concentris research management gmbh
@concentris.bsky.social
Success from the start: You focus on science - we do everything else
#ProposalWriting #ProjectManagement #dissemination #communication #ConferenceServices for EU-funded and German #research projects
🌐 www.concentris.de
#ProposalWriting #ProjectManagement #dissemination #communication #ConferenceServices for EU-funded and German #research projects
🌐 www.concentris.de
Reposted by concentris research management gmbh
🎉 Our new #mirobiome paper in #JHEP is out! We found distinct gut #virome shifts in #ACLF - from virulent to temperate #phages - with Lactococcus A + Enterococcus B phages linked to infections & higher 90-day mortality
👉 Read more: www.sciencedirect.com/science/arti...
📽️Video: youtu.be/0YF6qToBQUM
👉 Read more: www.sciencedirect.com/science/arti...
📽️Video: youtu.be/0YF6qToBQUM
October 24, 2025 at 11:33 AM
🎉 Our new #mirobiome paper in #JHEP is out! We found distinct gut #virome shifts in #ACLF - from virulent to temperate #phages - with Lactococcus A + Enterococcus B phages linked to infections & higher 90-day mortality
👉 Read more: www.sciencedirect.com/science/arti...
📽️Video: youtu.be/0YF6qToBQUM
👉 Read more: www.sciencedirect.com/science/arti...
📽️Video: youtu.be/0YF6qToBQUM
Reposted by concentris research management gmbh
🌍 The MICROB-PREDICT team met in Münster, Germany from 1–2 October for its 14th Steering Committee Meeting!
👉 Team leaders discussed results from 20 new papers about late-stage #LiverDisease #cirrhosis #biomarkers and IPR topics as the project nears its final phase.
The finish line is in sight!
👉 Team leaders discussed results from 20 new papers about late-stage #LiverDisease #cirrhosis #biomarkers and IPR topics as the project nears its final phase.
The finish line is in sight!
October 24, 2025 at 11:18 AM
🌍 The MICROB-PREDICT team met in Münster, Germany from 1–2 October for its 14th Steering Committee Meeting!
👉 Team leaders discussed results from 20 new papers about late-stage #LiverDisease #cirrhosis #biomarkers and IPR topics as the project nears its final phase.
The finish line is in sight!
👉 Team leaders discussed results from 20 new papers about late-stage #LiverDisease #cirrhosis #biomarkers and IPR topics as the project nears its final phase.
The finish line is in sight!
Register for this exciting and high-calibre panel discussion on early cancer detection and the impact of artificial intelligence!
📅 15 October 2025
🕑 14 - 15:00 CEST
📍 online
Register using this link: events.teams.microsoft.com/event/1fba7a...
#oncology #MedSky #OncoSky
📅 15 October 2025
🕑 14 - 15:00 CEST
📍 online
Register using this link: events.teams.microsoft.com/event/1fba7a...
#oncology #MedSky #OncoSky
🎙️Join us for the webinar “Approaches to Early Cancer Diagnosis & the Impact of #AIinOncology”
🗣️ Moderated by Federica Zanca, EIC Programme Manager
👥 Panelists:
@phireproject.bsky.social – Massimo Alfano
@pancaid.bsky.social – @nuriamalats.bsky.social
#PANCAIM – John Hermans
#Webinar
🗣️ Moderated by Federica Zanca, EIC Programme Manager
👥 Panelists:
@phireproject.bsky.social – Massimo Alfano
@pancaid.bsky.social – @nuriamalats.bsky.social
#PANCAIM – John Hermans
#Webinar
October 8, 2025 at 3:58 PM
Register for this exciting and high-calibre panel discussion on early cancer detection and the impact of artificial intelligence!
📅 15 October 2025
🕑 14 - 15:00 CEST
📍 online
Register using this link: events.teams.microsoft.com/event/1fba7a...
#oncology #MedSky #OncoSky
📅 15 October 2025
🕑 14 - 15:00 CEST
📍 online
Register using this link: events.teams.microsoft.com/event/1fba7a...
#oncology #MedSky #OncoSky
Reposted by concentris research management gmbh
Next week: the final DECISION General Assembly in Madrid! 🎉
Celebrating 5+ years of science, collaboration, & results
@rautoupe.bsky.social @concentris.bsky.social
@navarrabiomed.bsky.social
@bioeticayderecho.bsky.social
@medblab.bsky.social
@europeliver.bsky.social
@easlnews.bsky.social et al
Celebrating 5+ years of science, collaboration, & results
@rautoupe.bsky.social @concentris.bsky.social
@navarrabiomed.bsky.social
@bioeticayderecho.bsky.social
@medblab.bsky.social
@europeliver.bsky.social
@easlnews.bsky.social et al
October 1, 2025 at 8:02 AM
Next week: the final DECISION General Assembly in Madrid! 🎉
Celebrating 5+ years of science, collaboration, & results
@rautoupe.bsky.social @concentris.bsky.social
@navarrabiomed.bsky.social
@bioeticayderecho.bsky.social
@medblab.bsky.social
@europeliver.bsky.social
@easlnews.bsky.social et al
Celebrating 5+ years of science, collaboration, & results
@rautoupe.bsky.social @concentris.bsky.social
@navarrabiomed.bsky.social
@bioeticayderecho.bsky.social
@medblab.bsky.social
@europeliver.bsky.social
@easlnews.bsky.social et al
Reposted by concentris research management gmbh
✨Final spotlight of this series: Our open access protocol on a self-medication #MouseModel of #ChronicPain that helps assess spontaneous #PainRelief & #DrugAbuse liability
🔗 doi.org/10.21769/Bio...
Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado
#Neuroscience #Analgesics
🔗 doi.org/10.21769/Bio...
Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado
#Neuroscience #Analgesics
October 3, 2025 at 6:59 PM
✨Final spotlight of this series: Our open access protocol on a self-medication #MouseModel of #ChronicPain that helps assess spontaneous #PainRelief & #DrugAbuse liability
🔗 doi.org/10.21769/Bio...
Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado
#Neuroscience #Analgesics
🔗 doi.org/10.21769/Bio...
Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado
#Neuroscience #Analgesics
Reposted by concentris research management gmbh
Reposted by concentris research management gmbh
5️⃣ García-Blanco et al. (2002): www.jci.org/articles/vie...
📖 miRNA signatures associated with vulnerability to food addiction in mice & humans
💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction.
💡Targeting those miRNAs may modify maladaptive eating phenotypes.
📖 miRNA signatures associated with vulnerability to food addiction in mice & humans
💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction.
💡Targeting those miRNAs may modify maladaptive eating phenotypes.
JCI -
miRNA signatures associated with vulnerability to food addiction in mice and humans
www.jci.org
October 3, 2025 at 6:27 PM
5️⃣ García-Blanco et al. (2002): www.jci.org/articles/vie...
📖 miRNA signatures associated with vulnerability to food addiction in mice & humans
💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction.
💡Targeting those miRNAs may modify maladaptive eating phenotypes.
📖 miRNA signatures associated with vulnerability to food addiction in mice & humans
💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction.
💡Targeting those miRNAs may modify maladaptive eating phenotypes.
Reposted by concentris research management gmbh
4️⃣ academic.oup.com/ismej/articl...
📖 Presence of #Blastocystis in #GutMicrobiota associated with decreased executive function
💡Blastocystis colonisation in the gut is associated with measurable deficits in executive #CognitiveFunction, suggesting a possible #GutBrainAxis influence on cognition.
📖 Presence of #Blastocystis in #GutMicrobiota associated with decreased executive function
💡Blastocystis colonisation in the gut is associated with measurable deficits in executive #CognitiveFunction, suggesting a possible #GutBrainAxis influence on cognition.
Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function
AbstractGrowing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in hum
academic.oup.com
October 3, 2025 at 6:22 PM
4️⃣ academic.oup.com/ismej/articl...
📖 Presence of #Blastocystis in #GutMicrobiota associated with decreased executive function
💡Blastocystis colonisation in the gut is associated with measurable deficits in executive #CognitiveFunction, suggesting a possible #GutBrainAxis influence on cognition.
📖 Presence of #Blastocystis in #GutMicrobiota associated with decreased executive function
💡Blastocystis colonisation in the gut is associated with measurable deficits in executive #CognitiveFunction, suggesting a possible #GutBrainAxis influence on cognition.
Reposted by concentris research management gmbh
3️⃣ doi.org/10.3389/fpsy...
📖 Tetrahydrocannabinol #THC exposure in #adolescence elevates #impulsivity-like behaviour in #adulthood in a self-administration mouse model
💡Young-age THC exposure may produce a lasting impulsivity increase & neurochemical changes that predispose to #AddictiveBehaviour.
📖 Tetrahydrocannabinol #THC exposure in #adolescence elevates #impulsivity-like behaviour in #adulthood in a self-administration mouse model
💡Young-age THC exposure may produce a lasting impulsivity increase & neurochemical changes that predispose to #AddictiveBehaviour.
Frontiers | THC exposure during adolescence increases impulsivity-like behavior in adulthood in a WIN 55,212-2 self-administration mouse model
Cannabis addiction is a chronically relapsing disorder lacking effective treatment. Regular cannabis consumption typically begins during adolescence, and thi...
doi.org
October 3, 2025 at 6:18 PM
3️⃣ doi.org/10.3389/fpsy...
📖 Tetrahydrocannabinol #THC exposure in #adolescence elevates #impulsivity-like behaviour in #adulthood in a self-administration mouse model
💡Young-age THC exposure may produce a lasting impulsivity increase & neurochemical changes that predispose to #AddictiveBehaviour.
📖 Tetrahydrocannabinol #THC exposure in #adolescence elevates #impulsivity-like behaviour in #adulthood in a self-administration mouse model
💡Young-age THC exposure may produce a lasting impulsivity increase & neurochemical changes that predispose to #AddictiveBehaviour.
Reposted by concentris research management gmbh
1️⃣ Del Mar Cajiao-Manrique, Maldonado & Martín-García (2023) doi.org/10.3389/fpha...
📖 A self-administration mouse model to study #CannabinoidAddiction
💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.
📖 A self-administration mouse model to study #CannabinoidAddiction
💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.
Frontiers | A male mouse model of WIN 55,212–2 self-administration to study cannabinoid addiction
We have established for the first time a mouse model of cannabinoid addiction using WIN 55,212-2 intravenous self-administration (0.0125 mg/kg/infusion) in C...
doi.org
October 3, 2025 at 6:04 PM
1️⃣ Del Mar Cajiao-Manrique, Maldonado & Martín-García (2023) doi.org/10.3389/fpha...
📖 A self-administration mouse model to study #CannabinoidAddiction
💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.
📖 A self-administration mouse model to study #CannabinoidAddiction
💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.
Reposted by concentris research management gmbh
🧬🐭👩🦰👨🦰 Translational research - from mice to humans - was central to #QSPainRelief: For better #PainRelief, safer #PainMedication and improved #ChronicPain treatment.
✅ Less pain
😵💫 Fewer side effects
☺️ Better QoL
✨ Here are 5 key papers about 🧠-mechanisms linked to #addiction #cognition #impulsivity
✅ Less pain
😵💫 Fewer side effects
☺️ Better QoL
✨ Here are 5 key papers about 🧠-mechanisms linked to #addiction #cognition #impulsivity
October 3, 2025 at 6:02 PM
🧬🐭👩🦰👨🦰 Translational research - from mice to humans - was central to #QSPainRelief: For better #PainRelief, safer #PainMedication and improved #ChronicPain treatment.
✅ Less pain
😵💫 Fewer side effects
☺️ Better QoL
✨ Here are 5 key papers about 🧠-mechanisms linked to #addiction #cognition #impulsivity
✅ Less pain
😵💫 Fewer side effects
☺️ Better QoL
✨ Here are 5 key papers about 🧠-mechanisms linked to #addiction #cognition #impulsivity
Reposted by concentris research management gmbh
A more #PainRelief-relevant follow-up of the 2020 Sci. Rep. paper is this article by Ricarte, Dalton & Giraldo (2021), a year later:
🔗 doi.org/10.1021/acs....
🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR
👉 #morphine and #fentanyl elicit different activation patterns
🔗 doi.org/10.1021/acs....
🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR
👉 #morphine and #fentanyl elicit different activation patterns
October 3, 2025 at 4:21 PM
A more #PainRelief-relevant follow-up of the 2020 Sci. Rep. paper is this article by Ricarte, Dalton & Giraldo (2021), a year later:
🔗 doi.org/10.1021/acs....
🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR
👉 #morphine and #fentanyl elicit different activation patterns
🔗 doi.org/10.1021/acs....
🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR
👉 #morphine and #fentanyl elicit different activation patterns
Reposted by concentris research management gmbh
🔬 Wanna know the P-values for #agonist-dependent #GPCR activation?
👏 One of our 2 high-impact Nature publications was also the 1st QSPainRelief article:
📈 Bruzzese, Dalton & Giraldo (2020) present their #MolecularDynamics work & the best statistics to analyse it.
🔗 www.nature.com/articles/s41...
👏 One of our 2 high-impact Nature publications was also the 1st QSPainRelief article:
📈 Bruzzese, Dalton & Giraldo (2020) present their #MolecularDynamics work & the best statistics to analyse it.
🔗 www.nature.com/articles/s41...
October 3, 2025 at 4:07 PM
🔬 Wanna know the P-values for #agonist-dependent #GPCR activation?
👏 One of our 2 high-impact Nature publications was also the 1st QSPainRelief article:
📈 Bruzzese, Dalton & Giraldo (2020) present their #MolecularDynamics work & the best statistics to analyse it.
🔗 www.nature.com/articles/s41...
👏 One of our 2 high-impact Nature publications was also the 1st QSPainRelief article:
📈 Bruzzese, Dalton & Giraldo (2020) present their #MolecularDynamics work & the best statistics to analyse it.
🔗 www.nature.com/articles/s41...
Reposted by concentris research management gmbh
Here's another important QSPainRelief publication about allosteric sites at #GPCRs: They can be identified by looking at how strongly certain receptor sites are coupled to #conformational changes that occur during activation.
🔗 doi.org/10.3390/ijms...
#allostery #pharmacology #receptors #ligands
🔗 doi.org/10.3390/ijms...
#allostery #pharmacology #receptors #ligands
October 3, 2025 at 3:31 PM
Here's another important QSPainRelief publication about allosteric sites at #GPCRs: They can be identified by looking at how strongly certain receptor sites are coupled to #conformational changes that occur during activation.
🔗 doi.org/10.3390/ijms...
#allostery #pharmacology #receptors #ligands
🔗 doi.org/10.3390/ijms...
#allostery #pharmacology #receptors #ligands
Reposted by concentris research management gmbh
Speaking of #allostery: What happens when you mutate the #CannabinoidReceptor (CB1) in silico with a single-point mutation?
Find out👉: doi.org/10.1021/acso...
Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation
#GPCR
Find out👉: doi.org/10.1021/acso...
Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation
#GPCR
October 3, 2025 at 1:31 PM
Speaking of #allostery: What happens when you mutate the #CannabinoidReceptor (CB1) in silico with a single-point mutation?
Find out👉: doi.org/10.1021/acso...
Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation
#GPCR
Find out👉: doi.org/10.1021/acso...
Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation
#GPCR
Reposted by concentris research management gmbh
🎯Feature Alert 🚨
This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about
👉 WHERE molecules bind
👉 HOW FAST
👉 and in WHICH SEQUENCE
🔗 doi.org/10.1016/j.dr...
#allostery #pharmacology #DrugDesign #GPCRs
This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about
👉 WHERE molecules bind
👉 HOW FAST
👉 and in WHICH SEQUENCE
🔗 doi.org/10.1016/j.dr...
#allostery #pharmacology #DrugDesign #GPCRs
October 3, 2025 at 1:22 PM
🎯Feature Alert 🚨
This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about
👉 WHERE molecules bind
👉 HOW FAST
👉 and in WHICH SEQUENCE
🔗 doi.org/10.1016/j.dr...
#allostery #pharmacology #DrugDesign #GPCRs
This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about
👉 WHERE molecules bind
👉 HOW FAST
👉 and in WHICH SEQUENCE
🔗 doi.org/10.1016/j.dr...
#allostery #pharmacology #DrugDesign #GPCRs
Reposted by concentris research management gmbh
🚀 Time-dependent #ligand-receptor #BindingKinetics and functionality in a #heterodimeric receptor model by Ortiz et al. (2024): Predicting how 2 drugs bind to a receptor complex over time - with implications for combination-therapies and #DrugDesign💊
🔗 doi.org/10.1016/j.bc...
#Pharmacology #GPCRs
🔗 doi.org/10.1016/j.bc...
#Pharmacology #GPCRs
October 3, 2025 at 12:29 PM
🚀 Time-dependent #ligand-receptor #BindingKinetics and functionality in a #heterodimeric receptor model by Ortiz et al. (2024): Predicting how 2 drugs bind to a receptor complex over time - with implications for combination-therapies and #DrugDesign💊
🔗 doi.org/10.1016/j.bc...
#Pharmacology #GPCRs
🔗 doi.org/10.1016/j.bc...
#Pharmacology #GPCRs
Reposted by concentris research management gmbh
🔦 Spotlight on link.springer.com/article/10.1...
🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs
✅ Accurate for 7 drugs
✅ First mechanistic #CNS PBPK #model in mice
✅ Strong translational potential
#TranslationalPharmacology #DrugDevelopment
🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs
✅ Accurate for 7 drugs
✅ First mechanistic #CNS PBPK #model in mice
✅ Strong translational potential
#TranslationalPharmacology #DrugDevelopment
October 3, 2025 at 12:13 PM
🔦 Spotlight on link.springer.com/article/10.1...
🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs
✅ Accurate for 7 drugs
✅ First mechanistic #CNS PBPK #model in mice
✅ Strong translational potential
#TranslationalPharmacology #DrugDevelopment
🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs
✅ Accurate for 7 drugs
✅ First mechanistic #CNS PBPK #model in mice
✅ Strong translational potential
#TranslationalPharmacology #DrugDevelopment
Reposted by concentris research management gmbh
The paper by Budda et al. (2024) relates to the earlier publication by Gülave et al. (2023): doi.org/10.1016/j.ej...
🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!
🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!
October 3, 2025 at 11:19 AM
The paper by Budda et al. (2024) relates to the earlier publication by Gülave et al. (2023): doi.org/10.1016/j.ej...
🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!
🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!
Reposted by concentris research management gmbh
🧠 Non-linear blood-brain barrier #BBB transport & dosing influence #receptor #occupancy ratios of #morphine and #MorphineMetabolites (M3G + M6G) in the #pain matrix.
💡This might also explain some inter-individual differences!
🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
#ChronicPain #opioids
💡This might also explain some inter-individual differences!
🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
#ChronicPain #opioids
October 3, 2025 at 11:08 AM
🧠 Non-linear blood-brain barrier #BBB transport & dosing influence #receptor #occupancy ratios of #morphine and #MorphineMetabolites (M3G + M6G) in the #pain matrix.
💡This might also explain some inter-individual differences!
🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
#ChronicPain #opioids
💡This might also explain some inter-individual differences!
🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
#ChronicPain #opioids
Reposted by concentris research management gmbh
🔬By Bertayli et al (2024): PK-PD modelling of #morphine, #pregabalin & their combination shows synergistic #analgesia.
Potential impact:
👉 Lowering #opioid doses
👉 Maintaining treatment efficacy
👉 Reducing side effects & abuse liability
🔗 www.page-meeting.org/default.asp?...
#ChronicPain #Pain
Potential impact:
👉 Lowering #opioid doses
👉 Maintaining treatment efficacy
👉 Reducing side effects & abuse liability
🔗 www.page-meeting.org/default.asp?...
#ChronicPain #Pain
October 3, 2025 at 10:21 AM
🔬By Bertayli et al (2024): PK-PD modelling of #morphine, #pregabalin & their combination shows synergistic #analgesia.
Potential impact:
👉 Lowering #opioid doses
👉 Maintaining treatment efficacy
👉 Reducing side effects & abuse liability
🔗 www.page-meeting.org/default.asp?...
#ChronicPain #Pain
Potential impact:
👉 Lowering #opioid doses
👉 Maintaining treatment efficacy
👉 Reducing side effects & abuse liability
🔗 www.page-meeting.org/default.asp?...
#ChronicPain #Pain
Reposted by concentris research management gmbh
📖 Just published 💊
👉 Introducing a rigorous theoretical framework for better #quantification of #drug-target #ResidenceTime (RT) - a key metric in #BindingKinetics that has lacked a firm quantitative foundation to date 👏
🔗 www.sciencedirect.com/science/arti...
#Pharmacology #ComputationalBiology
👉 Introducing a rigorous theoretical framework for better #quantification of #drug-target #ResidenceTime (RT) - a key metric in #BindingKinetics that has lacked a firm quantitative foundation to date 👏
🔗 www.sciencedirect.com/science/arti...
#Pharmacology #ComputationalBiology
October 3, 2025 at 9:47 AM
📖 Just published 💊
👉 Introducing a rigorous theoretical framework for better #quantification of #drug-target #ResidenceTime (RT) - a key metric in #BindingKinetics that has lacked a firm quantitative foundation to date 👏
🔗 www.sciencedirect.com/science/arti...
#Pharmacology #ComputationalBiology
👉 Introducing a rigorous theoretical framework for better #quantification of #drug-target #ResidenceTime (RT) - a key metric in #BindingKinetics that has lacked a firm quantitative foundation to date 👏
🔗 www.sciencedirect.com/science/arti...
#Pharmacology #ComputationalBiology
Reposted by concentris research management gmbh
🧪 Our new paper on the #pharmacokinetics of P-glycoprotein substrates in #brainECF shows how #invitro transport data can guide #invivo 🧠🐭🚶♀️predictions, but that high variability still limits the robustness of these predictions.
🔗 link.springer.com/article/10.1...
👉LeiCNS-PK3.4 PBPK model #CNS #brain
🔗 link.springer.com/article/10.1...
👉LeiCNS-PK3.4 PBPK model #CNS #brain
October 3, 2025 at 9:35 AM
🧪 Our new paper on the #pharmacokinetics of P-glycoprotein substrates in #brainECF shows how #invitro transport data can guide #invivo 🧠🐭🚶♀️predictions, but that high variability still limits the robustness of these predictions.
🔗 link.springer.com/article/10.1...
👉LeiCNS-PK3.4 PBPK model #CNS #brain
🔗 link.springer.com/article/10.1...
👉LeiCNS-PK3.4 PBPK model #CNS #brain
Reposted by concentris research management gmbh
🫶 Our recent review shows that #SocialSupport is a powerful boost for #MentalHealth in #ChronicPain ⚡ , but its impact on pain intensity and daily function is less clear.
👉 Social support is crucial, but HOW matters
🔗 doi.org/10.1371/jour...
#QoL #PainResearch #Pain
@plosone.org @efic.bsky.social
👉 Social support is crucial, but HOW matters
🔗 doi.org/10.1371/jour...
#QoL #PainResearch #Pain
@plosone.org @efic.bsky.social
October 3, 2025 at 7:48 AM
🫶 Our recent review shows that #SocialSupport is a powerful boost for #MentalHealth in #ChronicPain ⚡ , but its impact on pain intensity and daily function is less clear.
👉 Social support is crucial, but HOW matters
🔗 doi.org/10.1371/jour...
#QoL #PainResearch #Pain
@plosone.org @efic.bsky.social
👉 Social support is crucial, but HOW matters
🔗 doi.org/10.1371/jour...
#QoL #PainResearch #Pain
@plosone.org @efic.bsky.social