concentris research management gmbh
@concentris.bsky.social
Success from the start: You focus on science - we do everything else
#ProposalWriting #ProjectManagement #dissemination #communication #ConferenceServices for EU-funded and German #research projects
🌐 www.concentris.de
#ProposalWriting #ProjectManagement #dissemination #communication #ConferenceServices for EU-funded and German #research projects
🌐 www.concentris.de
Reposted by concentris research management gmbh
Reposted by concentris research management gmbh
5️⃣ García-Blanco et al. (2002): www.jci.org/articles/vie...
📖 miRNA signatures associated with vulnerability to food addiction in mice & humans
💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction.
💡Targeting those miRNAs may modify maladaptive eating phenotypes.
📖 miRNA signatures associated with vulnerability to food addiction in mice & humans
💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction.
💡Targeting those miRNAs may modify maladaptive eating phenotypes.
JCI -
miRNA signatures associated with vulnerability to food addiction in mice and humans
www.jci.org
October 3, 2025 at 6:27 PM
5️⃣ García-Blanco et al. (2002): www.jci.org/articles/vie...
📖 miRNA signatures associated with vulnerability to food addiction in mice & humans
💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction.
💡Targeting those miRNAs may modify maladaptive eating phenotypes.
📖 miRNA signatures associated with vulnerability to food addiction in mice & humans
💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction.
💡Targeting those miRNAs may modify maladaptive eating phenotypes.
Reposted by concentris research management gmbh
4️⃣ academic.oup.com/ismej/articl...
📖 Presence of #Blastocystis in #GutMicrobiota associated with decreased executive function
💡Blastocystis colonisation in the gut is associated with measurable deficits in executive #CognitiveFunction, suggesting a possible #GutBrainAxis influence on cognition.
📖 Presence of #Blastocystis in #GutMicrobiota associated with decreased executive function
💡Blastocystis colonisation in the gut is associated with measurable deficits in executive #CognitiveFunction, suggesting a possible #GutBrainAxis influence on cognition.
Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function
AbstractGrowing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in hum
academic.oup.com
October 3, 2025 at 6:22 PM
4️⃣ academic.oup.com/ismej/articl...
📖 Presence of #Blastocystis in #GutMicrobiota associated with decreased executive function
💡Blastocystis colonisation in the gut is associated with measurable deficits in executive #CognitiveFunction, suggesting a possible #GutBrainAxis influence on cognition.
📖 Presence of #Blastocystis in #GutMicrobiota associated with decreased executive function
💡Blastocystis colonisation in the gut is associated with measurable deficits in executive #CognitiveFunction, suggesting a possible #GutBrainAxis influence on cognition.
Reposted by concentris research management gmbh
3️⃣ doi.org/10.3389/fpsy...
📖 Tetrahydrocannabinol #THC exposure in #adolescence elevates #impulsivity-like behaviour in #adulthood in a self-administration mouse model
💡Young-age THC exposure may produce a lasting impulsivity increase & neurochemical changes that predispose to #AddictiveBehaviour.
📖 Tetrahydrocannabinol #THC exposure in #adolescence elevates #impulsivity-like behaviour in #adulthood in a self-administration mouse model
💡Young-age THC exposure may produce a lasting impulsivity increase & neurochemical changes that predispose to #AddictiveBehaviour.
Frontiers | THC exposure during adolescence increases impulsivity-like behavior in adulthood in a WIN 55,212-2 self-administration mouse model
Cannabis addiction is a chronically relapsing disorder lacking effective treatment. Regular cannabis consumption typically begins during adolescence, and thi...
doi.org
October 3, 2025 at 6:18 PM
3️⃣ doi.org/10.3389/fpsy...
📖 Tetrahydrocannabinol #THC exposure in #adolescence elevates #impulsivity-like behaviour in #adulthood in a self-administration mouse model
💡Young-age THC exposure may produce a lasting impulsivity increase & neurochemical changes that predispose to #AddictiveBehaviour.
📖 Tetrahydrocannabinol #THC exposure in #adolescence elevates #impulsivity-like behaviour in #adulthood in a self-administration mouse model
💡Young-age THC exposure may produce a lasting impulsivity increase & neurochemical changes that predispose to #AddictiveBehaviour.
Reposted by concentris research management gmbh
1️⃣ Del Mar Cajiao-Manrique, Maldonado & Martín-García (2023) doi.org/10.3389/fpha...
📖 A self-administration mouse model to study #CannabinoidAddiction
💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.
📖 A self-administration mouse model to study #CannabinoidAddiction
💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.
Frontiers | A male mouse model of WIN 55,212–2 self-administration to study cannabinoid addiction
We have established for the first time a mouse model of cannabinoid addiction using WIN 55,212-2 intravenous self-administration (0.0125 mg/kg/infusion) in C...
doi.org
October 3, 2025 at 6:04 PM
1️⃣ Del Mar Cajiao-Manrique, Maldonado & Martín-García (2023) doi.org/10.3389/fpha...
📖 A self-administration mouse model to study #CannabinoidAddiction
💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.
📖 A self-administration mouse model to study #CannabinoidAddiction
💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.
Reposted by concentris research management gmbh
A more #PainRelief-relevant follow-up of the 2020 Sci. Rep. paper is this article by Ricarte, Dalton & Giraldo (2021), a year later:
🔗 doi.org/10.1021/acs....
🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR
👉 #morphine and #fentanyl elicit different activation patterns
🔗 doi.org/10.1021/acs....
🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR
👉 #morphine and #fentanyl elicit different activation patterns
October 3, 2025 at 4:21 PM
A more #PainRelief-relevant follow-up of the 2020 Sci. Rep. paper is this article by Ricarte, Dalton & Giraldo (2021), a year later:
🔗 doi.org/10.1021/acs....
🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR
👉 #morphine and #fentanyl elicit different activation patterns
🔗 doi.org/10.1021/acs....
🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR
👉 #morphine and #fentanyl elicit different activation patterns
Reposted by concentris research management gmbh
Here's another important QSPainRelief publication about allosteric sites at #GPCRs: They can be identified by looking at how strongly certain receptor sites are coupled to #conformational changes that occur during activation.
🔗 doi.org/10.3390/ijms...
#allostery #pharmacology #receptors #ligands
🔗 doi.org/10.3390/ijms...
#allostery #pharmacology #receptors #ligands
October 3, 2025 at 3:31 PM
Here's another important QSPainRelief publication about allosteric sites at #GPCRs: They can be identified by looking at how strongly certain receptor sites are coupled to #conformational changes that occur during activation.
🔗 doi.org/10.3390/ijms...
#allostery #pharmacology #receptors #ligands
🔗 doi.org/10.3390/ijms...
#allostery #pharmacology #receptors #ligands
Reposted by concentris research management gmbh
Speaking of #allostery: What happens when you mutate the #CannabinoidReceptor (CB1) in silico with a single-point mutation?
Find out👉: doi.org/10.1021/acso...
Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation
#GPCR
Find out👉: doi.org/10.1021/acso...
Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation
#GPCR
October 3, 2025 at 1:31 PM
Speaking of #allostery: What happens when you mutate the #CannabinoidReceptor (CB1) in silico with a single-point mutation?
Find out👉: doi.org/10.1021/acso...
Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation
#GPCR
Find out👉: doi.org/10.1021/acso...
Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation
#GPCR
Reposted by concentris research management gmbh
The paper by Budda et al. (2024) relates to the earlier publication by Gülave et al. (2023): doi.org/10.1016/j.ej...
🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!
🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!
October 3, 2025 at 11:19 AM
The paper by Budda et al. (2024) relates to the earlier publication by Gülave et al. (2023): doi.org/10.1016/j.ej...
🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!
🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!