Carolien van de Sandt
@cvandesandt.bsky.social
Team leader Murdoch Children’s Research Institute (MCRI) and Honorary Senior Research Fellow at the University of Melbourne | Immunology | Virology | Influenza | COVID19 | Aging | T cells | TCRs
Pinned
How does antiviral #immunity against #influenza evolve across human lifespan? 👶➡️👧➡️👱➡️👵
Our study in Nature Immunology investigates the difference in CD8 T cell response across human lifespan - a🧵⬇️ go.unimelb.edu.au/627s
Katherine Kedzierska, Fabio Luciani, The Doherty Institute
Our study in Nature Immunology investigates the difference in CD8 T cell response across human lifespan - a🧵⬇️ go.unimelb.edu.au/627s
Katherine Kedzierska, Fabio Luciani, The Doherty Institute
Many congratulations to @pogorely.bsky.social & @pgtimmune.bsky.social and their team, very excited to see this work finally published! Such a fantastic new method for TCR analysis! Looking forward to using it myself :)
Excited to see our TIRTL-seq method published in Nature Methods www.nature.com/articles/s41...! Some updates after the revision: (1/4)
TIRTL-seq: deep, quantitative and affordable paired TCR repertoire sequencing - Nature Methods
TIRTL-seq is a high-throughput method for paired T cell receptor sequencing at the cohort scale.
www.nature.com
November 28, 2025 at 12:49 AM
Many congratulations to @pogorely.bsky.social & @pgtimmune.bsky.social and their team, very excited to see this work finally published! Such a fantastic new method for TCR analysis! Looking forward to using it myself :)
I'm deeply honoured & grateful to have been awarded the #CSLCentenaryFellowship at the #AAHMS dinner last week
Many thanks to my mentors & colleagues for their support
Congratulations to my Fellow winner @rhyswg.bsky.social
#MedicalResearch
#CSLCentenaryFellowships
#WomenInSTEMM
@mcri.bsky.social
Many thanks to my mentors & colleagues for their support
Congratulations to my Fellow winner @rhyswg.bsky.social
#MedicalResearch
#CSLCentenaryFellowships
#WomenInSTEMM
@mcri.bsky.social
November 7, 2025 at 7:50 AM
I'm deeply honoured & grateful to have been awarded the #CSLCentenaryFellowship at the #AAHMS dinner last week
Many thanks to my mentors & colleagues for their support
Congratulations to my Fellow winner @rhyswg.bsky.social
#MedicalResearch
#CSLCentenaryFellowships
#WomenInSTEMM
@mcri.bsky.social
Many thanks to my mentors & colleagues for their support
Congratulations to my Fellow winner @rhyswg.bsky.social
#MedicalResearch
#CSLCentenaryFellowships
#WomenInSTEMM
@mcri.bsky.social
Big congratulations well deserved winners who did amazing work!! 🥳🥳
October 23, 2025 at 2:45 PM
Big congratulations well deserved winners who did amazing work!! 🥳🥳
Reposted by Carolien van de Sandt
Key takeaways from today’s #ESWI2025 plenary:
🇺🇸 Shifting US priorities reshape global research
🇪🇺🇨🇦 EU & Canada face widening funding gaps
👩🔬Early-career scientists struggle to find stable paths need support from established scientists
🔄 Collaboration & support are essential
🇺🇸 Shifting US priorities reshape global research
🇪🇺🇨🇦 EU & Canada face widening funding gaps
👩🔬Early-career scientists struggle to find stable paths need support from established scientists
🔄 Collaboration & support are essential
October 21, 2025 at 10:16 AM
Key takeaways from today’s #ESWI2025 plenary:
🇺🇸 Shifting US priorities reshape global research
🇪🇺🇨🇦 EU & Canada face widening funding gaps
👩🔬Early-career scientists struggle to find stable paths need support from established scientists
🔄 Collaboration & support are essential
🇺🇸 Shifting US priorities reshape global research
🇪🇺🇨🇦 EU & Canada face widening funding gaps
👩🔬Early-career scientists struggle to find stable paths need support from established scientists
🔄 Collaboration & support are essential
What a great session and fantastic advice from the panel on how to navigate your career. With fantastic questions from our ECR/ECaS audience.
Choose/find a path that you are passionate about and a career is rarely a straight line
Choose/find a path that you are passionate about and a career is rarely a straight line
October 22, 2025 at 10:15 AM
What a great session and fantastic advice from the panel on how to navigate your career. With fantastic questions from our ECR/ECaS audience.
Choose/find a path that you are passionate about and a career is rarely a straight line
Choose/find a path that you are passionate about and a career is rarely a straight line
Great work by @chinweetan.bsky.social , @Len Dalit and @groomlab.bsky.social and her team understanding the signatures behind T folicular helper heterogeneity! ⬇️
#ImmunoSky
#ImmunoSky
Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social
Thread below...
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social
Thread below...
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology
Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...
www.nature.com
September 12, 2025 at 6:39 AM
Great work by @chinweetan.bsky.social , @Len Dalit and @groomlab.bsky.social and her team understanding the signatures behind T folicular helper heterogeneity! ⬇️
#ImmunoSky
#ImmunoSky
📢 Very proud to present @tejas-the-tcell.bsky.social 2nd First Author paper published in @pnas.org where he showed that key #TCR repertoires & gene expression profiles can be found in #influenza CD8 T central memory cell pools across the human lifespan. #AgingResearch
doi.org/10.1073/pnas.2501167122
doi.org/10.1073/pnas.2501167122
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
doi.org
July 25, 2025 at 12:37 AM
📢 Very proud to present @tejas-the-tcell.bsky.social 2nd First Author paper published in @pnas.org where he showed that key #TCR repertoires & gene expression profiles can be found in #influenza CD8 T central memory cell pools across the human lifespan. #AgingResearch
doi.org/10.1073/pnas.2501167122
doi.org/10.1073/pnas.2501167122
Reposted by Carolien van de Sandt
Thanks for the memories! Proud to have our study on central memory CD8+ T cells across the human lifespan published in PNAS today!
You can read our paper: go.unimelb.edu.au/rp7p
Or our article: go.unimelb.edu.au/jp7p
@thedohertyinst.bsky.social @cvandesandt.bsky.social @katherinekedz.bsky.social
You can read our paper: go.unimelb.edu.au/rp7p
Or our article: go.unimelb.edu.au/jp7p
@thedohertyinst.bsky.social @cvandesandt.bsky.social @katherinekedz.bsky.social
Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan | PNAS
Central memory CD8+ T cells (Tcm) represent the prominent memory T cell subset in
human blood, yet the persistence of T cell receptor (TCR) clonoty...
go.unimelb.edu.au
July 23, 2025 at 4:49 AM
Thanks for the memories! Proud to have our study on central memory CD8+ T cells across the human lifespan published in PNAS today!
You can read our paper: go.unimelb.edu.au/rp7p
Or our article: go.unimelb.edu.au/jp7p
@thedohertyinst.bsky.social @cvandesandt.bsky.social @katherinekedz.bsky.social
You can read our paper: go.unimelb.edu.au/rp7p
Or our article: go.unimelb.edu.au/jp7p
@thedohertyinst.bsky.social @cvandesandt.bsky.social @katherinekedz.bsky.social
Reposted by Carolien van de Sandt
🚨 #ESWI2025 🚨 Key upcoming deadlines
🐦 Early bird registration ends on 30 June 2025
🚀 Extra call for abstracts in #Molecular #Virology open until 31 July 2025
🚀 Late breaker abstract submission is open until 10 August eswiconference.org/abstract-sub...
🐦 Early bird registration ends on 30 June 2025
🚀 Extra call for abstracts in #Molecular #Virology open until 31 July 2025
🚀 Late breaker abstract submission is open until 10 August eswiconference.org/abstract-sub...
June 20, 2025 at 10:05 AM
🚨 #ESWI2025 🚨 Key upcoming deadlines
🐦 Early bird registration ends on 30 June 2025
🚀 Extra call for abstracts in #Molecular #Virology open until 31 July 2025
🚀 Late breaker abstract submission is open until 10 August eswiconference.org/abstract-sub...
🐦 Early bird registration ends on 30 June 2025
🚀 Extra call for abstracts in #Molecular #Virology open until 31 July 2025
🚀 Late breaker abstract submission is open until 10 August eswiconference.org/abstract-sub...
📢Very proud to present @jetvddijssel.bsky.social her final paper for her PhD in @eurjimmunol.bsky.social where we used the latest #Nanovial technology to activate CD8 T cells and link their TCRs to IFNy levels without the need to fix them! doi.org/10.1002/eji.... @thedohertyinst.bsky.social @Sanquin
Linking Epitope‐Specific T‐Cell Receptors to IFNγ Secretion Using Nanovial Technology
To link IFNγ-secretion levels of epitope-specific T-cells with their TCRαβ, we coated nanovials with pHLA-I to capture and activate epitope-specific T-cells and their secreted IFNγ, followed by index...
onlinelibrary.wiley.com
May 24, 2025 at 6:51 AM
📢Very proud to present @jetvddijssel.bsky.social her final paper for her PhD in @eurjimmunol.bsky.social where we used the latest #Nanovial technology to activate CD8 T cells and link their TCRs to IFNy levels without the need to fix them! doi.org/10.1002/eji.... @thedohertyinst.bsky.social @Sanquin
Reposted by Carolien van de Sandt
🗓️ Only 3 weeks to go! 📍#ESWI2025
📆 20–23 October 2025 | Valencia, Spain
📝 Abstract submission deadline: 16 May 2025
🚨 Don’t miss your chance to contribute to the largest European #scientific conference on #Influenza & #AcuteRespiratoryVirus diseases
eswiconference.org/abstract-sub...
📆 20–23 October 2025 | Valencia, Spain
📝 Abstract submission deadline: 16 May 2025
🚨 Don’t miss your chance to contribute to the largest European #scientific conference on #Influenza & #AcuteRespiratoryVirus diseases
eswiconference.org/abstract-sub...
April 24, 2025 at 1:48 PM
🗓️ Only 3 weeks to go! 📍#ESWI2025
📆 20–23 October 2025 | Valencia, Spain
📝 Abstract submission deadline: 16 May 2025
🚨 Don’t miss your chance to contribute to the largest European #scientific conference on #Influenza & #AcuteRespiratoryVirus diseases
eswiconference.org/abstract-sub...
📆 20–23 October 2025 | Valencia, Spain
📝 Abstract submission deadline: 16 May 2025
🚨 Don’t miss your chance to contribute to the largest European #scientific conference on #Influenza & #AcuteRespiratoryVirus diseases
eswiconference.org/abstract-sub...
Your immune system gradually loses it top team players when we get older 👱➡️👵
Our study in @ebiomedicine.bsky.social investigates how long good immune cells stay around – a 🧵⬇️ go.unimelb.edu.au/4sep
@katherinekedz.bsky.social @thedohertyinst.bsky.social #Influenza #AgingResearch #Immunity #TCR
Our study in @ebiomedicine.bsky.social investigates how long good immune cells stay around – a 🧵⬇️ go.unimelb.edu.au/4sep
@katherinekedz.bsky.social @thedohertyinst.bsky.social #Influenza #AgingResearch #Immunity #TCR
April 24, 2025 at 10:58 AM
Your immune system gradually loses it top team players when we get older 👱➡️👵
Our study in @ebiomedicine.bsky.social investigates how long good immune cells stay around – a 🧵⬇️ go.unimelb.edu.au/4sep
@katherinekedz.bsky.social @thedohertyinst.bsky.social #Influenza #AgingResearch #Immunity #TCR
Our study in @ebiomedicine.bsky.social investigates how long good immune cells stay around – a 🧵⬇️ go.unimelb.edu.au/4sep
@katherinekedz.bsky.social @thedohertyinst.bsky.social #Influenza #AgingResearch #Immunity #TCR
Do age & CMV affect the generation of T cell responses against novel pathogens? 🧑🔬 Our @eurjimmunol.bsky.social study shows broad & robust memory #SARS-CoV-2 specific T cell response regardless of age or CMV #Ageingresearch.🧵⬇️ go.unimelb.edu.au/w76p @jetvddijssel.bsky.social @Sanquin @TheDohertyInst
March 13, 2025 at 11:54 PM
Do age & CMV affect the generation of T cell responses against novel pathogens? 🧑🔬 Our @eurjimmunol.bsky.social study shows broad & robust memory #SARS-CoV-2 specific T cell response regardless of age or CMV #Ageingresearch.🧵⬇️ go.unimelb.edu.au/w76p @jetvddijssel.bsky.social @Sanquin @TheDohertyInst
Interested to learn about potential off-target effects from the #BCGvaccine on the #SARSCoV2 vaccine response? Check out the latest work by @nicolemessina.bsky.social and her team @mcri.bsky.social with whom we collaborated! ⬇️
I’m excited to share our new study of the off-target effects of #BCGVaccine on response to #SARSCoV2 & #COVID-19 vaccines. We analysed immune responses before & after COVID-19 vaccination in healthcare workers in the #BRACE RCT. 💉🦠 #Immunology #IDsky #Immunosky doi.org/10.1002/cti2...
<em>Clinical & Translational Immunology</em> | ASI Journal | Wiley Online Library
Bacille Calmette–Guérin (BCG), the vaccine for tuberculosis, has immunomodulatory effects that may underpin its off-target effects on infectious disease risk and vaccine responses. This study used bl....
doi.org
February 4, 2025 at 8:09 AM
Interested to learn about potential off-target effects from the #BCGvaccine on the #SARSCoV2 vaccine response? Check out the latest work by @nicolemessina.bsky.social and her team @mcri.bsky.social with whom we collaborated! ⬇️
Reposted by Carolien van de Sandt
🌟 #ESWI 🏆 Awards are open for #EarlyCareerScientists! 🌟
✨ Claude Hannoun Prize for Best Body of Work
📅 Deadline: 28 February 2025
Apply now 👉 www.eswiconference.org/eswi-awards/...
@cvandesandt.bsky.social was 2023 winner! 💬 eswi.org/site/young-s... Will you be next?
✨ Claude Hannoun Prize for Best Body of Work
📅 Deadline: 28 February 2025
Apply now 👉 www.eswiconference.org/eswi-awards/...
@cvandesandt.bsky.social was 2023 winner! 💬 eswi.org/site/young-s... Will you be next?
The Tenth ESWI Influenza Conference - Valencia 2025
www.eswiconference.org
January 10, 2025 at 2:38 PM
🌟 #ESWI 🏆 Awards are open for #EarlyCareerScientists! 🌟
✨ Claude Hannoun Prize for Best Body of Work
📅 Deadline: 28 February 2025
Apply now 👉 www.eswiconference.org/eswi-awards/...
@cvandesandt.bsky.social was 2023 winner! 💬 eswi.org/site/young-s... Will you be next?
✨ Claude Hannoun Prize for Best Body of Work
📅 Deadline: 28 February 2025
Apply now 👉 www.eswiconference.org/eswi-awards/...
@cvandesandt.bsky.social was 2023 winner! 💬 eswi.org/site/young-s... Will you be next?
📢 Great opportunity for #EarlyCareerResearchers working on respiratory virus infections like #Influenza #Covid_19 #RSV or #Vaccine innovations & those from under-represented communities ⬇️🧑🔬
Put in your application before Feb 28th!
More information: eswiconference.org/eswi-awards
#ECR #Awards #ESWI
Put in your application before Feb 28th!
More information: eswiconference.org/eswi-awards
#ECR #Awards #ESWI
🌟 #ESWI 🏆 Awards are now open for #EarlyCareerScientists! 🌟 #ESWI2025
📅 Deadline: 28 February 2025
✨ Claude Hannoun Prize for Best Body of Work
✨ Young Scientist Vaccine Innovative Award
✨ Diversity, Equity, and Inclusion Award
🔗 Learn more: eswiconference.org/eswi-awards/
📅 Deadline: 28 February 2025
✨ Claude Hannoun Prize for Best Body of Work
✨ Young Scientist Vaccine Innovative Award
✨ Diversity, Equity, and Inclusion Award
🔗 Learn more: eswiconference.org/eswi-awards/
December 20, 2024 at 4:00 AM
📢 Great opportunity for #EarlyCareerResearchers working on respiratory virus infections like #Influenza #Covid_19 #RSV or #Vaccine innovations & those from under-represented communities ⬇️🧑🔬
Put in your application before Feb 28th!
More information: eswiconference.org/eswi-awards
#ECR #Awards #ESWI
Put in your application before Feb 28th!
More information: eswiconference.org/eswi-awards
#ECR #Awards #ESWI
Reposted by Carolien van de Sandt
💭 What's at the top of @cvandesandt.bsky.social wish list for #vaccineplatformtechnology in the short-term? To include high-risk groups in clinical trials ensuring vaccines are as effective as for healthy individuals.
🎧 Tune in to #ESWIAirborne on #FluVaccines shorturl.at/jvVt2
#ESWIEducationHub
🎧 Tune in to #ESWIAirborne on #FluVaccines shorturl.at/jvVt2
#ESWIEducationHub
December 11, 2024 at 2:26 PM
💭 What's at the top of @cvandesandt.bsky.social wish list for #vaccineplatformtechnology in the short-term? To include high-risk groups in clinical trials ensuring vaccines are as effective as for healthy individuals.
🎧 Tune in to #ESWIAirborne on #FluVaccines shorturl.at/jvVt2
#ESWIEducationHub
🎧 Tune in to #ESWIAirborne on #FluVaccines shorturl.at/jvVt2
#ESWIEducationHub
Reposted by Carolien van de Sandt
🎯Prestigious Academic Journals @bsky.app
Active:
Science: @science.org
Nature: @natureportfolio.bsky.social
Still Not Active:
Cell: @cellpress.bsky.social
Active Medical Journals:
NEJM: @nejm.org
JAMA: @jama.com
Lancet: @thelancet.bsky.social
BMJ: @bmj.com
Active:
Science: @science.org
Nature: @natureportfolio.bsky.social
Still Not Active:
Cell: @cellpress.bsky.social
Active Medical Journals:
NEJM: @nejm.org
JAMA: @jama.com
Lancet: @thelancet.bsky.social
BMJ: @bmj.com
The New England Journal of Medicine | Research & Review Articles on Disease & Clinical Practice
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of importance ...
nejm.org
December 7, 2024 at 10:08 AM
🎯Prestigious Academic Journals @bsky.app
Active:
Science: @science.org
Nature: @natureportfolio.bsky.social
Still Not Active:
Cell: @cellpress.bsky.social
Active Medical Journals:
NEJM: @nejm.org
JAMA: @jama.com
Lancet: @thelancet.bsky.social
BMJ: @bmj.com
Active:
Science: @science.org
Nature: @natureportfolio.bsky.social
Still Not Active:
Cell: @cellpress.bsky.social
Active Medical Journals:
NEJM: @nejm.org
JAMA: @jama.com
Lancet: @thelancet.bsky.social
BMJ: @bmj.com
Reposted by Carolien van de Sandt
Check out our new preprint where we investigated the attachment and replication of a clade 2.3.4.4b HPAIV H5N1 isolate (Caspian Gull origin) in human respiratory tissues.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A 2022 avian H5N1 influenza A virus from clade 2.3.4.4b attaches to and replicates better in human respiratory epithelium than a 2005 H5N1 virus from clade 2.3.2.1
Background Highly pathogenic avian influenza (HPAI) H5 viruses of the A/Goose/Guangdong/1/1996 (GsGd) lineage pose significant global risks to wildlife, domestic animals, and humans. Recent cross-spec...
www.biorxiv.org
December 2, 2024 at 5:45 PM
Check out our new preprint where we investigated the attachment and replication of a clade 2.3.4.4b HPAIV H5N1 isolate (Caspian Gull origin) in human respiratory tissues.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Carolien van de Sandt
BLUESKY MEGA-THREAD
Altmetric is thrilled and also LITERALLY RELIEVED to officially announce:
We are now tracking research attention as it happens on Bluesky!
We have been picking up posts on the site since late Oct.
Our team is on Bluesky all day answering questions.
Let's get into it!
Altmetric is thrilled and also LITERALLY RELIEVED to officially announce:
We are now tracking research attention as it happens on Bluesky!
We have been picking up posts on the site since late Oct.
Our team is on Bluesky all day answering questions.
Let's get into it!
December 3, 2024 at 2:00 PM
BLUESKY MEGA-THREAD
Altmetric is thrilled and also LITERALLY RELIEVED to officially announce:
We are now tracking research attention as it happens on Bluesky!
We have been picking up posts on the site since late Oct.
Our team is on Bluesky all day answering questions.
Let's get into it!
Altmetric is thrilled and also LITERALLY RELIEVED to officially announce:
We are now tracking research attention as it happens on Bluesky!
We have been picking up posts on the site since late Oct.
Our team is on Bluesky all day answering questions.
Let's get into it!
How does antiviral #immunity against #influenza evolve across human lifespan? 👶➡️👧➡️👱➡️👵
Our study in Nature Immunology investigates the difference in CD8 T cell response across human lifespan - a🧵⬇️ go.unimelb.edu.au/627s
Katherine Kedzierska, Fabio Luciani, The Doherty Institute
Our study in Nature Immunology investigates the difference in CD8 T cell response across human lifespan - a🧵⬇️ go.unimelb.edu.au/627s
Katherine Kedzierska, Fabio Luciani, The Doherty Institute
November 30, 2024 at 11:10 AM
How does antiviral #immunity against #influenza evolve across human lifespan? 👶➡️👧➡️👱➡️👵
Our study in Nature Immunology investigates the difference in CD8 T cell response across human lifespan - a🧵⬇️ go.unimelb.edu.au/627s
Katherine Kedzierska, Fabio Luciani, The Doherty Institute
Our study in Nature Immunology investigates the difference in CD8 T cell response across human lifespan - a🧵⬇️ go.unimelb.edu.au/627s
Katherine Kedzierska, Fabio Luciani, The Doherty Institute