieved unprecedented resolution, offering valuable insights across diverse material systems, including in th
academic.oup.com
August 5, 2025 at 5:02 PM
Our new zippy ptychography code, PtyRAD is now out in print. 3D Multislice reconstructions that used to take a day, now can be done in about an hour!
🧪⚛️ #ptycho
paper and install links:
academic.oup.com/mam/article/...
🧪⚛️ #ptycho
paper and install links:
academic.oup.com/mam/article/...
Our hands-on workshop on Electron #Ptychography ! ⚛️🧪 using our new fast python code starts tomorrow, Tuesday, July 8. Lecture Schedule is below, for folks who want to listen in on-line. We hope to post the tutorial and code walk through videos later.
cornell.zoom.us/j/9512638476...
cornell.zoom.us/j/9512638476...
July 8, 2025 at 4:19 AM
Our hands-on workshop on Electron #Ptychography ! ⚛️🧪 using our new fast python code starts tomorrow, Tuesday, July 8. Lecture Schedule is below, for folks who want to listen in on-line. We hope to post the tutorial and code walk through videos later.
cornell.zoom.us/j/9512638476...
cornell.zoom.us/j/9512638476...
Reposted by David A Muller
This is fantastic, do read it.
July 4, 2025 at 5:10 PM
This is fantastic, do read it.
Took a break and conducted some pier review last week. 12/10
July 1, 2025 at 6:34 AM
Took a break and conducted some pier review last week. 12/10
Reposted by David A Muller
One of my favorite things is seeing how publishers around the world reinterpret covers for foreign language editions of our books. The Alchemy of Us is being published in Korean. A side by side comparison -- same great content, totally different vibe.
November 25, 2024 at 8:44 PM
One of my favorite things is seeing how publishers around the world reinterpret covers for foreign language editions of our books. The Alchemy of Us is being published in Korean. A side by side comparison -- same great content, totally different vibe.
Celebrating Hari’s thesis defense with a NaNbO3-themed cake. It is layered in 3D to match his paper rdcu.be/eiV0u
June 16, 2025 at 10:51 PM
Celebrating Hari’s thesis defense with a NaNbO3-themed cake. It is layered in 3D to match his paper rdcu.be/eiV0u
Reposted by David A Muller
The end of US leadership in science, technology, and innovation.
All in one little table.
A tremendous gift to China, courtesy of the GOP.
nsf-gov-resources.nsf.gov/files/00-NSF...
All in one little table.
A tremendous gift to China, courtesy of the GOP.
nsf-gov-resources.nsf.gov/files/00-NSF...
May 30, 2025 at 9:26 PM
The end of US leadership in science, technology, and innovation.
All in one little table.
A tremendous gift to China, courtesy of the GOP.
nsf-gov-resources.nsf.gov/files/00-NSF...
All in one little table.
A tremendous gift to China, courtesy of the GOP.
nsf-gov-resources.nsf.gov/files/00-NSF...
Danielle was one of Lena’s students 🧪
Revealing the Crystalline Architecture of Semicrystalline Ion Exchange Membranes for the Design of Conductive and Durable Alkaline Anion Exchange Membranes pubmed.ncbi.nlm.nih.gov/40415331/ #cryoem
May 28, 2025 at 5:02 AM
Danielle was one of Lena’s students 🧪
So the crazy thing here is the company this is supposed to be about is Corning. The company famous for its glass research. And the across the board metric is a measure of how similar individual atom positions are in their CRYSTAL structures. So much is nuts here, but that should have been a red flag
May 17, 2025 at 1:16 PM
So the crazy thing here is the company this is supposed to be about is Corning. The company famous for its glass research. And the across the board metric is a measure of how similar individual atom positions are in their CRYSTAL structures. So much is nuts here, but that should have been a red flag
Reposted by David A Muller
Pat Bagley, Salt Lake Tribune
May 7, 2025 at 2:01 AM
Pat Bagley, Salt Lake Tribune
“From chocolate chips to computer chips” 🧪⚛️
Discover the cutting-edge characterization facilities at the Cornell Center for Materials Research (CCMR).Reach out to schedule a visit or discuss your needs! More info on becoming a user can be found here: www.ccmr.cornell.edu/facilities/b...
April 23, 2025 at 9:18 PM
“From chocolate chips to computer chips” 🧪⚛️
Betteridge's law: "Any headline that ends in a question mark can be answered by the word no."
There is a NSF FAQ includes questions like: "Can I still work with Minority Serving Institutions (MSIs)" and "There are still gaps in the achievements of certain groups of people. Can we still research those?"
NEW: NSF announces it's "terminating awards that are not aligned with agency priorities...including but not limited to those on diversity, equity, and inclusion (DEI) and misinformation/disinformation." #HigherEd #AcademicSky
April 18, 2025 at 8:06 PM
Betteridge's law: "Any headline that ends in a question mark can be answered by the word no."
We're holding a hands-on workshop on Electron #Ptychography ! ⚛️🧪 using our new fast python code
When: July 8-11, Cornell University, Ithaca NY
Organizers: David Muller, Jim LeBeau, Steve Zeltmann
Applications on a rolling basis until full
www.ccmr.cornell.edu/facilities/p...
When: July 8-11, Cornell University, Ithaca NY
Organizers: David Muller, Jim LeBeau, Steve Zeltmann
Applications on a rolling basis until full
www.ccmr.cornell.edu/facilities/p...
April 16, 2025 at 6:10 AM
We're holding a hands-on workshop on Electron #Ptychography ! ⚛️🧪 using our new fast python code
When: July 8-11, Cornell University, Ithaca NY
Organizers: David Muller, Jim LeBeau, Steve Zeltmann
Applications on a rolling basis until full
www.ccmr.cornell.edu/facilities/p...
When: July 8-11, Cornell University, Ithaca NY
Organizers: David Muller, Jim LeBeau, Steve Zeltmann
Applications on a rolling basis until full
www.ccmr.cornell.edu/facilities/p...
USC vs MIT
April 13, 2025 at 9:42 PM
USC vs MIT
This has been going for a while. When I worked at Lumon, erm Lucent Technologies in the late 90’s this similarity was also noted, but that is was also inflamed. Still an improvement on the previous deathstar logo
April 12, 2025 at 9:03 PM
This has been going for a while. When I worked at Lumon, erm Lucent Technologies in the late 90’s this similarity was also noted, but that is was also inflamed. Still an improvement on the previous deathstar logo
Our center helping out local businesses including biotech startups 🧪⚛️
Check out today's #CornellChronicle to learn how one local company came to CCMR for technical assistance and then what happened next...
news.cornell.edu/stories/2025...
#materialsscience #advancedmaterials #foodpackaging #sustainability #localimpact #innovation #technology #ResearchandDevelopment
news.cornell.edu/stories/2025...
#materialsscience #advancedmaterials #foodpackaging #sustainability #localimpact #innovation #technology #ResearchandDevelopment
Snapshot shows Cornell’s impact on local economy | Cornell Chronicle
Cornell drives economic growth in Ithaca and region via student and visitor spending, increased entrepreneurship, taxes and fees, and contributions to local municipalities and nonprofits.
news.cornell.edu
April 12, 2025 at 12:03 AM
Our center helping out local businesses including biotech startups 🧪⚛️
Well, tomorrow is going to be fun 🧪⚛️
April 9, 2025 at 3:29 AM
Well, tomorrow is going to be fun 🧪⚛️
Field theory - Cornell style
Look carefully for the spherical horse in the background. Foals due soon
Look carefully for the spherical horse in the background. Foals due soon
March 24, 2025 at 12:39 AM
Field theory - Cornell style
Look carefully for the spherical horse in the background. Foals due soon
Look carefully for the spherical horse in the background. Foals due soon
After reading this statement, it is worth remembering that the I in DEI is Inclusion. The opposite of Inclusion is separateness. The Afrikaans word for separateness is Apartheid
March 20, 2025 at 4:49 AM
After reading this statement, it is worth remembering that the I in DEI is Inclusion. The opposite of Inclusion is separateness. The Afrikaans word for separateness is Apartheid