Cole Scholtz
@colescholtz.bsky.social
Chemist, Father, Enjoyer of all things card game
Current Post-Doc in the Parker Lab (Washington University STL) focused on analytical methods for emerging organic water contaminates.
All views are my own.
Current Post-Doc in the Parker Lab (Washington University STL) focused on analytical methods for emerging organic water contaminates.
All views are my own.
Reposted by Cole Scholtz
September 18, 2025 at 11:41 PM
And its finally out! Check out my recent article investigating the role of BRD4 in inflammation. But what excites me the most: we explore the safety side of things, and reduce the risk of BET side effects by >50 fold through more selective molecules.
pubs.acs.org/doi/10.1021/...
#chemsky
pubs.acs.org/doi/10.1021/...
#chemsky
Efficacy and Toxicity Analysis of Selective BET Bromodomain Inhibitors in Models of Inflammatory Liver Disease
BET bromodomain inhibitors demonstrate significant promise as anti-inflammatory agents. However, clinical data demonstrated that nonselective BET bromodomain inhibitors led to significant dose-limitin...
pubs.acs.org
April 15, 2025 at 11:49 PM
And its finally out! Check out my recent article investigating the role of BRD4 in inflammation. But what excites me the most: we explore the safety side of things, and reduce the risk of BET side effects by >50 fold through more selective molecules.
pubs.acs.org/doi/10.1021/...
#chemsky
pubs.acs.org/doi/10.1021/...
#chemsky
Reposted by Cole Scholtz
Share with US students who had their offers of admission withdrawn for PhD programs:
Apply to Canada. Check out Canadian professors, and contact us. Our system works differently here, and we are all still, technically, able to accept students for Fall 2025.
Apply to Canada. Check out Canadian professors, and contact us. Our system works differently here, and we are all still, technically, able to accept students for Fall 2025.
March 13, 2025 at 12:44 AM
Share with US students who had their offers of admission withdrawn for PhD programs:
Apply to Canada. Check out Canadian professors, and contact us. Our system works differently here, and we are all still, technically, able to accept students for Fall 2025.
Apply to Canada. Check out Canadian professors, and contact us. Our system works differently here, and we are all still, technically, able to accept students for Fall 2025.
Reposted by Cole Scholtz
I know some of my relatives think this shit. Fortunately they’ve been at it for years and I already blocked them on everything blockable.
The nature of a cult is that it will turn you against your own family. Your loved ones will cheer as you are led off to the camps because hurting even you is what is necessary to bring on the glorious nation. apnews.com/article/trum...
Thrust into unemployment, axed federal workers face relatives who celebrate their firing
Scrambling to replace their health insurance and to find new work, some fired federal workers are running into another unexpected unpleasantry: Relatives cheering their job loss.
apnews.com
March 8, 2025 at 3:07 PM
I know some of my relatives think this shit. Fortunately they’ve been at it for years and I already blocked them on everything blockable.
Reposted by Cole Scholtz
Graduate programs ceasing admissions in the US due to funding being cut off is going to cause a really interesting predicament for private industry when companies want to hire trained researchers in 4-5 years.
March 1, 2025 at 11:35 PM
Graduate programs ceasing admissions in the US due to funding being cut off is going to cause a really interesting predicament for private industry when companies want to hire trained researchers in 4-5 years.
Reposted by Cole Scholtz
Next year, the EU will require cars to have buttons & dials -- not just touchscreens -- to get a top safety rating.
This is a great move. Drivers can fiddle with knobs & buttons without taking their eyes off the road, but they can't do that with touchscreens.
(Even better: Tesla will hate this)
This is a great move. Drivers can fiddle with knobs & buttons without taking their eyes off the road, but they can't do that with touchscreens.
(Even better: Tesla will hate this)
Cars will need fewer screens and more buttons to earn five-star safety rating in Europe
Euro NCAP will release new testing guidelines in 2026.
www.theverge.com
February 27, 2025 at 4:27 PM
Next year, the EU will require cars to have buttons & dials -- not just touchscreens -- to get a top safety rating.
This is a great move. Drivers can fiddle with knobs & buttons without taking their eyes off the road, but they can't do that with touchscreens.
(Even better: Tesla will hate this)
This is a great move. Drivers can fiddle with knobs & buttons without taking their eyes off the road, but they can't do that with touchscreens.
(Even better: Tesla will hate this)
Reposted by Cole Scholtz
Every scientist, long before they were a scientist, was a little kid who stood in front of a fish tank or stared up at the stars or turned over a rock to look at the bugs underneath and said “wow”. On the best days, working in science still feels like that.
February 19, 2025 at 2:08 AM
Every scientist, long before they were a scientist, was a little kid who stood in front of a fish tank or stared up at the stars or turned over a rock to look at the bugs underneath and said “wow”. On the best days, working in science still feels like that.
Reposted by Cole Scholtz
Watery Grave painted after Sir John Everett Millais's 1851-52 work 'Ophelia'.
February 12, 2025 at 5:39 PM
Watery Grave painted after Sir John Everett Millais's 1851-52 work 'Ophelia'.
This is where I really miss bookmarks. Just spent 15 min sorting through and trying to find the helpful post on recrystallization. Can’t find it for the life of me #chemsky
January 29, 2025 at 5:10 PM
This is where I really miss bookmarks. Just spent 15 min sorting through and trying to find the helpful post on recrystallization. Can’t find it for the life of me #chemsky
Reposted by Cole Scholtz
I’m Canadian so I respect that I’m steps removed from all this, but if you’re a US elected official, coming on here to post, “AND he’s also done THIS horrible thing!”
…if your post does not then CONTINUE with, “and I’m doing THIS about it,” then just fuck off.
…if your post does not then CONTINUE with, “and I’m doing THIS about it,” then just fuck off.
January 28, 2025 at 9:03 PM
I’m Canadian so I respect that I’m steps removed from all this, but if you’re a US elected official, coming on here to post, “AND he’s also done THIS horrible thing!”
…if your post does not then CONTINUE with, “and I’m doing THIS about it,” then just fuck off.
…if your post does not then CONTINUE with, “and I’m doing THIS about it,” then just fuck off.
Reposted by Cole Scholtz
I believe the general internet tradition on these kinds of things is well known.
techcrunch.com/2023/04/21/m...
techcrunch.com/2023/04/21/m...
January 22, 2025 at 11:53 PM
I believe the general internet tradition on these kinds of things is well known.
techcrunch.com/2023/04/21/m...
techcrunch.com/2023/04/21/m...
Reposted by Cole Scholtz
Can we talk people out of donating to Salvation Army entirely, please!
They force their charity recipients to attend religious conversion sessions as part of receiving assistance.
AND they're wildly transphobic and homophobic!
Fund better charities!
They force their charity recipients to attend religious conversion sessions as part of receiving assistance.
AND they're wildly transphobic and homophobic!
Fund better charities!
Salvation Army says holiday donations down 50 per cent since mail strike began (Canada)
Salvation Army says holiday donations down 50 per cent since mail strike began - Canada News
The Salvation Army says holiday donations are down 50 per cent since the Canada Post strike began, amounting to a drop of roughly $9.3 million in seasonal giving compared to this time last year.
www.castanet.net
December 9, 2024 at 2:11 PM
Can we talk people out of donating to Salvation Army entirely, please!
They force their charity recipients to attend religious conversion sessions as part of receiving assistance.
AND they're wildly transphobic and homophobic!
Fund better charities!
They force their charity recipients to attend religious conversion sessions as part of receiving assistance.
AND they're wildly transphobic and homophobic!
Fund better charities!
Reposted by Cole Scholtz
Check out some of our latest work in the style of Wes Anderson! We love recycling in any form 🐥♻️ #wesandersontrend #recycling #chemistry #chemsky
November 23, 2024 at 2:59 PM
Check out some of our latest work in the style of Wes Anderson! We love recycling in any form 🐥♻️ #wesandersontrend #recycling #chemistry #chemsky
Getting into painting again, so posting some old work here for inspiration :) #mtg #mtgalters
November 14, 2024 at 2:46 PM
Getting into painting again, so posting some old work here for inspiration :) #mtg #mtgalters
Reposted by Cole Scholtz
Hey Bluesky. Newest piece.
November 13, 2024 at 4:06 AM
Hey Bluesky. Newest piece.
Officially made the migration, so I’d thought I’d start off with some shameless self promotion. Wanted to share the preprint of a great collab with the Mayo Clinic, where we examine the role of BET selectivity in inflammation.
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Efficacy and toxicity analysis of selective BET bromodomain inhibitors in models of inflammatory liver disease
BET bromodomain inhibitors demonstrate significant promise as anti-inflammatory agents targeting a variety of inflammatory disorders. However, clinical data has demonstrated that the administration of...
chemrxiv.org
November 11, 2024 at 12:54 PM
Officially made the migration, so I’d thought I’d start off with some shameless self promotion. Wanted to share the preprint of a great collab with the Mayo Clinic, where we examine the role of BET selectivity in inflammation.
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...