Corcoran Lab
@corcoranlab.bsky.social
she/her
Molecular virologist and Associate professor at the University of Calgary, Canada.
Molecular virologist and Associate professor at the University of Calgary, Canada.
Reposted by Corcoran Lab
New Online! Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods
Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods
Nature Reviews Molecular Cell Biology, Published online: 06 October 2025; doi:10.1038/s41580-025-00895-4Co-transcriptional mRNA maturation is a complex, multistep process. This Review focuses on how the development of long-read sequencing methods enabled investigating the timing, coordination and outcomes of alternative uses of transcription start sites, splice sites and polyadenylation sites and their disease implications.
bit.ly
October 6, 2025 at 1:32 PM
New Online! Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods
Reposted by Corcoran Lab
This is an incredibly moving thread.
Bluetorial: Women, courage, and leadership
What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
March 9, 2025 at 11:40 AM
This is an incredibly moving thread.
Reposted by Corcoran Lab
The world may be horrible at the moment, but I am thrilled to share a preprint on our work to develop novel diagnostics and tools to study #Oropouche virus, (probably) the most important virus that you’ve never heard of:
doi.org/10.1101/2025...
Bluetorial follows 🟦🧵
doi.org/10.1101/2025...
Bluetorial follows 🟦🧵
Protein-based tools for the detection and characterisation of Oropouche virus infection
Oropouche fever is a neglected tropical viral disease endemic to Latin America and the Caribbean. Oropouche fever is caused by Oropouche virus (OROV), an orthobunyavirus with a tri-segmented (-)ssRNA ...
doi.org
March 2, 2025 at 1:39 PM
The world may be horrible at the moment, but I am thrilled to share a preprint on our work to develop novel diagnostics and tools to study #Oropouche virus, (probably) the most important virus that you’ve never heard of:
doi.org/10.1101/2025...
Bluetorial follows 🟦🧵
doi.org/10.1101/2025...
Bluetorial follows 🟦🧵
Reposted by Corcoran Lab
@rorymulloy.bsky.social et al illuminate mechanism rewarding evolution of novel transcriptional start sites in SARS-CoV-2 during its adaptation to humans 👀. From: @corcoranlab.bsky.social www.biorxiv.org/content/10.1...
A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses
Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...
www.biorxiv.org
March 2, 2025 at 5:46 PM
@rorymulloy.bsky.social et al illuminate mechanism rewarding evolution of novel transcriptional start sites in SARS-CoV-2 during its adaptation to humans 👀. From: @corcoranlab.bsky.social www.biorxiv.org/content/10.1...
Reposted by Corcoran Lab
Pre-print is up! SARS-2 produces a truncated N protein to antagonize multiple antiviral pathways. A very collaborative project in the @corcoranlab.bsky.social with @nogasharlin.bsky.social, Danyel Evseev, and Max Bui-Marinos, and of course the boss Jenn Corcoran
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 2, 2025 at 5:59 PM
Pre-print is up! SARS-2 produces a truncated N protein to antagonize multiple antiviral pathways. A very collaborative project in the @corcoranlab.bsky.social with @nogasharlin.bsky.social, Danyel Evseev, and Max Bui-Marinos, and of course the boss Jenn Corcoran
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Our newest work reveals that SARS-CoV-2 evolved to produce a truncated version of its N protein to antagonize antiviral responses. This 'mini' N, called N*M210, sequesters dsRNA, blocks interferon activation, defeats RNaseL & disassembles stress granules and p-bodies. www.biorxiv.org/content/10.1...
A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses
Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...
www.biorxiv.org
February 27, 2025 at 3:35 AM
Our newest work reveals that SARS-CoV-2 evolved to produce a truncated version of its N protein to antagonize antiviral responses. This 'mini' N, called N*M210, sequesters dsRNA, blocks interferon activation, defeats RNaseL & disassembles stress granules and p-bodies. www.biorxiv.org/content/10.1...